RGD Reference Report - Expression of CXC chemokine IP-10/Mob-1 by primary hepatocytes following heat shock. - Rat Genome Database

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Expression of CXC chemokine IP-10/Mob-1 by primary hepatocytes following heat shock.

Authors: Hassanshahi, G  Patel, SS  Jafarzadeh, AA  Dickson, AJ 
Citation: Hassanshahi G, etal., Saudi Med J. 2007 Apr;28(4):514-8.
RGD ID: 2311382
Pubmed: PMID:17457469   (View Abstract at PubMed)

OBJECTIVE: To examine the expression of chemokine IP-10/Mob-1 of hepatocytes in responses to the stress imposed during isolation by collagenase perfusion. METHODS: This study was performed in the Faculty of Life Sciences University of Manchester during 2001-2005. We employed western and northern blotting analysis to detect IP-10/Mob-1 in isolated and cultured hepatocytes in response to isolation stresses and under heat shock stimulation in this project. RESULTS: We showed that the ELR-CXC chemokine, IP-10/Mob-1 is secreted from isolated rat hepatocytes immediately after isolation and early during culture and IP-10/Mob-1, expression by hepatocytes was also stimulated in response to heat shock. CONCLUSION: It seems that hepatocytes mimic the experiences of liver injury in vivo such as during stress, trauma, or after insults, and therefore, produce stress related agents like IP-10/Mob-1 chemokine to overcome such a injurious condition following isolation and heat shock stimulation. This study also provides a useful model to study the regulation of expression of this chemokines in vitro.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cxcl10Ratcellular response to heat  IEP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cxcl10Ratextracellular space  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl10  (C-X-C motif chemokine ligand 10)


Additional Information