RGD Reference Report - Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection. - Rat Genome Database

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Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection.

Authors: Svensson, Mattias  Zubairi, Soombul  Maroof, Asher  Kazi, Fatima  Taniguchi, Masaru  Kaye, Paul M 
Citation: Svensson M, etal., Infect Immun. 2005 Nov;73(11):7541-7. doi: 10.1128/IAI.73.11.7541-7547.2005.
RGD ID: 27095947
Pubmed: PMID:16239557   (View Abstract at PubMed)
PMCID: PMC1273891   (View Article at PubMed Central)
DOI: DOI:10.1128/IAI.73.11.7541-7547.2005   (Journal Full-text)

Gamma interferon (IFN-gamma)-regulated chemokines of the CXC family have been implicated as key regulators of a variety of T-cell-dependent inflammatory processes. However, the cellular source(s) of IFN-gamma that regulates their early expression has rarely been defined. Here, we have directly addressed this question in mice after Leishmania donovani infection. Comparison of CXCL10 mRNA accumulation in normal and IFN-gamma-deficient mice confirmed an absolute requirement for IFN-gamma for sustained (24 h) expression of CXCL10 mRNA accumulation in this model. In normal mice, IFN-gamma was produced by both CD3int NK1.1+ NKT cells and CD3- NK1.1+ NK cells, as detected by intracellular flow cytometry. Strikingly, B6.Jalpha281-/- mice lacking NKT cells that express the invariant Valpha14Jalpha18 T-cell-receptor alpha chain, although retaining a significant population of IFN-gamma-producing NK cells and NKT cells, were unable to sustain CXCL10 mRNA accumulation. These data indicate that invariant NKT cells are indispensable for the regulation of hepatic CXCL10 gene expression during L. donovani infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CXCL10Humanvisceral leishmaniasis  ISOCxcl10 (Mus musculus)mRNA:increased expression:liverRGD 
Cxcl10Ratvisceral leishmaniasis  ISOCxcl10 (Mus musculus)mRNA:increased expression:liverRGD 
Cxcl10Mousevisceral leishmaniasis  IEP mRNA:increased expression:liverRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl10  (C-X-C motif chemokine ligand 10)

Genes (Mus musculus)
Cxcl10  (C-X-C motif chemokine ligand 10)

Genes (Homo sapiens)
CXCL10  (C-X-C motif chemokine ligand 10)


Additional Information