ADAM28 (ADAM metallopeptidase domain 28)

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Gene: ADAM28 (ADAM metallopeptidase domain 28) Canis lupus familiaris

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Symbol:

ADAM28

Name:

ADAM metallopeptidase domain 28

RGD ID:

12264978

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); immunoglobulin receptor binding (inferred); metal ion binding (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH asbestos-related lung carcinoma (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

disintegrin and metalloproteinase domain-containing protein 28

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	33,092,645 - 33,147,791 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	33,092,628 - 33,264,710 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	33,677,242 - 33,732,321 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	33,298,789 - 33,353,872 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	33,299,274 - 33,470,021 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	33,246,937 - 33,302,028 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	33,103,486 - 33,158,752 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	33,261,650 - 33,316,886 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asbestos-related lung carcinoma (ISO)

breast cancer (ISO)

breast carcinoma (ISO)

colorectal cancer (ISO)

estrogen-receptor positive breast cancer (ISO)

hereditary spastic paraplegia (ISO)

invasive ductal carcinoma (ISO)

liver cancer (ISO)

lung adenocarcinoma (ISO)

lung metastasis (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

Prostatic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

cell surface (ISO)

membrane (IEA)

mitochondrion (IEA)

plasma membrane (IEA)

Molecular Function

hydrolase activity (IEA)

immunoglobulin receptor binding (IEA)

metal ion binding (IEA)

metalloendopeptidase activity (IEA)

metallopeptidase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ADAM28
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	33,092,645 - 33,147,791 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	33,092,628 - 33,264,710 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	33,677,242 - 33,732,321 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	33,298,789 - 33,353,872 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	33,299,274 - 33,470,021 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	33,246,937 - 33,302,028 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	33,103,486 - 33,158,752 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	33,261,650 - 33,316,886 (-)	NCBI		UU_Cfam_GSD_1.0

ADAM28
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	24,294,069 - 24,359,014 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	24,294,069 - 24,359,014 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	24,151,582 - 24,216,527 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	24,207,525 - 24,268,671 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	23,115,137 - 23,176,304 (+)	NCBI		Celera
Cytogenetic Map	8	p21.2	NCBI
HuRef	8	22,696,187 - 22,757,353 (+)	NCBI		HuRef
CHM1_1	8	24,353,747 - 24,414,881 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	24,569,171 - 24,634,154 (+)	NCBI		T2T-CHM13v2.0

Adam28
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	68,842,447 - 68,893,338 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	68,843,476 - 68,893,291 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	68,604,998 - 68,655,889 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	68,606,027 - 68,655,842 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	69,224,084 - 69,273,899 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	67,560,209 - 67,609,172 (-)	NCBI		MGSCv36	mm8
Celera	14	66,379,012 - 66,429,923 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	35.69	NCBI

Adam28
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	50,184,286 - 50,250,605 (-)	NCBI		GRCr8
mRatBN7.2	15	43,774,463 - 43,840,726 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	42,944,467 - 43,840,672 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	47,893,627 - 47,958,632 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	49,005,105 - 49,070,113 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	45,864,488 - 45,929,498 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	50,356,745 - 50,425,911 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	50,358,192 - 50,425,900 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	54,088,439 - 54,158,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	49,020,423 - 49,085,202 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	49,036,202 - 49,100,982 (-)	NCBI
Celera	15	43,474,975 - 43,539,804 (-)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

Adam28
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	47,319,382 - 47,409,380 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	47,304,711 - 47,409,369 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADAM28
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	42,796,292 - 42,863,608 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	18,523,249 - 18,602,127 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	23,549,892 - 23,623,859 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	20,474,820 - 20,540,955 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	20,474,029 - 20,540,692 (+)	Ensembl	panpan1.1		panPan2

Adam28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	10,905,896 - 10,954,986 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936555	7,617,822 - 7,664,215 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936555	7,615,639 - 7,660,776 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAM28
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	8,375,212 - 8,438,615 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	8,375,169 - 8,438,622 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	9,418,095 - 9,481,491 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAM28
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	22,424,260 - 22,483,878 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	22,430,579 - 22,488,257 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	19,696,502 - 19,763,128 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adam28
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	19,432,817 - 19,497,686 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	19,427,871 - 19,499,510 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ADAM28
896 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022409856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038435396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038510335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038573786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038638102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_845863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002619086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002619087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005301823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005344810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005378676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005412488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000302	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000014470 ⟹ ENSCAFP00000013383

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	25	33,092,628 - 33,148,033 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000078276 ⟹ ENSCAFP00000063273

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	25	33,092,628 - 33,264,710 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000086567 ⟹ ENSCAFP00000052114

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	25	33,092,628 - 33,148,033 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027000 ⟹ ENSCAFP00845021247

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	25	33,299,274 - 33,470,021 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027190 ⟹ ENSCAFP00845021390

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	25	33,299,274 - 33,354,020 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027386 ⟹ ENSCAFP00845021556

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	25	33,299,274 - 33,354,020 (-)	Ensembl

RefSeq Acc Id:

XM_038435396 ⟹ XP_038291324

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	25	33,298,789 - 33,353,872 (-)	NCBI

RefSeq Acc Id:

XM_038510335 ⟹ XP_038366263

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	25	33,246,937 - 33,302,028 (-)	NCBI

RefSeq Acc Id:

XM_038573786 ⟹ XP_038429714

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	25	33,261,650 - 33,316,886 (-)	NCBI

RefSeq Acc Id:

XM_038638102 ⟹ XP_038494030

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	25	33,103,486 - 33,158,752 (-)	NCBI

RefSeq Acc Id:

XM_845863 ⟹ XP_850956

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	25	33,092,645 - 33,147,789 (-)	NCBI
Dog10K_Boxer_Tasha	25	33,677,242 - 33,732,321 (-)	NCBI

Sequence:

show sequence

TCCTGAAGCAGAGACAGGAATGAGCCCAGAGTTTCATTCTGTCTTGCTTGAGCAGAGGCAGGGA
CAGCGGAGGAGCAGAGGAGCAGTGCTCTCCCAGGGAGCACGAAGGGAAGGCGCTGCACCCCTGA
ACTCACCTATCATGTTGCAGGGGATTCTTCTGACCACCACTTTCCTCCTTTGGCCAGTTCCAGT
AAATACTATCAAGGAACTCCCTGGAATAAAGAACTATGAAGTGGTTTATCCCAGAAGACTTCAT
CCACTACATAAAAGAGAGGTCAAGGACCCAGACCAACAGGAAAAATTTGAAACCGAATTGAAGT
ATAAAATGACTGTTAATGGGAAAATTGCAGTACTTTACTTGAAAAAAAACAATGGTCTCCTTGC
TCCTGGTTACACGGAAACACATTATAATTCCACTGGAGAGGAGATCACCACAAGCCCACAAATC
ATGGATGACTGCTATTACCAAGGACACATCATTAATGAAAAGGTTTCAGATGCTAGCATCAGCA
CATGTAGGGGTCTAAGGGGCTACTTCAGTCAGGGAGATCAAAAATACCTCATTGAACCTTTAAG
CCCCACCAATGATGATGGGCAGGAACATGCACTTTTCAAGTATGATCCCCATGAAAAGAAGACT
AACAGCACCTGTGGGATGGATAACATATTGTGGGCACATGGATCTCGGCAGAGTGTGGCCACCA
GACTGGTGAAATCAAATGACCAGAAGGGTCCAGAACGTAAGAAATACATAGAATATTATTTGGT
CCTGGATAATGGTGAGTTTAAAAAGTACAATCAAGATCGAGAGAAAATAAGAAAGAGGGTGTTT
GAAATGGCCAATTATGTCAACATGCTTTATAAAAAGCTGAATACTCATGTGGCCTTAGTCGGTA
TAGAAATCTGGAATGATGAGGATAAAATAAAGATAACCCCAAATGCAAGCTCCACCCTGGAAAA
TTTTTCCAAATGGAGGGGAAGTGTCCTCCGAAAAAGAAAACCTCATGATATCGCTCAGTTAATC
ACAGCAACAAAACTTTCTGGAACAACTGTGGGCCTTGCTTTCATGTCTACAATGTGCTCTCCTT
ATCATTCTGTTGGCATTGTTCAGGACCACAGTAGCAACGTACTTAGAGTAGCAGGGACCATGGC
CCATGAAATGGGCCATAACTTTGGAATGTTTCATGACTCCTATGTTTGCAAGTGCCCTTCGACA
ATATGTGTGATGGACAGAGCACTAAGCTTCTACCTACCTACAGACTTCAGTTCCTGCAGCCGTG
TCAGCTATGACAAGTTCTTTGAAGACAAACTATCAAATTGCCTTTTCAACGCCCCATTGCCCAC
TGATATCATATCCATCCCAATCTGTGGGAACCAGGTGGTAGAAATGGGAGAGGACTGTGATTGT
GGGACTCCGGAGGAATGTACCAACATTTGCTGTGATGCTAAAATTTGTAAAATCAAAGCAAATT
TTCAATGTGCAATAGGAGAATGCTGTGAAAAATGCCAGTTTAAAAAGGCTGGTGCAGTATGCAG
ACCAGCAAAAGATGAGTGTGACCTGCCGGAAATGTGTGATGGCAAATCTGGTATTTGCCCTGAT
GACAGATTCCGAGTCAATGGCTTCCCTTGCCAAAATGGGAAGGGCTACTGTTTGATGGGGCTGT
GCCCCACGCTGCAGGAGCAGTGCACCGAGCTATGGGGATCAGGGACCAAGGTTGCAGATAGATC
GTGCTACAGCAGGAATGAAGGTGGATCAAAGTATGGATACTGTCGCAAAGTGGAGGACAGACCT
ATCCCCTGCAAAGCAAGTGATGCCATGTGTGGGAAGTTGTTCTGTCAAGGTGGGTCAGATAACT
TGCCCTGGAGAGGACATATAGTAACTTTCCTGACATGTAAAACATTTAATCCTGAAGACAGCAG
TCAAGAAATAGGCATGGTAGCCAATGGAACGAAGTGTGGAAACAAGAAGGTTTGCATTAATGCC
GAATGTGTGGATATCGAAAGAGCATACAAATCAACCAATTGCTCCTCCAAGTGCAAAGGACATG
CTGTGTGTGACCACGAGCTCCAGTGTCAGTGTAAAGAAGGATGGGCCCCTCCTGATTGTGATGA
CTCCTCAGTGGTCTTCCACTTCTCCATTGTGGTTGGGGTGCTGTTCCCTGTGGCTGTCATATCT
GTGGTGGTTGCTGTGGTAATCTGGCACCAAAGTACCAGAGGAAAGCAGAAGGAAGTCCAGAGGC
CACTGTCTACTACTGGCACCAGGCCTCGCAGACAGAAGAGGAACCCACAGACAGGGAAGGCTGT
TCAACCCCAAGAGATGAGTCAGATGAAGCTCCATTCACCTGATCTGCCAGTAGAGGGCAATGAG
CCTCCAGCTTCTTTTCTAATTACGAAGCCAGATTTTCCACCACCACCGATTCCTACATCTGTGT
CATCTTCTTTCCTTGGATCCGATCCAAAAGTCTAAAGCAGCAACAAAGCAAGGATGGATGGGGT
AATGATCAATTTGGAAAACTGGATAATCTGGATGGAAGAGAAATATACTTACTTTCTCATTATT
TGCTCTTGATACTTAAGGATGTTAACATTTCTTGATTCATCTTATACTTTGAGGAGATTAAACA
GAAATTTTCAAGAGAGATATACTCTTGAGAATCTTTGTATGAATTTGCAATCTCTATCCTCCAT
ACTCTTGAGAAAGAAGAGGATTCTAAACAAGCAGCTGTGAATCTGAAATCTCTAATTAGGTGAC
ATTTCTAGACATCCTCCCTTTTCTTATTGTAATGTTGGCTAATATTTCCTCAAATATTTTGAAC
ATCTTGATTTTCTCATTTAGTAAGAAATAATTTACCCTCAAATTAAAAAAAACAAAAAATCCCC
CAAGAAATCACAGGAAACTGGGGGCAATGGAAGAAAATTGTATATTTATCATTAGATGACTAAC
AACATCTTGATGTTTTAACCATTAACCTGTCAAATTAGAGCCCTAGGAACAAAAGTATATAAAC
ATTCTCTCTGATTGATAAAACATCTTATTCCTACATTATCTTTTGCAATCCTTATTAGCTGTAC
CATTTGAAGTTTGCTACAAATTAATAAAACTTTATTAAT

hide sequence

RefSeq Acc Id:

XR_002619086

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	25	33,092,645 - 33,147,790 (-)	NCBI
Dog10K_Boxer_Tasha	25	33,677,242 - 33,732,321 (-)	NCBI

Sequence:

show sequence

TTCCTGAAGCAGAGACAGGAATGAGCCCAGAGTTTCATTCTGTCTTGCTTGAGCAGAGGCAGGG
ACAGCGGAGGAGCAGAGGAGCAGTGCTCTCCCAGGGAGCACGAAGGGAAGGCGCTGCACCCCTG
AACTCACCTATCATGTTGCAGGGGATTCTTCTGACCACCACTTTCCTCCTTTGGCCAGTTCCAG
TAAATACTATCAAGGAACTCCCTGGAATAAAGAACTATGAAGTGGTTTATCCCAGAAGACTTCA
TCCACTACATAAAAGAGAGGTCAAGGACCCAGACCAACAGGAAAAATTTGAAACCGAATTGAAG
TATAAAATGACTGTTAATGGGAAAATTGCAGTACTTTACTTGAAAAAAAACAATGGTCTCCTTG
CTCCTGGTTACACGGAAACACATTATAATTCCACTGGAGAGGAGATCACCACAAGCCCACAAAT
CATGGATGACTGCTATTACCAAGGACACATCATTAATGAAAAGGTTTCAGATGCTAGCATCAGC
ACATGTAGGGGTCTAAGGGGCTACTTCAGTCAGGGAGATCAAAAATACCTCATTGAACCTTTAA
GCCCCACCAATGATGATGGGCAGGAACATGCACTTTTCAAGTATGATCCCCATGAAAAGAAGAC
TAACAGCACCTGTGGGATGGATAACATATTGTGGGCACATGGATCTCGGCAGAGTGTGGCCACC
AGACTGGTGAAATCAAATGACCAGAAGGGTCCAGAACGTAAGAAATACATAGAATATTATTTGG
TCCTGGATAATGGTGAGTTTAAAAAGTACAATCAAGATCGAGAGAAAATAAGAAAGAGGGTGTT
TGAAATGGCCAATTATGTCAACATGCTTTATAAAAAGCTGAATACTCATGTGGCCTTAGTCGGT
ATAGAAATCTGGAATGATGAGGATAAAATAAAGATAACCCCAAATGCAAGCTCCACCCTGGAAA
ATTTTTCCAAATGGAGGGGAAGTGTCCTCCGAAAAAGAAAACCTCATGATATCGCTCAGTTAAT
CACAGCAACAAAACTTTCTGGAACAACTGTGGGCCTTGCTTTCATGTCTACAATGTGCTCTCCT
TATCATTCTGTTGGCATTGTTCAGGACCACAGTAGCAACGTACTTAGAGTAGCAGGGACCATGG
CCCATGAAATGGGCCATAACTTTGGAATGTTTCATGACTCCTATGTTTGCAAGTGCCCTTCGAC
AATATGTGTGATGGACAGAGCACTAAGCTTCTACCTACCTACAGACTTCAGTTCCTGCAGCCGT
GTCAGCTATGACAAGTTCTTTGAAGACAAACTATCAAATTGCCTTTTCAACGCCCCATTGCCCA
CTGATATCATATCCATCCCAATCTGTGGGAACCAGGTGGTAGAAATGGGAGAGGACTGTGATTG
TGGGACTCCGGAGGAATGTACCAACATTTGCTGTGATGCTAAAATTTGTAAAATCAAAGCAAAT
TTTCAATGTGCAATAGGAGAATGCTGTGAAAAATGCCAGTTTAAAAAGGCTGGTGCAGTATGCA
GACCAGCAAAAGATGAGTGTGACCTGCCGGAAATGTGTGATGGCAAATCTGGTATTTGCCCTGA
TGACAGATTCCGAGTCAATGGCTTCCCTTGCCAAAATGGGAAGGGCTACTGTTTGATGGGGCTG
TGCCCCACGCTGCAGGAGCAGTGCACCGAGCTATGGGGATCAGGGACCAAGGTTGCAGATAGAT
CGTGCTACAGCAGGAATGAAGGTGGATCAAAGTATGGATACTGTCGCAAAGTGGAGGACAGACC
TATCCCCTGCAAAGCAAGTGATGCCATGTGTGGGAAGTTGTTCTGTCAAGGTGGGTCAGATAAC
TTGCCCTGGAGAGGACATATAGTAACTTTCCTGACATGTAAAACATTTAATCCTGAAGACAGCA
GTCAAGAAATAGGCATGGTAGCCAATGGAACGAAGTGTGGAAACAAGAAGGTTTGCATTAATGC
CGAATGTGTGGATATCGAAAGAGCATACAAATCAACCAATTGCTCCTCCAAGTGCAAAGGACAT
GCTGTGTGTGACCACGAGCTCCAGTGTCAGTGTAAAGAAGGATGGGCCCCTCCTGATTGTGATG
ACTCCTCAGTGGTCTTCCGTAGACTTCTCCATTGTGGTTGGGGTGCTGTTCCCTGTGGCTGTCA
TATCTGTGGTGGTTGCTGTGGTAATCTGGCACCAAAGTACCAGAGGAAAGCAGAAGGAAGTCCA
GAGGCCACTGTCTACTACTGGCACCAGGCCTCGCAGACAGAAGAGGAACCCACAGACAGGGAAG
GCTGTTCAACCCCAAGAGATGAGTCAGATGAAGCTCCATTCACCTGATCTGCCAGTAGAGGGCA
ATGAGCCTCCAGCTTCTTTTCTAATTACGAAGCCAGATTTTCCACCACCACCGATTCCTACATC
TGTGTCATCTTCTTTCCTTGGATCCGATCCAAAAGTCTAAAGCAGCAACAAAGCAAGGATGGAT
GGGGTAATGATCAATTTGGAAAACTGGATAATCTGGATGGAAGAGAAATATACTTACTTTCTCA
TTATTTGCTCTTGATACTTAAGGATGTTAACATTTCTTGATTCATCTTATACTTTGAGGAGATT
AAACAGAAATTTTCAAGAGAGATATACTCTTGAGAATCTTTGTATGAATTTGCAATCTCTATCC
TCCATACTCTTGAGAAAGAAGAGGATTCTAAACAAGCAGCTGTGAATCTGAAATCTCTAATTAG
GTGACATTTCTAGACATCCTCCCTTTTCTTATTGTAATGTTGGCTAATATTTCCTCAAATATTT
TGAACATCTTGATTTTCTCATTTAGTAAGAAATAATTTACCCTCAAATTAAAAAAAACAAAAAA
TCCCCCAAGAAATCACAGGAAACTGGGGGCAATGGAAGAAAATTGTATATTTATCATTAGATGA
CTAACAACATCTTGATGTTTTAACCATTAACCTGTCAAATTAGAGCCCTAGGAACAAAAGTATA
TAAACATTCTCTCTGATTGATAAAACATCTTATTCCTACATTATCTTTTGCAATCCTTATTAGC
TGTACCATTTGAAGTTTGCTACAAATTAATAAAACTTTATTAAT

hide sequence

RefSeq Acc Id:

XR_005301823

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	25	33,298,789 - 33,353,872 (-)	NCBI

RefSeq Acc Id:

XR_005344810

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	25	33,246,937 - 33,302,028 (-)	NCBI

RefSeq Acc Id:

XR_005378676

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	25	33,261,650 - 33,316,886 (-)	NCBI

RefSeq Acc Id:

XR_005412488

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	25	33,103,486 - 33,158,752 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038291324	(Get FASTA)	NCBI Sequence Viewer
	XP_038366263	(Get FASTA)	NCBI Sequence Viewer
	XP_038429714	(Get FASTA)	NCBI Sequence Viewer
	XP_038494030	(Get FASTA)	NCBI Sequence Viewer
	XP_850956	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000013383.4
	ENSCAFP00000052114.2
	ENSCAFP00000063273.1
	ENSCAFP00030034005.1
	ENSCAFP00030034147.1
	ENSCAFP00040034238.1
	ENSCAFP00040034354.1
	ENSCAFP00845021247.1
	ENSCAFP00845021390
	ENSCAFP00845021390.1
	ENSCAFP00845021556.1

RefSeq Acc Id:

XP_850956 ⟸ XM_845863

- UniProtKB:

A0A8P0SE54 (UniProtKB/TrEMBL), A0A8C0P4L2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSPEFHSVLLEQRQGQRRSRGAVLSQGARREGAAPLNSPIMLQGILLTTTFLLWPVPVNTIKEL
PGIKNYEVVYPRRLHPLHKREVKDPDQQEKFETELKYKMTVNGKIAVLYLKKNNGLLAPGYTET
HYNSTGEEITTSPQIMDDCYYQGHIINEKVSDASISTCRGLRGYFSQGDQKYLIEPLSPTNDDG
QEHALFKYDPHEKKTNSTCGMDNILWAHGSRQSVATRLVKSNDQKGPERKKYIEYYLVLDNGEF
KKYNQDREKIRKRVFEMANYVNMLYKKLNTHVALVGIEIWNDEDKIKITPNASSTLENFSKWRG
SVLRKRKPHDIAQLITATKLSGTTVGLAFMSTMCSPYHSVGIVQDHSSNVLRVAGTMAHEMGHN
FGMFHDSYVCKCPSTICVMDRALSFYLPTDFSSCSRVSYDKFFEDKLSNCLFNAPLPTDIISIP
ICGNQVVEMGEDCDCGTPEECTNICCDAKICKIKANFQCAIGECCEKCQFKKAGAVCRPAKDEC
DLPEMCDGKSGICPDDRFRVNGFPCQNGKGYCLMGLCPTLQEQCTELWGSGTKVADRSCYSRNE
GGSKYGYCRKVEDRPIPCKASDAMCGKLFCQGGSDNLPWRGHIVTFLTCKTFNPEDSSQEIGMV
ANGTKCGNKKVCINAECVDIERAYKSTNCSSKCKGHAVCDHELQCQCKEGWAPPDCDDSSVVFH
FSIVVGVLFPVAVISVVVAVVIWHQSTRGKQKEVQRPLSTTGTRPRRQKRNPQTGKAVQPQEMS
QMKLHSPDLPVEGNEPPASFLITKPDFPPPPIPTSVSSSFLGSDPKV

hide sequence

Ensembl Acc Id:

ENSCAFP00000063273 ⟸ ENSCAFT00000078276

Ensembl Acc Id:

ENSCAFP00000013383 ⟸ ENSCAFT00000014470

Ensembl Acc Id:

ENSCAFP00000052114 ⟸ ENSCAFT00000086567

RefSeq Acc Id:

XP_038366263 ⟸ XM_038510335

RefSeq Acc Id:

XP_038494030 ⟸ XM_038638102

RefSeq Acc Id:	XP_038291324 ⟸ XM_038435396
- UniProtKB:	A0A8C0Z3H9 (UniProtKB/TrEMBL), A0A8I3NT94 (UniProtKB/TrEMBL), A0A8C0P4L2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038429714 ⟸ XM_038573786
- UniProtKB:	A0A8C0P4L2 (UniProtKB/TrEMBL), A0A8C0P506 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845021247 ⟸ ENSCAFT00845027000

Ensembl Acc Id:

ENSCAFP00845021556 ⟸ ENSCAFT00845027386

Ensembl Acc Id:

ENSCAFP00845021390 ⟸ ENSCAFT00845027190

Protein Domains

Disintegrin EGF-like Peptidase M12B

Promoters

RGD ID:

13687782

Promoter ID:

EPDNEW_C5852

Type:

single initiation site

Name:

ADAM28_1

Description:

ADAM metallopeptidase domain 28

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	25	33,147,754 - 33,147,814	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000009056	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030021232	UniProtKB/TrEMBL
	ENSCAFG00040021155	UniProtKB/TrEMBL
	ENSCAFG00845015078	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000014470.5	UniProtKB/TrEMBL
	ENSCAFT00000078276.2	UniProtKB/TrEMBL
	ENSCAFT00000086567.2	UniProtKB/TrEMBL
	ENSCAFT00030038989.1	UniProtKB/TrEMBL
	ENSCAFT00030039152.1	UniProtKB/TrEMBL
	ENSCAFT00040039252.1	UniProtKB/TrEMBL
	ENSCAFT00040039374.1	UniProtKB/TrEMBL
	ENSCAFT00845027000.1	UniProtKB/TrEMBL
	ENSCAFT00845027190	ENTREZGENE
	ENSCAFT00845027190.1	UniProtKB/TrEMBL
	ENSCAFT00845027386.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.390.10	UniProtKB/TrEMBL
	4.10.70.10	UniProtKB/TrEMBL
InterPro	ADAM_Cys-rich	UniProtKB/TrEMBL
	Disintegrin_CS	UniProtKB/TrEMBL
	Disintegrin_dom	UniProtKB/TrEMBL
	Disintegrin_dom_sf	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	Reprolysin_adamalysin	UniProtKB/TrEMBL
NCBI Gene	ADAM28	ENTREZGENE
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/TrEMBL
	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 28	UniProtKB/TrEMBL
Pfam	ADAM_CR	UniProtKB/TrEMBL
	Disintegrin	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
PRINTS	DISINTEGRIN	UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	DISINTEGRIN_1	UniProtKB/TrEMBL
	DISINTEGRIN_2	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
SMART	ACR	UniProtKB/TrEMBL
	DISIN	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	SSF57552	UniProtKB/TrEMBL
UniProt	A0A8C0P4L2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0P506	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0TAS0_CANLF	UniProtKB/TrEMBL
	A0A8C0Z3H9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NL17_CANLF	UniProtKB/TrEMBL
	A0A8I3NLQ8_CANLF	UniProtKB/TrEMBL
	A0A8I3NT94	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SE54	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0T4K3_CANLF	UniProtKB/TrEMBL
	A0A8P0TEU1_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:37582	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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