ITGB1 (integrin subunit beta 1) - Rat Genome Database

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Gene: ITGB1 (integrin subunit beta 1) Canis lupus familiaris
Analyze
Symbol: ITGB1
Name: integrin subunit beta 1
RGD ID: 12093625
Description: ENCODES a protein that exhibits actin binding (ortholog); alpha-actinin binding (ortholog); C-X3-C chemokine binding (ortholog); INVOLVED IN axon extension (ortholog); basement membrane organization (ortholog); bicellular tight junction assembly (ortholog); PARTICIPATES IN altered Reelin signaling pathway; glomerulonephritis pathway; integrin mediated signaling pathway; ASSOCIATED WITH Brain Injuries, Traumatic (ortholog); calcinosis (ortholog); cardiomyopathy (ortholog); FOUND IN acrosomal vesicle (ortholog); adherens junction (ortholog); basement membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: integrin beta 1; integrin beta-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.123,728,472 - 3,757,696 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl23,670,596 - 3,756,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha23,811,003 - 3,857,059 (+)NCBI
ROS_Cfam_1.024,006,817 - 4,053,107 (+)NCBI
UMICH_Zoey_3.123,785,306 - 3,831,383 (+)NCBI
UNSW_CanFamBas_1.023,819,236 - 3,865,356 (+)NCBI
UU_Cfam_GSD_1.023,939,078 - 3,985,170 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (ISO)
basement membrane organization  (ISO)
bicellular tight junction assembly  (ISO)
calcium-independent cell-matrix adhesion  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle tissue development  (ISO)
CD40 signaling pathway  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (ISO)
cell fate specification  (ISO)
cell migration  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell projection organization  (ISO)
cell-cell adhesion mediated by integrin  (ISO)
cell-matrix adhesion  (ISO)
cell-substrate adhesion  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to vitamin D  (ISO)
dendrite morphogenesis  (ISO)
establishment of mitotic spindle orientation  (ISO)
establishment of Sertoli cell barrier  (ISO)
formation of radial glial scaffolds  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
germ cell migration  (ISO)
heterotypic cell-cell adhesion  (ISO)
in utero embryonic development  (ISO)
integrin-mediated signaling pathway  (ISO)
lamellipodium assembly  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte tethering or rolling  (ISO)
maternal process involved in female pregnancy  (ISO)
mesodermal cell differentiation  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
neuron projection development  (ISO)
phagocytosis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of glutamate uptake involved in transmission of nerve impulse  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of wound healing  (ISO)
protein transport within lipid bilayer  (ISO)
reactive gliosis  (ISO)
receptor internalization  (ISO)
regulation of cell cycle  (ISO)
regulation of collagen catabolic process  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of inward rectifier potassium channel activity  (ISO)
regulation of spontaneous synaptic transmission  (ISO)
response to activity  (ISO)
response to gonadotropin  (ISO)
response to nutrient levels  (ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
sarcomere organization  (ISO)
stress fiber assembly  (ISO)
tissue homeostasis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16611743   PMID:18806266   PMID:19776354   PMID:20457839   PMID:29748377  


Genomics

Comparative Map Data
ITGB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.123,728,472 - 3,757,696 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl23,670,596 - 3,756,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha23,811,003 - 3,857,059 (+)NCBI
ROS_Cfam_1.024,006,817 - 4,053,107 (+)NCBI
UMICH_Zoey_3.123,785,306 - 3,831,383 (+)NCBI
UNSW_CanFamBas_1.023,819,236 - 3,865,356 (+)NCBI
UU_Cfam_GSD_1.023,939,078 - 3,985,170 (+)NCBI
ITGB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1032,887,273 - 33,005,792 (-)EnsemblGRCh38hg38GRCh38
GRCh381032,900,318 - 32,958,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371033,189,246 - 33,247,158 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361033,229,326 - 33,287,204 (-)NCBINCBI36hg18NCBI36
Build 341033,236,244 - 33,264,492NCBI
Celera1032,954,580 - 33,012,639 (-)NCBI
Cytogenetic Map10p11.22NCBI
HuRef1032,908,756 - 32,966,834 (-)NCBIHuRef
CHM1_11033,190,855 - 33,248,907 (-)NCBICHM1_1
Itgb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398129,412,135 - 129,460,060 (+)NCBIGRCm39mm39
GRCm39 Ensembl8129,412,135 - 129,459,681 (+)Ensembl
GRCm388128,685,654 - 128,733,579 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8128,685,654 - 128,733,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv378131,209,554 - 131,257,479 (+)NCBIGRCm37mm9NCBIm37
MGSCv368131,571,871 - 131,619,287 (+)NCBImm8
Celera8133,002,434 - 133,050,263 (+)NCBICelera
Cytogenetic Map8E2NCBI
Itgb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21956,705,123 - 56,753,199 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1956,705,171 - 56,753,195 (+)Ensembl
Rnor_6.01961,677,512 - 61,725,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1961,677,542 - 61,725,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01972,324,582 - 72,372,325 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,600,095 - 58,647,531 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11958,605,791 - 58,652,463 (-)NCBI
Celera1956,037,604 - 56,085,651 (+)NCBICelera
Cytogenetic Map19q12NCBI
Itgb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554624,454,809 - 4,484,842 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554624,454,809 - 4,483,227 (+)NCBIChiLan1.0ChiLan1.0
ITGB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11033,608,978 - 33,662,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1033,608,978 - 33,644,031 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01033,023,573 - 33,081,384 (-)NCBIMhudiblu_PPA_v0panPan3
Itgb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934411,966,401 - 11,996,275 (-)NCBI
SpeTri2.0NW_0049365741,465,981 - 1,495,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1056,078,398 - 56,173,795 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11056,078,393 - 56,130,608 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21061,450,695 - 61,502,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1932,201,030 - 32,258,247 (-)NCBI
ChlSab1.1 Ensembl932,202,204 - 32,258,154 (-)Ensembl
Vero_WHO_p1.0NW_02366605641,260,215 - 41,317,418 (-)NCBI
Itgb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248058,748,848 - 8,800,259 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022406138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038469003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038469004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038529709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038529710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038658027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038658028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000006178   ⟹   ENSCAFP00000005722
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl23,670,596 - 3,756,715 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000085069   ⟹   ENSCAFP00000054227
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl23,728,543 - 3,756,961 (+)Ensembl
RefSeq Acc Id: XM_022406138   ⟹   XP_022261846
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.123,728,472 - 3,757,696 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022406139   ⟹   XP_022261847
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.123,728,472 - 3,757,696 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038455730   ⟹   XP_038311658
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha23,811,003 - 3,857,059 (+)NCBI
RefSeq Acc Id: XM_038455731   ⟹   XP_038311659
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha23,811,004 - 3,857,059 (+)NCBI
RefSeq Acc Id: XM_038469003   ⟹   XP_038324931
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.123,785,306 - 3,831,383 (+)NCBI
RefSeq Acc Id: XM_038469004   ⟹   XP_038324932
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.123,785,307 - 3,831,383 (+)NCBI
RefSeq Acc Id: XM_038529709   ⟹   XP_038385637
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.023,939,078 - 3,985,170 (+)NCBI
RefSeq Acc Id: XM_038529710   ⟹   XP_038385638
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.023,939,079 - 3,985,170 (+)NCBI
RefSeq Acc Id: XM_038593949   ⟹   XP_038449877
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.023,819,236 - 3,865,356 (+)NCBI
RefSeq Acc Id: XM_038593950   ⟹   XP_038449878
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.023,819,237 - 3,865,356 (+)NCBI
RefSeq Acc Id: XM_038658027   ⟹   XP_038513955
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.024,006,817 - 4,053,107 (+)NCBI
RefSeq Acc Id: XM_038658028   ⟹   XP_038513956
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.024,006,818 - 4,053,107 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_022261846   ⟸   XM_022406138
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022261847   ⟸   XM_022406139
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000005722   ⟸   ENSCAFT00000006178
RefSeq Acc Id: ENSCAFP00000054227   ⟸   ENSCAFT00000085069
RefSeq Acc Id: XP_038324931   ⟸   XM_038469003
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038324932   ⟸   XM_038469004
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038449877   ⟸   XM_038593949
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038449878   ⟸   XM_038593950
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038513955   ⟸   XM_038658027
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513956   ⟸   XM_038658028
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038311658   ⟸   XM_038455730
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038311659   ⟸   XM_038455731
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038385637   ⟸   XM_038529709
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038385638   ⟸   XM_038529710
- Peptide Label: isoform X2

Promoters
RGD ID:13682367
Promoter ID:EPDNEW_C437
Type:single initiation site
Name:ITGB1_1
Description:integrin subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.123,728,567 - 3,728,627EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003821 Ensembl, ENTREZGENE
NCBI Gene ITGB1 ENTREZGENE
VGNC ID VGNC:42136 ENTREZGENE