MMP3 (matrix metallopeptidase 3 (stromelysin 1, progelatinase)) - Rat Genome Database

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Gene: MMP3 (matrix metallopeptidase 3 (stromelysin 1, progelatinase)) Canis lupus familiaris
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Symbol: MMP3
Name: matrix metallopeptidase 3 (stromelysin 1, progelatinase)
RGD ID: 12343665
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); metallopeptidase activity (ortholog); peptidase activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to cell-matrix adhesion (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Otitis Media (ortholog); allergic contact dermatitis (ortholog); FOUND IN cell body (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: matrix metalloproteinase-3; MMP-3; SL-1; stromelysin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,949,631 - 28,957,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBI
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBI
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBI
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBI
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Otitis Media  (ISO)
allergic contact dermatitis  (ISO)
Alport syndrome  (ISO)
arteriosclerosis  (ISO)
ataxia telangiectasia  (ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Carotid Artery Injuries  (ISO)
carotid stenosis  (ISO)
cartilage disease  (ISO)
cataract  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Allograft Nephropathy  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivochalasis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
crescentic glomerulonephritis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
gastric ulcer  (ISO)
glomerulonephritis  (ISO)
Gouty Arthritis  (ISO)
Hyperalgesia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
intellectual disability  (ISO)
Knee Osteoarthritis  (ISO)
lung cancer  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
osteoarthritis  (ISO)
Parkinsonism  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
polymyalgia rheumatica  (ISO)
primary biliary cholangitis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Sjogren's syndrome  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
Tendon Injuries  (ISO)
thrombosis  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)
von Hippel-Lindau disease  (ISO)
Wounds, Penetrating  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:15782307   PMID:21281193  


Genomics

Comparative Map Data
MMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,949,631 - 28,957,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBI
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBI
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBI
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBI
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBI
MMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,317 (-)NCBICHM1_1
Mmp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,445,822 - 7,455,975 (+)NCBIGRCm39mm39
GRCm39 Ensembl97,445,822 - 7,455,975 (+)Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBImm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.284,640,397 - 4,653,963 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl84,640,416 - 4,653,961 (+)Ensembl
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111101,267,561 - 101,275,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBIMhudiblu_PPA_v0panPan3
MMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,216,156 - 94,224,437 (-)NCBI
ChlSab1.1 Ensembl194,216,173 - 94,224,264 (-)Ensembl
Vero_WHO_p1.0NW_02366604331,654,560 - 31,662,871 (+)NCBI
Mmp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462487839,282 - 47,386 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1
Low 4 3 1 4
Below cutoff 5 3 4 1 2 1 3 3 4 6 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023908   ⟹   ENSCAFP00000022195
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069421   ⟹   ENSCAFP00000065307
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)Ensembl
RefSeq Acc Id: NM_001002967   ⟹   NP_001002967
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1528,949,631 - 28,957,915 (+)NCBI
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBI
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBI
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBI
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBI
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO63580 (Get FASTA)   NCBI Sequence Viewer  
  Q6Y4Q5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002967   ⟸   NM_001002967
- Peptide Label: precursor
- UniProtKB: Q6Y4Q5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000065307   ⟸   ENSCAFT00000069421
RefSeq Acc Id: ENSCAFP00000022195   ⟸   ENSCAFT00000023908


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015063 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000022195 ENTREZGENE
Ensembl Transcript ENSCAFT00000023908 ENTREZGENE
NCBI Gene MMP3 ENTREZGENE
UniProt Q6Y4Q5 ENTREZGENE