RB1 (RB transcriptional corepressor 1) - Rat Genome Database

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Gene: RB1 (RB transcriptional corepressor 1) Canis lupus familiaris
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Symbol: RB1
Name: RB transcriptional corepressor 1
RGD ID: 12173885
Description: ENCODES a protein that exhibits disordered domain specific binding (ortholog); DNA-binding transcription factor binding (ortholog); enzyme binding (ortholog); INVOLVED IN aortic valve morphogenesis (ortholog); apoptotic process (ortholog); cell division (ortholog); PARTICIPATES IN ceramide signaling pathway; G1/S transition pathway; RNA polymerase III transcription pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cyclin/CDK positive transcription elongation factor complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: retinoblastoma 1 (including osteosarcoma); retinoblastoma protein; retinoblastoma-associated protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,061,621 - 3,204,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,063,239 - 3,257,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,090,617 - 3,235,458 (-)NCBI
ROS_Cfam_1.0223,143,918 - 3,320,581 (-)NCBI
UMICH_Zoey_3.1222,960,514 - 3,106,149 (-)NCBI
UNSW_CanFamBas_1.0223,023,421 - 3,169,707 (-)NCBI
UU_Cfam_GSD_1.0223,028,586 - 3,174,226 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
Autosomal Recessive Woolly Hair  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1  (ISO)
basal cell carcinoma  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 13q14 deletion syndrome  (ISO)
disease of cellular proliferation  (ISO)
ductal carcinoma in situ  (ISO)
embryonal carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
familial retinoblastoma  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
glioblastoma proneural subtype  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
hypotrichosis 8  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intestinal pseudo-obstruction  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oligodendroglioma  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
retinoblastoma  (ISO)
seminoma  (ISO)
Sezary's disease  (ISO)
small cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
trilateral retinoblastoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
apoptotic process  (ISO)
cell division  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chondrocyte differentiation  (ISO)
digestive tract development  (ISO)
enucleate erythrocyte differentiation  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
glial cell apoptotic process  (ISO)
hepatocyte apoptotic process  (ISO)
maintenance of mitotic sister chromatid cohesion  (ISO)
myoblast differentiation  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myofibroblast differentiation  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of tau-protein kinase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription involved in G1/S transition of mitotic cell cycle  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
neuron maturation  (ISO)
neuron projection development  (ISO)
positive regulation of collagen fibril organization  (ISO)
positive regulation of extracellular matrix organization  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of mitotic metaphase/anaphase transition  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
protein localization to chromosome, centromeric region  (ISO)
Ras protein signal transduction  (ISO)
regulation of cell cycle  (ISO)
regulation of cell growth  (ISO)
regulation of cohesin loading  (ISO)
regulation of lipid kinase activity  (ISO)
regulation of mitotic cell cycle  (ISO)
sister chromatid biorientation  (ISO)
skeletal muscle cell differentiation  (ISO)
spermatogenesis  (ISO)
striated muscle cell differentiation  (ISO)
tissue homeostasis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8894053   PMID:9632747   PMID:10612248   PMID:18562222   PMID:27033932  


Genomics

Comparative Map Data
RB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,061,621 - 3,204,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,063,239 - 3,257,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,090,617 - 3,235,458 (-)NCBI
ROS_Cfam_1.0223,143,918 - 3,320,581 (-)NCBI
UMICH_Zoey_3.1222,960,514 - 3,106,149 (-)NCBI
UNSW_CanFamBas_1.0223,023,421 - 3,169,707 (-)NCBI
UU_Cfam_GSD_1.0223,028,586 - 3,174,226 (-)NCBI
RB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1348,303,744 - 48,599,436 (+)EnsemblGRCh38hg38GRCh38
GRCh381348,303,751 - 48,481,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,877,887 - 49,056,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,775,884 - 47,954,027 (+)NCBINCBI36hg18NCBI36
Build 341347,775,911 - 47,954,023NCBI
Celera1329,932,627 - 30,110,747 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,670,144 - 29,848,118 (+)NCBIHuRef
CHM1_11348,845,597 - 49,023,603 (+)NCBICHM1_1
Rb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,430,298 - 73,563,446 (-)NCBIGRCm39mm39
GRCm39 Ensembl1473,421,113 - 73,563,262 (-)Ensembl
GRCm381473,192,858 - 73,325,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,183,673 - 73,325,822 (-)EnsemblGRCm38mm10GRCm38
MGSCv371473,595,309 - 73,725,598 (-)NCBIGRCm37mm9NCBIm37
MGSCv361471,929,656 - 72,059,895 (-)NCBImm8
Celera1470,715,843 - 70,870,859 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.73NCBI
Rb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21548,371,295 - 48,502,473 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)Ensembl
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Celera1548,020,828 - 48,147,805 (-)NCBICelera
Cytogenetic Map15q11NCBI
Rb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,960,661 - 2,124,576 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554311,960,765 - 2,124,576 (+)NCBIChiLan1.0ChiLan1.0
RB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11348,155,608 - 48,326,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1348,155,795 - 48,324,575 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01329,453,872 - 29,624,665 (+)NCBIMhudiblu_PPA_v0panPan3
Rb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945158,103,473 - 158,265,512 (+)NCBI
SpeTri2.0NW_0049365651,596,227 - 1,746,706 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,186,759 - 19,317,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,186,754 - 19,317,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,648,360 - 19,770,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1326,220,783 - 26,393,671 (+)NCBI
ChlSab1.1 Ensembl326,220,803 - 26,394,546 (+)Ensembl
Vero_WHO_p1.0NW_02366605717,512,606 - 17,688,151 (-)NCBI
Rb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247486,358,588 - 6,533,217 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 11 3 6 6 12 2 10 5
Low 4 11 6 3 6 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000007150   ⟹   ENSCAFP00000006618
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl223,063,239 - 3,257,726 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000045816   ⟹   ENSCAFP00000036686
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl223,063,239 - 3,204,628 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082390   ⟹   ENSCAFP00000057502
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl223,064,267 - 3,204,628 (-)Ensembl
RefSeq Acc Id: XM_022408288   ⟹   XP_022263996
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1223,061,621 - 3,204,625 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038430930   ⟹   XP_038286858
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0223,143,918 - 3,320,581 (-)NCBI
RefSeq Acc Id: XM_038456910   ⟹   XP_038312838
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha223,090,617 - 3,235,458 (-)NCBI
RefSeq Acc Id: XM_038506301   ⟹   XP_038362229
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1222,960,514 - 3,106,149 (-)NCBI
RefSeq Acc Id: XM_038569496   ⟹   XP_038425424
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0223,028,586 - 3,174,226 (-)NCBI
RefSeq Acc Id: XM_038634344   ⟹   XP_038490272
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0223,023,421 - 3,169,707 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_022263996   ⟸   XM_022408288
- Sequence:
RefSeq Acc Id: ENSCAFP00000036686   ⟸   ENSCAFT00000045816
RefSeq Acc Id: ENSCAFP00000057502   ⟸   ENSCAFT00000082390
RefSeq Acc Id: ENSCAFP00000006618   ⟸   ENSCAFT00000007150
RefSeq Acc Id: XP_038362229   ⟸   XM_038506301
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038490272   ⟸   XM_038634344
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038286858   ⟸   XM_038430930
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038312838   ⟸   XM_038456910
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038425424   ⟸   XM_038569496
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004436 Ensembl, ENTREZGENE
NCBI Gene RB1 ENTREZGENE
VGNC ID VGNC:45389 ENTREZGENE