EPO (erythropoietin) - Rat Genome Database

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Gene: EPO (erythropoietin) Canis lupus familiaris
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Symbol: EPO
Name: erythropoietin
RGD ID: 12139666
Description: ENCODES a protein that exhibits erythropoietin receptor binding (ortholog); INVOLVED IN acute-phase response (ortholog); aging (ortholog); apoptotic process (ortholog); PARTICIPATES IN erythropoietin signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute-Phase Reaction (ortholog); AIDS Dementia Complex (ortholog); FOUND IN cell body (ortholog); cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: erythropoietin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,994,211 - 8,995,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,994,211 - 8,996,144 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,698,441 - 10,700,425 (-)NCBI
ROS_Cfam_1.068,928,384 - 8,930,368 (-)NCBI
UMICH_Zoey_3.168,780,936 - 8,782,920 (-)NCBI
UNSW_CanFamBas_1.068,759,117 - 8,761,101 (-)NCBI
UU_Cfam_GSD_1.068,940,837 - 8,942,821 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute-Phase Reaction  (ISO)
AIDS Dementia Complex  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anastomotic Leak  (ISO)
anemia  (ISO)
beta thalassemia  (ISO)
Brain Hypoxia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
calcinosis  (ISO)
Cardiogenic Shock  (ISO)
cardiomyopathy  (ISO)
central nervous system disease  (ISO)
cholangiocarcinoma  (ISO)
cognitive disorder  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diamond-Blackfan Anemia-Like  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Sarcoma  (ISO)
familial erythrocytosis 5  (ISO)
Fatigue  (ISO)
Fetal Distress  (ISO)
gastric ulcer  (ISO)
glaucoma  (ISO)
heart disease  (ISO)
hemolytic anemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Inflammation  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
Limb Ischemia  (ISO)
Liver Reperfusion Injury  (ISO)
macular retinal edema  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
pancytopenia  (ISO)
Paraneoplastic Syndromes  (ISO)
Parkinson's disease  (ISO)
placental insufficiency  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
polyneuropathy  (ISO)
porphyria  (ISO)
Pregnancy Complications  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinopathy of prematurity  (ISO)
severe combined immunodeficiency  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
Subdural Hematoma, Acute  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Tubulointerstitial Fibrosis  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
vascular dementia  (ISO)
vascular disease  (ISO)
Venous Thrombosis  (ISO)
Ventricular Fibrillation  (ISO)
ventricular septal defect  (ISO)
Ventricular Tachycardia  (ISO)
visual epilepsy  (ISO)
Weight Loss  (ISO)
Wounds, Penetrating  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA)
acute-phase response  (ISO)
aging  (ISO)
apoptotic process  (ISO)
cellular hyperosmotic response  (ISO)
embryo implantation  (ISO)
erythrocyte differentiation  (ISO,ISS)
erythrocyte maturation  (IEA)
erythropoietin-mediated signaling pathway  (IBA,ISS)
hemoglobin biosynthetic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcium ion transport into cytosol  (ISO)
negative regulation of cation channel activity  (ISO)
negative regulation of erythrocyte apoptotic process  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of Ras protein signal transduction  (IBA)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to axon injury  (ISO)
response to dexamethasone  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient  (ISO)
response to salt stress  (ISO)
response to testosterone  (ISO)
response to vitamin A  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8364201   PMID:15286000   PMID:15916748  


Genomics

Comparative Map Data
EPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,994,211 - 8,995,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,994,211 - 8,996,144 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,698,441 - 10,700,425 (-)NCBI
ROS_Cfam_1.068,928,384 - 8,930,368 (-)NCBI
UMICH_Zoey_3.168,780,936 - 8,782,920 (-)NCBI
UNSW_CanFamBas_1.068,759,117 - 8,761,101 (-)NCBI
UU_Cfam_GSD_1.068,940,837 - 8,942,821 (-)NCBI
EPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7100,720,468 - 100,723,700 (+)EnsemblGRCh38hg38GRCh38
GRCh387100,720,468 - 100,723,700 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,318,091 - 100,321,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,156,359 - 100,159,259 (+)NCBINCBI36hg18NCBI36
Build 34799,963,073 - 99,965,972NCBI
Celera795,048,997 - 95,051,893 (+)NCBI
Cytogenetic Map7q22.1NCBI
HuRef794,949,230 - 94,952,126 (+)NCBIHuRef
CHM1_17100,248,723 - 100,251,623 (+)NCBICHM1_1
CRA_TCAGchr7v2799,678,028 - 99,680,928 (+)NCBI
Epo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,481,282 - 137,484,078 (-)NCBIGRCm39mm39
GRCm39 Ensembl5137,481,282 - 137,531,504 (-)Ensembl
GRCm385137,483,020 - 137,485,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,483,020 - 137,533,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,924,248 - 137,927,044 (-)NCBIGRCm37mm9NCBIm37
MGSCv365137,712,873 - 137,715,533 (-)NCBImm8
Celera5134,466,358 - 134,469,154 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.5NCBI
Epo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,204,258 - 19,207,948 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1222,274,828 - 22,278,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01222,274,828 - 22,278,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,291,481 - 24,294,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,551,768 - 19,555,208 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11219,541,291 - 19,544,730 (-)NCBI
Celera1221,009,353 - 21,012,793 (+)NCBICelera
Cytogenetic Map12q12NCBI
Epo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573203,441 - 206,355 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573203,875 - 206,078 (-)NCBIChiLan1.0ChiLan1.0
EPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17106,148,062 - 106,150,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,148,062 - 106,150,974 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0792,747,671 - 92,750,886 (+)NCBIMhudiblu_PPA_v0panPan3
Epo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,290,130 - 133,295,627 (-)NCBI
SpeTri2.0NW_004936543742,722 - 745,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,620,508 - 8,622,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,620,508 - 8,622,936 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,014,859 - 8,017,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,487,222 - 12,491,986 (-)NCBI
ChlSab1.1 Ensembl2812,489,766 - 12,491,908 (-)Ensembl
Vero_WHO_p1.0NW_0236660703,816,537 - 3,820,180 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system integumental system nervous system reproductive system respiratory system
High
Medium
Low
Below cutoff 2 1 1 3 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000022549   ⟹   ENSCAFP00000020937
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl68,994,211 - 8,996,144 (-)Ensembl
RefSeq Acc Id: NM_001006646   ⟹   NP_001006647
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.168,994,211 - 8,995,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038480397   ⟹   XP_038336325
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.168,780,936 - 8,782,920 (-)NCBI
RefSeq Acc Id: XM_038533714   ⟹   XP_038389642
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha610,698,441 - 10,700,425 (-)NCBI
RefSeq Acc Id: XM_038538855   ⟹   XP_038394783
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.068,940,837 - 8,942,821 (-)NCBI
RefSeq Acc Id: XM_038602984   ⟹   XP_038458912
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,759,117 - 8,761,101 (-)NCBI
RefSeq Acc Id: XM_038667690   ⟹   XP_038523618
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.068,928,384 - 8,930,368 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001006647   ⟸   NM_001006646
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSCAFP00000020937   ⟸   ENSCAFT00000022549
RefSeq Acc Id: XP_038336325   ⟸   XM_038480397
RefSeq Acc Id: XP_038458912   ⟸   XM_038602984
RefSeq Acc Id: XP_038523618   ⟸   XM_038667690
RefSeq Acc Id: XP_038389642   ⟸   XM_038533714
RefSeq Acc Id: XP_038394783   ⟸   XM_038538855


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014203 Ensembl, ENTREZGENE
NCBI Gene EPO ENTREZGENE
UniProt P33707 ENTREZGENE
VGNC ID VGNC:40422 ENTREZGENE