RGD Reference Report - KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression. - Rat Genome Database

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KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression.

Authors: Tang, W  Inagaki, Y  Kokudo, N  Guo, Q  Seyama, Y  Nakata, M  Imamura, H  Sano, K  Sugawara, Y  Makuuchi, M 
Citation: Tang W, etal., World J Gastroenterol. 2005 Sep 21;11(35):5450-4.
RGD ID: 2324649
Pubmed: PMID:16222735   (View Abstract at PubMed)
PMCID: PMC4320352   (View Article at PubMed Central)

AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029). CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MUC1HumanLymphatic Metastasis  IEP associated with Common Bile Duct NeoplasmsRGD 
Muc1RatLymphatic Metastasis  ISOMUC1 (Homo sapiens)associated with Common Bile Duct NeoplasmsRGD 
Muc1MouseLymphatic Metastasis  ISOMUC1 (Homo sapiens)associated with Common Bile Duct NeoplasmsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc1  (mucin 1, cell surface associated)

Genes (Mus musculus)
Muc1  (mucin 1, transmembrane)

Genes (Homo sapiens)
MUC1  (mucin 1, cell surface associated)


Additional Information