RGD Reference Report - Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. - Rat Genome Database

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Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.

Authors: Perl, AK  Dahl, U  Wilgenbus, P  Cremer, H  Semb, H  Christofori, G 
Citation: Perl AK, etal., Nat Med. 1999 Mar;5(3):286-91.
RGD ID: 2326067
Pubmed: PMID:10086383   (View Abstract at PubMed)
DOI: DOI:10.1038/6502   (Journal Full-text)

As in the development of many human cancers, in a transgenic mouse model of beta-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient RiplTag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents tumor metastasis. The results indicate that the loss of NCAM-mediated cell adhesion is one rate-limiting step in the actual metastatic dissemination of beta tumor cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NCAM1HumanLymphatic Metastasis  ISONcam1 (Mus musculus) RGD 
Ncam1RatLymphatic Metastasis  ISONcam1 (Mus musculus) RGD 
Ncam1MouseLymphatic Metastasis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ncam1  (neural cell adhesion molecule 1)

Genes (Mus musculus)
Ncam1  (neural cell adhesion molecule 1)

Genes (Homo sapiens)
NCAM1  (neural cell adhesion molecule 1)


Additional Information