CTLA4 (cytotoxic T-lymphocyte associated protein 4) - Rat Genome Database

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Gene: CTLA4 (cytotoxic T-lymphocyte associated protein 4) Canis lupus familiaris
Analyze
Symbol: CTLA4
Name: cytotoxic T-lymphocyte associated protein 4
RGD ID: 12252727
Description: INVOLVED IN negative regulation of T cell proliferation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); adult T-cell leukemia/lymphoma (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD152; costimulatory molecule B7 receptor CD152; CTLA-4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated antigen 4; soluble form of cytotoxic T-lymphocyte antigen 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13712,647,712 - 12,653,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,634,563 - 12,653,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3713,530,863 - 13,537,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03712,584,278 - 12,590,425 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3712,528,644 - 12,590,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13712,541,354 - 12,547,516 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03712,504,724 - 12,510,894 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03712,505,745 - 12,511,890 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
Alstrom syndrome  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
Asparagine Synthetase Deficiency  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune hepatitis  (ISO)
Autoimmune Hypothyroidism  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type V  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
celiac disease  (ISO)
Chronic Bronchitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
common variable immunodeficiency 1  (ISO)
contact dermatitis  (ISO)
Cryptogenic Cirrhosis  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Melanoma  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
immunoglobulin alpha deficiency  (ISO)
Inflammation  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
latent autoimmune diabetes in adults  (ISO)
lung disease  (ISO)
lupus nephritis  (ISO)
Lymphadenopathy  (ISO)
Lymphatic Metastasis  (ISO)
malaria  (ISO)
melanoma  (ISO)
monoclonal gammopathy of uncertain significance  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
non-Hodgkin lymphoma  (ISO)
oral submucous fibrosis  (ISO)
peripheral nervous system disease  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary immunodeficiency disease  (ISO)
primary pulmonary hypertension  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 12  (ISO)
urinary schistosomiasis  (ISO)
vitiligo  (ISO)

References
Additional References at PubMed
PMID:10663567   PMID:19667932   PMID:22301074   PMID:28392507   PMID:30032202   PMID:33129194  


Genomics

Comparative Map Data
CTLA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13712,647,712 - 12,653,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,634,563 - 12,653,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3713,530,863 - 13,537,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03712,584,278 - 12,590,425 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3712,528,644 - 12,590,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13712,541,354 - 12,547,516 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03712,504,724 - 12,510,894 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03712,505,745 - 12,511,890 (+)NCBIUU_Cfam_GSD_1.0
CTLA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382203,867,771 - 203,873,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2203,853,888 - 203,873,965 (+)EnsemblGRCh38hg38GRCh38
GRCh372204,732,494 - 204,738,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,440,754 - 204,446,928 (+)NCBINCBI36Build 36hg18NCBI36
Build 342204,558,016 - 204,564,189NCBI
Celera2198,487,330 - 198,493,462 (+)NCBICelera
Cytogenetic Map2q33.2NCBI
HuRef2196,579,809 - 196,585,939 (+)NCBIHuRef
CHM1_12204,739,066 - 204,745,196 (+)NCBICHM1_1
T2T-CHM13v2.02204,349,656 - 204,355,847 (+)NCBIT2T-CHM13v2.0
Ctla4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,948,184 - 60,954,991 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl160,926,159 - 60,954,991 (+)EnsemblGRCm39 Ensembl
GRCm38160,909,025 - 60,915,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,887,000 - 60,915,832 (+)EnsemblGRCm38mm10GRCm38
MGSCv37160,965,869 - 60,972,674 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36160,853,571 - 60,860,376 (+)NCBIMGSCv36mm8
Celera161,424,040 - 61,430,841 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.58NCBI
Ctla4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8969,812,859 - 69,819,959 (+)NCBIGRCr8
mRatBN7.2962,318,874 - 62,325,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl962,319,312 - 62,324,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx970,821,431 - 70,826,972 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0975,937,041 - 75,942,584 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0974,255,613 - 74,261,154 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0967,699,397 - 67,706,068 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,699,379 - 67,706,065 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,509,236 - 67,515,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4959,495,773 - 59,501,300 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1959,642,754 - 59,648,282 (+)NCBI
Celera959,742,231 - 59,747,758 (+)NCBICelera
Cytogenetic Map9q32NCBI
Ctla4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545711,028,698 - 11,073,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545711,028,707 - 11,034,898 (-)NCBIChiLan1.0ChiLan1.0
CTLA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213106,472,380 - 106,478,722 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B106,487,372 - 106,493,704 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B91,054,917 - 91,106,234 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B209,239,417 - 209,244,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,239,417 - 209,244,498 (+)Ensemblpanpan1.1panPan2
Ctla4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303160,849,279 - 160,854,996 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936631484,356 - 489,643 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936631484,356 - 489,643 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTLA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15107,282,927 - 107,289,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115107,283,081 - 107,288,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,627,675 - 118,632,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTLA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11089,637,176 - 89,644,436 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1089,638,314 - 89,642,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040109,742,081 - 109,748,529 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctla4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476512,449,205 - 12,454,324 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476512,449,205 - 12,454,324 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTLA4
40 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000020440   ⟹   ENSCAFP00000018967
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3712,647,712 - 12,653,874 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000072909   ⟹   ENSCAFP00000064847
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3712,634,563 - 12,653,874 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000084058   ⟹   ENSCAFP00000053577
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3712,647,745 - 12,652,818 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032279   ⟹   ENSCAFP00845025234
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3712,528,644 - 12,590,422 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032352   ⟹   ENSCAFP00845025290
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3712,584,278 - 12,590,422 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032408   ⟹   ENSCAFP00845025336
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3712,584,311 - 12,589,366 (+)Ensembl
RefSeq Acc Id: NM_001003106   ⟹   NP_001003106
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13712,647,712 - 12,653,874 (+)NCBI
Dog10K_Boxer_Tasha3713,530,863 - 13,537,025 (+)NCBI
ROS_Cfam_1.03712,584,278 - 12,590,422 (+)NCBI
UMICH_Zoey_3.13712,541,354 - 12,547,516 (+)NCBI
UNSW_CanFamBas_1.03712,504,724 - 12,510,894 (+)NCBI
UU_Cfam_GSD_1.03712,505,745 - 12,511,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038447290   ⟹   XP_038303218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03712,584,428 - 12,590,425 (+)NCBI
RefSeq Acc Id: NP_001003106   ⟸   NM_001003106
- UniProtKB: Q9XSI1 (UniProtKB/Swiss-Prot),   Q9TT02 (UniProtKB/Swiss-Prot),   Q9GKP2 (UniProtKB/TrEMBL),   A0A8C0TW59 (UniProtKB/TrEMBL),   F1PUZ6 (UniProtKB/TrEMBL),   A0A8C0QTI4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000053577   ⟸   ENSCAFT00000084058
Ensembl Acc Id: ENSCAFP00000018967   ⟸   ENSCAFT00000020440
Ensembl Acc Id: ENSCAFP00000064847   ⟸   ENSCAFT00000072909
RefSeq Acc Id: XP_038303218   ⟸   XM_038447290
- Peptide Label: isoform X1
- UniProtKB: A0A8I3P3L7 (UniProtKB/TrEMBL),   A0A8P0PDF5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845025336   ⟸   ENSCAFT00845032408
Ensembl Acc Id: ENSCAFP00845025290   ⟸   ENSCAFT00845032352
Ensembl Acc Id: ENSCAFP00845025234   ⟸   ENSCAFT00845032279

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012876 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022592 UniProtKB/TrEMBL
  ENSCAFG00040025435 UniProtKB/TrEMBL
  ENSCAFG00845018252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020440.5 UniProtKB/TrEMBL
  ENSCAFT00000072909.2 UniProtKB/TrEMBL
  ENSCAFT00000084058.2 UniProtKB/TrEMBL
  ENSCAFT00030041497.1 UniProtKB/TrEMBL
  ENSCAFT00030041543.1 UniProtKB/TrEMBL
  ENSCAFT00030041596.1 UniProtKB/TrEMBL
  ENSCAFT00030041639.1 UniProtKB/TrEMBL
  ENSCAFT00040047450.1 UniProtKB/TrEMBL
  ENSCAFT00040047456.1 UniProtKB/TrEMBL
  ENSCAFT00040047468.1 UniProtKB/TrEMBL
  ENSCAFT00040047478.1 UniProtKB/TrEMBL
  ENSCAFT00040047485.1 UniProtKB/TrEMBL
  ENSCAFT00845032279.1 UniProtKB/TrEMBL
  ENSCAFT00845032352 ENTREZGENE
  ENSCAFT00845032352.1 UniProtKB/TrEMBL
  ENSCAFT00845032408.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CTLA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTLA4/CD28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403696 UniProtKB/TrEMBL
NCBI Gene CTLA4 ENTREZGENE
PANTHER PTHR11494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11494:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CTLANTIGEN4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1E1GF27_CANLF UniProtKB/TrEMBL
  A0A8C0QTI4 ENTREZGENE
  A0A8C0TRX1_CANLF UniProtKB/TrEMBL
  A0A8C0TW59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TWM1_CANLF UniProtKB/TrEMBL
  A0A8C0TWP1_CANLF UniProtKB/TrEMBL
  A0A8C0TXW6_CANLF UniProtKB/TrEMBL
  A0A8I3P3L7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PDF5 ENTREZGENE, UniProtKB/TrEMBL
  CTLA4_CANLF UniProtKB/Swiss-Prot
  F1PUZ6 ENTREZGENE
  Q9GKP2 ENTREZGENE, UniProtKB/TrEMBL
  Q9TT02 ENTREZGENE
  Q9XSI1 ENTREZGENE
UniProt Secondary F1PUZ6 UniProtKB/TrEMBL
  Q9TT02 UniProtKB/Swiss-Prot
VGNC ID VGNC:59440 ENTREZGENE