ABCB1 (ATP binding cassette subfamily B member 1) - Rat Genome Database

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Gene: ABCB1 (ATP binding cassette subfamily B member 1) Canis lupus familiaris
Analyze
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
RGD ID: 12063362
Description: ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); floppase activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN brain development (ortholog); carbohydrate export (ortholog); cellular hyperosmotic salinity response (ortholog); PARTICIPATES IN axitinib pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ASSOCIATED WITH toxic encephalopathy; acquired immunodeficiency syndrome (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); brush border membrane (ortholog); INTERACTS WITH 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; allicin; digoxin
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-dependent translocase ABCB1; MDR1; multidrug resistance p-glycoprotein; multidrug resistance protein 1; p-gp
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,644,891 - 13,852,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,542,647 - 13,742,727 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,216,483 - 13,313,885 (-)NCBI
ROS_Cfam_1.01413,410,127 - 13,507,439 (-)NCBI
UMICH_Zoey_3.11413,613,256 - 13,710,576 (-)NCBI
UNSW_CanFamBas_1.01413,339,096 - 13,436,445 (-)NCBI
UU_Cfam_GSD_1.01413,622,793 - 13,720,201 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
adrenocortical carcinoma  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
Anthracycline-induced Cardiotoxicity  (ISO)
asthma  (ISO)
Behcet's disease  (ISO)
Breast Neoplasms  (ISO)
cannabis abuse  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
COVID-19  (ISO)
Critical Illness  (ISO)
Crohn's disease  (ISO)
Cronkhite-Canada syndrome  (ISO)
cryoglobulinemia  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
disease of mental health  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalitis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Eosinophilia  (ISO)
epilepsy  (ISO)
Escherichia Coli Infections  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
familial Mediterranean fever  (ISO)
familial temporal lobe epilepsy 3  (ISO)
Fetal Growth Retardation  (ISO)
Genetic Predisposition to Disease  (ISO)
Genetic Translocation  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Helicobacter Infections  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
idiopathic generalized epilepsy  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 13  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Latent Tuberculosis  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Nausea  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
obstructive sleep apnea  (ISO)
Orthostatic Hypotension  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Pain, Postoperative  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
ST Elevation Myocardial Infarction  (ISO)
status epilepticus  (ISO)
temporal lobe epilepsy  (ISO)
toxic encephalopathy  (IAGP,ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
visual epilepsy  (ISO)
Vomiting  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (ISO)
carbohydrate export  (ISO)
carboxylic acid transmembrane transport  (IEA)
cellular hyperosmotic salinity response  (ISO)
cellular response to alkaloid  (ISO)
cellular response to antibiotic  (ISO)
cellular response to borneol  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to external biotic stimulus  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mycotoxin  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to tumor necrosis factor  (ISO)
ceramide translocation  (IBA)
circadian rhythm  (ISO)
daunorubicin transport  (ISO)
establishment of blood-brain barrier  (ISO)
establishment of blood-retinal barrier  (ISO)
export across plasma membrane  (ISO)
G2/M transition of mitotic cell cycle  (IEA)
hormone transport  (ISO)
intestinal absorption  (ISO)
lactation  (ISO)
maintenance of blood-brain barrier  (ISO)
negative regulation of cell death  (ISO)
phospholipid translocation  (IBA)
placenta development  (ISO)
positive regulation of anion channel activity  (IEA)
positive regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of response to drug  (ISO)
protein localization to bicellular tight junction  (ISO)
regulation of chloride transport  (IEA)
regulation of intestinal absorption  (ISO)
regulation of response to osmotic stress  (IEA)
response to antineoplastic agent  (ISO)
response to cadmium ion  (ISO)
response to codeine  (ISO)
response to cyclosporin A  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to glucagon  (ISO)
response to glycoside  (ISO)
response to hypoxia  (ISO)
response to isoquinoline alkaloid  (ISO)
response to L-glutamate  (ISO)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to quercetin  (ISO)
response to thyroxine  (ISO)
response to vitamin A  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
stem cell proliferation  (IEA)
terpenoid transport  (ISO)
transepithelial transport  (IEA)
transmembrane transport  (ISO)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IEA,ISO)
xenobiotic transport across blood-brain barrier  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:9568108   PMID:12429346   PMID:12559367   PMID:15289602   PMID:16223335   PMID:16594604   PMID:17199425   PMID:17316722   PMID:17333245   PMID:17846232   PMID:17916018   PMID:18003606  
PMID:18537875   PMID:18605373   PMID:18650266   PMID:18795852   PMID:18922637   PMID:19059762   PMID:19152588   PMID:19171022   PMID:19733104   PMID:19836857   PMID:20043790   PMID:20103600  
PMID:20731191   PMID:21334003   PMID:21488961   PMID:22184139   PMID:22554937   PMID:22691950   PMID:22721613   PMID:22998209   PMID:23773525   PMID:24302812   PMID:24332606   PMID:24582422  
PMID:24939474   PMID:25157887   PMID:25522789   PMID:25928919   PMID:26822006   PMID:27234542   PMID:27528038   PMID:29958524   PMID:30020547   PMID:31113564   PMID:31685133   PMID:31743433  


Genomics

Comparative Map Data
ABCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,644,891 - 13,852,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,542,647 - 13,742,727 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,216,483 - 13,313,885 (-)NCBI
ROS_Cfam_1.01413,410,127 - 13,507,439 (-)NCBI
UMICH_Zoey_3.11413,613,256 - 13,710,576 (-)NCBI
UNSW_CanFamBas_1.01413,339,096 - 13,436,445 (-)NCBI
UU_Cfam_GSD_1.01413,622,793 - 13,720,201 (-)NCBI
ABCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl787,503,017 - 87,713,323 (-)EnsemblGRCh38hg38GRCh38
GRCh38787,503,017 - 87,713,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37787,132,333 - 87,342,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,970,884 - 87,180,500 (-)NCBINCBI36hg18NCBI36
Build 34786,777,598 - 86,987,215NCBI
Celera781,837,832 - 82,047,176 (-)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,744,182 - 81,952,578 (-)NCBIHuRef
CHM1_1787,063,281 - 87,272,756 (-)NCBICHM1_1
CRA_TCAGchr7v2786,464,691 - 86,673,953 (-)NCBI
Abcb1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,617,091 - 8,798,575 (+)NCBIGRCm39mm39
GRCm39 Ensembl58,710,077 - 8,798,575 (+)Ensembl
GRCm3858,567,091 - 8,748,575 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,660,077 - 8,748,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,660,092 - 8,748,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,666,098 - 8,754,525 (+)NCBImm8
Celera58,580,580 - 8,668,151 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
Abcb1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2425,357,467 - 25,529,941 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl425,158,362 - 25,442,709 (-)Ensembl
Rnor_6.0422,339,829 - 22,517,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,276,390 - 22,448,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,709,855 - 21,796,628 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1421,709,854 - 21,796,626 (+)NCBI
Celera420,849,575 - 20,934,573 (-)NCBICelera
Cytogenetic Map4q12NCBI
Abcb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554324,911,774 - 5,085,349 (-)NCBIChiLan1.0ChiLan1.0
ABCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1793,147,217 - 93,355,231 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,147,950 - 93,243,238 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0779,497,536 - 79,706,277 (-)NCBIMhudiblu_PPA_v0panPan3
Abcb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,693,137 - 26,871,076 (-)NCBI
SpeTri2.0NW_0049367631,225,355 - 1,308,257 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1993,049,955 - 93,146,469 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,530,015 - 102,626,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,211,044 - 61,430,691 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2161,322,748 - 61,529,274 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604242,634,559 - 42,749,353 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 18 6 6 9 1
Low 3 4 4 6 2 3 8 9 6
Below cutoff 1 4 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014118873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014118874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB066299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF045016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF092810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF403240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF536758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ419568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY582533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN877923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ068953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ617477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000002896   ⟹   ENSCAFP00000002684
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1413,644,892 - 13,742,727 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061997   ⟹   ENSCAFP00000063353
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1413,644,578 - 13,742,727 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070452   ⟹   ENSCAFP00000060327
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1413,542,647 - 13,742,727 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090274   ⟹   ENSCAFP00000045395
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1413,644,892 - 13,742,727 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000092086   ⟹   ENSCAFP00000061150
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1413,644,578 - 13,742,727 (-)Ensembl
RefSeq Acc Id: NM_001003215   ⟹   NP_001003215
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11413,644,891 - 13,742,216 (-)NCBI
Dog10K_Boxer_Tasha1413,216,483 - 13,313,885 (-)NCBI
ROS_Cfam_1.01413,410,127 - 13,506,822 (-)NCBI
UMICH_Zoey_3.11413,613,256 - 13,710,576 (-)NCBI
UNSW_CanFamBas_1.01413,339,096 - 13,436,445 (-)NCBI
UU_Cfam_GSD_1.01413,622,793 - 13,720,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038685912   ⟹   XP_038541840
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01413,410,127 - 13,507,439 (-)NCBI
RefSeq Acc Id: XM_038685913   ⟹   XP_038541841
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01413,410,127 - 13,506,828 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001003215   ⟸   NM_001003215
- UniProtKB: Q4PLA8 (UniProtKB/TrEMBL),   Q8HZQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000060327   ⟸   ENSCAFT00000070452
RefSeq Acc Id: ENSCAFP00000061150   ⟸   ENSCAFT00000092086
RefSeq Acc Id: ENSCAFP00000045395   ⟸   ENSCAFT00000090274
RefSeq Acc Id: ENSCAFP00000002684   ⟸   ENSCAFT00000002896
RefSeq Acc Id: ENSCAFP00000063353   ⟸   ENSCAFT00000061997
RefSeq Acc Id: XP_038541840   ⟸   XM_038685912
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038541841   ⟸   XM_038685913
- Peptide Label: isoform X2

Promoters
RGD ID:13685731
Promoter ID:EPDNEW_C3799
Type:initiation region
Name:ABCB1_1
Description:ATP binding cassette subfamily B member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11413,742,822 - 13,742,882EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 13666599 13666600 G T snv Rhodesian Ridgeback (RR123), Airedale Terrier (TA001), Rhodesian Ridgeback (RR098)
14 13687551 13687552 C T snv Kunming Dog (KM5)
14 13696625 13696626 G A snv Yellowstone Wolf (SRS661496)
14 13710943 13710944 T G snv Golden Retriever (GR1078)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001835 Ensembl
NCBI Gene ABCB1 ENTREZGENE
UniProt Q4PLA8 ENTREZGENE
  Q8HZQ9 ENTREZGENE
VGNC ID VGNC:37431 ENTREZGENE