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RGD ID: 12063362
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
Acc ID: CHEBI:28445
Term: vincristine
Definition: A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Chemical ID: MESH:D014750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB1affects response to substanceEXP 6480464CTDABCB1 protein affects the susceptibility to VincristinePMID:24975508
ABCB1increases exportEXP 6480464CTDABCB1 protein results in increased export of VincristinePMID:28093773
ABCB1multiple interactionsEXP 6480464CTDvalspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]PMID:24975508
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