RGD Reference Report - P-glycoprotein expression and distribution in the rat placenta during pregnancy. - Rat Genome Database

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P-glycoprotein expression and distribution in the rat placenta during pregnancy.

Authors: Novotna, M  Libra, A  Kopecky, M  Pavek, P  Fendrich, Z  Semecky, V  Staud, F 
Citation: Novotna M, etal., Reprod Toxicol. 2004 Aug-Sep;18(6):785-92.
RGD ID: 8657145
Pubmed: PMID:15279876   (View Abstract at PubMed)
DOI: DOI:10.1016/j.reprotox.2004.04.014   (Journal Full-text)

P-glycoprotein (P-gp) is a drug efflux transporter that limits the entry of various potentially toxic drugs and xenobiotics into the fetus and is thus considered a placental protective mechanism. In this study, P-gp expression was investigated in the rat chorioallantoic placenta over the course of pregnancy. Three methods have been employed: real-time RT-PCR, western blotting and immunohistochemistry. The expression of mdr1a and mdr1b genes was demonstrated as early as on the 11th gestation day (gd) and increased with advancing gestation. Western blotting analysis revealed the presence of P-gp in the rat placenta starting from gd 13 onwards. P-gp was localized in the developing labyrinth zone of the placenta on gd 13; from gd 15 up to the term P-gp was seen as a dot like continuous line in the syncytiotrophoblast layers. Our data confirm the presence of P-gp in the rat chorioallantoic placenta starting soon after its development, which may signify the involvement of P-gp in transplacental pharmacokinetics during the whole period of placental maturing.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Abcb1aRatplacenta development  IEP  RGD 
Abcb1bRatplacenta development  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abcb1a  (ATP binding cassette subfamily B member 1A)
Abcb1b  (ATP-binding cassette, sub-family B member 1B)


Additional Information