ABCB1 (ATP binding cassette subfamily B member 1) - Rat Genome Database

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Gene: ABCB1 (ATP binding cassette subfamily B member 1) Chlorocebus sabaeus
Analyze
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
RGD ID: 18724322
Description: ENCODES a protein that exhibits transmembrane transporter activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); cellular response to alkaloid (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN axitinib pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); acute lymphoblastic leukemia (ortholog); adrenocortical carcinoma (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); brush border membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-dependent translocase ABCB1; multidrug resistance protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,211,044 - 61,430,691 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2161,322,748 - 61,529,274 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604242,634,559 - 42,749,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
adrenocortical carcinoma  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
Anthracycline-induced Cardiotoxicity  (ISO)
antisocial personality disorder  (ISO)
asthma  (ISO)
Audiogenic Epilepsy  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
Breast Neoplasms  (ISO)
cannabis abuse  (ISO)
cannabis dependence  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
COVID-19  (ISO)
Critical Illness  (ISO)
Crohn's disease  (ISO)
cryoglobulinemia  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
disease of mental health  (ISO)
Disease Progression  (ISO)
drug dependence  (ISO)
Drug Overdose  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalitis  (ISO)
ENCEPHALOPATHY, ACUTE TRANSIENT  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Eosinophilia  (ISO)
epilepsy  (ISO)
Escherichia Coli Infections  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial adenomatous polyposis  (ISO)
familial hyperlipidemia  (ISO)
familial Mediterranean fever  (ISO)
familial temporal lobe epilepsy 3  (ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (ISO)
Genetic Predisposition to Disease  (ISO)
Genetic Translocation  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Helicobacter Infections  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
heroin dependence  (ISO)
human immunodeficiency virus infectious disease  (ISO)
idiopathic generalized epilepsy  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 13  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Latent Tuberculosis  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Nausea  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
neutropenia  (ISO)
obstructive sleep apnea  (ISO)
opiate dependence  (ISO)
Orthostatic Hypotension  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
Postoperative Pain  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
ST Elevation Myocardial Infarction  (ISO)
status epilepticus  (ISO)
temporal lobe epilepsy  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Vomiting  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
carboxylic acid transmembrane transport  (IEA)
cellular hyperosmotic salinity response  (ISO)
cellular response to alkaloid  (ISO)
cellular response to antibiotic  (ISO)
cellular response to borneol  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to external biotic stimulus  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mycotoxin  (ISO)
cellular response to nonylphenol  (ISO)
cellular response to tumor necrosis factor  (ISO)
ceramide translocation  (IEA)
circadian rhythm  (ISO)
daunorubicin transport  (ISO)
establishment of blood-brain barrier  (ISO)
establishment of blood-retinal barrier  (ISO)
export across plasma membrane  (IEA)
female pregnancy  (ISO)
G2/M transition of mitotic cell cycle  (IEA)
hormone transport  (ISO)
intestinal absorption  (ISO)
lactation  (ISO)
maintenance of blood-brain barrier  (ISO)
negative regulation of sensory perception of pain  (ISO)
oligopeptide export from mitochondrion  (IEA)
phospholipid translocation  (IEA)
placenta development  (ISO)
positive regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of response to drug  (ISO)
protein localization to bicellular tight junction  (ISO)
regulation of chloride transport  (IEA)
regulation of intestinal absorption  (ISO)
response to alcohol  (ISO)
response to antineoplastic agent  (ISO)
response to cadmium ion  (ISO)
response to codeine  (ISO)
response to cyclosporin A  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to glucagon  (ISO)
response to glycoside  (ISO)
response to hypoxia  (ISO)
response to L-glutamate  (ISO)
response to lipopolysaccharide  (ISO)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to progesterone  (ISO)
response to quercetin  (ISO)
response to thyroxine  (ISO)
response to vitamin A  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
stem cell proliferation  (IEA)
terpenoid transport  (ISO)
transepithelial transport  (IEA)
transmembrane transport  (IEA,ISO)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IEA,ISO)
xenobiotic transport across blood-brain barrier  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ABCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,211,044 - 61,430,691 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2161,322,748 - 61,529,274 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604242,634,559 - 42,749,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ABCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38787,503,017 - 87,713,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl787,503,017 - 87,713,323 (-)EnsemblGRCh38hg38GRCh38
GRCh37787,132,333 - 87,342,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,970,884 - 87,180,500 (-)NCBINCBI36Build 36hg18NCBI36
Build 34786,777,598 - 86,987,215NCBI
Celera781,837,832 - 82,047,176 (-)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef781,744,182 - 81,952,578 (-)NCBIHuRef
CHM1_1787,063,281 - 87,272,756 (-)NCBICHM1_1
T2T-CHM13v2.0788,752,787 - 88,963,178 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2786,464,691 - 86,673,953 (-)NCBI
Abcb1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,617,091 - 8,798,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,710,077 - 8,798,575 (+)EnsemblGRCm39 Ensembl
GRCm3858,567,091 - 8,748,575 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,660,077 - 8,748,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,660,092 - 8,748,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,666,098 - 8,754,525 (+)NCBIMGSCv36mm8
Celera58,580,580 - 8,668,151 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
Abcb1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,312,403 - 26,488,456 (-)NCBIGRCr8
mRatBN7.2425,357,467 - 25,529,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,158,362 - 25,442,709 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,355,700 - 30,438,098 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,281,938 - 26,364,336 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,656,062 - 24,738,283 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,339,829 - 22,517,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,276,390 - 22,448,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,709,855 - 21,796,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1421,709,854 - 21,796,626 (+)NCBI
Celera420,849,575 - 20,934,573 (-)NCBICelera
Cytogenetic Map4q12NCBI
Abcb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554324,911,774 - 5,085,349 (-)NCBIChiLan1.0ChiLan1.0
ABCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26105,382,570 - 105,590,973 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17153,647,208 - 153,855,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0779,497,536 - 79,706,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1793,147,217 - 93,355,231 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,147,950 - 93,243,238 (-)Ensemblpanpan1.1panPan2
ABCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,644,891 - 13,852,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,542,647 - 13,742,727 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,216,483 - 13,313,885 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01413,410,127 - 13,507,439 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1413,409,565 - 13,507,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11413,613,256 - 13,710,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,339,096 - 13,436,445 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01413,622,793 - 13,720,201 (-)NCBIUU_Cfam_GSD_1.0
Abcb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,693,137 - 26,871,076 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367631,226,482 - 1,297,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367631,225,355 - 1,308,257 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1993,049,955 - 93,146,469 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,530,015 - 102,626,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000010481   ⟹   ENSCSAP00000008574
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2161,322,748 - 61,529,274 (+)Ensembl
RefSeq Acc Id: XM_007982288   ⟹   XP_007980479
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12161,323,301 - 61,430,691 (+)NCBI
Vero_WHO_p1.0NW_02366604242,634,559 - 42,747,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007982290   ⟹   XP_007980481
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12161,211,044 - 61,430,691 (+)NCBI
Vero_WHO_p1.0NW_02366604242,634,559 - 42,747,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007982291   ⟹   XP_007980482
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12161,323,301 - 61,430,691 (+)NCBI
Vero_WHO_p1.0NW_02366604242,634,559 - 42,747,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038004571   ⟹   XP_037860499
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604242,634,559 - 42,749,353 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007980479 (Get FASTA)   NCBI Sequence Viewer  
  XP_007980481 (Get FASTA)   NCBI Sequence Viewer  
  XP_007980482 (Get FASTA)   NCBI Sequence Viewer  
  XP_037860499 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008574.1
RefSeq Acc Id: XP_007980481   ⟸   XM_007982290
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RIY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007980479   ⟸   XM_007982288
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RIY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007980482   ⟸   XM_007982291
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RIY5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000008574   ⟸   ENSCSAT00000010481
RefSeq Acc Id: XP_037860499   ⟸   XM_038004571
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RIY5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012391 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010481.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/TrEMBL
NCBI Gene ABCB1 ENTREZGENE
PANTHER ALPHA-FACTOR-TRANSPORTING ATPASE UniProtKB/TrEMBL
  ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt A0A0D9RIY5 ENTREZGENE, UniProtKB/TrEMBL