RGD Reference Report - Higher frequency of C.3435 of the ABCB1 gene in patients with tramadol dependence disorder. - Rat Genome Database

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Higher frequency of C.3435 of the ABCB1 gene in patients with tramadol dependence disorder.

Authors: Enabah, Dalia  El Baz, Heba  Moselhy, Hamdy 
Citation: Enabah D, etal., Am J Drug Alcohol Abuse. 2014 Jul;40(4):317-20. doi: 10.3109/00952990.2014.925468. Epub 2014 Jun 20.
RGD ID: 401827941
Pubmed: PMID:24950410   (View Abstract at PubMed)
DOI: DOI:10.3109/00952990.2014.925468   (Journal Full-text)


BACKGROUND: Polymorphic variation at the ABCB1 gene has been shown to affect the pharmacodynamics and kinetics of various drugs.
AIM: This study aimed to determine the frequency of occurrence of Single Nucleotide Polymorphism (SNP) in position A118G OPRM1 (rs1799971) gene and C.3435 (rs1045642) gene in tramadol users in comparison with normal controls.
METHODS: This was a cross sectional case-control outpatient study. The study sample consisted of 127 subjects (74 tramadol-dependents and 50 healthy controls). All patients fulfilled the Diagnostic and Statistical Manual IV Criteria for substance dependence (on tramadol). Genotyping of the OPRM1 gene 118 SNP and ABCB1 genes C.3435 SNP was performed by PCR, followed by restriction fragment length polymorphism identification.
RESULTS: A significant association was found between the ABCB1 gene T allele at the polymorphic site 3435 and tramadol dependence. No significant association was observed with the A118G OPRM1 gene.
CONCLUSION: The high frequency of ABCB1 gene T allele present at the polymorphic site 3435 could provide a protective mechanism from tramadol dependence disorder. Further study, using a larger sample, would be useful in further evaluating the possible role of ABCB1 gene polymorphisms.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABCB1Humanopiate dependence  IAGP DNA:SNP: :3435C>T (rs1045642) (human)RGD 
Abcb1aRatopiate dependence  ISOABCB1 (Homo sapiens)DNA:SNP: :3435C>T (rs1045642) (human)RGD 
Abcb1aMouseopiate dependence  ISOABCB1 (Homo sapiens)DNA:SNP: :3435C>T (rs1045642) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abcb1a  (ATP binding cassette subfamily B member 1A)

Genes (Mus musculus)
Abcb1a  (ATP-binding cassette, sub-family B member 1A)

Genes (Homo sapiens)
ABCB1  (ATP binding cassette subfamily B member 1)


Additional Information