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Gene: ABCB4 (ATP binding cassette subfamily B member 4) Homo sapiens
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Symbol: ABCB4
Name: ATP binding cassette subfamily B member 4
Description: Exhibits ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in several processes, including cellular response to bile acid; phospholipid translocation; and positive regulation of lipid transport. Localizes to several cellular components, including the actin cytoskeleton; apical plasma membrane; and focal adhesion. Implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC21; ATP-binding cassette sub-family B member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; GBD1; ICP3; MDR2; MDR2/3; MDR3; multidrug resistance protein 3; multiple drug resistance 3; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein 3; P-glycoprotein-3/multiple drug resistance-3; PFIC-3; PGY3; phosphatidylcholine translocator ABCB4
Orthologs:
Mus musculus (house mouse) : Abcb4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Abcb4 (ATP binding cassette subfamily B member 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ABCB4 (ATP binding cassette subfamily B member 4)
Canis lupus familiaris (dog) : ABCB4 (ATP binding cassette subfamily B member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcb4 (ATP binding cassette subfamily B member 4)
Sus scrofa (pig) : ABCB4 (ATP binding cassette subfamily B member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38787,398,988 - 87,476,722 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37787,031,361 - 87,105,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,869,297 - 86,942,955 (-)NCBINCBI36hg18NCBI36
Build 34786,676,016 - 86,754,402NCBI
Celera781,736,239 - 81,809,903 (-)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,642,357 - 81,716,022 (-)NCBIHuRef
CHM1_1786,961,467 - 87,035,121 (-)NCBICHM1_1
CRA_TCAGchr7v2786,362,871 - 86,436,531 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ABCB4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736946
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.