RGD Reference Report - ANX7, a candidate tumor suppressor gene for prostate cancer. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ANX7, a candidate tumor suppressor gene for prostate cancer.

Authors: Srivastava, M  Bubendorf, L  Srikantan, V  Fossom, L  Nolan, L  Glasman, M  Leighton, X  Fehrle, W  Pittaluga, S  Raffeld, M  Koivisto, P  Willi, N  Gasser, TC  Kononen, J  Sauter, G  Kallioniemi, OP  Srivastava, S  Pollard, HB 
Citation: Srivastava M, etal., Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4575-80. Epub 2001 Apr 3.
RGD ID: 2292656
Pubmed: PMID:11287641   (View Abstract at PubMed)
PMCID: PMC31876   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.071055798   (Journal Full-text)

The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. To test whether ANX7 might be a candidate TSG, we examined the ANX7-dependent suppression of human tumor cell growth, stage-specific ANX7 expression in 301 prostate specimens on a prostate tissue microarray, and loss of heterozygosity (LOH) of microsatellite markers at or near the ANX7 locus. Here we report that human tumor cell proliferation and colony formation are markedly reduced when the wild-type ANX7 gene is transfected into two prostate tumor cell lines, LNCaP and DU145. Consistently, analysis of ANX7 protein expression in human prostate tumor microarrays reveals a significantly higher rate of loss of ANX7 expression in metastatic and local recurrences of hormone refractory prostate cancer as compared with primary tumors (P = 0.0001). Using four microsatellite markers at or near the ANX7 locus, and laser capture microdissected tumor cells, 35% of the 20 primary prostate tumors show LOH. The microsatellite marker closest to the ANX7 locus showed the highest rate of LOH, including one homozygous deletion. We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neoplasm Metastasis  IEP 2292656associated with Prostatic Neoplasms and protein:decreased expression:prostate glandRGD 
Neoplasm Metastasis  ISOANXA7 (Homo sapiens)2292656; 2292656associated with Prostatic Neoplasms and protein:decreased expression:prostate glandRGD 

Objects Annotated

Genes (Rattus norvegicus)
Anxa7  (annexin A7)

Genes (Mus musculus)
Anxa7  (annexin A7)

Genes (Homo sapiens)
ANXA7  (annexin A7)


Additional Information