OGG1 (8-oxoguanine DNA glycosylase) - Rat Genome Database

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Gene: OGG1 (8-oxoguanine DNA glycosylase) Canis lupus familiaris
Analyze
Symbol: OGG1
Name: 8-oxoguanine DNA glycosylase
RGD ID: 12265339
Description: ENCODES a protein that exhibits 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity (ortholog); damaged DNA binding (ortholog); DNA N-glycosylase activity (ortholog); INVOLVED IN acute inflammatory response (ortholog); aging (ortholog); base-excision repair (ortholog); PARTICIPATES IN base excision repair pathway; ASSOCIATED WITH adenocarcinoma (ortholog); allergic contact dermatitis (ortholog); angiomyolipoma (ortholog); FOUND IN mitochondrion (ortholog); nuclear matrix (ortholog); nuclear speck (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: N-glycosylase/DNA lyase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,486,150 - 8,491,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,480,005 - 8,491,264 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,519,224 - 8,524,513 (-)NCBI
ROS_Cfam_1.0208,515,436 - 8,520,730 (-)NCBI
UMICH_Zoey_3.1208,237,911 - 8,243,202 (-)NCBI
UNSW_CanFamBas_1.0208,582,435 - 8,587,727 (-)NCBI
UU_Cfam_GSD_1.0208,556,049 - 8,561,340 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
allergic contact dermatitis  (ISO)
angiomyolipoma  (ISO)
Atrioventricular Septal Defect 2  (ISO)
basal cell carcinoma  (ISO)
brain disease  (ISO)
breast cancer  (ISO)
cataract  (ISO)
cholangiocarcinoma  (ISO)
Chromosome Aberrations  (ISO)
clear cell renal cell carcinoma  (ISO)
developmental coordination disorder  (ISO)
Discoid Lupus Erythematosus  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Gallbladder Neoplasms  (ISO)
Genetic Predisposition to Disease  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heart disease  (ISO)
hepatitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperplasia  (ISO)
Kidney Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
male infertility  (ISO)
middle cerebral artery infarction  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
nonpapillary renal cell carcinoma  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Premature Birth  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Prenatal Injuries  (ISO)
primary open angle glaucoma  (ISO)
progressive supranuclear palsy  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pterygium  (ISO)
renal cell carcinoma  (ISO)
sarcoma  (ISO)
senile cataract  (ISO)
skin disease  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Tongue Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
Urologic Neoplasms  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
OGG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,486,150 - 8,491,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,480,005 - 8,491,264 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,519,224 - 8,524,513 (-)NCBI
ROS_Cfam_1.0208,515,436 - 8,520,730 (-)NCBI
UMICH_Zoey_3.1208,237,911 - 8,243,202 (-)NCBI
UNSW_CanFamBas_1.0208,582,435 - 8,587,727 (-)NCBI
UU_Cfam_GSD_1.0208,556,049 - 8,561,340 (-)NCBI
OGG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl39,749,944 - 9,788,219 (+)EnsemblGRCh38hg38GRCh38
GRCh3839,749,952 - 9,788,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3739,791,636 - 9,808,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3639,765,705 - 9,783,342 (+)NCBINCBI36hg18NCBI36
Build 3439,766,653 - 9,783,311NCBI
Celera39,726,330 - 9,743,054 (+)NCBI
Cytogenetic Map3p25.3NCBI
HuRef39,727,975 - 9,744,701 (+)NCBIHuRef
CHM1_139,741,823 - 9,758,548 (+)NCBICHM1_1
Ogg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,303,871 - 113,311,838 (+)NCBIGRCm39mm39
GRCm39 Ensembl6113,303,933 - 113,312,029 (+)Ensembl
GRCm386113,326,972 - 113,334,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,326,972 - 113,335,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv376113,276,970 - 113,284,182 (+)NCBIGRCm37mm9NCBIm37
MGSCv366113,292,788 - 113,299,961 (+)NCBImm8
Celera6115,153,980 - 115,161,188 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.75NCBI
Ogg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24146,474,701 - 146,481,959 (+)NCBI
Rnor_6.0 Ensembl4145,282,797 - 145,289,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04145,282,828 - 145,289,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04208,580,193 - 208,586,457 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,209,745 - 149,219,081 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,454,585 - 149,463,922 (+)NCBI
Celera4135,032,266 - 135,038,520 (+)NCBICelera
Cytogenetic Map4q42NCBI
Ogg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,277,365 - 1,282,793 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,277,362 - 1,282,949 (+)NCBIChiLan1.0ChiLan1.0
OGG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.139,940,955 - 9,972,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,940,955 - 9,947,335 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v039,702,311 - 9,742,283 (+)NCBIMhudiblu_PPA_v0panPan3
Ogg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,490,887 - 15,501,164 (+)NCBI
SpeTri2.0NW_0049366023,411,106 - 3,418,826 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11366,038,669 - 66,045,478 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,102,660 - 73,108,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OGG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12245,757,414 - 45,763,690 (+)NCBI
Vero_WHO_p1.0NW_023666041120,772,448 - 120,811,082 (-)NCBI
Ogg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247314,383,000 - 4,388,486 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 5 22 6 6 6 6 4 12 8 10 6
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022406407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_541781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000008609   ⟹   ENSCAFP00000007977
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl208,484,581 - 8,491,264 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077423   ⟹   ENSCAFP00000052444
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl208,486,151 - 8,491,264 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083299   ⟹   ENSCAFP00000064242
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl208,480,005 - 8,491,264 (-)Ensembl
RefSeq Acc Id: XM_022406407   ⟹   XP_022262115
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,487,981 - 8,491,447 (-)NCBI
Dog10K_Boxer_Tasha208,521,055 - 8,524,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022406408   ⟹   XP_022262116
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,488,694 - 8,491,447 (-)NCBI
Dog10K_Boxer_Tasha208,521,198 - 8,524,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022406409   ⟹   XP_022262117
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,486,965 - 8,491,448 (-)NCBI
Dog10K_Boxer_Tasha208,520,036 - 8,524,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038427032   ⟹   XP_038282960
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0208,515,436 - 8,520,730 (-)NCBI
RefSeq Acc Id: XM_038427033   ⟹   XP_038282961
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0208,517,270 - 8,520,730 (-)NCBI
RefSeq Acc Id: XM_038427034   ⟹   XP_038282962
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0208,517,413 - 8,520,730 (-)NCBI
RefSeq Acc Id: XM_038427035   ⟹   XP_038282963
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0208,516,251 - 8,520,730 (-)NCBI
RefSeq Acc Id: XM_038502823   ⟹   XP_038358751
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1208,237,911 - 8,243,202 (-)NCBI
RefSeq Acc Id: XM_038502824   ⟹   XP_038358752
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1208,239,742 - 8,243,202 (-)NCBI
RefSeq Acc Id: XM_038502825   ⟹   XP_038358753
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1208,239,885 - 8,243,202 (-)NCBI
RefSeq Acc Id: XM_038502826   ⟹   XP_038358754
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1208,238,723 - 8,243,202 (-)NCBI
RefSeq Acc Id: XM_038565746   ⟹   XP_038421674
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0208,556,049 - 8,561,340 (-)NCBI
RefSeq Acc Id: XM_038565747   ⟹   XP_038421675
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0208,557,883 - 8,561,340 (-)NCBI
RefSeq Acc Id: XM_038565748   ⟹   XP_038421676
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0208,558,026 - 8,561,340 (-)NCBI
RefSeq Acc Id: XM_038565749   ⟹   XP_038421677
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0208,556,864 - 8,561,340 (-)NCBI
RefSeq Acc Id: XM_038629871   ⟹   XP_038485799
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0208,582,435 - 8,587,727 (-)NCBI
RefSeq Acc Id: XM_038629872   ⟹   XP_038485800
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0208,584,269 - 8,587,727 (-)NCBI
RefSeq Acc Id: XM_038629873   ⟹   XP_038485801
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0208,584,412 - 8,587,727 (-)NCBI
RefSeq Acc Id: XM_038629874   ⟹   XP_038485802
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0208,583,250 - 8,587,727 (-)NCBI
RefSeq Acc Id: XM_541781   ⟹   XP_541781
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,486,150 - 8,491,446 (-)NCBI
Dog10K_Boxer_Tasha208,519,224 - 8,524,513 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_541781   ⟸   XM_541781
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022262117   ⟸   XM_022406409
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022262115   ⟸   XM_022406407
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_022262116   ⟸   XM_022406408
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000052444   ⟸   ENSCAFT00000077423
RefSeq Acc Id: ENSCAFP00000064242   ⟸   ENSCAFT00000083299
RefSeq Acc Id: ENSCAFP00000007977   ⟸   ENSCAFT00000008609
RefSeq Acc Id: XP_038358751   ⟸   XM_038502823
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038358754   ⟸   XM_038502826
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038358752   ⟸   XM_038502824
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038358753   ⟸   XM_038502825
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038485799   ⟸   XM_038629871
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038485802   ⟸   XM_038629874
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038485800   ⟸   XM_038629872
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038485801   ⟸   XM_038629873
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038282960   ⟸   XM_038427032
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282963   ⟸   XM_038427035
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038282961   ⟸   XM_038427033
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038282962   ⟸   XM_038427034
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038421674   ⟸   XM_038565746
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038421677   ⟸   XM_038565749
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038421675   ⟸   XM_038565747
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038421676   ⟸   XM_038565748
- Peptide Label: isoform X2
Protein Domains
ENDO3c   OGG_N

Promoters
RGD ID:13686792
Promoter ID:EPDNEW_C4859
Type:single initiation site
Name:OGG1_1
Description:8-oxoguanine DNA glycosylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,491,270 - 8,491,330EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005344 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000052444 ENTREZGENE
  ENSCAFP00000064242 ENTREZGENE
NCBI Gene OGG1 ENTREZGENE
VGNC ID VGNC:44109 ENTREZGENE