RGD Reference Report - PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer. - Rat Genome Database

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PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer.

Authors: Wang, Guihua  Yang, Xi  Li, Chuan  Cao, Xiaonian  Luo, Xuelai  Hu, Junbo 
Citation: Wang G, etal., Mol Cancer Ther. 2014 Jul;13(7):1837-47. doi: 10.1158/1535-7163.MCT-14-0049. Epub 2014 May 16.
RGD ID: 13432045
Pubmed: PMID:24837077   (View Abstract at PubMed)
DOI: DOI:10.1158/1535-7163.MCT-14-0049   (Journal Full-text)

Class IA PI3K plays an essential role in the invasion and metastasis of cancer. However, the mechanisms and specific functions of PI3K isoforms in tumor invasion and metastasis are not fully understood. We evaluated the role of PIK3R3, a PI3K regulatory subunit encoded by the PIK3R3 gene, in colorectal cancer invasion and metastasis. Clinical specimens and cell lines data show that the expression level of PIK3R3 is associated with colorectal cancer metastasis. Overexpression of PIK3R3 increases tumor migration and invasion in vitro and promotes metastasis of colorectal cancers in vivo. Furthermore, we investigated that the overexpression of PIK3R3 depends on SNAI2, inducing significant epithelial-to-mesenchymal transition (EMT). Downregulation of PIK3R3 reverses this process, which possibly contributes to the enhanced invasive and metastasizing abilities of colorectal cancer cells. In this study, we found that PIK3R3 plays an important role in colorectal cancer metastasis and might be a potential and specific target for therapies against metastatic colorectal cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neoplasm Metastasis  IMP 13432045associated with Adenocarcinoma and ColonRGD 
Neoplasm Metastasis  ISOPIK3R3 (Homo sapiens)13432045; 13432045associated with Adenocarcinoma and ColonRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pik3r3  (phosphoinositide-3-kinase regulatory subunit 3)

Genes (Mus musculus)
Pik3r3  (phosphoinositide-3-kinase regulatory subunit 3)

Genes (Homo sapiens)
PIK3R3  (phosphoinositide-3-kinase regulatory subunit 3)


Additional Information