ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) - Rat Genome Database

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Gene: ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) Canis lupus familiaris
Analyze
Symbol: ENPP1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
RGD ID: 12306226
Description: ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); cyclic-GMP-AMP hydrolase activity (ortholog); INVOLVED IN 3'-phosphoadenosine 5'-phosphosulfate metabolic process (ortholog); adipose tissue development (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN insulin signaling pathway; niacin metabolic pathway; pantothenic acid metabolic pathway; ASSOCIATED WITH Aortic Calcification (ortholog); aortic valve disease 1 (ortholog); arterial calcification of infancy (ortholog); FOUND IN apical dendrite (ortholog); basal dendrite (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ectonucleotide pyrophosphatase/phosphodiesterase family member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11251,985 - 322,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1252,103 - 322,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11,243,885 - 1,317,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,146 - 117,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,283 - 118,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,290 - 167,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,450 - 112,214 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01209,085 - 282,880 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-phosphoadenosine 5'-phosphosulfate metabolic process  (ISO)
adipose tissue development  (ISO)
adult locomotory behavior  (ISO)
adult walking behavior  (ISO)
aorta development  (ISO)
apoptotic process involved in development  (ISO)
artery development  (ISO)
articular cartilage development  (ISO)
ATP metabolic process  (IEA)
axon regeneration  (ISO)
B-1 B cell homeostasis  (ISO)
biomineral tissue development  (ISO)
bone development  (ISO)
bone growth  (ISO)
bone mineralization  (ISO)
bone mineralization involved in bone maturation  (ISO)
bone remodeling  (ISO)
bone resorption  (ISO)
bone trabecula formation  (ISO)
calcium ion homeostasis  (ISO)
cartilage development  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular homeostasis  (ISO)
cellular response to acidic pH  (ISO)
cellular response to cAMP  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to sodium phosphate  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cementum mineralization  (ISO)
central nervous system myelination  (ISO)
cerebellum development  (ISO)
cerebral cortex development  (ISO)
collagen-activated signaling pathway  (ISO)
defense response to protozoan  (ISO)
determination of adult lifespan  (ISO)
diphosphate metabolic process  (ISO)
endochondral bone morphogenesis  (ISO)
endochondral ossification  (ISO)
establishment of localization in cell  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
fatty acid metabolic process  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
gene expression  (ISO)
generation of precursor metabolites and energy  (ISO)
glucose homeostasis  (ISO)
glucose import  (ISO)
glycolytic process  (ISO)
heart development  (ISO)
hematopoietic stem cell migration to bone marrow  (ISO)
hippocampus development  (ISO)
hormone metabolic process  (ISO)
immune response  (IEA)
inflammatory response to antigenic stimulus  (ISO)
inhibition of non-skeletal tissue mineralization  (ISO)
inorganic diphosphate transport  (IEA)
intracellular phosphate ion homeostasis  (ISO)
kidney development  (ISO)
leukocyte activation involved in inflammatory response  (ISO)
ligamentous ossification  (ISO)
liver development  (ISO)
long-term synaptic potentiation  (ISO)
macrophage differentiation  (ISO)
magnesium ion homeostasis  (ISO)
melanocyte differentiation  (ISO)
microglia differentiation  (ISO)
microglial cell migration  (ISO)
middle ear morphogenesis  (ISO)
mitochondrion organization  (ISO)
morphogenesis of an epithelium  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
mucus secretion  (ISO)
multicellular organism growth  (ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of fat cell differentiation  (IEA)
negative regulation of glucose import  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of ossification  (ISO)
negative regulation of protein autophosphorylation  (ISO)
neuron apoptotic process  (ISO)
nucleic acid metabolic process  (ISO)
nucleoside triphosphate catabolic process  (IEA)
odontogenesis  (ISO)
olfactory bulb development  (ISO)
oligodendrocyte apoptotic process  (ISO)
organic phosphonate metabolic process  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
phosphate ion homeostasis  (ISO)
phosphate-containing compound metabolic process  (ISO)
plasma cell differentiation  (ISO)
post-embryonic forelimb morphogenesis  (ISO)
regulation of bone mineralization  (IEA)
response to ATP  (ISO)
response to dietary excess  (ISO)
response to Gram-positive bacterium  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to magnesium ion  (ISO)
response to mechanical stimulus  (ISO)
response to platelet-derived growth factor  (ISO)
response to sodium phosphate  (ISO)
response to vitamin B6  (ISO)
response to wounding  (ISO)
sensory perception of mechanical stimulus  (ISO)
sensory perception of sound  (ISO)
sensory perception of temperature stimulus  (ISO)
sequestering of triglyceride  (ISO)
skin development  (ISO)
smoothened signaling pathway  (ISO)
spinal cord development  (ISO)
striatum development  (ISO)
T cell differentiation  (ISO)
tooth mineralization  (ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasculogenesis  (ISO)
vesicle-mediated transport  (IEA)
vitamin D3 metabolic process  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ENPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11251,985 - 322,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1252,103 - 322,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11,243,885 - 1,317,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,146 - 117,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,283 - 118,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,290 - 167,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,450 - 112,214 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01209,085 - 282,880 (-)NCBIUU_Cfam_GSD_1.0
ENPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,808,020 - 131,895,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,808,016 - 131,895,155 (+)EnsemblGRCh38hg38GRCh38
GRCh376132,129,160 - 132,216,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,170,853 - 132,254,043 (+)NCBINCBI36Build 36hg18NCBI36
Build 346132,170,852 - 132,254,043NCBI
Celera6132,876,272 - 132,963,416 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,704,724 - 129,791,900 (+)NCBIHuRef
CHM1_16132,392,926 - 132,480,050 (+)NCBICHM1_1
T2T-CHM13v2.06133,002,962 - 133,090,181 (+)NCBIT2T-CHM13v2.0
Enpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,513,812 - 24,588,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,513,812 - 24,588,057 (-)EnsemblGRCm39 Ensembl
GRCm381024,637,914 - 24,712,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,637,914 - 24,712,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,361,217 - 24,431,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,330,827 - 24,401,518 (-)NCBIMGSCv36mm8
Celera1025,583,320 - 25,641,223 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
Enpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,518,051 - 22,583,044 (+)NCBIGRCr8
mRatBN7.2120,698,746 - 20,763,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,698,764 - 20,763,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,475,435 - 20,539,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,475,432 - 26,539,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,675,339 - 20,739,097 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,748,201 - 21,813,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,748,261 - 21,813,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,228,262 - 23,292,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,223,678 - 21,287,411 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,223,940 - 21,288,766 (+)NCBI
Celera119,451,097 - 19,514,516 (+)NCBICelera
Cytogenetic Map1p12NCBI
Enpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,415,737 - 12,480,359 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,416,147 - 12,477,214 (+)NCBIChiLan1.0ChiLan1.0
ENPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,797,817 - 151,882,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,704,715 - 149,789,744 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,591,858 - 129,673,000 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,698,904 - 133,783,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,698,640 - 133,783,644 (+)Ensemblpanpan1.1panPan2
Enpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,195,622 - 120,237,836 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937067194,375 - 246,607 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,722,721 - 31,796,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,724,290 - 31,796,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,240,330 - 35,281,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,670,416 - 41,755,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604013,807,051 - 13,921,708 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,917,689 - 5,982,308 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,918,005 - 5,983,480 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ENPP1
399 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 5 22 6 6 6 6 6 10 8 10 6
Below cutoff 2

Sequence


RefSeq Acc Id: ENSCAFT00000000001   ⟹   ENSCAFP00000000001
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1252,103 - 322,718 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000010   ⟹   ENSCAFP00845000005
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl148,283 - 118,098 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000011   ⟹   ENSCAFP00845000006
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl149,956 - 118,098 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000016   ⟹   ENSCAFP00845000008
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl149,956 - 118,098 (-)Ensembl
RefSeq Acc Id: XM_003638785   ⟹   XP_003638833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11251,985 - 322,081 (-)NCBI
Dog10K_Boxer_Tasha11,243,885 - 1,317,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038465097   ⟹   XP_038321025
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1193,290 - 167,054 (-)NCBI
RefSeq Acc Id: XM_038525686   ⟹   XP_038381614
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01209,085 - 282,880 (-)NCBI
RefSeq Acc Id: XM_038589975   ⟹   XP_038445903
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0138,450 - 112,214 (-)NCBI
RefSeq Acc Id: XM_038653811   ⟹   XP_038509739
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0144,146 - 117,941 (-)NCBI
RefSeq Acc Id: XP_003638833   ⟸   XM_003638785
- UniProtKB: A0A8C0PJE1 (UniProtKB/TrEMBL),   A0A8I3RQK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000001   ⟸   ENSCAFT00000000001
RefSeq Acc Id: XP_038321025   ⟸   XM_038465097
RefSeq Acc Id: XP_038445903   ⟸   XM_038589975
RefSeq Acc Id: XP_038509739   ⟸   XM_038653811
- UniProtKB: A0A8C0PJE1 (UniProtKB/TrEMBL),   A0A8I3RQK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381614   ⟸   XM_038525686
- UniProtKB: A0A8C0LZR9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000005   ⟸   ENSCAFT00845000010
RefSeq Acc Id: ENSCAFP00845000008   ⟸   ENSCAFT00845000016
RefSeq Acc Id: ENSCAFP00845000006   ⟸   ENSCAFT00845000011
Protein Domains
SMB

Promoters
RGD ID:13681934
Promoter ID:EPDNEW_C1
Type:single initiation site
Name:ENPP1_1
Description:ectonucleotide pyrophosphatase/phosphodiesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11322,080 - 322,140EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000001 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002536 UniProtKB/TrEMBL
  ENSCAFG00040000002 UniProtKB/TrEMBL
  ENSCAFG00845000008 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000001.5 UniProtKB/TrEMBL
  ENSCAFT00030004684.1 UniProtKB/TrEMBL
  ENSCAFT00040000002.1 UniProtKB/TrEMBL
  ENSCAFT00845000010 ENTREZGENE
  ENSCAFT00845000010.1 UniProtKB/TrEMBL
  ENSCAFT00845000011.1 UniProtKB/TrEMBL
  ENSCAFT00845000016.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.570.10 UniProtKB/TrEMBL
  3.40.720.10 UniProtKB/TrEMBL
  4.10.410.20 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease_sf UniProtKB/TrEMBL
  Extracellular_endonuc_su_A UniProtKB/TrEMBL
  His-Me_finger_sf UniProtKB/TrEMBL
  Phosphodiest/P_Trfase UniProtKB/TrEMBL
  Somatomedin_B-like_dom_sf UniProtKB/TrEMBL
  Somatomedin_B_chordata UniProtKB/TrEMBL
  Somatomedin_B_dom UniProtKB/TrEMBL
KEGG Report cfa:100856150 UniProtKB/TrEMBL
NCBI Gene ENPP1 ENTREZGENE
PANTHER ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE UniProtKB/TrEMBL
  PTHR10151:SF77 UniProtKB/TrEMBL
Pfam Endonuclease_NS UniProtKB/TrEMBL
  Phosphodiest UniProtKB/TrEMBL
  Somatomedin_B UniProtKB/TrEMBL
PRINTS SOMATOMEDINB UniProtKB/TrEMBL
PROSITE SMB_1 UniProtKB/TrEMBL
  SMB_2 UniProtKB/TrEMBL
SMART Endonuclease_NS UniProtKB/TrEMBL
  NUC UniProtKB/TrEMBL
  SM00201 UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
  SSF54060 UniProtKB/TrEMBL
  SSF90188 UniProtKB/TrEMBL
UniProt A0A8C0LZR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PJE1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3M8K6_CANLF UniProtKB/TrEMBL
  A0A8I3RNU9_CANLF UniProtKB/TrEMBL
  A0A8I3RQK2 ENTREZGENE, UniProtKB/TrEMBL
  Q6JDL5_CANLF UniProtKB/TrEMBL
  Q6JDL6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40374 ENTREZGENE