RGD Reference Report - Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development. - Rat Genome Database

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Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development.

Authors: Cognato, Giana de Paula  Czepielewski, Rafael Sanguinetti  Sarkis, João José Freitas  Bogo, Maurício Reis  Bonan, Carla Denise 
Citation: Cognato Gde P, etal., Int J Dev Neurosci. 2008 Oct;26(6):593-8. doi: 10.1016/j.ijdevneu.2008.05.001. Epub 2008 May 9.
RGD ID: 13204724
Pubmed: PMID:18565716   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ijdevneu.2008.05.001   (Journal Full-text)

Ecto-nucleotide pyrophosphatases/phosphodiesterases (E-NPPs) are membrane-bound ecto-enzymes involved in the modulation of purinergic signaling. Important physiological roles related to brain development have been associated to purinergic neurotransmission. NPP1, two splice isoforms of NPP2, and NPP3 have already been identified in adult rat brain. However, there are no studies evaluating the mRNA expression of these NPP members during the brain development. The effort of the present study was to map NPP gene expression pattern in olfactory bulb, hippocampus, cerebral cortex, striatum, and cerebellum at crucial ages for rat development (7, 14, 21, 60, and 150 days old) by a semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) strategy. Our results demonstrated an increase in the relative expression of NPP1 throughout the aging in all structures analyzed, except in hippocampus, where the higher expression has been detected in 14 days old rats. Both NPP2 isoforms have shown a similar pattern of expression among all structures. The relative expression of NPP3 decreased during the aging mainly on cerebellum, hippocampus, and olfactory bulb. Altogether, the different patterns of NPP gene expression during rat brain development reinforce the idea that each enzyme may play a distinct role on modulating the purinergic signaling throughout aging.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cerebellum development  IEP 13204724 RGD 
cerebral cortex development  IEP 13204724 RGD 
hippocampus development  IEP 13204724 RGD 
olfactory bulb development  IEP 13204724 RGD 
striatum development  IEP 13204724 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Enpp1  (ectonucleotide pyrophosphatase/phosphodiesterase 1)


Additional Information