RGD Reference Report - TrkC plays an essential role in breast tumor growth and metastasis. - Rat Genome Database

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TrkC plays an essential role in breast tumor growth and metastasis.

Authors: Jin, Wook  Kim, Gyoung Mi  Kim, Min Soo  Lim, Mi Hee  Yun, Chohee  Jeong, Joon  Nam, Jeong-Seok  Kim, Seong-Jin 
Citation: Jin W, etal., Carcinogenesis. 2010 Nov;31(11):1939-47. doi: 10.1093/carcin/bgq180. Epub 2010 Aug 28.
RGD ID: 150520014
Pubmed: PMID:20802235   (View Abstract at PubMed)
DOI: DOI:10.1093/carcin/bgq180   (Journal Full-text)

Tropomyosin-related kinase (Trk) C, a member of the Trk family of neurotrophin receptors, has been implicated in the growth and survival of human cancer tissues. Here, we report that TrkC is frequently overexpressed in human breast cancers and plays an essential role in tumor growth and metastasis. Ectopic expression of TrkC in non-malignant mammary epithelial cells suppressed anoikis, which correlated with activation of the Ras-mitogen-activated protein kinase and phosphatidylinositol-3-OH kinase (PI3K)/Akt pathways, and reduced expression of the metastatic regulator Twist. Furthermore, suppression of TrkC expression in highly metastatic mammary carcinoma cells inhibited their growth in vitro, as well as their ability to metastasize from the mammary gland to the lung in vivo. These results have identified TrkC as a critical regulator of breast cancer cell growth and metastasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NTRK3HumanAnimal Mammary Neoplasms amelioratesISONtrk3 (Mus musculus) RGD 
Ntrk3RatAnimal Mammary Neoplasms amelioratesISONtrk3 (Mus musculus) RGD 
Ntrk3MouseAnimal Mammary Neoplasms amelioratesIMP  RGD 
NTRK3Humaninvasive ductal carcinoma  IEP mRNA and protein:increased expression:breast:RGD 
Ntrk3Ratinvasive ductal carcinoma  ISONTRK3 (Homo sapiens)mRNA and protein:increased expression:breast:RGD 
Ntrk3Mouseinvasive ductal carcinoma  ISONTRK3 (Homo sapiens)mRNA and protein:increased expression:breast:RGD 
NTRK3Humanlung metastasis amelioratesISONtrk3 (Mus musculus)associated with mammary carcinomaRGD 
Ntrk3Ratlung metastasis amelioratesISONtrk3 (Mus musculus)associated with mammary carcinomaRGD 
Ntrk3Mouselung metastasis amelioratesIMP associated with mammary carcinomaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)

Genes (Mus musculus)
Ntrk3  (neurotrophic tyrosine kinase, receptor, type 3)

Genes (Homo sapiens)
NTRK3  (neurotrophic receptor tyrosine kinase 3)


Additional Information