MUC1 (mucin 1, cell surface associated) - Rat Genome Database

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Gene: MUC1 (mucin 1, cell surface associated) Canis lupus familiaris
Analyze
Symbol: MUC1
Name: mucin 1, cell surface associated
RGD ID: 12091882
Description: ENCODES a protein that exhibits p53 binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); transcription coregulator activity (ortholog); INVOLVED IN cellular response to retinoic acid (ortholog); DNA damage response, signal transduction by p53 class mediator (ortholog); DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); allergic conjunctivitis (ortholog); allergic rhinitis (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); chromatin (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endometrial mucin-1; mucin 1, transmembrane; mucin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,338,939 - 42,344,690 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,340,375 - 42,344,690 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,831,252 - 41,835,267 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,208,174 - 42,213,894 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,209,579 - 42,213,894 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,989,397 - 41,993,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,043,322 - 42,047,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,326,882 - 42,331,197 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 2  (ISO)
bacterial conjunctivitis  (ISO)
biliary tract benign neoplasm  (ISO)
bird fancier's lung  (ISO)
blepharitis  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
bronchopulmonary dysplasia  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
common bile duct neoplasm  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
Diabetes Complications  (ISO)
dry eye syndrome  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fetal Growth Retardation  (ISO)
Gallbladder Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
Hematologic Neoplasms  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunodeficiency 42  (ISO)
interstitial lung disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
measles  (ISO)
Mesothelioma  (ISO)
MHC class II deficiency  (ISO)
mucinous adenocarcinoma  (ISO)
multiple myeloma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
obstructive sleep apnea  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
parathyroid carcinoma  (ISO)
Peritoneal Neoplasms  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
severe congenital neutropenia 3  (ISO)
severe congenital neutropenia 5  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
urinary bladder cancer  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16413213   PMID:19453277   PMID:21937430   PMID:22726603   PMID:22947252   PMID:30032202  


Genomics

Comparative Map Data
MUC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,338,939 - 42,344,690 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,340,375 - 42,344,690 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,831,252 - 41,835,267 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,208,174 - 42,213,894 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,209,579 - 42,213,894 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,989,397 - 41,993,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,043,322 - 42,047,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,326,882 - 42,331,197 (+)NCBIUU_Cfam_GSD_1.0
MUC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,185,824 - 155,192,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,185,824 - 155,192,916 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,158,300 - 155,162,706 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,424,924 - 153,429,324 (-)NCBINCBI36Build 36hg18NCBI36
Build 341151,971,671 - 151,975,732NCBI
Celera1128,229,565 - 128,235,983 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,521,570 - 126,525,810 (-)NCBIHuRef
CHM1_11156,554,155 - 156,558,213 (-)NCBICHM1_1
T2T-CHM13v2.01154,325,440 - 154,331,478 (-)NCBIT2T-CHM13v2.0
Muc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,136,363 - 89,140,688 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,136,364 - 89,140,688 (+)EnsemblGRCm39 Ensembl
GRCm38389,229,056 - 89,233,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,229,057 - 89,233,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv37389,032,974 - 89,037,291 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,314,979 - 89,319,296 (+)NCBIMGSCv36mm8
Celera389,262,943 - 89,267,242 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.02NCBI
Muc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,933,312 - 176,938,497 (+)NCBIGRCr8
mRatBN7.22174,635,989 - 174,640,738 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,635,995 - 174,640,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,781,854 - 181,786,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,804,226 - 179,808,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,404,055 - 174,408,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,543,137 - 188,547,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,543,137 - 188,547,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,957,206 - 207,962,396 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,399,482 - 181,403,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,352,002 - 181,353,687 (+)NCBI
Celera2168,578,421 - 168,583,038 (+)NCBICelera
RH 3.4 Map21155.0RGD
Cytogenetic Map2q34NCBI
Muc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555451,657,728 - 1,662,112 (-)NCBIChiLan1.0ChiLan1.0
MUC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,649,069 - 94,655,513 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,381,477 - 94,386,968 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,533,508 - 130,537,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,141,969 - 134,146,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,141,969 - 134,145,850 (-)Ensemblpanpan1.1panPan2
Muc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,661,448 - 25,667,022 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365804,691,870 - 4,694,092 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1494,626,317 - 94,631,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,409,143 - 103,413,841 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MUC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,641,701 - 8,646,739 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,642,842 - 8,646,962 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,970,061 - 7,974,280 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248852,339,281 - 2,343,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MUC1
44 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 8
Low 5 13 1 1 2 8 8 6
Below cutoff 4 9 5 6 5 4 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026980   ⟹   ENSCAFP00000025082
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl742,340,375 - 42,344,690 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845023239   ⟹   ENSCAFP00845018229
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl742,209,579 - 42,213,894 (+)Ensembl
RefSeq Acc Id: NM_001194977   ⟹   NP_001181906
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1742,340,375 - 42,344,690 (+)NCBI
Dog10K_Boxer_Tasha741,831,252 - 41,835,267 (+)NCBI
ROS_Cfam_1.0742,209,579 - 42,213,894 (+)NCBI
UMICH_Zoey_3.1741,989,397 - 41,993,712 (+)NCBI
UNSW_CanFamBas_1.0742,043,322 - 42,047,575 (+)NCBI
UU_Cfam_GSD_1.0742,326,882 - 42,331,197 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038670504   ⟹   XP_038526432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0742,208,174 - 42,213,894 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001181906 (Get FASTA)   NCBI Sequence Viewer  
  XP_038526432 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAU12571 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000025082.4
  ENSCAFP00030040577.1
  ENSCAFP00040002090.1
  ENSCAFP00845018229
  ENSCAFP00845018229.1
Reference Protein Sequences
RefSeq Acc Id: NP_001181906   ⟸   NM_001194977
- Peptide Label: precursor
- UniProtKB: A0A8C0PE41 (UniProtKB/TrEMBL),   A0A8I3NKL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000025082   ⟸   ENSCAFT00000026980
RefSeq Acc Id: XP_038526432   ⟸   XM_038670504
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K111 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845018229   ⟸   ENSCAFT00845023239
Protein Domains
SEA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017037 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030025158 UniProtKB/TrEMBL
  ENSCAFG00040001299 UniProtKB/TrEMBL
  ENSCAFG00845013058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026980.6 UniProtKB/TrEMBL
  ENSCAFT00030046430.1 UniProtKB/TrEMBL
  ENSCAFT00040002439.1 UniProtKB/TrEMBL
  ENSCAFT00845023239 ENTREZGENE
  ENSCAFT00845023239.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.600 UniProtKB/TrEMBL
InterPro SEA_dom UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:448784 UniProtKB/TrEMBL
NCBI Gene MUC1 ENTREZGENE
PANTHER MUCIN-1 UniProtKB/TrEMBL
  MUCIN-1-RELATED UniProtKB/TrEMBL
Pfam SEA UniProtKB/TrEMBL
PROSITE SEA UniProtKB/TrEMBL
SMART SEA UniProtKB/TrEMBL
Superfamily-SCOP SSF82671 UniProtKB/TrEMBL
UniProt A0A8C0K111 ENTREZGENE
  A0A8C0PE41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NKL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NIM1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:55753 ENTREZGENE