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Gene: PLAUR (plasminogen activator, urokinase receptor) Canis lupus familiaris

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Symbol:

PLAUR

Name:

plasminogen activator, urokinase receptor

RGD ID:

12301312

Description:

ENCODES a protein that exhibits cell-matrix adhesion mediator activity (ortholog); enzyme activator activity (ortholog); enzyme binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); epithelial cell differentiation involved in prostate gland development (ortholog); mesenchymal cell differentiation (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); alcohol-associated liver disease (ortholog); autistic disorder (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); protein complex involved in cell-matrix adhesion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

urokinase plasminogen activator surface receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	111,476,804 - 111,490,876 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	111,476,893 - 111,490,880 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	110,957,047 - 110,970,796 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	112,087,347 - 112,101,189 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	1	111,675,381 - 111,689,348 (+)	NCBI		UMICH_Zoey_3.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

alcohol-associated liver disease (ISO)

autistic disorder (ISO)

Bacteremia (ISO)

carcinoma (ISO)

cardiovascular system disease (ISO)

cerebral infarction (ISO)

cervical cancer (ISO)

chronic obstructive pulmonary disease (ISO)

clear cell renal cell carcinoma (ISO)

colorectal cancer (ISO)

Crohn's disease (ISO)

disease of cellular proliferation (ISO)

end stage renal disease (ISO)

esophageal cancer (ISO)

hepatitis B (ISO)

hepatocellular carcinoma (ISO)

human immunodeficiency virus infectious disease (ISO)

Inflammation (ISO)

liver cirrhosis (ISO)

Lung Injury (ISO)

Lyme disease (ISO)

melanoma (ISO)

melioidosis (ISO)

meningitis (ISO)

myocardial infarction (ISO)

Nasal Polyps (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

obesity (ISO)

ovarian serous cystadenocarcinoma (ISO)

perinatal necrotizing enterocolitis (ISO)

peritonitis (ISO)

pre-eclampsia (ISO)

prion disease (ISO)

Prostatic Neoplasms (ISO)

pulmonary tuberculosis (ISO)

Reperfusion Injury (ISO)

rheumatoid arthritis (ISO)

Sepsis (ISO)

sinusitis (ISO)

Spinal Cord Injuries (ISO)

status epilepticus (ISO)

stomach cancer (ISO)

Systemic Inflammatory Response Syndrome (ISO)

systemic juvenile rheumatoid arthritis (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

toxic shock syndrome (ISO)

type 2 diabetes mellitus (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-matrix adhesion (ISO)

epithelial cell differentiation involved in prostate gland development (ISO)

mesenchymal cell differentiation (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of intrinsic apoptotic signaling pathway (ISO)

plasminogen activation (ISO)

positive regulation of epidermal growth factor receptor signaling pathway (ISO)

positive regulation of extracellular matrix disassembly (ISO)

positive regulation of homotypic cell-cell adhesion (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of release of cytochrome c from mitochondria (ISO)

protein localization to cell surface (ISO)

regulation of cell adhesion (ISO)

skeletal muscle tissue regeneration (ISO)

spermatogenesis (ISO)

Cellular Component

cell surface (ISO)

plasma membrane (ISO)

protein complex involved in cell-matrix adhesion (ISO)

serine-type endopeptidase complex (ISO)

Molecular Function

cell-matrix adhesion mediator activity (ISO)

enzyme activator activity (ISO)

enzyme binding (ISO)

protein domain specific binding (ISO)

signaling receptor binding (ISO)

urokinase plasminogen activator receptor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

fibroblast growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:26286429

Genomics

Comparative Map Data

PLAUR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	111,476,804 - 111,490,876 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	111,476,893 - 111,490,880 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	110,957,047 - 110,970,796 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	112,087,347 - 112,101,189 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	1	111,675,381 - 111,689,348 (+)	NCBI		UMICH_Zoey_3.1

PLAUR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	43,646,095 - 43,670,169 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	43,645,672 - 43,670,547 (-)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	19	44,150,247 - 44,174,321 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	48,842,088 - 48,866,342 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	48,844,571 - 48,866,342	NCBI
Celera	19	40,952,740 - 40,977,471 (-)	NCBI		Celera
Cytogenetic Map	19	q13.31	NCBI
HuRef	19	40,580,832 - 40,605,572 (-)	NCBI		HuRef
CHM1_1	19	44,151,900 - 44,176,634 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	46,467,757 - 46,492,325 (-)	NCBI		T2T-CHM13v2.0

Plaur
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	24,161,857 - 24,175,393 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	24,161,875 - 24,175,394 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	24,460,937 - 24,475,970 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	24,462,484 - 24,475,968 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	7	25,247,519 - 25,260,892 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	24,171,260 - 24,184,634 (+)	NCBI		MGSCv36	mm8
Celera	7	19,076,593 - 19,089,968 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	10.92	NCBI

Plaur
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	89,181,363 - 89,196,308 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	89,178,453 - 89,198,130 (+)	Ensembl				GRCr8
mRatBN7.2	1	80,053,440 - 80,068,384 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	80,050,324 - 80,068,595 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	85,446,800 - 85,461,972 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	93,996,901 - 94,011,843 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	87,202,621 - 87,217,793 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	1	87,801,232 - 87,816,175 (+)	NCBI
Lyon_Normotensive	1	92,938,222 - 92,953,165 (+)	NCBI
Lyon_Hypertensive	1	89,482,090 - 89,497,260 (+)	NCBI
F344_StmMcwi	1	87,926,812 - 87,941,755 (+)	NCBI
Rnor_6.0	1	81,328,171 - 81,344,954 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	81,328,183 - 81,344,708 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	1	82,587,242 - 82,602,924 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	79,708,646 - 79,712,881 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	74,507,638 - 74,521,525 (+)	NCBI		Celera
RGSC_v3.1	1	79,786,756 - 79,791,047 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

Plaur
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	1,378,793 - 1,393,324 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955555	1,378,505 - 1,393,395 (-)	NCBI	ChiLan1.0	ChiLan1.0

Plaur
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	15	11,597,977 - 11,612,756 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024409349	16,493,551 - 16,503,390 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936706	840,968 - 855,552 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLAUR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	50,489,777 - 50,505,418 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	6	50,489,773 - 50,505,453 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	46,349,485 - 46,365,098 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLAUR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	6	14,182,416 - 14,205,367 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666073	16,711,568 - 16,734,916 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	6	37,161,957 - 37,191,867 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2

Plaur
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624907	1,174,648 - 1,188,919 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624907	1,174,448 - 1,189,377 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	29	4,671,352 - 4,690,126 (+)	Ensembl

Plaur
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	170,237,074 - 170,252,694 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in PLAUR
206 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014119989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038467960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038656777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000007613 ⟹ ENSCAFP00000007049

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	1	111,476,893 - 111,490,880 (+)	Ensembl

RefSeq Acc Id:

XM_014119989 ⟹ XP_013975464

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	1	111,476,804 - 111,490,876 (+)	NCBI
Dog10K_Boxer_Tasha	1	110,957,047 - 110,970,796 (+)	NCBI

Sequence:

show sequence

TTCAATCCCGTGCTGAGGTCCCGTAGCAGGAGGAAGGAGAAGCGGAATTTGCACCTTGGCAGCC
GGGAGACAGCTGTGACCATGGCCACATGAGTCACAGCAGAGCCAGCCCCCTACTCCTGGCCGGC
CGCGCCCTGGCAAAGGAAGTGTTTGAAGAGGAGGGACGGAGCGGTGCAGGGAGCCACAGACAGG
AGCTGCTTCCAGACATGGGCCATCCGCTGCTGCTGCCGCTGCTGGGGCTGTTGCTTCAGACCTG
CGTTCCAGTCTCCTGGAGCCTGCAGTGCATGCTGTGTGGGACTACTGGGAAGTGCCAGGTGGAA
GAGTGTACCCCTGGCCAGGACCTCTGCAGGACCACGATCATGCGCATATGGGAAGATGGTGATG
AGCTGGAGGTGGTGGAGAGAGGCTGTACCCACCCAGAGAAGAGCAACAGGACCATGAGCTATCG
GACAGGCATGAAGATCATCACTCTTACGGAAGCCGTATGTGGGACCAACTTGTGCAACAAACCC
ACCTCTGGTCGGGTTTCCACCTTTCCCCGAACCCGAAGCCGTTACCTCGAATGTGTTTCCTGCG
GCTCCTCAGATCTGAGCTGTGAGAGGGGCTTGGACCAGAGCCTGCAATGCCGCAGCCCTACAGA
ACAGTGTGTGGAAGTGGTGACCCACAGGGGCCTGGAAGACAGTCCAAGGGATGAGCACCACACC
CGCGGCTGTGGCAACCTCCCGGGCTGCCCAGGCCCCACCGGCTTCCACAACAACCACACCTTCC
ACTTCCTGCAGTGCTGCAACACCACCAAATGCAATGCGGGCCCAGTCCTGGAGCTTCAAAACCT
GCCTCTGAACGGCCTCCAGTGTTTCGGCTGTGAGGGGAACAGCACCCATGGTTGTTCCTCCGAA
GAGACTTCCTTGATTGCCTGCCGAGGCCCCATGAACCAATGTCTGGACGCCACGGGCACTAATG
GGCTGGGCAACCCGAGCTACACAGTTCGAGGCTGTGCGACCCCCTCATGGTGCCAGAGTCTCCA
CGTGGCTGAAGCCTTCAGCATGACCCATCTCAATGTCTCATGCTGTACTGGGAACAGCTGTAAC
CACCCAATCCTGGATCACCAGCCTCGCATAGGCAGTGCCCCCCGGCCTGGTCCTGCCCACCTCA
GCCTCACCGTCACCTTGCTACTAACTGCCAGACTATGGGGAGGCACTCTCCTCTGGACCTGATC
CCCCACTCCCCCTACCCTGGCTGGATCCAGGGATGTCAGCTGCCCTCAGCTCCCAGCCCTGCAG
ACTTGCTGTGTGACCTCAGGCCAGTGTGCCACCCTCTCTGGGTCTGTTTTCCCAGCCATTAGGA
CACCTGTCTCACAGAGTTGCAGAACCAGGAGAGAAAAGCTGAAGAAAGACCGCAGGCCAGCAAG
AGAGGTTTATTATGTTAGCAGTGTTGCACCGTTGTTGTTATTATTAATTAATATTTGTTTTATT
TAATATTTTATACTTAAATAAAGATTTTTATACCAATGAA

hide sequence

RefSeq Acc Id:

XM_038467960 ⟹ XP_038323888

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	1	111,675,381 - 111,689,348 (+)	NCBI

RefSeq Acc Id:

XM_038656777 ⟹ XP_038512705

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	1	112,087,347 - 112,101,189 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_013975464	(Get FASTA)	NCBI Sequence Viewer
	XP_038323888	(Get FASTA)	NCBI Sequence Viewer
	XP_038512705	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013975464 ⟸ XM_014119989

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSHSRASPLLLAGRALAKEVFEEEGRSGAGSHRQELLPDMGHPLLLPLLGLLLQTCVPVSWSLQ
CMLCGTTGKCQVEECTPGQDLCRTTIMRIWEDGDELEVVERGCTHPEKSNRTMSYRTGMKIITL
TEAVCGTNLCNKPTSGRVSTFPRTRSRYLECVSCGSSDLSCERGLDQSLQCRSPTEQCVEVVTH
RGLEDSPRDEHHTRGCGNLPGCPGPTGFHNNHTFHFLQCCNTTKCNAGPVLELQNLPLNGLQCF
GCEGNSTHGCSSEETSLIACRGPMNQCLDATGTNGLGNPSYTVRGCATPSWCQSLHVAEAFSMT
HLNVSCCTGNSCNHPILDHQPRIGSAPRPGPAHLSLTVTLLLTARLWGGTLLWT

hide sequence

Ensembl Acc Id:

ENSCAFP00000007049 ⟸ ENSCAFT00000007613

RefSeq Acc Id:	XP_038323888 ⟸ XM_038467960
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038512705 ⟸ XM_038656777
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000004730	Ensembl
NCBI Gene	PLAUR	ENTREZGENE
VGNC ID	VGNC:56920	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)