RGD Reference Report - Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia. - Rat Genome Database

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Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia.

Authors: Toldi, G  Biro, E  Szalay, B  Stenczer, B  Molvarec, A  Rigo, J  Vasarhelyi, B  Beko, G 
Citation: Toldi G, etal., Clin Chem Lab Med. 2011 Nov;49(11):1873-6. Epub 2011 Jul 4.
RGD ID: 6484119
Pubmed: PMID:21722073   (View Abstract at PubMed)
DOI: DOI:10.1515/CCLM.2011.656   (Journal Full-text)

BACKGROUND: Preeclampsia is characterized by a maternal systemic inflammatory response and the impairment of maternal immune tolerance present in healthy pregnancy. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the monitoring of systemic inflammation. We aimed to assess the levels of suPAR and other markers of systemic inflammation in preeclampsia compared to healthy pregnancy. METHODS: We determined plasma suPAR, IL-6 and high sensitivity C-reactive protein (hs-CRP) levels in plasma samples of 62 healthy pregnant and 41 preeclamptic women in the third trimester of pregnancy. RESULTS: Plasma suPAR levels were elevated in preeclampsia [3.18 (2.30-4.71) ng/mL vs. 2.02 (1.81-2.40) ng/mL, p=0.0001, median (interquartile range)]. IL-6 and hs-CRP levels were also higher compared with healthy pregnancy [5.99 (2.97-18.12) pg/mL vs. 1.41 (1.00-2.70) pg/mL, p=0.0001 and 6.60 (3.55-15.40) mg/L vs. 3.90 (2.10-7.25) mg/L, p=0.006, respectively, median (interquartile range)]. Linear regression analyses revealed an association between individual plasma suPAR and log IL-6 levels as well as log hs-CRP levels. CONCLUSIONS: suPAR levels are elevated in preeclampsia and vary in a narrower range compared with IL-6 and hs-CRP. ROC analysis indicated that monitoring of suPAR levels is a suitable tool for the detection of systemic inflammation in pregnancy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pre-eclampsia  IEP 6484119protein:increased expression:plasmaRGD 
pre-eclampsia  ISOPLAUR (Homo sapiens)6484119; 6484119protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Plaur  (plasminogen activator, urokinase receptor)

Genes (Mus musculus)
Plaur  (plasminogen activator, urokinase receptor)

Genes (Homo sapiens)
PLAUR  (plasminogen activator, urokinase receptor)


Additional Information