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Soluble urokinase plasminogen activator receptor (suPAR) is associated with metabolic changes in HIV-1-infected africans: a prospective study.

Authors: Fourie, CM  Van Rooyen, JM  Kruger, A  Olsen, MH  Eugen-Olsen, J  Schutte, R  Schutte, AE 
Citation: Fourie CM, etal., Inflammation. 2012 Feb;35(1):221-9.
Pubmed: (View Article at PubMed) PMID:21384094
DOI: Full-text: DOI:10.1007/s10753-011-9308-6

Soluble urokinase plasminogen activator receptor (suPAR) is associated with inflammation and may predict lipodystrophy and dysmetabolism in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy. We aimed to assess firstly, whether suPAR levels are elevated in treated and untreated HIV-1-infected Africans compared to uninfected controls at baseline and at a 3-year follow-up, and secondly whether suPAR levels are correlated with cardiovascular and/or metabolic changes. SuPAR, cardiovascular, and metabolic variables were assessed and the percentage change was determined. HIV-1-infected black South Africans had significantly higher suPAR levels than uninfected controls at baseline and at follow-up 3 years later. However, only the treated HIV-1-infected participants showed an increase in suPAR levels at follow-up. The treated group also showed signs of lipodystrophy and their baseline suPAR levels correlated positively with an increased waist circumference. This study indicates that suPAR levels increase and that baseline suPAR is associated with an increase in abdominal fat distribution in HIV-infected black Africans on antiretroviral therapy.

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RGD Object Information
RGD ID: 6484120
Created: 2012-06-08
Species: All species
Last Modified: 2012-06-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.