ZFHX3 (zinc finger homeobox 3) - Rat Genome Database

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Gene: ZFHX3 (zinc finger homeobox 3) Canis lupus familiaris
Analyze
Symbol: ZFHX3
Name: zinc finger homeobox 3
RGD ID: 12337403
Description: ENCODES a protein that exhibits transcription cis-regulatory region binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); negative regulation of myoblast differentiation (ortholog); positive regulation of cell adhesion (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); autism spectrum disorder (ortholog); autoimmune hepatitis (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AT-binding transcription factor 1; ATBF1; zinc finger homeobox protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1578,450,963 - 78,635,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl578,455,005 - 78,610,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha578,441,233 - 78,600,526 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,880,298 - 79,039,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,884,635 - 79,127,274 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,710,322 - 78,869,472 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0578,398,650 - 78,557,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0579,031,731 - 79,190,942 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ZFHX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1578,450,963 - 78,635,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl578,455,005 - 78,610,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha578,441,233 - 78,600,526 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,880,298 - 79,039,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,884,635 - 79,127,274 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,710,322 - 78,869,472 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0578,398,650 - 78,557,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0579,031,731 - 79,190,942 (-)NCBIUU_Cfam_GSD_1.0
ZFHX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,782,885 - 73,891,930 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,782,885 - 73,891,871 (-)EnsemblGRCh38hg38GRCh38
GRCh371672,816,784 - 73,925,829 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361671,374,285 - 71,639,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 341671,378,455 - 71,639,775NCBI
Celera1657,132,611 - 57,398,274 (-)NCBICelera
Cytogenetic Map16q22.2-q22.3NCBI
HuRef1658,584,915 - 58,866,797 (-)NCBIHuRef
CHM1_11674,229,746 - 74,505,362 (-)NCBICHM1_1
T2T-CHM13v2.01678,600,697 - 79,709,756 (-)NCBIT2T-CHM13v2.0
Zfhx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398109,005,975 - 109,688,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,669,276 - 109,688,262 (+)EnsemblGRCm39 Ensembl
GRCm388108,279,311 - 108,961,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,942,644 - 108,961,630 (+)EnsemblGRCm38mm10GRCm38
MGSCv378111,238,544 - 111,485,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368111,603,773 - 111,846,367 (+)NCBIMGSCv36mm8
Celera8112,939,113 - 113,186,662 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map856.02NCBI
Zfhx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,789,146 - 53,795,664 (+)NCBIGRCr8
mRatBN7.21936,257,196 - 36,886,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1936,630,254 - 36,881,771 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01942,753,983 - 42,925,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,758,127 - 42,920,344 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01953,580,987 - 53,764,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41938,547,428 - 38,783,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1936,050,820 - 36,295,322 (+)NCBICelera
Cytogenetic Map19q12NCBI
Zfhx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554845,474,769 - 5,789,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554845,470,203 - 5,746,325 (-)NCBIChiLan1.0ChiLan1.0
ZFHX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21881,085,000 - 81,357,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11687,015,073 - 87,287,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01651,936,471 - 52,209,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11672,631,428 - 72,895,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1672,635,666 - 72,808,360 (-)Ensemblpanpan1.1panPan2
Zfhx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934938,353,405 - 39,283,347 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,080,302 - 21,231,544 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,005,242 - 21,235,992 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFHX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl615,698,199 - 15,863,270 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1615,693,987 - 15,941,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2615,056,290 - 15,160,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFHX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,912,325 - 56,174,010 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,907,983 - 56,085,112 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604718,623,958 - 18,901,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfhx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474615,098,960 - 15,254,127 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474615,094,890 - 15,330,653 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZFHX3
1472 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 15 6 10 2
Low 2 5 7 6 6 6 6 6 6 8 4
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000032240   ⟹   ENSCAFP00000030025
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl578,455,005 - 78,610,033 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845015203   ⟹   ENSCAFP00845011804
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl578,884,635 - 79,127,274 (-)Ensembl
RefSeq Acc Id: XM_014114048   ⟹   XP_013969523
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1578,450,963 - 78,635,615 (-)NCBI
Dog10K_Boxer_Tasha578,441,233 - 78,600,525 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038477262   ⟹   XP_038333190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1578,710,322 - 78,869,471 (-)NCBI
RefSeq Acc Id: XM_038538466   ⟹   XP_038394394
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0579,031,731 - 79,190,941 (-)NCBI
RefSeq Acc Id: XM_038602585   ⟹   XP_038458513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0578,398,650 - 78,557,828 (-)NCBI
RefSeq Acc Id: XM_038667190   ⟹   XP_038523118
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0578,880,298 - 79,039,663 (-)NCBI
RefSeq Acc Id: XR_002627074
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1578,456,552 - 78,635,615 (-)NCBI
Dog10K_Boxer_Tasha578,447,100 - 78,600,526 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005326257
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1578,716,197 - 78,869,472 (-)NCBI
RefSeq Acc Id: XR_005360121
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0579,037,607 - 79,190,942 (-)NCBI
RefSeq Acc Id: XP_013969523   ⟸   XM_014114048
- UniProtKB: A0A8P0NLA3 (UniProtKB/TrEMBL),   A0A8C0MY45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000030025   ⟸   ENSCAFT00000032240
RefSeq Acc Id: XP_038333190   ⟸   XM_038477262
RefSeq Acc Id: XP_038458513   ⟸   XM_038602585
RefSeq Acc Id: XP_038523118   ⟸   XM_038667190
- UniProtKB: A0A8C0MY45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038394394   ⟸   XM_038538466
- UniProtKB: A0A8C0MY45 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011804   ⟸   ENSCAFT00845015203
Protein Domains
C2H2-type   Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020243 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011578 UniProtKB/TrEMBL
  ENSCAFG00845008627 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000032240.6 UniProtKB/TrEMBL
  ENSCAFT00030021402.1 UniProtKB/TrEMBL
  ENSCAFT00845015203 ENTREZGENE
  ENSCAFT00845015203.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Matrin/U1-like-C_Znf_C2H2 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene ZFHX3 ENTREZGENE
PANTHER ZINC FINGER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  ZINC FINGER HOMEOBOX PROTEIN 3 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
  ZnF_U1 UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8C0MY45 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N972_CANLF UniProtKB/TrEMBL
  A0A8P0NLA3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48607 ENTREZGENE