AGTR2 (angiotensin II receptor type 2) - Rat Genome Database

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Gene: AGTR2 (angiotensin II receptor type 2) Canis lupus familiaris
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Symbol: AGTR2
Name: angiotensin II receptor type 2
RGD ID: 12273996
Description: ENCODES a protein that exhibits angiotensin type II receptor activity (ortholog); transcription factor binding (ortholog); INVOLVED IN aldosterone secretion (ortholog); angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); brain renin-angiotensin system (ortholog); PARTICIPATES IN angiotensin II signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: angiotensin II type 2 receptor; type-2 angiotensin II receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X88,703,551 - 88,708,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX88,705,765 - 88,706,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX74,841,362 - 74,845,718 (+)NCBI
ROS_Cfam_1.0X90,431,596 - 90,435,944 (+)NCBI
UMICH_Zoey_3.1X87,892,846 - 87,897,203 (+)NCBI
UNSW_CanFamBas_1.0X89,651,006 - 89,655,363 (+)NCBI
UU_Cfam_GSD_1.0X89,385,692 - 89,390,050 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aldosterone secretion  (ISO)
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
brain renin-angiotensin system  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular sodium ion homeostasis  (ISO)
cerebellar cortex development  (ISO)
dopamine biosynthetic process  (ISO)
exploration behavior  (ISO)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (ISO)
inflammatory response  (ISO)
intracellular signal transduction  (ISO)
kidney development  (ISO)
kidney morphogenesis  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of heart rate  (ISO)
negative regulation of icosanoid secretion  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of norepinephrine secretion  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of metanephric glomerulus development  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of metanephros size  (ISO)
regulation of protein import into nucleus  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
renin-angiotensin regulation of aldosterone production  (ISO)
response to organonitrogen compound  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8855304   PMID:19783782   PMID:19791474  


Genomics

Comparative Map Data
AGTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X88,703,551 - 88,708,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX88,705,765 - 88,706,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX74,841,362 - 74,845,718 (+)NCBI
ROS_Cfam_1.0X90,431,596 - 90,435,944 (+)NCBI
UMICH_Zoey_3.1X87,892,846 - 87,897,203 (+)NCBI
UNSW_CanFamBas_1.0X89,651,006 - 89,655,363 (+)NCBI
UU_Cfam_GSD_1.0X89,385,692 - 89,390,050 (+)NCBI
AGTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX116,170,744 - 116,174,974 (+)EnsemblGRCh38hg38GRCh38
GRCh38X116,170,744 - 116,174,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X115,301,997 - 115,306,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X115,215,986 - 115,220,253 (+)NCBINCBI36hg18NCBI36
Build 34X115,113,884 - 115,117,702NCBI
CeleraX115,832,555 - 115,836,822 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX104,838,955 - 104,843,260 (+)NCBIHuRef
CHM1_1X115,212,791 - 115,217,059 (+)NCBICHM1_1
Agtr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X21,350,863 - 21,355,072 (+)NCBIGRCm39mm39
GRCm39 EnsemblX21,350,783 - 21,355,403 (+)Ensembl
GRCm38X21,484,624 - 21,488,833 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX21,484,544 - 21,489,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X21,061,752 - 21,065,957 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X20,641,585 - 20,646,123 (+)NCBImm8
CeleraX19,607,387 - 19,611,593 (+)NCBICelera
Cytogenetic MapXA2NCBI
cM MapX16.71NCBI
Agtr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X112,119,673 - 112,124,060 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX112,120,228 - 112,124,057 (+)Ensembl
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX111,375,374 - 111,376,465 (+)NCBICelera
Cytogenetic MapXq34NCBI
Agtr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555343,653,157 - 3,654,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555343,653,112 - 3,654,248 (-)NCBIChiLan1.0ChiLan1.0
AGTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X115,670,022 - 115,674,287 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX115,671,594 - 115,672,685 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X105,252,903 - 105,257,171 (+)NCBIMhudiblu_PPA_v0panPan3
Agtr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X87,731,904 - 87,736,189 (+)NCBI
SpeTri2.0NW_00493647913,252,678 - 13,255,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX95,269,300 - 95,270,388 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X95,267,709 - 95,272,237 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X109,822,530 - 109,826,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606528,955,602 - 28,958,335 (+)NCBI
Agtr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624967327,627 - 332,000 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1
Low 4
Below cutoff 3 3 9 2 6 6 8 8 7 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022416190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038586592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038586593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ195093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000029009   ⟹   ENSCAFP00000026975
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX88,705,765 - 88,706,853 (+)Ensembl
RefSeq Acc Id: XM_022416190   ⟹   XP_022271898
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X88,703,552 - 88,708,451 (+)NCBI
Dog10K_Boxer_TashaX74,841,362 - 74,845,718 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022416191   ⟹   XP_022271899
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X88,703,551 - 88,708,451 (+)NCBI
Dog10K_Boxer_TashaX74,841,362 - 74,845,718 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022416192   ⟹   XP_022271900
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X88,703,551 - 88,708,451 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038449048   ⟹   XP_038304976
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X90,431,596 - 90,435,944 (+)NCBI
RefSeq Acc Id: XM_038449049   ⟹   XP_038304977
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X90,431,596 - 90,435,944 (+)NCBI
RefSeq Acc Id: XM_038525024   ⟹   XP_038380952
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X87,892,846 - 87,897,203 (+)NCBI
RefSeq Acc Id: XM_038525025   ⟹   XP_038380953
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X87,892,846 - 87,897,203 (+)NCBI
RefSeq Acc Id: XM_038586592   ⟹   XP_038442520
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X89,385,692 - 89,390,050 (+)NCBI
RefSeq Acc Id: XM_038586593   ⟹   XP_038442521
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X89,385,692 - 89,390,050 (+)NCBI
RefSeq Acc Id: XM_038651008   ⟹   XP_038506936
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X89,651,006 - 89,655,363 (+)NCBI
RefSeq Acc Id: XM_038651009   ⟹   XP_038506937
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X89,651,006 - 89,655,363 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_022271899   ⟸   XM_022416191
- Sequence:
RefSeq Acc Id: XP_022271900   ⟸   XM_022416192
- Sequence:
RefSeq Acc Id: XP_022271898   ⟸   XM_022416190
- Sequence:
RefSeq Acc Id: ENSCAFP00000026975   ⟸   ENSCAFT00000029009
RefSeq Acc Id: XP_038380952   ⟸   XM_038525024
RefSeq Acc Id: XP_038380953   ⟸   XM_038525025
RefSeq Acc Id: XP_038506936   ⟸   XM_038651008
RefSeq Acc Id: XP_038506937   ⟸   XM_038651009
RefSeq Acc Id: XP_038304976   ⟸   XM_038449048
RefSeq Acc Id: XP_038304977   ⟸   XM_038449049
RefSeq Acc Id: XP_038442520   ⟸   XM_038586592
RefSeq Acc Id: XP_038442521   ⟸   XM_038586593


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018264 Ensembl, ENTREZGENE
NCBI Gene AGTR2 ENTREZGENE
VGNC ID VGNC:37721 ENTREZGENE