RGD Reference Report - Overexpression of WRAP53 is associated with development and progression of esophageal squamous cell carcinoma. - Rat Genome Database

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Overexpression of WRAP53 is associated with development and progression of esophageal squamous cell carcinoma.

Authors: Rao, Xuguang  Huang, Daofu  Sui, Xuxia  Liu, Gefei  Song, Xuhong  Xie, Jinglian  Huang, Dongyang 
Citation: Rao X, etal., PLoS One. 2014 Mar 13;9(3):e91670. doi: 10.1371/journal.pone.0091670. eCollection 2014.
RGD ID: 21081532
Pubmed: PMID:24626331   (View Abstract at PubMed)
PMCID: PMC3953598   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0091670   (Journal Full-text)


BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer whose underlying molecular mechanisms are poorly understood. The natural antisense transcript (NAT) WRAP53 regulates p53 expression and WRAP53 protein is a component of telomerase. NATs play key roles in carcinogenesis, and although WRAP53 is known to increase cancer cell survival, its role in ESCC clinicopathology is unknown. The aim of this study was to investigate WRAP53 expression in ESCC and to correlate it with clinicopathological characteristics.
METHODS: WRAP53 mRNA and protein expression was measured by quantitative PCR (qRT-PCR) and western blotting, respectively, in 4 ESSC cells lines and in 45 paired ESCC and non-neoplastic esophageal mucosa tissues. To correlate WRAP53 protein expression with clinicopathological characteristics, immunohistochemistry (IHC) was performed on 134 ESCC and 85 non-neoplastic esophageal mucosa tissues.
RESULTS: Expression of WRAP53 was detected in all ESCC cell lines and was upregulated in the ESCC tissues compared with the corresponding non-neoplastic tissues (P<0.01). More cells expressed WRAP53 protein in the ESCC tissues than in the non-neoplastic tissues (P<0.01). Overexpression of WRAP53 was significantly correlated with tumor infiltration depth (P = 0.000), clinical stage (P = 0.001), and lymph node metastasis (P = 0.025). Wrap53 expression was not correlated with age, gender, or tumor differentiation.
CONCLUSION: This report indicates increased expression of WRAP53 in ESCC and that WRAP53 overexpression is correlated with tumor progression. WRAP53 may play a significant role in ESCC; accordingly, WRAP53 could be a useful biomarker for ESCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WRAP53Humanesophagus squamous cell carcinoma disease_progressionIEP  RGD 
Wrap53Ratesophagus squamous cell carcinoma disease_progressionISOWRAP53 (Homo sapiens) RGD 
Wrap53Mouseesophagus squamous cell carcinoma disease_progressionISOWRAP53 (Homo sapiens) RGD 
WRAP53HumanLymphatic Metastasis  IEP associated with esophagus squamous cell carcinomaRGD 
Wrap53RatLymphatic Metastasis  ISOWRAP53 (Homo sapiens)associated with esophagus squamous cell carcinomaRGD 
Wrap53MouseLymphatic Metastasis  ISOWRAP53 (Homo sapiens)associated with esophagus squamous cell carcinomaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Wrap53  (WD repeat containing, antisense to TP53)

Genes (Mus musculus)
Wrap53  (WD repeat containing, antisense to Trp53)

Genes (Homo sapiens)
WRAP53  (WD repeat containing antisense to TP53)


Additional Information