CYP19A1 (cytochrome P450 family 19 subfamily A member 1) - Rat Genome Database

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Gene: CYP19A1 (cytochrome P450 family 19 subfamily A member 1) Canis lupus familiaris
Analyze
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
RGD ID: 12359083
Description: ENCODES a protein that exhibits aromatase activity (ortholog); heme binding (ortholog); oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (ortholog); INVOLVED IN adrenal gland development (ortholog); androgen catabolic process (ortholog); androgen metabolic process (ortholog); PARTICIPATES IN aromatase inhibitor pathway; estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); amenorrhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aromatase; CYP19; CYPXIX; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, family 17, subfamily A, polypeptide 1; estrogen synthase; estrogen synthetase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,954,020 - 17,056,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,957,215 - 16,988,353 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,883,348 - 16,914,898 (-)NCBI
ROS_Cfam_1.03017,098,681 - 17,221,672 (-)NCBI
UMICH_Zoey_3.13017,024,100 - 17,055,822 (-)NCBI
UNSW_CanFamBas_1.03017,141,587 - 17,173,348 (-)NCBI
UU_Cfam_GSD_1.03017,248,285 - 17,280,035 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
androgen catabolic process  (ISO)
androgen metabolic process  (ISO)
bile acid metabolic process  (ISO)
biphenyl metabolic process  (ISO)
bone development  (ISO)
C21-steroid hormone metabolic process  (ISO)
calcineurin-mediated signaling  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
estrogen biosynthetic process  (ISO)
female genitalia development  (ISO)
female gonad development  (ISO)
granulocyte differentiation  (ISO)
hippocampus development  (ISO)
hypothalamus development  (ISO)
luteinization  (ISO)
male gonad development  (ISO)
mammary gland development  (ISO)
melatonin metabolic process  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of chronic inflammatory response  (ISO)
negative regulation of macrophage chemotaxis  (ISO)
phthalate metabolic process  (ISO)
positive regulation of estradiol secretion  (ISO)
prostate gland growth  (ISO)
regulation of synapse structure or activity  (ISO)
response to cesium ion  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to herbicide  (ISO)
response to ionizing radiation  (ISO)
response to metal ion  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
testosterone biosynthetic process  (ISO)
uterus development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:19227133   PMID:26899138   PMID:32657440  


Genomics

Comparative Map Data
CYP19A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,954,020 - 17,056,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,957,215 - 16,988,353 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,883,348 - 16,914,898 (-)NCBI
ROS_Cfam_1.03017,098,681 - 17,221,672 (-)NCBI
UMICH_Zoey_3.13017,024,100 - 17,055,822 (-)NCBI
UNSW_CanFamBas_1.03017,141,587 - 17,173,348 (-)NCBI
UU_Cfam_GSD_1.03017,248,285 - 17,280,035 (-)NCBI
CYP19A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1551,208,057 - 51,338,601 (-)EnsemblGRCh38hg38GRCh38
GRCh381551,208,057 - 51,338,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371551,500,254 - 51,630,793 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361549,288,961 - 49,418,086 (-)NCBINCBI36hg18NCBI36
Celera1528,393,650 - 28,524,194 (-)NCBI
Cytogenetic Map15q21.2NCBI
HuRef1528,330,314 - 28,460,872 (-)NCBIHuRef
CHM1_11551,618,344 - 51,748,904 (-)NCBICHM1_1
Cyp19a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,073,221 - 54,175,448 (-)NCBIGRCm39mm39
GRCm39 Ensembl954,073,221 - 54,175,394 (-)Ensembl
GRCm38954,165,937 - 54,268,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,165,937 - 54,268,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,013,744 - 54,041,249 (-)NCBIGRCm37mm9NCBIm37
MGSCv36953,964,074 - 53,991,581 (-)NCBImm8
Celera951,408,025 - 51,435,376 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.49NCBI
Cyp19a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2854,553,165 - 54,580,758 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl858,744,849 - 58,772,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0858,744,849 - 58,772,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0857,321,085 - 57,348,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1857,671,013 - 57,691,109 (-)NCBI
Celera854,044,272 - 54,071,684 (-)NCBICelera
Cytogenetic Map8q24NCBI
LOC102023780
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554093,266,233 - 3,313,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554093,198,622 - 3,313,072 (+)NCBIChiLan1.0ChiLan1.0
CYP19A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11548,486,688 - 48,616,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1548,486,688 - 48,521,554 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01530,152,924 - 30,282,854 (-)NCBIMhudiblu_PPA_v0panPan3
LOC101954950
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864095,258,165 - 95,328,751 (-)NCBI
SpeTri2.0NW_00493647113,107,603 - 13,136,910 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP19A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1120,367,667 - 120,695,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,652,172 - 120,695,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21133,903,926 - 133,936,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP19A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12632,074,260 - 32,164,926 (+)NCBI
ChlSab1.1 Ensembl2632,132,425 - 32,164,277 (+)Ensembl
Vero_WHO_p1.0NW_023666048109,028,218 - 109,061,355 (-)NCBI
LOC101702005
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247319,053,644 - 9,100,212 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 7
Low 6 1 1 5
Below cutoff 5 5 16 6 6 6 6 6 11 5 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ854107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000024355   ⟹   ENSCAFP00000022607
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3016,957,215 - 16,988,353 (-)Ensembl
RefSeq Acc Id: NM_001008715   ⟹   NP_001008715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,957,215 - 16,988,353 (-)NCBI
Dog10K_Boxer_Tasha3016,883,348 - 16,914,898 (-)NCBI
ROS_Cfam_1.03017,101,876 - 17,133,428 (-)NCBI
UMICH_Zoey_3.13017,024,100 - 17,055,822 (-)NCBI
UNSW_CanFamBas_1.03017,141,587 - 17,173,348 (-)NCBI
UU_Cfam_GSD_1.03017,248,285 - 17,280,035 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412491   ⟹   XP_022268199
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 17,041,822 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412492   ⟹   XP_022268200
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 17,056,728 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412493   ⟹   XP_022268201
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 17,021,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412494   ⟹   XP_022268202
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 17,056,728 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412495   ⟹   XP_022268203
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 16,988,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412496   ⟹   XP_022268204
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 16,984,457 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412497   ⟹   XP_022268205
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 16,987,566 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412498   ⟹   XP_022268206
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,954,020 - 16,988,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038441736   ⟹   XP_038297664
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,187,165 (-)NCBI
RefSeq Acc Id: XM_038441737   ⟹   XP_038297665
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,202,034 (-)NCBI
RefSeq Acc Id: XM_038441738   ⟹   XP_038297666
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,202,034 (-)NCBI
RefSeq Acc Id: XM_038441739   ⟹   XP_038297667
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,221,672 (-)NCBI
RefSeq Acc Id: XM_038441740   ⟹   XP_038297668
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,143,880 (-)NCBI
RefSeq Acc Id: XM_038441741   ⟹   XP_038297669
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,133,432 (-)NCBI
RefSeq Acc Id: XM_038441742   ⟹   XP_038297670
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,133,300 (-)NCBI
RefSeq Acc Id: XM_038441743   ⟹   XP_038297671
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,132,657 (-)NCBI
RefSeq Acc Id: XM_038441744   ⟹   XP_038297672
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03017,098,681 - 17,133,410 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001008715   ⟸   NM_001008715
- UniProtKB: Q5QQX7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_022268202   ⟸   XM_022412494
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022268200   ⟸   XM_022412492
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022268199   ⟸   XM_022412491
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022268201   ⟸   XM_022412493
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022268203   ⟸   XM_022412495
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_022268206   ⟸   XM_022412498
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022268205   ⟸   XM_022412497
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022268204   ⟸   XM_022412496
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000022607   ⟸   ENSCAFT00000024355
RefSeq Acc Id: XP_038297667   ⟸   XM_038441739
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038297666   ⟸   XM_038441738
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038297665   ⟸   XM_038441737
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038297664   ⟸   XM_038441736
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038297668   ⟸   XM_038441740
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038297669   ⟸   XM_038441741
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038297672   ⟸   XM_038441744
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038297670   ⟸   XM_038441742
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038297671   ⟸   XM_038441743
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015338 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000022607 ENTREZGENE
Ensembl Transcript ENSCAFT00000024355 ENTREZGENE
NCBI Gene CYP19A1 ENTREZGENE
UniProt Q5QQX7 ENTREZGENE
VGNC ID VGNC:50331 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 CYP19A1  cytochrome P450 family 19 subfamily A member 1    cytochrome P450, family 17, subfamily A, polypeptide 1  Symbol and/or name change 5135510 APPROVED