AXL (AXL receptor tyrosine kinase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: AXL (AXL receptor tyrosine kinase) Canis lupus familiaris
Analyze
Symbol: AXL
Name: AXL receptor tyrosine kinase
RGD ID: 12328928
Description: ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN host cell surface (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO; tyrosine-protein kinase receptor UFO
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBI
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBI
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBI
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBI
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic cell clearance  (ISO)
blood vessel remodeling  (IEA,ISO)
cell differentiation  (ISO)
cell maturation  (IEA)
cell migration  (IBA)
cellular response to extracellular stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-alpha  (IEA)
cellular response to lipopolysaccharide  (IEA)
dendritic cell differentiation  (IEA)
enzyme linked receptor protein signaling pathway  (ISO)
erythrocyte homeostasis  (IEA,ISO)
forebrain cell migration  (IEA,ISO)
inflammatory response  (IEA,ISO)
natural killer cell differentiation  (IBA,ISO)
negative regulation of apoptotic process  (IBA,ISO)
negative regulation of cytokine production  (ISO)
negative regulation of dendritic cell apoptotic process  (IEA)
negative regulation of interferon-gamma production  (IEA)
negative regulation of lymphocyte activation  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
nervous system development  (IBA)
neuron migration  (IEA,ISO)
neutrophil clearance  (IEA,ISO)
ovulation cycle  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IEA)
phagocytosis  (IBA,ISO)
platelet activation  (IBA,ISO)
positive regulation of cytokine-mediated signaling pathway  (IEA)
positive regulation of kinase activity  (IBA)
positive regulation of natural killer cell differentiation  (IEA)
positive regulation of pinocytosis  (IEA)
positive regulation of protein kinase B signaling  (IBA)
positive regulation of viral life cycle  (IEA)
protein kinase B signaling  (IEA,ISO)
secretion by cell  (IEA,ISO)
spermatogenesis  (IEA,ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vagina development  (IEA,ISO)
viral entry into host cell  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
AXL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBI
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBI
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBI
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBI
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBI
AXL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1941,219,223 - 41,261,766 (+)EnsemblGRCh38hg38GRCh38
GRCh381941,219,223 - 41,261,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,725,128 - 41,767,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,416,948 - 46,459,511 (+)NCBINCBI36hg18NCBI36
Build 341946,416,662 - 46,459,510NCBI
Celera1938,525,268 - 38,567,818 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,157,135 - 38,200,127 (+)NCBIHuRef
CHM1_11941,724,837 - 41,767,370 (+)NCBICHM1_1
Axl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBIGRCm39mm39
GRCm39 Ensembl725,456,698 - 25,488,130 (-)Ensembl
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIGRCm37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBImm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
Axl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,265,656 - 81,296,278 (-)NCBI
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
Axl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
AXL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11946,719,615 - 46,761,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,719,615 - 46,761,747 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01938,211,555 - 38,254,464 (+)NCBIMhudiblu_PPA_v0panPan3
Axl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBI
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,245,673 - 49,277,914 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,245,802 - 49,277,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,979,820 - 45,009,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2645,072,278 - 45,073,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AXL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,537,718 - 35,580,143 (+)NCBI
ChlSab1.1 Ensembl635,537,773 - 35,580,716 (+)Ensembl
Vero_WHO_p1.0NW_02366607313,772,922 - 13,815,487 (+)NCBI
Axl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462490776,236 - 106,765 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 12 6 6 9 9 6
Low 1 5 10 6 6 6 3 8 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022405907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038468079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI464144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000008119   ⟹   ENSCAFP00000007520
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000064026   ⟹   ENSCAFP00000048536
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)Ensembl
RefSeq Acc Id: XM_022405907   ⟹   XP_022261615
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11112,699,679 - 112,727,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038445377   ⟹   XP_038301305
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1112,104,006 - 112,130,593 (-)NCBI
RefSeq Acc Id: XM_038445413   ⟹   XP_038301341
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1112,104,006 - 112,130,668 (-)NCBI
RefSeq Acc Id: XM_038445431   ⟹   XP_038301359
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBI
RefSeq Acc Id: XM_038445470   ⟹   XP_038301398
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBI
RefSeq Acc Id: XM_038468079   ⟹   XP_038324007
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBI
RefSeq Acc Id: XM_038528810   ⟹   XP_038384738
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01113,484,923 - 113,511,565 (-)NCBI
RefSeq Acc Id: XM_038528811   ⟹   XP_038384739
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01113,484,923 - 113,511,640 (-)NCBI
RefSeq Acc Id: XM_038528812   ⟹   XP_038384740
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBI
RefSeq Acc Id: XM_038528813   ⟹   XP_038384741
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBI
RefSeq Acc Id: XM_038593083   ⟹   XP_038449011
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01112,491,561 - 112,518,188 (-)NCBI
RefSeq Acc Id: XM_038593084   ⟹   XP_038449012
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01112,491,561 - 112,518,263 (-)NCBI
RefSeq Acc Id: XM_038593085   ⟹   XP_038449013
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBI
RefSeq Acc Id: XM_038593086   ⟹   XP_038449014
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBI
RefSeq Acc Id: XM_038656900   ⟹   XP_038512828
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01113,298,102 - 113,324,905 (-)NCBI
RefSeq Acc Id: XM_038656901   ⟹   XP_038512829
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01113,298,102 - 113,324,980 (-)NCBI
RefSeq Acc Id: XM_038656902   ⟹   XP_038512830
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBI
RefSeq Acc Id: XM_038656903   ⟹   XP_038512831
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_022261615   ⟸   XM_022405907
- Sequence:
RefSeq Acc Id: ENSCAFP00000048536   ⟸   ENSCAFT00000064026
RefSeq Acc Id: ENSCAFP00000007520   ⟸   ENSCAFT00000008119
RefSeq Acc Id: XP_038324007   ⟸   XM_038468079
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038449014   ⟸   XM_038593086
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038449013   ⟸   XM_038593085
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038449012   ⟸   XM_038593084
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038449011   ⟸   XM_038593083
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038512831   ⟸   XM_038656903
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038512830   ⟸   XM_038656902
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038512829   ⟸   XM_038656901
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038512828   ⟸   XM_038656900
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038301398   ⟸   XM_038445470
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038301359   ⟸   XM_038445431
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038301341   ⟸   XM_038445413
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038301305   ⟸   XM_038445377
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038384741   ⟸   XM_038528813
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038384740   ⟸   XM_038528812
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038384739   ⟸   XM_038528811
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038384738   ⟸   XM_038528810
- Peptide Label: isoform X1
Promoters
RGD ID:13682292
Promoter ID:EPDNEW_C357
Type:initiation region
Name:AXL_1
Description:AXL receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11112,727,133 - 112,727,193EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005041 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000007520 UniProtKB/TrEMBL
  ENSCAFP00000048536 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008119 UniProtKB/TrEMBL
  ENSCAFT00000064026 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene AXL ENTREZGENE
Pfam fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A5F4C2T2_CANLF UniProtKB/TrEMBL
  F1PGV4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38326 ENTREZGENE