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Gene: CASP9 (caspase 9) Canis lupus familiaris

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Symbol:

CASP9

Name:

caspase 9

RGD ID:

12338615

Description:

ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glial cell apoptotic process (ortholog); kidney development (ortholog); leukocyte apoptotic process (ortholog); PARTICIPATES IN endometrial cancer pathway; intrinsic apoptotic pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); alcohol use disorder (ortholog); Alzheimer's disease (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH 1,4-phenylenediamine; calcium oxalate; diosgenin

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

caspase 9, apoptosis-related cysteine protease; caspase-9; ICE-LAP6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CASP9 (caspase 9)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CASP9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CASP9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CASP9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	82,033,759 - 82,076,710 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	82,031,563 - 82,090,484 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	78,571,149 - 78,590,692 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	82,683,018 - 82,723,170 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	82,682,995 - 82,725,574 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	79,435,738 - 79,455,337 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	80,453,740 - 80,473,245 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	81,519,391 - 81,539,023 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	Acute Liver Failure	treatment	ISO	RGD:61867	9068941		RGD	PMID:26238033\|REF_RGD_ID:13782174
CASP9	Dog	alcohol use disorder	treatment	ISO	RGD:61867	9068941		RGD	PMID:30926569\|REF_RGD_ID:598092600
CASP9	Dog	Alzheimer's disease	treatment	ISO	RGD:61867	9068941		RGD	PMID:29777699\|REF_RGD_ID:13782186
CASP9	Dog	Alzheimer's disease		ISO	RGD:69147	9068941		RGD	PMID:12633148\|REF_RGD_ID:13782269
CASP9	Dog	amyotrophic lateral sclerosis		ISO	RGD:61867	9068941	protein:increased activity:spinal cord	RGD	PMID:16847061\|REF_RGD_ID:2311466
CASP9	Dog	bacterial infectious disease		ISO	RGD:62159	9068941	associated with Diabetes Mellitus, Non-Insulin-Dependent	RGD	PMID:16443785\|REF_RGD_ID:2311430
CASP9	Dog	Brain Hypoxia-Ischemia		ISO	RGD:61867	9068941		RGD	PMID:23046993\|REF_RGD_ID:13782359
CASP9	Dog	Brain Hypoxia-Ischemia	treatment	ISO	RGD:61867	9068941		RGD	PMID:24089674\|REF_RGD_ID:155882465
CASP9	Dog	breast cancer		ISO	RGD:69147	9068941	mRNA:decreased expression:breast	RGD	PMID:17011986\|REF_RGD_ID:2290492
CASP9	Dog	bronchopulmonary dysplasia		ISO	RGD:61867	9068941		RGD	PMID:26431790\|REF_RGD_ID:11537057
CASP9	Dog	cataract	treatment	ISO	RGD:61867	9068941		RGD	PMID:23508955\|REF_RGD_ID:13782357
CASP9	Dog	Cerebral Hemorrhage	treatment	ISO	RGD:61867	9068941		RGD	PMID:28096675\|REF_RGD_ID:13782306
CASP9	Dog	Chemical and Drug Induced Liver Injury	treatment	ISO	RGD:61867	9068941		RGD	PMID:30926569\|REF_RGD_ID:598092600
CASP9	Dog	colorectal cancer		ISO	RGD:69147	9068941	DNA:SNP:promoter:-1263A>G (human)	RGD	PMID:21538054\|REF_RGD_ID:13210582
CASP9	Dog	colorectal cancer	no_association	ISO	RGD:69147	9068941	DNA:SNPs::rs4646077, rs4233532, rs2881930 (human)	RGD	PMID:23303631\|REF_RGD_ID:13210584
CASP9	Dog	Diabetes Complications	treatment	ISO	RGD:61867	9068941	associated with Diabetes Mellitus, Experimental	RGD	PMID:24252320\|REF_RGD_ID:13782355
CASP9	Dog	Diabetic Cardiomyopathies	treatment	ISO	RGD:61867	9068941		RGD	PMID:28992627\|REF_RGD_ID:13782299
CASP9	Dog	Diabetic Nephropathies	treatment	ISO	RGD:61867	9068941	associated with Diabetes Mellitus, Experimental	RGD	PMID:29606028\|PMID:30038056\|REF_RGD_ID:13782342\|REF_RGD_ID:13792586
CASP9	Dog	diabetic retinopathy		ISO	RGD:69147	9068941	associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activation:retina	RGD	PMID:18369072\|REF_RGD_ID:2311244
CASP9	Dog	dilated cardiomyopathy		ISO	RGD:61867	9068941		RGD	PMID:26004897\|REF_RGD_ID:13782348
CASP9	Dog	endometritis	treatment	ISO	RGD:61867	9068941		RGD	PMID:26920733\|REF_RGD_ID:13782281
CASP9	Dog	Endotoxemia	treatment	ISO	RGD:61867	9068941		RGD	PMID:23214195\|REF_RGD_ID:10400903
CASP9	Dog	Experimental Autoimmune Encephalomyelitis		ISO	RGD:61867	9068941	protein:increased expression:spinal cord	RGD	PMID:18521931\|REF_RGD_ID:2311436
CASP9	Dog	Experimental Autoimmune Myocarditis	treatment	ISO	RGD:62159	9068941		RGD	PMID:23833961\|REF_RGD_ID:13702874
CASP9	Dog	Experimental Diabetes Mellitus		ISO	RGD:61867	9068941	protein:increased activity, increased expression:pituitary gland	RGD	PMID:15976052\|REF_RGD_ID:2311319
CASP9	Dog	Experimental Mammary Neoplasms	treatment	ISO	RGD:61867	9068941		RGD	PMID:26699876\|REF_RGD_ID:13782283
CASP9	Dog	Experimental Mammary Neoplasms		ISO	RGD:61867	9068941		RGD	PMID:17297389\|REF_RGD_ID:2315933
CASP9	Dog	Experimental Mammary Neoplasms	severity	ISO	RGD:61867	9068941		RGD	PMID:20732338\|REF_RGD_ID:10053708
CASP9	Dog	Experimental Mammary Neoplasms		ISO	RGD:62159	9068941		RGD	PMID:20012353\|REF_RGD_ID:2315928
CASP9	Dog	Experimental Radiation Injuries	treatment	ISO	RGD:61867	9068941		RGD	PMID:24939579\|REF_RGD_ID:13782350
CASP9	Dog	focal segmental glomerulosclerosis	treatment	ISO	RGD:61867	9068941		RGD	PMID:28245472\|REF_RGD_ID:13782344
CASP9	Dog	heart disease		ISO	RGD:61867	9068941	associated with Multiple Trauma	RGD	PMID:28825094\|REF_RGD_ID:13782301
CASP9	Dog	heart disease		ISO	RGD:61867	9068941	associated with Diabetes Mellitus, Experimental;protein:increased activation:heart	RGD	PMID:15805231\|REF_RGD_ID:2311320
CASP9	Dog	hepatocellular carcinoma	treatment	ISO	RGD:61867	9068941		RGD	PMID:29133031\|REF_RGD_ID:13782296
CASP9	Dog	Huntington's disease	severity	ISO	RGD:69147	9068941	protein:increased expression:caudate nucleus:	RGD	PMID:12095160\|REF_RGD_ID:13432083
CASP9	Dog	Huntington's disease	severity	ISO	RGD:62159	9068941	protein:increased expression:striatum:	RGD	PMID:12095160\|REF_RGD_ID:13432083
CASP9	Dog	Hypercholesterolemia		ISO	RGD:61867	9068941		RGD	PMID:24484682\|REF_RGD_ID:13782354
CASP9	Dog	hypertension		ISO	RGD:61867	9068941		RGD	PMID:27929425\|REF_RGD_ID:13782308
CASP9	Dog	Intestinal Reperfusion Injury	treatment	ISO	RGD:61867	9068941		RGD	PMID:23946597\|REF_RGD_ID:13782356
CASP9	Dog	kidney disease		ISO	RGD:61867	9068941		RGD	PMID:29257007\|REF_RGD_ID:13782293
CASP9	Dog	liver cirrhosis		ISO	RGD:62159	9068941	associated with cholestasis	RGD	PMID:29105510\|REF_RGD_ID:13782297
CASP9	Dog	Liver Reperfusion Injury	treatment	ISO	RGD:61867	9068941		RGD	PMID:23364428\|REF_RGD_ID:13782358
CASP9	Dog	Liver Reperfusion Injury	ameliorates	ISO	RGD:62159	9068941		RGD	PMID:34144219\|REF_RGD_ID:329812011
CASP9	Dog	lung non-small cell carcinoma		ISO	RGD:69147	9068941	DNA, mRNA:SNP, decreased expression:exon, lung:rs1052576 (human)	RGD	PMID:17285546\|REF_RGD_ID:13434907
CASP9	Dog	lung non-small cell carcinoma	no_association	ISO	RGD:69147	9068941	DNA:SNP:exon:rs1052571 (human)	RGD	PMID:17285546\|REF_RGD_ID:13434907
CASP9	Dog	lung non-small cell carcinoma		ISO	RGD:69147	9068941	mRNA:splice variant:lung	RGD	PMID:20972334\|REF_RGD_ID:9999427
CASP9	Dog	lung non-small cell carcinoma		ISO	RGD:69147	9068941	mRNA:increased expression:lung	RGD	PMID:16231180\|REF_RGD_ID:13434909
CASP9	Dog	lung non-small cell carcinoma		ISO	RGD:69147	9068941	DNA:SNP: :rs4645981 (human)	RGD	PMID:20661084\|REF_RGD_ID:13434908
CASP9	Dog	Lymphatic Metastasis		ISO	RGD:69147	9068941	associated with Carcinoma, Non-Small-Cell Lung;DNA:SNP:exon:rs1052576 (human)	RGD	PMID:17285546\|REF_RGD_ID:13434907
CASP9	Dog	middle cerebral artery infarction	treatment	ISO	RGD:61867	9068941		RGD	PMID:26868427\|REF_RGD_ID:13782346
CASP9	Dog	Myocardial Reperfusion Injury		ISO	RGD:61867	9068941	protein:increased activity:cardiomyocyte,endothelial cell	RGD	PMID:11934844\|REF_RGD_ID:13782263
CASP9	Dog	Myocardial Reperfusion Injury	ameliorates	ISO	RGD:62159	9068941		RGD	PMID:30259997\|REF_RGD_ID:329337366
CASP9	Dog	Myocardial Reperfusion Injury	treatment	ISO	RGD:61867	9068941		RGD	PMID:29538428\|REF_RGD_ID:13782276
CASP9	Dog	NSAID-Enteropathy		ISO	RGD:61867	9068941		RGD	PMID:25014874\|REF_RGD_ID:13782349
CASP9	Dog	osteoarthritis	treatment	ISO	RGD:61867	9068941		RGD	PMID:29138829\|REF_RGD_ID:13782343
CASP9	Dog	pancreatic cancer	treatment	ISO	RGD:69147	9068941		RGD	PMID:19209030\|REF_RGD_ID:13462046
CASP9	Dog	pancreatic cancer	susceptibility	ISO	RGD:69147	9068941	DNA:snp:promoter:g.-1263A>G (human)	RGD	PMID:20357690\|REF_RGD_ID:13451540
CASP9	Dog	Parkinson's disease		ISO	RGD:69147	9068941	protein:increased activity:blood, leukocyte	RGD	PMID:16505307\|REF_RGD_ID:13503345
CASP9	Dog	Parkinsonism	treatment	ISO	RGD:61867	9068941		RGD	PMID:26612350\|REF_RGD_ID:13503344
CASP9	Dog	post-traumatic stress disorder		ISO	RGD:61867	9068941		RGD	PMID:25331812\|REF_RGD_ID:13782181
CASP9	Dog	pre-malignant neoplasm	treatment	ISO	RGD:61867	9068941	associated with gastric adenocarcinoma	RGD	PMID:29588340\|REF_RGD_ID:13792594
CASP9	Dog	Reperfusion Injury	treatment	ISO	RGD:61867	9068941		RGD	PMID:29568770\|REF_RGD_ID:13792595
CASP9	Dog	scrapie		ISO	RGD:62159	9068941		RGD	PMID:27921253\|REF_RGD_ID:13782156
CASP9	Dog	Sepsis	treatment	ISO	RGD:61867	9068941		RGD	PMID:29180187\|REF_RGD_ID:13782295
CASP9	Dog	severe acute respiratory syndrome	disease_progression	ISO	RGD:69147	9068941	mRNA:increased expression:lung (human)	RGD	PMID:19635508\|REF_RGD_ID:5490168
CASP9	Dog	Spinal Cord Injuries		ISO	RGD:61867	9068941		RGD	PMID:21748659\|REF_RGD_ID:10053608
CASP9	Dog	Spinal Cord Injuries	treatment	ISO	RGD:61867	9068941		RGD	PMID:27339639\|REF_RGD_ID:13782345
CASP9	Dog	stomach cancer	treatment	ISO	RGD:69147	9068941	human cells in mouse model	RGD	PMID:29408335\|PMID:32106377\|REF_RGD_ID:127284846\|REF_RGD_ID:127284886
CASP9	Dog	Subarachnoid Hemorrhage	treatment	ISO	RGD:61867	9068941		RGD	PMID:26163325\|REF_RGD_ID:13782347
CASP9	Dog	Testis Reperfusion Injury		ISO	RGD:61867	9068941		RGD	PMID:26754107\|REF_RGD_ID:11555349
CASP9	Dog	transient cerebral ischemia		ISO	RGD:61867	9068941	associated with Diabetes Mellitus, Experimental;protein:increased expression:neocortex	RGD	PMID:15246841\|REF_RGD_ID:2311321
CASP9	Dog	transient cerebral ischemia		ISO	RGD:61867	9068941		RGD	PMID:21712070\|REF_RGD_ID:10053706
CASP9	Dog	traumatic brain injury	disease_progression	ISO	RGD:61867	9068941		RGD	PMID:12172380\|REF_RGD_ID:632018
CASP9	Dog	traumatic brain injury	severity	ISO	RGD:61867	9068941		RGD	PMID:15307896\|REF_RGD_ID:5509821
CASP9	Dog	type 1 diabetes mellitus		ISO	RGD:62159	9068941		RGD	PMID:14617576\|REF_RGD_ID:2311322
CASP9	Dog	type 1 diabetes mellitus		ISO	RGD:69147	9068941		RGD	PMID:17880769\|REF_RGD_ID:2311245
CASP9	Dog	type 2 diabetes mellitus		ISO	RGD:69147	9068941	DNA:SNP (human)	RGD	PMID:16038259\|REF_RGD_ID:2311246
CASP9	Dog	ureteral obstruction	treatment	ISO	RGD:61867	9068941		RGD	PMID:29781318\|REF_RGD_ID:13782341
CASP9	Dog	urinary bladder cancer	disease_progression	ISO	RGD:69147	9068941	DNA:SNP:exon:p.Q221R (rs1052576) (human)	RGD	PMID:19252927\|REF_RGD_ID:2315930
CASP9	Dog	urinary bladder cancer	susceptibility	ISO	RGD:69147	9068941	DNA:polymorphism, deletion: :1263A>G, 293del (human)	RGD	PMID:19412632\|REF_RGD_ID:2315929
CASP9	Dog	varicocele		ISO	RGD:61867	9068941	protein:increased expression:testis	RGD	PMID:19145435\|REF_RGD_ID:2311432

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	chromosome 1p36 deletion syndrome		ISO	RGD:69147	8554872	ClinVar Annotator: match by term: Chromosome 1p36 deletion syndrome	ClinVar
CASP9	Dog	Hereditary Pancreatitis		ISO	RGD:69147	8554872	ClinVar Annotator: match by term: Hereditary pancreatitis	ClinVar	PMID:23721890\|PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	brain ischemia		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:11756504
CASP9	Dog	Edema		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:19874808
CASP9	Dog	Myocardial Reperfusion Injury		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:14998631
CASP9	Dog	nervous system disease		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:11150333
CASP9	Dog	peripheral nervous system disease		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:20864405
CASP9	Dog	Prostatic Neoplasms		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:17199135
CASP9	Dog	retinal detachment		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:18497877
CASP9	Dog	transient cerebral ischemia		ISO	RGD:69147	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:11333366

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	1,4-phenylenediamine	multiple interactions	EXP		6480464	benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP9 protein]	CTD	PMID:20156547
CASP9	Dog	1,4-phenylenediamine	increases activity	EXP		6480464	4-phenylenediamine results in increased activity of CASP9 protein	CTD	PMID:20156547
CASP9	Dog	calcium oxalate	increases activity	EXP		6480464	Calcium Oxalate results in increased activity of CASP9 protein	CTD	PMID:25446497
CASP9	Dog	calcium oxalate	multiple interactions	EXP		6480464	Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein]	CTD	PMID:25446497
CASP9	Dog	diosgenin	multiple interactions	EXP		6480464	Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein]	CTD	PMID:25446497
CASP9	Dog	toosendanin	increases cleavage	EXP		6480464	toosendanin results in increased cleavage of CASP9 protein	CTD	PMID:36809669

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	apoptotic process	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	apoptotic process	involved_in	IBA	FB:FBgn0010501\|FB:FBgn0019972\|FB:FBgn0020381\|FB:FBgn0028381\|FB:FBgn0033051\|FB:FBgn0033659\|MGI:107739\|MGI:109383\|MGI:1261423\|MGI:1277950\|MGI:1312922\|MGI:1336166\|MGI:97295\|PANTHER:PTN000047947\|RGD:2275\|RGD:61867\|RGD:620944\|RGD:621758\|UniProtKB:A0A1D5PPP7\|UniProtKB:O15519\|UniProtKB:P42574\|UniProtKB:P49662\|UniProtKB:P55210\|UniProtKB:P55211\|UniProtKB:P55212\|UniProtKB:Q14790\|UniProtKB:Q8MKI5\|WB:WBGene00000417\|ZFIN:ZDB-GENE-011210-1\|ZFIN:ZDB-GENE-030825-3	150520179		GO_Central	GO_REF:0000033
CASP9	Dog	apoptotic process	acts_upstream_of_or_within	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	apoptotic process	involved_in	IEA	UniProtKB-KW:KW-0053	150520179		UniProt	GO_REF:0000043
CASP9	Dog	cellular response to dexamethasone stimulus	involved_in	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	cellular response to UV	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	DNA damage response	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	DNA damage response	acts_upstream_of_or_within	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	epithelial cell apoptotic process	acts_upstream_of_or_within	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	fibroblast apoptotic process	acts_upstream_of_or_within	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	glial cell apoptotic process		ISO	RGD:61867	9068941	microglia	RGD	PMID:18931364\|REF_RGD_ID:2313998
CASP9	Dog	intrinsic apoptotic signaling pathway	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	intrinsic apoptotic signaling pathway in response to DNA damage	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	intrinsic apoptotic signaling pathway in response to DNA damage	involved_in	IBA	PANTHER:PTN002572986\|UniProtKB:P55211	150520179		GO_Central	GO_REF:0000033
CASP9	Dog	kidney development		ISO	RGD:61867	9068941		RGD	PMID:27665619\|REF_RGD_ID:13703109
CASP9	Dog	leukocyte apoptotic process		ISO	RGD:61867	9068941		RGD	PMID:26861981\|REF_RGD_ID:13782282
CASP9	Dog	neuron apoptotic process	acts_upstream_of	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	positive regulation of apoptotic process		ISO	RGD:61867	9068941		RGD	PMID:17869439\|REF_RGD_ID:2314390
CASP9	Dog	positive regulation of apoptotic process	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	positive regulation of execution phase of apoptosis	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	positive regulation of neuron apoptotic process	acts_upstream_of_or_within	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	positive regulation of neuron apoptotic process	involved_in	IBA	MGI:1277950\|PANTHER:PTN000047947\|RGD:2275\|RGD:620945\|RGD:69274\|RGD:70967\|WB:WBGene00000417	150520179		GO_Central	GO_REF:0000033
CASP9	Dog	protein maturation	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	protein processing		ISO	RGD:61867	9068941		RGD	PMID:18316105\|REF_RGD_ID:2311460
CASP9	Dog	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
CASP9	Dog	proteolysis	involved_in	IEA	InterPro:IPR001309\|InterPro:IPR002138\|InterPro:IPR002398\|InterPro:IPR011600	150520179		InterPro	GO_REF:0000002
CASP9	Dog	regulation of apoptotic process	involved_in	IEA	InterPro:IPR001315	150520179		InterPro	GO_REF:0000002
CASP9	Dog	response to anesthetic		ISO	RGD:61867	9068941		RGD	PMID:27498600\|REF_RGD_ID:407574725
CASP9	Dog	response to auditory stimulus		ISO	RGD:8882041	9068941		RGD	PMID:14534835\|REF_RGD_ID:11554334\|RGD:11554334\|RGD:150520179
CASP9	Dog	response to cobalt ion		ISO	RGD:61867	9068941		RGD	PMID:18598848\|REF_RGD_ID:2311433
CASP9	Dog	response to estradiol		ISO	RGD:61867	9068941		RGD	PMID:18598848\|REF_RGD_ID:2311433
CASP9	Dog	response to ethanol		ISO	RGD:61867	9068941		RGD	PMID:30926569\|REF_RGD_ID:598092600
CASP9	Dog	response to hypoxia		ISO	RGD:61867	9068941		RGD	PMID:24089674\|REF_RGD_ID:155882465
CASP9	Dog	response to indole-3-methanol		ISO	RGD:61867	9068941		RGD	PMID:17297389\|REF_RGD_ID:2315933
CASP9	Dog	response to ischemia		ISO	RGD:61867	9068941		RGD	PMID:11934844\|REF_RGD_ID:13782263
CASP9	Dog	response to lipopolysaccharide		ISO	RGD:61867	9068941		RGD	PMID:18289516\|REF_RGD_ID:2293323
CASP9	Dog	response to UV	acts_upstream_of_or_within	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	signal transduction in response to DNA damage	involved_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	apoptosome	part_of	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	caspase complex	part_of	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	cytoplasm		ISO	RGD:61867	9068941	MMO:0000538	RGD	PMID:21630211\|REF_RGD_ID:408395141
CASP9	Dog	cytoplasm	is_active_in	IBA	FB:FBgn0010501\|FB:FBgn0019972\|FB:FBgn0020381\|FB:FBgn0028381\|FB:FBgn0033051\|MGI:107700\|MGI:107739\|MGI:1261423\|MGI:1277950\|MGI:1312922\|MGI:1336166\|MGI:97295\|PANTHER:PTN000047947\|RGD:620945\|UniProtKB:O15519\|UniProtKB:P31944\|UniProtKB:P42574\|UniProtKB:P49662\|UniProtKB:P51878\|UniProtKB:P55210\|UniProtKB:P55211\|UniProtKB:P55212\|UniProtKB:Q14790\|UniProtKB:Q6UXS9\|UniProtKB:Q8MKI5\|UniProtKB:Q92851\|UniProtKB:Q95ND5\|WB:WBGene00000417\|ZFIN:ZDB-GENE-000616-3\|ZFIN:ZDB-GENE-020812-1	150520179		GO_Central	GO_REF:0000033
CASP9	Dog	cytosol	located_in	IEA	UniProtKB:P55211\|UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	cytosol	is_active_in	IBA	MGI:107700\|MGI:1277950\|PANTHER:PTN008306143\|UniProtKB:P31944\|UniProtKB:P49662\|UniProtKB:P51878\|UniProtKB:P55211\|ZFIN:ZDB-GENE-000616-3\|ZFIN:ZDB-GENE-020812-1	150520179		GO_Central	GO_REF:0000033
CASP9	Dog	mitochondrion	is_active_in	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	nucleus	located_in	IEA	UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	protein-containing complex	part_of	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	cysteine-type endopeptidase activity	enables	IEA	UniProtKB:P55211\|UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	cysteine-type endopeptidase activity	enables	IBA	FB:FBgn0010501\|FB:FBgn0019972\|FB:FBgn0020381\|FB:FBgn0028381\|FB:FBgn0033659\|MGI:107700\|MGI:107739\|MGI:109383\|MGI:1261423\|MGI:1277950\|MGI:1312922\|MGI:97295\|PANTHER:PTN000047947\|RGD:620945\|UniProtKB:A0A1D5PPP7\|UniProtKB:F1NV61\|UniProtKB:P42574\|UniProtKB:P42575\|UniProtKB:P49662\|UniProtKB:P51878\|UniProtKB:P55210\|UniProtKB:P55211\|UniProtKB:P55212\|UniProtKB:Q14790\|UniProtKB:Q92851\|WB:WBGene00000417\|ZFIN:ZDB-GENE-000616-3\|ZFIN:ZDB-GENE-020812-1	150520179		GO_Central	GO_REF:0000033
CASP9	Dog	cysteine-type endopeptidase activity	enables	IEA	InterPro:IPR001309\|InterPro:IPR002138\|InterPro:IPR002398\|InterPro:IPR011600	150520179		InterPro	GO_REF:0000002
CASP9	Dog	cysteine-type peptidase activity		ISO	RGD:61867	9068941		RGD	PMID:16336964\|PMID:18316105\|REF_RGD_ID:2311460\|REF_RGD_ID:2314393
CASP9	Dog	cysteine-type peptidase activity	enables	IEA	UniProtKB-KW:KW-0788	150520179		UniProt	GO_REF:0000043
CASP9	Dog	cysteine-type peptidase activity	enables	IEA	InterPro:IPR015917	150520179		InterPro	GO_REF:0000002
CASP9	Dog	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
CASP9	Dog	identical protein binding	enables	ISO	UniProtKB:P55211-1	9068941	PMID:15941357	IntAct	PMID:15941357
CASP9	Dog	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
CASP9	Dog	peptidase activity	enables	IEA	UniProtKB:P55211\|UniProtKB:Q8C3Q9\|ensembl:ENSMUSP00000030747\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	protein binding	enables	ISO	PR:P12815\|PR:Q01853	9068941	PMID:14561754	MGI	PMID:14561754
CASP9	Dog	protein binding	enables	ISO	UniProtKB:O14727	9068941	PMID:10206961, PMID:10376594, PMID:19494828, PMID:20462491, PMID:21827945, PMID:9922454	IntAct	PMID:10206961\|PMID:10376594\|PMID:19494828\|PMID:20462491\|PMID:21827945\|PMID:9922454
CASP9	Dog	protein binding	enables	ISO	UniProtKB:Q13490\|UniProtKB:Q96CA5	9068941	PMID:11084335	IntAct	PMID:11084335
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P98170\|UniProtKB:Q13490\|UniProtKB:Q6PIA0\|UniProtKB:Q96CA5	9068941	PMID:25416956	IntAct	PMID:25416956
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P98170\|UniProtKB:Q13490\|UniProtKB:Q96CA5	9068941	PMID:31515488, PMID:32296183	IntAct	PMID:31515488\|PMID:32296183
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P98170\|UniProtKB:Q96CA5	9068941	PMID:11801603	IntAct	PMID:11801603
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P42574\|UniProtKB:P98170\|UniProtKB:Q13490	9068941	PMID:25241761	IntAct	PMID:25241761
CASP9	Dog	protein binding	enables	ISO	UniProtKB:Q13490	9068941	PMID:19153467	UniProt	PMID:19153467
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P98170	9068941	PMID:12620238, PMID:16189514, PMID:18022362, PMID:25502805, PMID:27107012, PMID:29997244, PMID:31467278	IntAct	PMID:12620238\|PMID:16189514\|PMID:18022362\|PMID:25502805\|PMID:27107012\|PMID:29997244\|PMID:31467278
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P42574	9068941	PMID:18723680	IntAct	PMID:18723680
CASP9	Dog	protein binding	enables	ISO	UniProtKB:Q96CA5	9068941	PMID:11024045	IntAct	PMID:11024045
CASP9	Dog	protein binding	enables	ISO	UniProtKB:O14727\|UniProtKB:Q5EG05	9068941	PMID:11821383	UniProt	PMID:11821383
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P43146	9068941	PMID:16537496, PMID:19721007	IntAct	PMID:16537496\|PMID:19721007
CASP9	Dog	protein binding	enables	ISO	UniProtKB:Q8WU39-2	9068941	PMID:11350957	UniProt	PMID:11350957
CASP9	Dog	protein binding	enables	ISO	UniProtKB:P00519	9068941	PMID:15657060	UniProt	PMID:15657060
CASP9	Dog	protein binding	enables	ISO	UniProtKB:O15392-1	9068941	PMID:11069302	UniProt	PMID:11069302
CASP9	Dog	protein binding		ISO	RGD:620692	9068941		RGD	PMID:18485100\|REF_RGD_ID:2314399
CASP9	Dog	protein binding	enables	ISO	UniProtKB:Q8XAL7	9068941	PMID:23516580, PMID:25519916	IntAct	PMID:23516580\|PMID:25519916
CASP9	Dog	protein binding	enables	ISO	UniProtKB:Q9HD36	9068941	PMID:19255499	ParkinsonsUK-UCL	PMID:19255499
CASP9	Dog	protein binding	enables	ISO	UniProtKB:Q13418	9068941	PMID:16936772	IntAct	PMID:16936772
CASP9	Dog	protein kinase binding	enables	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107
CASP9	Dog	SH3 domain binding	enables	IEA	UniProtKB:P55211\|ensembl:ENSP00000330237	150520179		Ensembl	GO_REF:0000107

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	endometrial cancer pathway		ISO	RGD:69147	9068941		RGD	PMID:17121923\|REF_RGD_ID:13432196
CASP9	Dog	intrinsic apoptotic pathway		ISO	RGD:61867	9068941		RGD	PMID:17869439\|PMID:18090083\|PMID:18817839\|PMID:18931364\|REF_RGD_ID:2313963\|REF_RGD_ID:2313998\|REF_RGD_ID:2314002\|REF_RGD_ID:2314390
CASP9	Dog	intrinsic apoptotic pathway		ISO	RGD:62159	9068941		RGD	PMID:17082813\|REF_RGD_ID:2314187
CASP9	Dog	intrinsic apoptotic pathway		ISO	RGD:69147	9068941		RGD	PMID:17082813\|REF_RGD_ID:2314187

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CASP9	Dog	phosphatidylinositol 3-kinase-Akt signaling pathway		ISO	RGD:69147	9068941		PID	PID:200197

PMID:20198571	PMID:22301074	PMID:30032202

CASP9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	82,033,759 - 82,076,710 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	82,031,563 - 82,090,484 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	78,571,149 - 78,590,692 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	82,683,018 - 82,723,170 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	82,682,995 - 82,725,574 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	79,435,738 - 79,455,337 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	80,453,740 - 80,473,245 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	81,519,391 - 81,539,023 (+)	NCBI		UU_Cfam_GSD_1.0

CASP9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	15,491,401 - 15,524,912 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	15,490,832 - 15,526,534 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	15,817,896 - 15,851,285 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	15,691,378 - 15,723,377 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	15,564,102 - 15,596,096	NCBI
Celera	1	14,301,661 - 14,333,662 (-)	NCBI		Celera
Cytogenetic Map	1	p36.21	NCBI
HuRef	1	14,337,387 - 14,370,798 (-)	NCBI		HuRef
CHM1_1	1	15,616,531 - 15,649,948 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	14,936,101 - 14,969,610 (-)	NCBI		T2T-CHM13v2.0

Casp9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	141,520,923 - 141,543,289 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	141,520,923 - 141,543,287 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	141,793,612 - 141,815,978 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	141,793,612 - 141,815,976 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	141,349,527 - 141,371,890 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	141,065,688 - 141,088,051 (+)	NCBI		MGSCv36	mm8
Celera	4	143,618,711 - 143,640,921 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	74.75	NCBI

Casp9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	154,108,872 - 154,126,628 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	154,109,046 - 154,126,626 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	156,793,940 - 156,811,532 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	158,567,234 - 158,584,828 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	158,556,396 - 158,573,978 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	160,356,211 - 160,373,774 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	160,355,833 - 160,373,778 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	164,067,734 - 164,085,297 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	160,704,234 - 160,721,796 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	160,714,421 - 160,731,984 (+)	NCBI
Celera	5	152,461,154 - 152,478,717 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Casp9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955527	2,613,683 - 2,629,738 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955527	2,613,691 - 2,630,217 (+)	NCBI	ChiLan1.0	ChiLan1.0

CASP9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	211,395,731 - 211,430,328 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	210,644,170 - 210,678,765 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	14,630,659 - 14,662,865 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	15,624,666 - 15,656,266 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	15,624,666 - 15,656,266 (-)	Ensembl	panpan1.1		panPan2

Casp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	37,353,117 - 37,371,367 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	3,178,097 - 3,196,130 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASP9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	74,706,516 - 74,730,007 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	74,707,597 - 74,730,033 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	69,087,179 - 69,111,408 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASP9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	116,772,819 - 116,798,402 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	116,772,155 - 116,798,930 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	20,315,214 - 20,346,777 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Casp9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	1,773,455 - 1,789,423 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	1,769,270 - 1,789,399 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in CASP9
914 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10


RefSeq Transcripts	NM_001031633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038657830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038657831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038657832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038657833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ116956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000025820 ⟹ ENSCAFP00000023977

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	82,033,798 - 82,053,348 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000025830 ⟹ ENSCAFP00000023986

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	82,033,759 - 82,090,484 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000044511 ⟹ ENSCAFP00000036961

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	82,033,759 - 82,076,334 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000076544 ⟹ ENSCAFP00000051103

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	82,031,563 - 82,052,426 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000085012 ⟹ ENSCAFP00000063413

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	82,033,759 - 82,052,426 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000093180 ⟹ ENSCAFP00000044747

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	82,033,759 - 82,052,426 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845000583 ⟹ ENSCAFP00845000401

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	82,682,995 - 82,725,574 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845000598 ⟹ ENSCAFP00845000414

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	82,682,995 - 82,702,576 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845000603 ⟹ ENSCAFP00845000418

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	82,682,995 - 82,701,113 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845000619 ⟹ ENSCAFP00845000432

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	82,682,995 - 82,700,514 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845000639 ⟹ ENSCAFP00845000450

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	82,683,069 - 82,702,587 (+)	Ensembl

RefSeq Acc Id:

NM_001031633 ⟹ NP_001026803

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	2	82,033,798 - 82,053,348 (+)	NCBI
Dog10K_Boxer_Tasha	2	78,571,149 - 78,590,692 (+)	NCBI
ROS_Cfam_1.0	2	82,683,069 - 82,702,587 (+)	NCBI
UMICH_Zoey_3.1	2	79,435,738 - 79,455,337 (+)	NCBI
UNSW_CanFamBas_1.0	2	80,453,740 - 80,473,245 (+)	NCBI
UU_Cfam_GSD_1.0	2	81,519,391 - 81,539,023 (+)	NCBI

Sequence:

show sequence

CCATGGACGAGGCGGAGCGGCGGGCCCTGCGGCGGTGCCGGGTGCGGCTGGTCCGCGAGCTGCAGGTGGCCGCGCTCTGGGACGCCCTGCTGAGCCGCGAGCTCTTCACGGCCGCCATGGTCGAGGAC
TTGCAGCATGCAGGCTCGGGGTCTCGGAGCGACCAGGCCAGGCAGCTGGTCATAGATCTAGAGACCCGAGGGAGTCAGGCCCTTCCTTTGTTCATATCCTGCTTGGAGGACACAGGCCAGGATGCGCT
GGCTTCGTGCCTGAGAATGAGTCGGCAAGCAGTAAAGCAGAATCCAGAGGCCACCAGACCCCTGGACCTCATGCCTGTGGTGCTTGGACCAACGAGACTCACACCAGAGGATCTCAGAGGGAAGGATC
CGTCAAAGCTGACTCCAGGAAAACTCGCTCCGGTGGTGCTGGGGCCAGCTGAGCTCCAGCCACAGGTTGTCAGACCATCGGTGCCCAGGCCAACGGACAATGGTTCTGGACGATTCAGTGACGTCTGT
GTTCAGGAGATTTCCAAGGGAAATGGTGATTTGGCGTACGCCCTGAACGCAGACCCCTGCGGCTACTGCCTCATCATCAACAACGTGAACTTCTGCCCCGAGTCAAGGCTCACGGCCCGCGGCGGCTC
CAATATCGACTGCGAGAAGCTGCAGCGACGCTTCTGTCTGCTGCGGTTCACGGTGGAGGTGAAGTGGGACCTGACGGCCAAGCAAATGGTCCAGGCTTTGGTGGAGCTGGCGCGGCGGGACCACAGCG
CTCTGGACTGCTGCGTGGTGGTCGTCCTGTCCCACGGCTGTGAGGCCAGCCACCGCCAGTTCCCAGGGGCCGTTTATGGCACAGATGGATGTCCTGTGTCCATTGAGAAAATTGTGAACATCTTCAAT
GGAACTGGCTGCCCCAGCTTGGGAGGGAAGCCCAAGCTCTTCTTTATCCAGGCCTGTGGTGGGGAGCAGAAAGACCATGGGTTTGCGGTGGCCTCCGCTTCCCCTGAAGACAGGAGCCCTGGCAGTGA
CTCTGAGCCAGACGCTGTCCCGTTCCAGGAAGGCCCAGGCCCCTTTGACCAGCTGGACGCCGTGTCTAGTTTGCCCACTCCCAGTGATATCTTTGTATCCTATTCCACCTTCCCAGGCTTTGTTTCCT
GGAGAAATACCAAGAGCGGCTCCTGGTACGTGGAGACCTTGGATGGTGTTTTTGAGCAGTGGGCTCACGCTGAAGACCTGCAGACCCTCCTGCTCAGGGTCGCTAATGCTGTTTCGCAGAAAGGAGTT
TACAAACAGATTCCCGGTTGTTTCAATTTCCTCCGGAAAAAACTCTATTTTAAAATGTAATGAGGCCCCTCACC

hide sequence

RefSeq Acc Id:

XM_038657830 ⟹ XP_038513758

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	2	82,683,024 - 82,723,170 (+)	NCBI

RefSeq Acc Id:

XM_038657831 ⟹ XP_038513759

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	2	82,683,024 - 82,722,089 (+)	NCBI

RefSeq Acc Id:

XM_038657832 ⟹ XP_038513760

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	2	82,683,024 - 82,722,089 (+)	NCBI

RefSeq Acc Id:

XM_038657833 ⟹ XP_038513761

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	2	82,683,018 - 82,723,170 (+)	NCBI


Protein RefSeqs	NP_001026803	(Get FASTA)	NCBI Sequence Viewer
	XP_038513758	(Get FASTA)	NCBI Sequence Viewer
	XP_038513759	(Get FASTA)	NCBI Sequence Viewer
	XP_038513760	(Get FASTA)	NCBI Sequence Viewer
	XP_038513761	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAZ22485	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000023977.4
	ENSCAFP00000023986.5
	ENSCAFP00000036961.3
	ENSCAFP00000044747.2
	ENSCAFP00000063413.2
	ENSCAFP00030022349.1
	ENSCAFP00030022386.1
	ENSCAFP00030022493.1
	ENSCAFP00040006290.1
	ENSCAFP00040006306.1
	ENSCAFP00040006336.1
	ENSCAFP00845000401.1
	ENSCAFP00845000414.1
	ENSCAFP00845000418.1
	ENSCAFP00845000432.1
	ENSCAFP00845000450
	ENSCAFP00845000450.1

RefSeq Acc Id:

NP_001026803 ⟸ NM_001031633

- UniProtKB:

Q45T68 (UniProtKB/TrEMBL), A0A8C0Q619 (UniProtKB/TrEMBL), A0A8I3MCG3 (UniProtKB/TrEMBL), A0A8P0NV46 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDEAERRALRRCRVRLVRELQVAALWDALLSRELFTAAMVEDLQHAGSGSRSDQARQLVIDLETRGSQALPLFISCLEDTGQDALASCLRMSRQAVKQNPEATRPLDLMPVVLGPTRLTPEDLRGKDP
SKLTPGKLAPVVLGPAELQPQVVRPSVPRPTDNGSGRFSDVCVQEISKGNGDLAYALNADPCGYCLIINNVNFCPESRLTARGGSNIDCEKLQRRFCLLRFTVEVKWDLTAKQMVQALVELARRDHSA
LDCCVVVVLSHGCEASHRQFPGAVYGTDGCPVSIEKIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDHGFAVASASPEDRSPGSDSEPDAVPFQEGPGPFDQLDAVSSLPTPSDIFVSYSTFPGFVSW
RNTKSGSWYVETLDGVFEQWAHAEDLQTLLLRVANAVSQKGVYKQIPGCFNFLRKKLYFKM

hide sequence

Ensembl Acc Id:

ENSCAFP00000023977 ⟸ ENSCAFT00000025820

Ensembl Acc Id:

ENSCAFP00000023986 ⟸ ENSCAFT00000025830

Ensembl Acc Id:

ENSCAFP00000044747 ⟸ ENSCAFT00000093180

Ensembl Acc Id:

ENSCAFP00000036961 ⟸ ENSCAFT00000044511

Protein Domains

CARD Caspase family p10 Caspase family p20

RGD ID:

13682648

Promoter ID:

EPDNEW_C715

Type:

multiple initiation site

Name:

CASP9_1

Description:

caspase-9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	2	82,033,780 - 82,033,840	EPDNEW

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000016279	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030013818	UniProtKB/TrEMBL
	ENSCAFG00040003796	UniProtKB/TrEMBL
	ENSCAFG00845000379	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000025820.5	UniProtKB/TrEMBL
	ENSCAFT00000025830.5	UniProtKB/TrEMBL
	ENSCAFT00000044511.4	UniProtKB/TrEMBL
	ENSCAFT00000085012.2	UniProtKB/TrEMBL
	ENSCAFT00000093180.2	UniProtKB/TrEMBL
	ENSCAFT00030025596.1	UniProtKB/TrEMBL
	ENSCAFT00030025639.1	UniProtKB/TrEMBL
	ENSCAFT00030025753.1	UniProtKB/TrEMBL
	ENSCAFT00040007230.1	UniProtKB/TrEMBL
	ENSCAFT00040007251.1	UniProtKB/TrEMBL
	ENSCAFT00040007284.1	UniProtKB/TrEMBL
	ENSCAFT00845000583.1	UniProtKB/TrEMBL
	ENSCAFT00845000598.1	UniProtKB/TrEMBL
	ENSCAFT00845000603.1	UniProtKB/TrEMBL
	ENSCAFT00845000619.1	UniProtKB/TrEMBL
	ENSCAFT00845000639	ENTREZGENE
	ENSCAFT00845000639.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	3.40.50.1460	UniProtKB/TrEMBL
InterPro	CARD	UniProtKB/TrEMBL
	Caspase-like_dom_sf	UniProtKB/TrEMBL
	Caspase_cys_AS	UniProtKB/TrEMBL
	Caspase_his_AS	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	Pept_C14	UniProtKB/TrEMBL
	Pept_C14_caspase	UniProtKB/TrEMBL
	Pept_C14_p10	UniProtKB/TrEMBL
	Pept_C14_p20	UniProtKB/TrEMBL
	Pept_C14A	UniProtKB/TrEMBL
KEGG Report	cfa:487432	UniProtKB/TrEMBL
NCBI Gene	CASP9	ENTREZGENE
PANTHER	CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18	UniProtKB/TrEMBL
	CASPASE-3	UniProtKB/TrEMBL
	PTHR10454	UniProtKB/TrEMBL
	PTHR10454:SF157	UniProtKB/TrEMBL
Pfam	CARD	UniProtKB/TrEMBL
	Peptidase_C14	UniProtKB/TrEMBL
PIRSF	Caspase_ICE	UniProtKB/TrEMBL
PRINTS	IL1BCENZYME	UniProtKB/TrEMBL
PROSITE	CARD	UniProtKB/TrEMBL
	CASPASE_CYS	UniProtKB/TrEMBL
	CASPASE_HIS	UniProtKB/TrEMBL
	CASPASE_P10	UniProtKB/TrEMBL
	CASPASE_P20	UniProtKB/TrEMBL
SMART	CARD	UniProtKB/TrEMBL
	CASc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47986	UniProtKB/TrEMBL
	SSF52129	UniProtKB/TrEMBL
UniProt	A0A8C0N9L5_CANLF	UniProtKB/TrEMBL
	A0A8C0N9P3_CANLF	UniProtKB/TrEMBL
	A0A8C0NET6_CANLF	UniProtKB/TrEMBL
	A0A8C0PZQ5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0Q619	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0QBG7_CANLF	UniProtKB/TrEMBL
	A0A8I3MAK3_CANLF	UniProtKB/TrEMBL
	A0A8I3MAP5_CANLF	UniProtKB/TrEMBL
	A0A8I3MCG3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MV67	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NV46	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0PCA1_CANLF	UniProtKB/TrEMBL
	A0A8P0SKK3_CANLF	UniProtKB/TrEMBL
	A0A8P0SRU9	ENTREZGENE, UniProtKB/TrEMBL
	Q45T68	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:58438	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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