Casp9 (caspase 9) - Rat Genome Database

Name: Casp9
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Casp9 (caspase 9) Ictidomys tridecemlineatus

Analyze

Symbol:

Casp9

Name:

caspase 9

RGD ID:

12631263

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); cysteine-type endopeptidase activity involved in apoptotic process (ortholog); cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to organic cyclic compound (ortholog); PARTICIPATES IN endometrial cancer pathway; intrinsic apoptotic pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apoptosome (ortholog); caspase complex (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

caspase-9

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CASP9 (caspase 9)	NCBI	Ortholog
Mus musculus (house mouse):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CASP9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CASP9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CASP9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CASP9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Casp9 (caspase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	37,353,117 - 37,371,367 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	3,178,097 - 3,196,130 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

Alzheimer's disease (ISO)

amyotrophic lateral sclerosis (ISO)

bacterial infectious disease (ISO)

Brain Hypoxia-Ischemia (ISO)

brain ischemia (ISO)

breast cancer (ISO)

bronchopulmonary dysplasia (ISO)

cataract (ISO)

Cerebral Hemorrhage (ISO)

chromosome 1p36 deletion syndrome (ISO)

colorectal cancer (ISO)

Diabetes Complications (ISO)

Diabetic Cardiomyopathies (ISO)

Diabetic Nephropathies (ISO)

diabetic retinopathy (ISO)

dilated cardiomyopathy (ISO)

Edema (ISO)

endometritis (ISO)

Endotoxemia (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Autoimmune Myocarditis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Mammary Neoplasms (ISO)

Experimental Radiation Injuries (ISO)

focal segmental glomerulosclerosis (ISO)

genetic disease (ISO)

heart disease (ISO)

hepatocellular carcinoma (ISO)

Hereditary Pancreatitis (ISO)

Huntington's disease (ISO)

Hypercholesterolemia (ISO)

hypertension (ISO)

Intestinal Reperfusion Injury (ISO)

kidney disease (ISO)

liver cirrhosis (ISO)

Liver Reperfusion Injury (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

middle cerebral artery infarction (ISO)

Myocardial Reperfusion Injury (ISO)

nervous system disease (ISO)

NSAID-Enteropathy (ISO)

osteoarthritis (ISO)

pancreatic cancer (ISO)

Parkinson's disease (ISO)

Parkinsonism (ISO)

peripheral nervous system disease (ISO)

post-traumatic stress disorder (ISO)

pre-malignant neoplasm (ISO)

Prostatic Neoplasms (ISO)

Reperfusion Injury (ISO)

retinal detachment (ISO)

scrapie (ISO)

Sepsis (ISO)

severe acute respiratory syndrome (ISO)

Spinal Cord Injuries (ISO)

stomach cancer (ISO)

Subarachnoid Hemorrhage (ISO)

Testis Reperfusion Injury (ISO)

transient cerebral ischemia (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

ureteral obstruction (ISO)

urinary bladder cancer (ISO)

varicocele (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO)

cellular response to dexamethasone stimulus (ISO)

cellular response to organic cyclic compound (ISO)

cellular response to UV (ISO)

DNA damage response (ISO)

epithelial cell apoptotic process (ISO)

fibroblast apoptotic process (ISO)

glial cell apoptotic process (ISO)

intrinsic apoptotic signaling pathway (ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

kidney development (ISO)

leukocyte apoptotic process (ISO)

neuron apoptotic process (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of neuron apoptotic process (ISO)

protein maturation (ISO)

protein processing (ISO)

response to auditory stimulus (ISO)

response to cobalt ion (ISO)

response to estradiol (ISO)

response to hypoxia (ISO)

response to ischemia (ISO)

response to lipopolysaccharide (ISO)

response to organic cyclic compound (ISO)

response to UV (ISO)

signal transduction in response to DNA damage (ISO)

Cellular Component

apoptosome (ISO)

caspase complex (ISO)

cytosol (ISO)

mitochondrion (ISO)

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

cysteine-type endopeptidase activity (ISO)

cysteine-type endopeptidase activity involved in apoptotic process (ISO)

cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ISO)

cysteine-type peptidase activity (ISO)

identical protein binding (ISO)

peptidase activity (ISO)

protein binding (ISO)

protein kinase binding (ISO)

SH3 domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endometrial cancer pathway (ISO)

intrinsic apoptotic pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Casp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	37,353,117 - 37,371,367 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	3,178,097 - 3,196,130 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASP9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	15,491,401 - 15,524,912 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	15,490,832 - 15,526,534 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	15,817,896 - 15,851,285 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	15,691,378 - 15,723,377 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	15,564,102 - 15,596,096	NCBI
Celera	1	14,301,661 - 14,333,662 (-)	NCBI		Celera
Cytogenetic Map	1	p36.21	NCBI
HuRef	1	14,337,387 - 14,370,798 (-)	NCBI		HuRef
CHM1_1	1	15,616,531 - 15,649,948 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	14,936,101 - 14,969,610 (-)	NCBI		T2T-CHM13v2.0

Casp9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	141,520,923 - 141,543,289 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	141,520,923 - 141,543,287 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	141,793,612 - 141,815,978 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	141,793,612 - 141,815,976 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	141,349,527 - 141,371,890 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	141,065,688 - 141,088,051 (+)	NCBI		MGSCv36	mm8
Celera	4	143,618,711 - 143,640,921 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	74.75	NCBI

Casp9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	154,108,872 - 154,126,628 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	154,109,046 - 154,126,626 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	156,793,940 - 156,811,532 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	158,567,234 - 158,584,828 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	158,556,396 - 158,573,978 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	160,356,211 - 160,373,774 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	160,355,833 - 160,373,778 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	164,067,734 - 164,085,297 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	160,704,234 - 160,721,796 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	160,714,421 - 160,731,984 (+)	NCBI
Celera	5	152,461,154 - 152,478,717 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Casp9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955527	2,613,683 - 2,629,738 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955527	2,613,691 - 2,630,217 (+)	NCBI	ChiLan1.0	ChiLan1.0

CASP9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	211,395,731 - 211,430,328 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	210,644,170 - 210,678,765 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	14,630,659 - 14,662,865 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	15,624,666 - 15,656,266 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	15,624,666 - 15,656,266 (-)	Ensembl	panpan1.1		panPan2

CASP9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	82,033,759 - 82,076,710 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	82,031,563 - 82,090,484 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	78,571,149 - 78,590,692 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	82,683,018 - 82,723,170 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	82,682,995 - 82,725,574 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	79,435,738 - 79,455,337 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	80,453,740 - 80,473,245 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	81,519,391 - 81,539,023 (+)	NCBI		UU_Cfam_GSD_1.0

CASP9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	74,706,516 - 74,730,007 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	74,707,597 - 74,730,033 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	69,087,179 - 69,111,408 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASP9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	116,772,819 - 116,798,402 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	116,772,155 - 116,798,930 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	20,315,214 - 20,346,777 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Casp9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	1,773,455 - 1,789,423 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	1,769,270 - 1,789,399 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021720413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040289147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_040289147 ⟹ XP_040145081

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	37,353,117 - 37,371,367 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_040145081	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3282214	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_040145081 ⟸ XM_040289147

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Casp9	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)