CASP9 (caspase 9) - Rat Genome Database

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Gene: CASP9 (caspase 9) Chlorocebus sabaeus
Analyze
Symbol: CASP9
Name: caspase 9
RGD ID: 18644475
Description: ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glial cell apoptotic process (ortholog); kidney development (ortholog); leukocyte apoptotic process (ortholog); PARTICIPATES IN endometrial cancer pathway; intrinsic apoptotic pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase-9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,772,819 - 116,798,402 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,772,155 - 116,798,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605420,315,214 - 20,346,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
bacterial infectious disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchopulmonary dysplasia  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
colorectal cancer  (ISO)
Diabetes Complications  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
focal segmental glomerulosclerosis  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Pancreatitis  (ISO)
Huntington's disease  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
middle cerebral artery infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nervous system disease  (ISO)
NSAID-Enteropathy  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
peripheral nervous system disease  (ISO)
post-traumatic stress disorder  (ISO)
pre-malignant neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Subarachnoid Hemorrhage  (ISO)
Testis Reperfusion Injury  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
varicocele  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CASP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,772,819 - 116,798,402 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,772,155 - 116,798,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605420,315,214 - 20,346,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CASP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,491,401 - 15,524,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,490,832 - 15,526,534 (-)EnsemblGRCh38hg38GRCh38
GRCh37115,817,896 - 15,851,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,691,378 - 15,723,377 (-)NCBINCBI36Build 36hg18NCBI36
Build 34115,564,102 - 15,596,096NCBI
Celera114,301,661 - 14,333,662 (-)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef114,337,387 - 14,370,798 (-)NCBIHuRef
CHM1_1115,616,531 - 15,649,948 (-)NCBICHM1_1
T2T-CHM13v2.0114,936,101 - 14,969,610 (-)NCBIT2T-CHM13v2.0
Casp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,520,923 - 141,543,289 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,520,923 - 141,543,287 (+)EnsemblGRCm39 Ensembl
GRCm384141,793,612 - 141,815,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,793,612 - 141,815,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv374141,349,527 - 141,371,890 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364141,065,688 - 141,088,051 (+)NCBIMGSCv36mm8
Celera4143,618,711 - 143,640,921 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.75NCBI
Casp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25154,108,872 - 154,126,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5154,109,046 - 154,126,626 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,793,940 - 156,811,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,567,234 - 158,584,828 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,556,396 - 158,573,978 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05160,356,211 - 160,373,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,355,833 - 160,373,778 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05164,067,734 - 164,085,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,704,234 - 160,721,796 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,714,421 - 160,731,984 (+)NCBI
Celera5152,461,154 - 152,478,717 (+)NCBICelera
Cytogenetic Map5q36NCBI
Casp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,613,683 - 2,629,738 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,613,691 - 2,630,217 (+)NCBIChiLan1.0ChiLan1.0
CASP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21211,395,731 - 211,430,328 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,644,170 - 210,678,765 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,630,659 - 14,662,865 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1115,624,666 - 15,656,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl115,624,666 - 15,656,266 (-)Ensemblpanpan1.1panPan2
CASP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,033,759 - 82,076,710 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,031,563 - 82,090,484 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,571,149 - 78,590,692 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,683,018 - 82,723,170 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,682,995 - 82,725,574 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,435,738 - 79,455,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0280,453,740 - 80,473,245 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,519,391 - 81,539,023 (+)NCBIUU_Cfam_GSD_1.0
Casp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,353,117 - 37,371,367 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364743,178,097 - 3,196,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl674,706,516 - 74,730,007 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1674,707,597 - 74,730,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,087,179 - 69,111,408 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Casp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247641,773,455 - 1,789,423 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247641,769,270 - 1,789,399 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CASP9
1030 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000017700   ⟹   ENSCSAP00000017173
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20116,772,155 - 116,798,930 (+)Ensembl
RefSeq Acc Id: XM_007980436   ⟹   XP_007978627
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120116,772,819 - 116,798,402 (+)NCBI
Vero_WHO_p1.0NW_02366605420,315,214 - 20,346,771 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007980437   ⟹   XP_007978628
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120116,772,857 - 116,798,125 (+)NCBI
Vero_WHO_p1.0NW_02366605420,315,214 - 20,346,777 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007978627 (Get FASTA)   NCBI Sequence Viewer  
  XP_007978628 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017173
  ENSCSAP00000017173.1
RefSeq Acc Id: XP_007978627   ⟸   XM_007980436
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S8I4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007978628   ⟸   XM_007980437
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000017173   ⟸   ENSCSAT00000017700


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000833 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017700.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD_CASP9 UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
NCBI Gene CASP9 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/TrEMBL
  CASPASE-3 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PIRSF Caspase_ICE UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A0D9S8I4 ENTREZGENE, UniProtKB/TrEMBL