ALK (ALK receptor tyrosine kinase) - Rat Genome Database

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Gene: ALK (ALK receptor tyrosine kinase) Canis lupus familiaris
Analyze
Symbol: ALK
Name: ALK receptor tyrosine kinase
RGD ID: 12321853
Description: ENCODES a protein that exhibits ATP binding (inferred); heparin binding (inferred); identical protein binding (inferred); INVOLVED IN adult behavior (ortholog); brain development (ortholog); hippocampus development (ortholog); ASSOCIATED WITH adrenocortical carcinoma (ortholog); anaplastic large cell lymphoma (ortholog); Brain Neoplasms (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ALK tyrosine kinase receptor; anaplastic lymphoma kinase (Ki-1); anaplastic lymphoma receptor tyrosine kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11723,010,308 - 23,688,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1723,010,308 - 23,688,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,797,195 - 23,482,846 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01723,570,633 - 24,250,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,572,834 - 24,250,519 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,869,939 - 23,549,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,932,402 - 23,612,861 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01723,038,591 - 23,719,569 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ALK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11723,010,308 - 23,688,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1723,010,308 - 23,688,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,797,195 - 23,482,846 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01723,570,633 - 24,250,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,572,834 - 24,250,519 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,869,939 - 23,549,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,932,402 - 23,612,861 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01723,038,591 - 23,719,569 (-)NCBIUU_Cfam_GSD_1.0
ALK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38229,192,774 - 29,921,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl229,192,774 - 29,921,586 (-)EnsemblGRCh38hg38GRCh38
GRCh37229,415,640 - 30,144,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36229,269,144 - 29,997,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 34229,327,292 - 30,056,083NCBI
Celera229,260,042 - 29,988,141 (-)NCBICelera
Cytogenetic Map2p23.2-p23.1NCBI
HuRef229,156,646 - 29,883,927 (-)NCBIHuRef
CHM1_1229,345,879 - 30,074,503 (-)NCBICHM1_1
T2T-CHM13v2.0229,236,229 - 29,965,553 (-)NCBIT2T-CHM13v2.0
Alk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391772,174,206 - 72,911,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1772,175,967 - 72,911,622 (-)EnsemblGRCm39 Ensembl
GRCm381771,868,988 - 72,604,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1771,868,972 - 72,604,627 (-)EnsemblGRCm38mm10GRCm38
MGSCv371772,218,328 - 72,953,647 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361771,009,971 - 71,745,160 (-)NCBIMGSCv36mm8
MGSCv361771,773,845 - 72,508,684 (-)NCBIMGSCv36mm8
Celera1776,136,594 - 76,877,724 (-)NCBICelera
Cytogenetic Map17E1.3NCBI
cM Map1743.77NCBI
Alk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8628,631,431 - 29,351,321 (+)NCBIGRCr8
mRatBN7.2622,879,653 - 23,599,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl622,880,625 - 23,598,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx623,211,130 - 23,929,220 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0623,526,957 - 24,245,096 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0623,008,575 - 23,732,971 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,696,415 - 23,203,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,696,397 - 23,203,775 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,690,337 - 33,703,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0632,580,744 - 33,082,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4623,009,061 - 23,730,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1623,700,711 - 23,727,905 (+)NCBI
Celera622,414,691 - 23,129,629 (+)NCBICelera
Cytogenetic Map6q14NCBI
Alk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546911,047,048 - 11,548,233 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546911,049,373 - 11,751,235 (-)NCBIChiLan1.0ChiLan1.0
ALK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21296,583,820 - 97,316,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A96,587,794 - 97,320,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A29,196,195 - 29,930,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A29,276,041 - 30,007,687 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A29,276,041 - 30,006,735 (-)Ensemblpanpan1.1panPan2
Alk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629267,167,996 - 67,810,992 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364933,028,608 - 3,671,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364933,624,288 - 3,671,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13109,411,146 - 110,105,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23116,847,214 - 116,923,998 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11477,632,809 - 78,408,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604533,719,552 - 34,471,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473811,095,134 - 11,288,891 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473811,094,699 - 12,010,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALK
9104 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 6 6 12 8
Below cutoff 5 5 16 6 6 6 6 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008540   ⟹   ENSCAFP00000007913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1723,010,308 - 23,688,841 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020686   ⟹   ENSCAFP00845016222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1723,572,834 - 24,250,519 (-)Ensembl
RefSeq Acc Id: XM_038452974   ⟹   XP_038308902
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1722,797,195 - 23,482,846 (-)NCBI
RefSeq Acc Id: XM_038498612   ⟹   XP_038354540
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11722,869,939 - 23,549,638 (-)NCBI
RefSeq Acc Id: XM_038561183   ⟹   XP_038417111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01723,038,591 - 23,719,569 (-)NCBI
RefSeq Acc Id: XM_038625230   ⟹   XP_038481158
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01722,932,402 - 23,612,861 (-)NCBI
RefSeq Acc Id: XM_038691158   ⟹   XP_038547086
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01723,570,633 - 24,250,513 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000007913   ⟸   ENSCAFT00000008540
RefSeq Acc Id: XP_038354540   ⟸   XM_038498612
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038481158   ⟸   XM_038625230
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038547086   ⟸   XM_038691158
- Peptide Label: isoform X1
- UniProtKB: P0DV84 (UniProtKB/Swiss-Prot),   A0A8C0LH75 (UniProtKB/TrEMBL),   A0A8I3NE96 (UniProtKB/TrEMBL),   A0A499UTR9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308902   ⟸   XM_038452974
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SAW4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038417111   ⟸   XM_038561183
- Peptide Label: isoform X1
- UniProtKB: P0DV84 (UniProtKB/Swiss-Prot),   A0A499UTR9 (UniProtKB/TrEMBL),   A0A8C0LH75 (UniProtKB/TrEMBL),   A0A8I3NE96 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845016222   ⟸   ENSCAFT00845020686
Protein Domains
MAM   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005297 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845011603 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008540.5 UniProtKB/TrEMBL
  ENSCAFT00845020686 ENTREZGENE
  ENSCAFT00845020686.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene ALK ENTREZGENE
PANTHER PTHR24416:SF276 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gly_rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A499UTR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LH75 ENTREZGENE
  A0A8I3NE96 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SAW4 ENTREZGENE, UniProtKB/TrEMBL
  ALK_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:37802 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-08 ALK  ALK receptor tyrosine kinase    anaplastic lymphoma receptor tyrosine kinase  Symbol and/or name change 5135510 APPROVED