MIR193A (microRNA mir-193a) - Rat Genome Database

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Gene: MIR193A (microRNA mir-193a) Canis lupus familiaris
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Symbol: MIR193A
Name: microRNA mir-193a (Ensembl:microRNA 193a)
RGD ID: 12155731
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-193a; microRNA 193a
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1941,316,481 - 41,316,536 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl941,316,474 - 41,316,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha940,478,752 - 40,478,807 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0942,137,126 - 42,137,181 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1940,921,299 - 40,921,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0941,216,119 - 41,216,174 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0941,291,881 - 41,291,936 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR193ADogarteriovenous malformation  ISORGD:13503829068941miRNA:decreased expression:blood plasma (human)RGDPMID:23051042|REF_RGD_ID:155582214
MIR193ADogcolon cancer amelioratesISORGD:13503829068941human cells in mouse modelRGDPMID:28211508|REF_RGD_ID:153344546
MIR193ADogcolon cancer exacerbatesISORGD:13503829068941human cells in mouse modelRGDPMID:30575330|REF_RGD_ID:153344588
MIR193ADogcolorectal cancer  ISORGD:13503829068941miRNA:increased expression:colorectum (human)RGDPMID:23322774|REF_RGD_ID:153002793
MIR193ADogcolorectal cancer disease_progressionISORGD:13503829068941RNA:increased expression:colorectum, blood (human)RGDPMID:23758639|REF_RGD_ID:153344558
MIR193ADogcolorectal cancer treatmentISORGD:13503829068941human cells in mouse modelRGDPMID:34299137|REF_RGD_ID:153344551
MIR193ADogesophagus squamous cell carcinoma exacerbatesISORGD:13503829068941miRNA:decreased expression:esophagus (human)RGDPMID:27203740|REF_RGD_ID:153323341
MIR193ADogExperimental Liver Neoplasms  ISORGD:16083039068941miRNA:decreased expression:liver (mouse)RGDPMID:30165047|REF_RGD_ID:153323340
MIR193ADoghepatoblastoma exacerbatesISORGD:13503829068941RNA:decreased expression:liver (human)RGDPMID:31541079|REF_RGD_ID:153344539
MIR193ADoghepatocellular carcinoma  ISORGD:13503829068941DNA:hypomethylationRGDPMID:28036298|REF_RGD_ID:153344564
MIR193ADoghepatocellular carcinoma disease_progressionISORGD:13503829068941miRNA:decreased expression:liver (human)RGDPMID:26263159|REF_RGD_ID:11070076
MIR193ADoghepatocellular carcinoma  ISORGD:13503829068941RNA:decreased expression:liver (human)RGDPMID:30710422|REF_RGD_ID:153344549
MIR193ADoghepatocellular carcinoma exacerbatesISORGD:13503829068941RNA:increased expression:blood serum (human)RGDPMID:32960907|REF_RGD_ID:153344563
MIR193ADogliver cirrhosis  ISORGD:13503829068941associated with hepatocellular carcinoma; RNA:decreased expression:liver (human)RGDPMID:24330766|REF_RGD_ID:153344567
MIR193ADoglung cancer  ISORGD:13503829068941DNA:hypermethylationRGDPMID:27669434|REF_RGD_ID:153344606
MIR193ADoglung cancer amelioratesISORGD:13503829068941human cells in mouse modelRGDPMID:27821145|PMID:29183007|REF_RGD_ID:153344578|REF_RGD_ID:153344580
MIR193ADoglung cancer treatmentISORGD:16083039068941 RGDPMID:35289739|REF_RGD_ID:153344587
MIR193ADoglung non-small cell carcinoma  ISORGD:13503829068941miRNA:decreased expression:lung (human)RGDPMID:26655272|REF_RGD_ID:11085320
MIR193ADoglung non-small cell carcinoma amelioratesISORGD:13503829068941human cells in mouse modelRGDPMID:31205511|REF_RGD_ID:153344584
MIR193ADoglung squamous cell carcinoma exacerbatesISORGD:13503829068941DNA:HypermethylationRGDPMID:22282464|REF_RGD_ID:153344598
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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
MIR193ADogcerebral palsy  ISORGD:13503828554872ClinVar Annotator: match by term: Cerebral palsyClinVarPMID:25741868
MIR193ADogDevelopmental Disabilities  ISORGD:13503828554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:22241097
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR193ADogCarcinoid Tumor  ISORGD:13503829068941CTD Direct Evidence: marker/mechanismCTDPMID:25105010
MIR193ADogChemical and Drug Induced Liver Injury  ISORGD:13503829068941CTD Direct Evidence: marker/mechanismCTDPMID:28545106
MIR193ADogLung Neoplasms  ISORGD:13503829068941CTD Direct Evidence: marker/mechanismCTDPMID:25105010
MIR193ADogMyocardial Reperfusion Injury  ISORGD:13503829068941CTD Direct Evidence: marker/mechanismCTDPMID:22050707
MIR193ADogpulmonary fibrosis  ISORGD:13503829068941CTD Direct Evidence: therapeuticCTDPMID:30744607
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR193ADogfocal segmental glomerulosclerosis  ISORGD:16083039068941 MouseDO 


Biological Process
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR193ADogcellular response to amino acid stimulus acts_upstream_of_or_withinISORGD:16083039068941 PMID:20548288MGIPMID:20548288
MIR193ADogcellular response to lipopolysaccharide acts_upstream_of_or_withinISORGD:16083039068941 PMID:21247879MGIPMID:21247879
MIR193ADogDNA damage response involved_inISORGD:13503829068941 PMID:25542424ARUK-UCLPMID:25542424
MIR193ADogmale sex differentiation acts_upstream_of_or_withinISORGD:16083039068941 PMID:23946534MGIPMID:23946534
MIR193ADogmiRNA-mediated gene silencing by mRNA destabilization involved_inISORGD:13503829068941 PMID:29725386BHF-UCLPMID:29725386
MIR193ADogmiRNA-mediated post-transcriptional gene silencing involved_inIEARfam:RF01895150520179 RNAcentralGO_REF:0000115
MIR193ADognegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis involved_inISORGD:13503829068941 PMID:28276476BHF-UCLPMID:28276476
MIR193ADognegative regulation of cell migration involved in sprouting angiogenesis involved_inISORGD:13503829068941 PMID:28276476BHF-UCLPMID:28276476
MIR193ADognegative regulation of G1/S transition of mitotic cell cycle involved_inISORGD:13503829068941 PMID:28276476BHF-UCLPMID:28276476
1 to 9 of 9 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR193ADogmRNA 3'-UTR binding enablesISORGD:13503829068941 PMID:25542424ARUK-UCLPMID:25542424
MIR193ADogmRNA base-pairing post-transcriptional repressor activity enablesISORGD:13503829068941 PMID:20829195, PMID:25542424, PMID:28276476, PMID:29725386, PMID:30451334ARUK-UCLPMID:20829195|PMID:25542424|PMID:28276476|PMID:29725386|PMID:30451334

PMID:16381832   PMID:18392026  



MIR193A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1941,316,481 - 41,316,536 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl941,316,474 - 41,316,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha940,478,752 - 40,478,807 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0942,137,126 - 42,137,181 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1940,921,299 - 40,921,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0941,216,119 - 41,216,174 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0941,291,881 - 41,291,936 (-)NCBIUU_Cfam_GSD_1.0
MIR193A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381731,559,996 - 31,560,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1731,559,996 - 31,560,083 (+)EnsemblGRCh38hg38GRCh38
GRCh371729,887,015 - 29,887,102 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361726,911,127 - 26,911,214 (+)NCBINCBI36Build 36hg18NCBI36
Celera1726,806,777 - 26,806,864 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1726,097,427 - 26,097,514 (+)NCBIHuRef
CHM1_11729,949,637 - 29,949,724 (+)NCBICHM1_1
T2T-CHM13v2.01732,505,775 - 32,505,862 (+)NCBIT2T-CHM13v2.0
Mir193a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,602,795 - 79,602,860 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,602,795 - 79,602,860 (+)EnsemblGRCm39 Ensembl
GRCm381179,711,969 - 79,712,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,711,969 - 79,712,034 (+)EnsemblGRCm38mm10GRCm38
MGSCv371179,525,471 - 79,525,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1189,344,581 - 89,344,646 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.02NCBI
Mir193a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,170,306 - 65,170,417 (-)NCBIGRCr8
mRatBN7.21064,672,343 - 64,672,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1064,672,343 - 64,672,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1069,300,596 - 69,300,707 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01068,805,990 - 68,806,101 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01064,269,827 - 64,269,938 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01067,065,885 - 67,065,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,065,885 - 67,065,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,583,957 - 64,584,068 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1063,641,174 - 63,641,285 (-)NCBICelera
Cytogenetic Map10q25NCBI
MIR193A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1243,336,969 - 43,337,048 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11243,336,969 - 43,337,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21245,165,038 - 45,165,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3

.



adipose tissue
alimentary part of gastrointestinal system
ectoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
1 1 1 1 1 2 1



Ensembl Acc Id: ENSCAFT00000039976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl941,316,474 - 41,316,542 (-)Ensembl
RefSeq Acc Id: NR_049385
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1941,316,481 - 41,316,536 (-)NCBI
Dog10K_Boxer_Tasha940,478,752 - 40,478,807 (-)NCBI
ROS_Cfam_1.0942,137,126 - 42,137,181 (-)NCBI
UMICH_Zoey_3.1940,921,299 - 40,921,354 (-)NCBI
UNSW_CanFamBas_1.0941,216,119 - 41,216,174 (-)NCBI
UU_Cfam_GSD_1.0941,291,881 - 41,291,936 (-)NCBI
Sequence:


Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000025693 Ensembl
  ENSCAFG00845014047 ENTREZGENE
Ensembl Transcript ENSCAFT00845025108 ENTREZGENE
miRBase MI0008159 ENTREZGENE
NCBI Gene MIR193A ENTREZGENE
RNAcentral URS0000367985 RNACentral
  URS00007E4EDA RNACentral
  URS0000E03B84 RNACentral


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR193A  microRNA mir-193a    microRNA 193a  Symbol and/or name change 5135510 APPROVED