ITGB3 (integrin subunit beta 3) - Rat Genome Database

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Gene: ITGB3 (integrin subunit beta 3) Canis lupus familiaris
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Symbol: ITGB3
Name: integrin subunit beta 3
RGD ID: 12349367
Description: ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); cell adhesion molecule binding (ortholog); enzyme binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute myeloid leukemia (ortholog); Arterial Occlusive Diseases (ortholog); FOUND IN alpha9-beta1 integrin-ADAM8 complex (ortholog); alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glycoprotein GPIIIa; GPIIIA; integrin beta-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,179,667 - 9,231,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,182,562 - 9,231,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,065,645 - 11,114,120 (+)NCBI
ROS_Cfam_1.0910,772,116 - 10,823,763 (-)NCBI
UMICH_Zoey_3.199,787,282 - 9,835,753 (-)NCBI
UNSW_CanFamBas_1.0917,686,480 - 17,734,963 (+)NCBI
UU_Cfam_GSD_1.0917,635,354 - 17,683,846 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute myeloid leukemia  (ISO)
Arterial Occlusive Diseases  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Bronchial Hyperreactivity  (ISO)
Carotid Artery Injuries  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
colorectal carcinoma  (ISO)
Coronary Disease  (ISO)
coronary thrombosis  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Glanzmann's thrombasthenia  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hantavirus Infections  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Hip Fractures  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Neonatal Alloimmune Thrombocytopenia  (ISO)
Neoplasm Metastasis  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
Pathologic Constriction  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 16  (ISO)
Platelet-Type Bleeding Disorder 23  (ISO)
Platelet-Type Bleeding Disorder 24  (ISO)
pneumonia  (ISO)
Posttransfusion Purpura  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Stroke  (ISO)
Sudden Cardiac Death  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (ISO)
cell adhesion mediated by integrin  (IBA)
cell migration  (IBA)
cell-matrix adhesion  (IBA,ISO)
cell-substrate adhesion  (ISO)
cell-substrate junction assembly  (ISO)
cellular response to drug  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
embryo implantation  (ISO)
heterotypic cell-cell adhesion  (ISO)
integrin-mediated signaling pathway  (IBA,IEA)
mesodermal cell differentiation  (ISO)
negative chemotaxis  (ISO)
negative regulation of cell death  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
platelet activation  (ISO)
platelet aggregation  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glomerular mesangial cell proliferation  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of T cell migration  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell migration  (ISO)
regulation of extracellular matrix organization  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein localization  (ISO)
regulation of protein tyrosine kinase activity  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of serotonin uptake  (ISO)
response to activity  (ISO)
response to platelet-derived growth factor  (ISO)
response to radiation  (ISO)
smooth muscle cell migration  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
viral entry into host cell  (ISO)

References
Additional References at PubMed
PMID:10482317   PMID:28256590  


Genomics

Comparative Map Data
ITGB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,179,667 - 9,231,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,182,562 - 9,231,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,065,645 - 11,114,120 (+)NCBI
ROS_Cfam_1.0910,772,116 - 10,823,763 (-)NCBI
UMICH_Zoey_3.199,787,282 - 9,835,753 (-)NCBI
UNSW_CanFamBas_1.0917,686,480 - 17,734,963 (+)NCBI
UU_Cfam_GSD_1.0917,635,354 - 17,683,846 (+)NCBI
ITGB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1747,253,827 - 47,313,743 (+)EnsemblGRCh38hg38GRCh38
GRCh381747,253,827 - 47,313,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371745,331,193 - 45,391,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,686,207 - 42,745,076 (+)NCBINCBI36hg18NCBI36
Build 341742,686,206 - 42,745,076NCBI
Celera1741,781,276 - 41,840,192 (+)NCBI
Cytogenetic Map17q21.32NCBI
HuRef1740,709,287 - 40,768,167 (+)NCBIHuRef
CHM1_11745,396,156 - 45,455,032 (+)NCBICHM1_1
Itgb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,498,826 - 104,561,302 (+)NCBIGRCm39mm39
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)Ensembl
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBImm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
Itgb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21089,509,917 - 89,564,679 (+)NCBI
Rnor_6.0 Ensembl1092,667,869 - 92,783,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01092,667,869 - 92,783,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01092,424,545 - 92,538,859 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1088,202,821 - 88,257,185 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Itgb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554789,788,192 - 9,830,254 (-)NCBIChiLan1.0ChiLan1.0
ITGB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11710,353,111 - 10,388,924 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01710,134,450 - 10,194,596 (-)NCBIMhudiblu_PPA_v0panPan3
Itgb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,320,810 - 16,379,027 (-)NCBI
SpeTri2.0NW_0049365412,822,789 - 2,871,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,693,505 - 16,752,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,694,466 - 16,752,228 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,718,915 - 16,775,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11659,372,171 - 59,431,434 (-)NCBI
Vero_WHO_p1.0NW_02366607730,082,743 - 30,143,493 (-)NCBI
Itgb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248491,895,378 - 1,952,755 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 1
Low 5 2 22 6 2 6 6 1 12 8 10 5
Below cutoff 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000021789   ⟹   ENSCAFP00000020239
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl99,184,711 - 9,231,451 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000037064   ⟹   ENSCAFP00000032511
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl99,182,562 - 9,231,451 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073422   ⟹   ENSCAFP00000057515
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl99,188,641 - 9,231,451 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073456   ⟹   ENSCAFP00000045001
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl99,182,627 - 9,231,451 (-)Ensembl
RefSeq Acc Id: NM_001003162   ⟹   NP_001003162
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.199,182,562 - 9,231,046 (-)NCBI
Dog10K_Boxer_Tasha911,065,645 - 11,114,120 (+)NCBI
ROS_Cfam_1.0910,775,226 - 10,823,748 (-)NCBI
UMICH_Zoey_3.199,787,282 - 9,835,753 (-)NCBI
UNSW_CanFamBas_1.0917,686,480 - 17,734,963 (+)NCBI
UU_Cfam_GSD_1.0917,635,354 - 17,683,846 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005624174   ⟹   XP_005624231
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.199,179,667 - 9,224,324 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022422528   ⟹   XP_022278236
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.199,184,576 - 9,231,061 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038674953   ⟹   XP_038530881
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0910,772,116 - 10,816,946 (-)NCBI
RefSeq Acc Id: XM_038674954   ⟹   XP_038530882
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0910,777,249 - 10,823,763 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001003162 (Get FASTA)   NCBI Sequence Viewer  
  XP_038530881 (Get FASTA)   NCBI Sequence Viewer  
  XP_038530882 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD13680 (Get FASTA)   NCBI Sequence Viewer  
  AAD49737 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005624231   ⟸   XM_005624174
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001003162   ⟸   NM_001003162
- Peptide Label: precursor
- UniProtKB: Q9TUN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022278236   ⟸   XM_022422528
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000020239   ⟸   ENSCAFT00000021789
RefSeq Acc Id: ENSCAFP00000045001   ⟸   ENSCAFT00000073456
RefSeq Acc Id: ENSCAFP00000057515   ⟸   ENSCAFT00000073422
RefSeq Acc Id: ENSCAFP00000032511   ⟸   ENSCAFT00000037064
RefSeq Acc Id: XP_038530881   ⟸   XM_038674953
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530882   ⟸   XM_038674954
- Peptide Label: isoform X2
Protein Domains
INB   Integrin_b_cyt   Integrin_B_tail   PSI

Promoters
RGD ID:13684442
Promoter ID:EPDNEW_C2512
Type:initiation region
Name:ITGB3_1
Description:integrin beta-3 precursor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.199,231,078 - 9,231,138EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013735 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000020239 UniProtKB/TrEMBL
  ENSCAFP00000032511 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000045001 UniProtKB/TrEMBL
  ENSCAFP00000057515 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021789 UniProtKB/TrEMBL
  ENSCAFT00000037064 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000073422 UniProtKB/TrEMBL
  ENSCAFT00000073456 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro EGF_extracell UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_beta-3 UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:403788 UniProtKB/TrEMBL
NCBI Gene ITGB3 ENTREZGENE
PANTHER PTHR10082 UniProtKB/TrEMBL
  PTHR10082:SF25 UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  Integrin_beta UniProtKB/TrEMBL
  PSI_integrin UniProtKB/TrEMBL
PIRSF Integrin_B UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/TrEMBL
PROSITE INTEGRIN_BETA UniProtKB/TrEMBL
SMART INB UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69687 UniProtKB/TrEMBL
UniProt A0A5F4BT33_CANLF UniProtKB/TrEMBL
  A0A5F4CXN1_CANLF UniProtKB/TrEMBL
  F1PPG5_CANLF UniProtKB/TrEMBL
  F6PMX8_CANLF UniProtKB/TrEMBL
  Q9TUN7 ENTREZGENE, UniProtKB/TrEMBL