EPHA2 (EPH receptor A2) - Rat Genome Database

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Gene: EPHA2 (EPH receptor A2) Canis lupus familiaris
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Symbol: EPHA2
Name: EPH receptor A2
RGD ID: 12292576
Description: ENCODES a protein that exhibits growth factor binding (ortholog); transmembrane receptor protein tyrosine kinase activity (ortholog); INVOLVED IN activation of GTPase activity (ortholog); axial mesoderm formation (ortholog); blood vessel development (ortholog); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH cataract (ortholog); cataract 6 multiple types (ortholog); cortical senile cataract (ortholog); FOUND IN cell surface (ortholog); focal adhesion (ortholog); lamellipodium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ephrin type-A receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,534,130 - 81,561,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,070,108 - 78,097,636 (+)NCBI
ROS_Cfam_1.0282,179,960 - 82,207,481 (+)NCBI
UMICH_Zoey_3.1278,933,025 - 78,960,551 (+)NCBI
UNSW_CanFamBas_1.0279,950,185 - 79,977,704 (+)NCBI
UU_Cfam_GSD_1.0281,018,093 - 81,045,632 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
axial mesoderm formation  (ISO)
blood vessel development  (ISO)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
blood vessel morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
cAMP metabolic process  (ISO)
cell chemotaxis  (ISO)
cell migration  (ISO)
cell motility  (ISO)
defense response to Gram-positive bacterium  (ISO)
ephrin receptor signaling pathway  (IEA,ISO)
inflammatory response  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
keratinocyte differentiation  (ISO)
lens fiber cell morphogenesis  (ISO)
mammary gland epithelial cell proliferation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of lymphangiogenesis  (ISO)
negative regulation of protein kinase B signaling  (ISO)
neural tube development  (ISO)
neuron differentiation  (ISO)
notochord cell development  (ISO)
notochord formation  (ISO)
notochord morphogenesis  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
peptidyl-tyrosine phosphorylation  (IEA)
pericyte cell differentiation  (ISO)
positive regulation of bicellular tight junction assembly  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
post-anal tail morphogenesis  (ISO)
protein kinase B signaling  (ISO)
protein localization to plasma membrane  (ISO)
regulation of angiogenesis  (ISO)
regulation of blood vessel endothelial cell migration  (ISO)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of lamellipodium assembly  (ISO)
response to growth factor  (ISO)
skeletal system development  (ISO)
vasculogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:19193766   PMID:21979959   PMID:28833247  


Genomics

Comparative Map Data
EPHA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,534,130 - 81,561,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,070,108 - 78,097,636 (+)NCBI
ROS_Cfam_1.0282,179,960 - 82,207,481 (+)NCBI
UMICH_Zoey_3.1278,933,025 - 78,960,551 (+)NCBI
UNSW_CanFamBas_1.0279,950,185 - 79,977,704 (+)NCBI
UU_Cfam_GSD_1.0281,018,093 - 81,045,632 (+)NCBI
EPHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl116,124,337 - 16,156,069 (-)EnsemblGRCh38hg38GRCh38
GRCh38116,124,337 - 16,156,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,450,832 - 16,482,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,323,419 - 16,355,151 (-)NCBINCBI36hg18NCBI36
Build 34116,196,138 - 16,227,870NCBI
Celera114,930,817 - 14,962,560 (-)NCBI
Cytogenetic Map1p36.13NCBI
HuRef114,968,749 - 15,000,153 (-)NCBIHuRef
CHM1_1116,249,454 - 16,281,203 (-)NCBICHM1_1
Epha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,028,532 - 141,056,695 (+)NCBIGRCm39mm39
GRCm39 Ensembl4141,028,551 - 141,056,695 (+)Ensembl
GRCm384141,301,221 - 141,329,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,301,240 - 141,329,384 (+)EnsemblGRCm38mm10GRCm38
MGSCv374140,857,155 - 140,885,293 (+)NCBIGRCm37mm9NCBIm37
MGSCv364140,573,316 - 140,601,454 (+)NCBImm8
Celera4143,116,872 - 143,145,199 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.67NCBI
Epha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25153,605,644 - 153,634,115 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5153,605,644 - 153,634,117 (+)Ensembl
Rnor_6.05159,845,773 - 159,874,203 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,558,669 - 163,586,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,185,143 - 160,214,727 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15160,190,327 - 160,224,048 (+)NCBI
Celera5151,971,932 - 152,000,092 (+)NCBICelera
Cytogenetic Map5q36NCBI
Epha2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,120,266 - 2,152,781 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,120,447 - 2,151,932 (+)NCBIChiLan1.0ChiLan1.0
EPHA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,253,509 - 16,284,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,253,513 - 16,284,787 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0115,259,915 - 15,292,983 (-)NCBIMhudiblu_PPA_v0panPan3
Epha2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,823,596 - 37,849,129 (-)NCBI
SpeTri2.0NW_0049364743,648,395 - 3,673,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,251,467 - 75,279,314 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,251,465 - 75,279,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,567,147 - 69,595,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,147,077 - 116,178,647 (+)NCBI
ChlSab1.1 Ensembl20116,147,040 - 116,178,644 (+)Ensembl
Vero_WHO_p1.0NW_02366605419,643,306 - 19,675,426 (+)NCBI
Epha2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247642,265,114 - 2,296,032 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 6 1 1 1 6 5 3
Low 3 5 16 5 5 5 3 12 5 3
Below cutoff 3 8

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022414281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038471008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038471009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038596144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038596145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038660228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038660229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_544546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY793106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000025418   ⟹   ENSCAFP00000023602
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000025475   ⟹   ENSCAFP00000023653
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089229   ⟹   ENSCAFP00000060089
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)Ensembl
RefSeq Acc Id: XM_022414281   ⟹   XP_022269989
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1281,535,272 - 81,560,871 (+)NCBI
Dog10K_Boxer_Tasha278,071,180 - 78,096,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038471008   ⟹   XP_038326936
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1278,933,025 - 78,960,551 (+)NCBI
RefSeq Acc Id: XM_038471009   ⟹   XP_038326937
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1278,934,097 - 78,959,700 (+)NCBI
RefSeq Acc Id: XM_038531880   ⟹   XP_038387808
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0281,018,093 - 81,045,632 (+)NCBI
RefSeq Acc Id: XM_038531881   ⟹   XP_038387809
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0281,019,165 - 81,044,781 (+)NCBI
RefSeq Acc Id: XM_038596144   ⟹   XP_038452072
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0279,950,185 - 79,977,704 (+)NCBI
RefSeq Acc Id: XM_038596145   ⟹   XP_038452073
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0279,951,248 - 79,976,852 (+)NCBI
RefSeq Acc Id: XM_038660228   ⟹   XP_038516156
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0282,179,960 - 82,207,481 (+)NCBI
RefSeq Acc Id: XM_038660229   ⟹   XP_038516157
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0282,181,025 - 82,206,630 (+)NCBI
RefSeq Acc Id: XM_544546   ⟹   XP_544546
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1281,534,130 - 81,561,722 (+)NCBI
Dog10K_Boxer_Tasha278,070,108 - 78,097,636 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_544546   ⟸   XM_544546
- Peptide Label: isoform X1
- UniProtKB: F1Q4C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022269989   ⟸   XM_022414281
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000023653   ⟸   ENSCAFT00000025475
RefSeq Acc Id: ENSCAFP00000023602   ⟸   ENSCAFT00000025418
RefSeq Acc Id: ENSCAFP00000060089   ⟸   ENSCAFT00000089229
RefSeq Acc Id: XP_038326936   ⟸   XM_038471008
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038326937   ⟸   XM_038471009
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038452072   ⟸   XM_038596144
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038452073   ⟸   XM_038596145
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038516156   ⟸   XM_038660228
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038516157   ⟸   XM_038660229
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038387808   ⟸   XM_038531880
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038387809   ⟸   XM_038531881
- Peptide Label: isoform X2

Promoters
RGD ID:13682643
Promoter ID:EPDNEW_C711
Type:multiple initiation site
Name:EPHA2_1
Description:EPH receptor A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1281,534,113 - 81,534,173EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016011 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000023653 ENTREZGENE
NCBI Gene EPHA2 ENTREZGENE
UniProt F1Q4C5 ENTREZGENE
VGNC ID VGNC:40405 ENTREZGENE