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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Liver Metastasis
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Accession:DOID:9006618 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to the liver.
Synonyms:exact_synonym: liver metastases;   metastatic liver disease;   secondary liver cancer


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Liver Metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO associated with colorectal cancer;mRNA:increased expression:liver (mouse) RGD PMID:20380732 RGD:25671446 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase severity ISO associated with skin melanoma;DNA:missense mutations:cds:
associated with colorectal cancer;DNA:missense mutation:cds:p.V600E (human)
associated with colorectal cancer;DNA:mutations:multiple
associated with colorectal cancer;DNA:mutation:cds:
associated with colorectal cancer;DNA:missense mutations:cds:pV599E,p.V600E (human)		 RGD PMID:22331825 PMID:23010994 PMID:26775732 PMID:27737491 PMID:28787433 RGD:11554843 RGD:14696791 RGD:15039394 RGD:18337264 RGD:18337265 NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 disease_progression ISO associated with colorectal cancer RGD PMID:27058904 RGD:14995463 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCL5 C-C motif chemokine ligand 5 treatment ISO associated with Animal Mammary Neoplasms; RGD PMID:15692764 RGD:14995455 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852 		JBrowse link
G CCND2 cyclin D2 ISO associated with colorectal cancer;protein:increased expression:colorectum RGD PMID:19508551 RGD:151665111 NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255 		JBrowse link
G CCNG1 cyclin G1 treatment ISO human cells in mouse model RGD PMID:10910035 RGD:151356987 NCBI chr 4:47,800,697...47,808,259
Ensembl chr 4:47,801,575...47,808,211 		JBrowse link
G CD44 CD44 molecule ISO associated with Breast Neoplasm;protein:increased expression:liver RGD PMID:17991717 RGD:2289349 NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107 		JBrowse link
G CHD4 chromodomain helicase DNA binding protein 4 ameliorates ISO associated with human colon adenocarcinoma cells in a mouse model RGD PMID:28486105 RGD:153323299 NCBI chr27:38,411,009...38,440,367
Ensembl chr27:38,411,075...38,439,958 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 treatment ISO associated with colon carcinoma; RGD PMID:30381616 RGD:27095891 NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 ameliorates ISO associated with colorectal cancer; human cells in mouse model RGD PMID:30789971 RGD:151893289 NCBI chr28:2,895,916...2,903,543 JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO associated with colorectal cancer; human colon adenocarcinoma cells in a mouse model RGD PMID:29679563 RGD:26884358 NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ameliorates ISO associated with colorectal cancer; human cells in mouse model
human cells in mouse model; associated with colorectal cancer		 RGD PMID:29436696 PMID:30789971 RGD:151893289 RGD:152023643 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740 		JBrowse link
G DAXX death domain associated protein exacerbates ISO associated with neuroendocrine tumor;DNA:mutations:CDS:multiple (human)
associated with pancreatic endocrine carcinoma;DNA:mutations:CDS:multiple (human)
associated with colon cancer; mRNA:decreased expression:liver (human)		 RGD PMID:30339629 PMID:30342802 PMID:31942198 RGD:152025194 RGD:152025199 RGD:152025203 NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 treatment ISO mRNA:increased expression:liver (mouse)
human cells in mouse model; nilotinib		 RGD PMID:29438985 PMID:30666650 PMID:33110221 RGD:151347537 RGD:151347685 RGD:151347840 NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 ameliorates ISO associated with colon carcinoma
associated with melanoma;		 RGD PMID:21701781 PMID:22071959 RGD:150429701 RGD:150429713 NCBI chr38:20,002,984...20,152,930
Ensembl chr38:20,008,057...20,152,275 		JBrowse link
G DOCK6 dedicator of cytokinesis 6 ameliorates ISO associated with stomach cancer; RGD PMID:29587866 RGD:155791564 NCBI chr20:50,029,354...50,066,829
Ensembl chr20:50,029,369...50,066,829 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 disease_progression ISO associated with colorectal cancer; RGD PMID:28846828 RGD:21408566 NCBI chr15:50,187,579...50,417,188
Ensembl chr15:50,189,240...50,417,195 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 ISO associated with colorectal cancer;mRNA:increased expression:colorectal mucosa: RGD PMID:19082464 RGD:25330357 NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit ISO human cells in mouse model RGD PMID:30114390 RGD:153344554 NCBI chr17:22,340,469...22,364,994
Ensembl chr17:22,341,322...22,361,772 		JBrowse link
G GPC3 glypican 3 ISO protein:increased expression:blood serum (human) RGD PMID:28801286 RGD:243065135 NCBI chr  X:104,313,426...104,751,215
Ensembl chr  X:104,313,591...104,751,756 		JBrowse link
G HMBS hydroxymethylbilane synthase ISO associated with colon adenocarcinoma;protein:decreased activity:liver(rat) RGD PMID:1386052 RGD:25440496 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G IL2 interleukin 2 treatment ISO associated with colon carcinoma
associated with Colorectal Neoplasms, Carcinoma, Hepatocellular;		 RGD PMID:9354462 PMID:11591892 RGD:14928215 RGD:8663446 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IQSEC1 IQ motif and Sec7 domain ArfGEF 1 ISO human cells in mouse model RGD PMID:22662237 RGD:153344589 NCBI chr20:3,241,058...3,403,394
Ensembl chr20:3,241,052...3,522,859 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 ISO associated with colon cancer;protein:increased expression:colon (human) RGD PMID:24533778 RGD:155259116 NCBI chr20:52,594,450...52,604,236
Ensembl chr20:52,594,536...52,602,150 		JBrowse link
G MIR148B microRNA mir-148b exacerbates ISO associated with stomach cancer; RGD PMID:29587866 RGD:155791564 NCBI chr27:975,146...975,206
Ensembl chr27:975,131...975,220 		JBrowse link
G MIR155 microRNA mir-155 ISO RGD PMID:26885061 RGD:21079444 NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833 		JBrowse link
G MIR200B microRNA mir-200b ISO associated with colorectal cancer;RNA:increased expression:liver: RGD PMID:28617555 RGD:14928321 NCBI chr 5:56,368,400...56,368,479
Ensembl chr 5:56,368,400...56,368,479 		JBrowse link
G MIR200C microRNA mir-200c ISO associated with colorectal cancer;RNA:increased expression:liver: RGD PMID:28617555 RGD:14928321 NCBI chr27:38,082,097...38,082,159
Ensembl chr27:38,082,091...38,082,169 		JBrowse link
G MIR223 microRNA mir-223 disease_progression ISO associated with colorectal cancer; RGD PMID:28846828 RGD:21408566 NCBI chr  X:50,838,131...50,838,233
Ensembl chr  X:50,838,131...50,838,233 		JBrowse link
G MIR494 microRNA mir-494 exacerbates ISO associated with pancreatic ductal adenocarcinoma; RGD PMID:24859161 RGD:156430321 NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465 		JBrowse link
G MPL MPL proto-oncogene, thrombopoietin receptor exacerbates
severity		 ISO associated with pancreatic cancer; protein:increased expression:liver, pancreas (human)
associated with pancreatic ductal adenocarcinoma; human cells in mouse model
associated with colorectal carcinoma;protein:increased expression:colorectum (human)		 RGD PMID:23747337 PMID:30770989 RGD:126925751 RGD:126925752 NCBI chr15:16,815,102...16,825,321
Ensembl chr15:16,815,294...16,825,350 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase susceptibility ISO associated with colorectal cancer;DNA:mutations:exons (human)
human gene in a mouse model;DNA:missense mutations:cds:p.G12V, p.Q61K (human)
associated with melanoma;DNA:mutations: exons (human)		 RGD PMID:26799184 PMID:28011498 PMID:28787433 RGD:14696774 RGD:14696791 RGD:14696792 NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788 		JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B treatment ISO mouse tumor cells in mouse recipient RGD PMID:31348125 RGD:151660353 NCBI chr10:12,267,891...12,384,522
Ensembl chr10:12,241,716...12,384,435 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:30404068 RGD:152995463 NCBI chr 4:69,903,393...70,013,168
Ensembl chr 4:69,936,379...70,010,566 		JBrowse link
G RNF43 ring finger protein 43 ISO associated with colorectal adenocarcinoma;mRNA:increased expression:liver (human) RGD PMID:28789449 RGD:151361221 NCBI chr 9:32,996,668...33,061,781
Ensembl chr 9:32,997,937...33,060,313 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 severity ISO associated with colon adenocarcinoma RGD PMID:11745822 RGD:151361130 NCBI chr18:53,810,468...53,819,021
Ensembl chr18:53,810,398...53,819,021 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 severity ISO associated with colon adenocarcinoma
associated with colon cancer		 RGD PMID:11718450 PMID:11745822 RGD:151361129 RGD:151361130 NCBI chr 5:65,313,105...65,343,858
Ensembl chr 5:65,313,105...65,343,858 		JBrowse link
G SMAD4 SMAD family member 4 treatment ISO associated with colorectal carcinoma;protein:decreased expression:colorectum:
associated with colorectal carcinoma; DNA:mutations: :		 RGD PMID:17390050 PMID:29551247 RGD:18937000 RGD:21066338 NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405 		JBrowse link
G SOX30 SRY-box transcription factor 30 ameliorates ISO RGD PMID:29739711 RGD:151660333 NCBI chr 4:52,587,163...52,615,945
Ensembl chr 4:52,587,355...52,615,945 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase disease_progression ISO associated with colon cancer;protein:increased activity:colon RGD PMID:7678609 RGD:150521542 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO associated with colorectal carcinoma;mRNA,protein:increased expression:liver: RGD PMID:22156924 RGD:15014782 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    disease of cellular proliferation 7263
      Neoplastic Processes 724
        Neoplasm Metastasis 493
          Liver Metastasis 41
Path 2
Term Annotations click to browse term
  disease 17773
    disease of anatomical entity 15145
      gastrointestinal system disease 6496
        Digestive System Neoplasms 3710
          Gastrointestinal Neoplasms 3596
            gastrointestinal system cancer 2838
              hepatobiliary system cancer 1059
                liver cancer 979
                  Liver Metastasis 41
paths to the root