VEGFA (vascular endothelial growth factor A) - Rat Genome Database

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Gene: VEGFA (vascular endothelial growth factor A) Canis lupus familiaris
Analyze
Symbol: VEGFA
Name: vascular endothelial growth factor A
RGD ID: 12166888
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); cytokine activity (ortholog); extracellular matrix binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); aging (ortholog); angiogenesis (ortholog); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; bevacizumab pharmacodynamics pathway; ASSOCIATED WITH acoustic neuroma (ortholog); acute chest syndrome (ortholog); acute kidney failure (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: vascular endothelial growth factor 188; vascular permeability factor; VEGF; VEGF-A; VPF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,209,032 - 12,224,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,208,231 - 12,224,965 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,235,225 - 12,250,737 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,693,104 - 12,708,614 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,691,593 - 12,708,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,217,730 - 12,233,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,305,204 - 12,320,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,398,451 - 12,413,981 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute chest syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adhesions of uterus  (ISO)
adult-onset Still's disease  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
angiosarcoma  (ISO)
Arteriovenous Fistula  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
attention deficit hyperactivity disorder  (ISO)
autoimmune hepatitis  (ISO)
Behcet's disease  (ISO)
blindness  (ISO)
brain edema  (ISO)
brain glioma  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
bullous pemphigoid  (ISO)
cardiomyopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (ISO)
chronic fatigue syndrome  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
decubitus ulcer  (ISO)
dermatitis herpetiformis  (ISO)
Diabetes Complications  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
DiGeorge syndrome  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
ductal carcinoma in situ  (ISO)
duodenal ulcer  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
erythema multiforme  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
extrinsic allergic alveolitis  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
gingivitis  (ISO)
glaucoma  (ISO)
glioblastoma  (ISO)
gliosarcoma  (ISO)
glomerulonephritis  (ISO)
Glomus Tympanicum Tumor  (ISO)
graft-versus-host disease  (ISO)
granulosa cell tumor  (ISO)
Graves' disease  (ISO)
Head and Neck Neoplasms  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
hepatopulmonary syndrome  (ISO)
Hypercholesterolemia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
impotence  (ISO)
Infantile Capillary Hemangioma  (ISO)
infantile Refsum disease  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intracranial aneurysm  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
inverted papilloma  (ISO)
ischemic colitis  (ISO)
Kawasaki disease  (ISO)
Kuhnt-Junius degeneration  (ISO)
larynx cancer  (ISO)
learning disability  (ISO)
limb ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myeloid leukemia  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
Neovascularization, Pathologic  (ISO)
Nerve Degeneration  (ISO)
neurofibromatosis 1  (ISO)
neurofibromatosis 2  (ISO)
neurofibrosarcoma  (ISO)
newborn respiratory distress syndrome  (ISO)
oral squamous cell carcinoma  (ISO)
osteochondrodysplasia  (ISO)
osteosarcoma  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic ductal carcinoma  (ISO)
Periodontal Atrophy  (ISO)
polyarteritis nodosa  (ISO)
polycystic ovary syndrome  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy in Diabetics  (ISO)
primary biliary cholangitis  (ISO)
primary sclerosing cholangitis  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary edema  (ISO)
renal cell carcinoma  (ISO)
renal Wilms' tumor  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinal ischemia  (ISO)
Retinal Neovascularization  (ISO)
retinal telangiectasia  (ISO)
retinal vein occlusion  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
seminoma  (ISO)
Skin Neoplasms  (ISO)
Small-For-Size Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
sudden infant death syndrome  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
Thrombotic Microangiopathies  (ISO)
Tongue Neoplasms  (ISO)
Tympanic Membrane Perforation  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveal melanoma  (ISO)
Wounds and Injuries  (ISO)
Zellweger syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA,ISS)
aging  (ISO)
angiogenesis  (IEA,ISO,ISS)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
apoptotic process  (ISO)
artery morphogenesis  (ISO)
basophil chemotaxis  (ISO)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
bone trabecula formation  (ISO)
bone trabecula morphogenesis  (ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
branching morphogenesis of an epithelial tube  (ISO)
camera-type eye morphogenesis  (ISO)
cardiac muscle cell development  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cell chemotaxis  (ISO)
cell differentiation  (IEA)
cell migration  (ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISS)
cell population proliferation  (ISO)
cell-cell adhesion  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hypoxia  (IEA,ISO,ISS)
cellular response to mechanical stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISS)
cellular response to wortmannin  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cellular stress response to acid chemical  (IEA)
commissural neuron axon guidance  (ISO)
coronary artery morphogenesis  (ISO)
coronary vein morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
endothelial cell chemotaxis  (IEA,ISS)
endothelial cell migration  (ISO)
endothelial cell proliferation  (ISO)
epithelial cell differentiation  (ISO)
epithelial cell maturation  (ISO)
epithelial cell proliferation  (ISO)
eye photoreceptor cell development  (ISO)
female pregnancy  (ISO)
heart morphogenesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
in utero embryonic development  (ISO)
induction of positive chemotaxis  (IBA)
kidney development  (ISO)
lactation  (ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung vasculature development  (ISO)
lymph vessel morphogenesis  (ISO)
lymphangiogenesis  (ISO)
macrophage differentiation  (IEA,ISS)
mammary gland alveolus development  (ISO)
mesenchymal cell proliferation  (ISO)
mesoderm development  (ISO)
monocyte differentiation  (IEA,ISS)
motor neuron migration  (ISS)
mRNA stabilization  (ISO)
negative regulation of adherens junction organization  (IEA)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of blood-brain barrier permeability  (IEA)
negative regulation of bone resorption  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (IEA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of establishment of endothelial barrier  (IEA)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of programmed cell death  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
nervous system development  (ISO)
neuroblast proliferation  (ISO)
neuron development  (ISO)
obsolete positive regulation of cellular component movement  (ISS)
outflow tract morphogenesis  (ISO)
ovarian follicle development  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IBA,IEA,ISO,ISS)
positive regulation of axon extension involved in axon guidance  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISS)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell adhesion  (IEA,ISS)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell migration by vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (IEA,ISS)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of CREB transcription factor activity  (IEA,ISS)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (IEA,ISS)
positive regulation of endothelial cell migration  (IEA,ISS)
positive regulation of endothelial cell proliferation  (IBA,IEA,ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of focal adhesion assembly  (IEA,ISS)
positive regulation of gene expression  (IEA)
positive regulation of histone deacetylase activity  (IEA)
positive regulation of lymphangiogenesis  (ISO)
positive regulation of MAP kinase activity  (IEA,ISS)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell chemotaxis  (IBA)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISS)
positive regulation of peptidyl-tyrosine autophosphorylation  (IEA,ISS)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of positive chemotaxis  (IEA,ISS)
positive regulation of protein autophosphorylation  (IEA,ISS)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein kinase C signaling  (IEA,ISS)
positive regulation of protein kinase D signaling  (IEA,ISS)
positive regulation of protein localization to early endosome  (ISO)
positive regulation of protein phosphorylation  (IBA,IEA,ISS)
positive regulation of protein-containing complex assembly  (IEA,ISS)
positive regulation of receptor internalization  (IEA,ISS)
positive regulation of retinal ganglion cell axon guidance  (ISO)
positive regulation of signal transduction  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sprouting angiogenesis  (IEA)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (IEA)
positive regulation of trophoblast cell migration  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular endothelial growth factor signaling pathway  (IEA)
positive regulation of vascular permeability  (IEA,ISO)
post-embryonic camera-type eye development  (ISO)
primitive erythrocyte differentiation  (ISO)
regulation of cell shape  (IEA,ISS)
regulation of endothelial cell differentiation  (ISO)
regulation of growth  (ISO)
regulation of hematopoietic progenitor cell differentiation  (ISO)
regulation of nitric oxide mediated signal transduction  (IEA,ISO)
regulation of retinal ganglion cell axon guidance  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to cold  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to folic acid  (ISO)
response to hypoxia  (IBA,IEA,ISO,ISS)
response to oxygen levels  (ISO)
response to progesterone  (ISO)
response to vitamin A  (ISO)
signal transduction  (IEA)
signal transduction  (IEA)
sprouting angiogenesis  (IBA)
stem cell proliferation  (ISO)
surfactant homeostasis  (ISO)
T-helper 1 type immune response  (ISO)
tube formation  (IEA,ISS)
vascular endothelial growth factor receptor signaling pathway  (IBA,IEA,ISO,ISS)
vascular endothelial growth factor receptor-2 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IBA,IEA)
vascular wound healing  (IEA)
vasculature development  (ISO)
vasodilation  (ISO)
VEGF-activated neuropilin signaling pathway  (ISO)
wound healing  (ISO)

Cellular Component
adherens junction  (IEA)
basement membrane  (ISO)
cell surface  (IEA,ISS)
cytoplasm  (IEA,ISS)
cytoplasm  (ISS)
extracellular region  (IEA)
extracellular space  (IBA,IEA,ISO,ISS)
membrane  (IEA)
membrane  (IEA)
nucleus  (ISO)
secretory granule  (IEA,ISS)
VEGF-A complex  (IEA,ISO)
vesicle  (ISO)

References
Additional References at PubMed
PMID:10661874   PMID:16496934   PMID:17099154   PMID:17467003   PMID:17888471   PMID:17993509   PMID:18039895   PMID:18429933   PMID:18461467   PMID:18717642   PMID:19057151   PMID:19175733  
PMID:20001231   PMID:20093695   PMID:20230578   PMID:20570280   PMID:20805568   PMID:21366824   PMID:22300704   PMID:22489798   PMID:22520817   PMID:23279467   PMID:24976305   PMID:25041787  
PMID:26850540   PMID:27543935   PMID:28956485   PMID:31696573   PMID:33348010  


Genomics

Comparative Map Data
VEGFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,209,032 - 12,224,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,208,231 - 12,224,965 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,235,225 - 12,250,737 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,693,104 - 12,708,614 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,691,593 - 12,708,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,217,730 - 12,233,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,305,204 - 12,320,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,398,451 - 12,413,981 (+)NCBIUU_Cfam_GSD_1.0
VEGFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,770,209 - 43,786,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl643,770,184 - 43,786,487 (+)EnsemblGRCh38hg38GRCh38
GRCh37643,737,946 - 43,754,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,845,931 - 43,862,202 (+)NCBINCBI36Build 36hg18NCBI36
Build 34643,845,923 - 43,860,314NCBI
Celera645,289,570 - 45,305,849 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,458,106 - 43,474,385 (+)NCBIHuRef
CHM1_1643,741,412 - 43,757,691 (+)NCBICHM1_1
T2T-CHM13v2.0643,599,722 - 43,616,002 (+)NCBIT2T-CHM13v2.0
Vegfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,327,919 - 46,343,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,327,919 - 46,343,295 (-)EnsemblGRCm39 Ensembl
GRCm381746,016,993 - 46,032,377 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,016,993 - 46,032,369 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,153,942 - 46,169,326 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,480,574 - 45,495,331 (-)NCBIMGSCv36mm8
Celera1749,448,065 - 49,463,499 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.79NCBI
Vegfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,955,300 - 14,970,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,955,300 - 14,970,641 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,540,015 - 23,555,341 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0928,602,643 - 28,617,969 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0926,903,445 - 26,918,771 (+)NCBIRnor_WKY
Rnor_6.0917,340,341 - 17,355,681 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,340,341 - 17,355,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,232,415 - 16,247,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,520,730 - 10,536,071 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1910,519,065 - 10,531,506 (+)NCBI
Celera912,701,425 - 12,716,765 (+)NCBICelera
Cytogenetic Map9q12NCBI
Vegfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554379,527,445 - 9,541,908 (+)NCBIChiLan1.0ChiLan1.0
VEGFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1644,651,855 - 44,666,353 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,650,365 - 44,666,353 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0643,361,053 - 43,377,366 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Vegfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,698,881 - 47,715,068 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,247,100 - 16,260,673 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647616,245,134 - 16,261,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VEGFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,746,052 - 38,761,366 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,746,393 - 38,762,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2744,459,821 - 44,475,711 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VEGFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,377,959 - 28,394,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604443,823,884 - 43,842,951 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vegfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475415,929,414 - 15,943,637 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VEGFA
101 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001110501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001110502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ133758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX009700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN349636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN427836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN441081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN877014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN877015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000003061   ⟹   ENSCAFP00000002842
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1212,208,231 - 12,224,965 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000003063   ⟹   ENSCAFP00000002844
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1212,208,231 - 12,224,965 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000049819   ⟹   ENSCAFP00000041911
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1212,208,231 - 12,224,965 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063883   ⟹   ENSCAFP00000045844
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1212,208,231 - 12,223,072 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075439   ⟹   ENSCAFP00000062329
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1212,208,231 - 12,223,072 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018561   ⟹   ENSCAFP00845014480
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1212,691,593 - 12,708,601 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018637   ⟹   ENSCAFP00845014544
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1212,692,538 - 12,708,601 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018694   ⟹   ENSCAFP00845014594
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1212,692,538 - 12,707,133 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018734   ⟹   ENSCAFP00845014626
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1212,692,538 - 12,707,133 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018769   ⟹   ENSCAFP00845014653
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1212,696,046 - 12,708,601 (+)Ensembl
RefSeq Acc Id: NM_001003175   ⟹   NP_001003175
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11212,209,032 - 12,224,978 (+)NCBI
Dog10K_Boxer_Tasha1212,235,225 - 12,250,737 (+)NCBI
ROS_Cfam_1.01212,693,104 - 12,708,614 (+)NCBI
UMICH_Zoey_3.11212,217,730 - 12,233,243 (+)NCBI
UNSW_CanFamBas_1.01212,305,204 - 12,320,707 (+)NCBI
UU_Cfam_GSD_1.01212,398,451 - 12,413,981 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001110501   ⟹   NP_001103971
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11212,209,032 - 12,224,978 (+)NCBI
Dog10K_Boxer_Tasha1212,235,225 - 12,250,737 (+)NCBI
ROS_Cfam_1.01212,693,104 - 12,708,614 (+)NCBI
UMICH_Zoey_3.11212,217,730 - 12,233,243 (+)NCBI
UNSW_CanFamBas_1.01212,305,204 - 12,320,707 (+)NCBI
UU_Cfam_GSD_1.01212,398,451 - 12,413,981 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001110502   ⟹   NP_001103972
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11212,209,032 - 12,224,978 (+)NCBI
Dog10K_Boxer_Tasha1212,235,225 - 12,250,737 (+)NCBI
ROS_Cfam_1.01212,693,104 - 12,708,614 (+)NCBI
UMICH_Zoey_3.11212,217,730 - 12,233,243 (+)NCBI
UNSW_CanFamBas_1.01212,305,204 - 12,320,707 (+)NCBI
UU_Cfam_GSD_1.01212,398,451 - 12,413,981 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001003175   ⟸   NM_001003175
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9XSF5 (UniProtKB/Swiss-Prot),   Q9MYV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001103971   ⟸   NM_001110501
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9MYV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001103972   ⟸   NM_001110502
- Peptide Label: isoform 3 precursor
- UniProtKB: Q9MYV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041911   ⟸   ENSCAFT00000049819
RefSeq Acc Id: ENSCAFP00000045844   ⟸   ENSCAFT00000063883
RefSeq Acc Id: ENSCAFP00000002844   ⟸   ENSCAFT00000003063
RefSeq Acc Id: ENSCAFP00000002842   ⟸   ENSCAFT00000003061
RefSeq Acc Id: ENSCAFP00000062329   ⟸   ENSCAFT00000075439
RefSeq Acc Id: ENSCAFP00845014544   ⟸   ENSCAFT00845018637
RefSeq Acc Id: ENSCAFP00845014653   ⟸   ENSCAFT00845018769
RefSeq Acc Id: ENSCAFP00845014626   ⟸   ENSCAFT00845018734
RefSeq Acc Id: ENSCAFP00845014594   ⟸   ENSCAFT00845018694
RefSeq Acc Id: ENSCAFP00845014480   ⟸   ENSCAFT00845018561
Protein Domains
Platelet-derived growth factor (PDGF) family

Promoters
RGD ID:13685442
Promoter ID:EPDNEW_C3511
Type:single initiation site
Name:VEGFA_1
Description:vascular endothelial growth factor A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11212,208,216 - 12,208,276EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001938 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845010533 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000002842.4 UniProtKB/TrEMBL
  ENSCAFP00000002844.4 UniProtKB/TrEMBL
  ENSCAFP00000041911.1 UniProtKB/TrEMBL
  ENSCAFP00000045844.1 UniProtKB/TrEMBL
  ENSCAFP00000062329.1 UniProtKB/TrEMBL
  ENSCAFP00000068792.1 UniProtKB/TrEMBL
  ENSCAFP00000073415.1 UniProtKB/TrEMBL
  ENSCAFP00845014480.1 UniProtKB/TrEMBL
  ENSCAFP00845014544.1 UniProtKB/TrEMBL
  ENSCAFP00845014594.1 UniProtKB/TrEMBL
  ENSCAFP00845014626.1 UniProtKB/TrEMBL
  ENSCAFP00845014653.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003061.6 UniProtKB/TrEMBL
  ENSCAFT00000003063.5 UniProtKB/TrEMBL
  ENSCAFT00000049819.4 UniProtKB/TrEMBL
  ENSCAFT00000063883.2 UniProtKB/TrEMBL
  ENSCAFT00000075439.2 UniProtKB/TrEMBL
  ENSCAFT00000100929.1 UniProtKB/TrEMBL
  ENSCAFT00000101355.1 UniProtKB/TrEMBL
  ENSCAFT00845018561.1 UniProtKB/TrEMBL
  ENSCAFT00845018637.1 UniProtKB/TrEMBL
  ENSCAFT00845018694.1 UniProtKB/TrEMBL
  ENSCAFT00845018734.1 UniProtKB/TrEMBL
  ENSCAFT00845018769.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.160.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PD_growth_factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF/VEGF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGF_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGF_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403802 UniProtKB/Swiss-Prot
NCBI Gene VEGFA ENTREZGENE
PANTHER VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASCULAR ENDOTHELIAL GROWTH FACTOR A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGF_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57593 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I3NGI3_CANLF UniProtKB/TrEMBL
  A0A8I3NRV8_CANLF UniProtKB/TrEMBL
  A0A8I3RVV6_CANLF UniProtKB/TrEMBL
  A0A8I3RVW5_CANLF UniProtKB/TrEMBL
  A0A8I3RVY3_CANLF UniProtKB/TrEMBL
  A0A8P0NSP1_CANLF UniProtKB/TrEMBL
  A0A8P0NW12_CANLF UniProtKB/TrEMBL
  A0A8P0PB78_CANLF UniProtKB/TrEMBL
  A0A8P0PHV8_CANLF UniProtKB/TrEMBL
  A0A8P0S7T9_CANLF UniProtKB/TrEMBL
  A0A8P0S852_CANLF UniProtKB/TrEMBL
  A0A8P0TS72_CANLF UniProtKB/TrEMBL
  Q9MYV3 ENTREZGENE
  Q9XSF5 ENTREZGENE
  VEGFA_CANLF UniProtKB/Swiss-Prot
UniProt Secondary Q9XSF3 UniProtKB/Swiss-Prot
  Q9XSF4 UniProtKB/Swiss-Prot
  Q9XSF5 UniProtKB/Swiss-Prot
VGNC ID VGNC:48250 ENTREZGENE