Vegfa (vascular endothelial growth factor A) - Rat Genome Database

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Gene: Vegfa (vascular endothelial growth factor A) Chinchilla lanigera
Analyze
Symbol: Vegfa
Name: vascular endothelial growth factor A
RGD ID: 9004778
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); cytokine activity (ortholog); extracellular matrix binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); aging (ortholog); angiogenesis (ortholog); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; bevacizumab pharmacodynamics pathway; ASSOCIATED WITH acoustic neuroma (ortholog); acute chest syndrome (ortholog); acute kidney failure (ortholog); FOUND IN adherens junction (ortholog); basement membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554379,527,445 - 9,541,908 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute chest syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adult-onset Still's disease  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
angiosarcoma  (ISO)
Arteriovenous Fistula  (ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
attention deficit hyperactivity disorder  (ISO)
autoimmune hepatitis  (ISO)
Behcet's disease  (ISO)
blindness  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
bullous pemphigoid  (ISO)
cardiomyopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (ISO)
chronic fatigue syndrome  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
decubitus ulcer  (ISO)
dermatitis herpetiformis  (ISO)
Diabetes Complications  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
ductal carcinoma in situ  (ISO)
duodenal ulcer  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
erythema multiforme  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Neoplasms  (ISO)
extrinsic allergic alveolitis  (ISO)
gastric ulcer  (ISO)
gingivitis  (ISO)
glaucoma  (ISO)
glioblastoma  (ISO)
gliosarcoma  (ISO)
glomerulonephritis  (ISO)
Glomus Tympanicum Tumor  (ISO)
Graft vs Host Disease  (ISO)
granulosa cell tumor  (ISO)
Graves' disease  (ISO)
Head and Neck Neoplasms  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
hepatopulmonary syndrome  (ISO)
Hypercholesterolemia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
inverted papilloma  (ISO)
ischemic colitis  (ISO)
Kawasaki disease  (ISO)
Kuhnt-Junius degeneration  (ISO)
learning disability  (ISO)
Limb Ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myeloid leukemia  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
neovascular glaucoma  (ISO)
Neovascularization, Pathologic  (ISO)
Nerve Degeneration  (ISO)
neurofibromatosis 1  (ISO)
neurofibromatosis 2  (ISO)
neurofibrosarcoma  (ISO)
osteochondrodysplasia  (ISO)
osteosarcoma  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic ductal carcinoma  (ISO)
Periodontal Atrophy  (ISO)
polyarteritis nodosa  (ISO)
polycystic ovary syndrome  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy in Diabetics  (ISO)
primary biliary cholangitis  (ISO)
primary sclerosing cholangitis  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary edema  (ISO)
renal cell carcinoma  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinal ischemia  (ISO)
Retinal Neovascularization  (ISO)
retinal telangiectasia  (ISO)
retinal vein occlusion  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
seminoma  (ISO)
Skin Neoplasms  (ISO)
Small-For-Size Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
sudden infant death syndrome  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
Thrombotic Microangiopathies  (ISO)
Tongue Neoplasms  (ISO)
Tympanic Membrane Perforation  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveal melanoma  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
aging  (ISO)
angiogenesis  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
artery morphogenesis  (ISO)
basophil chemotaxis  (ISO)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
bone trabecula formation  (ISO)
bone trabecula morphogenesis  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
camera-type eye morphogenesis  (ISO)
cardiac muscle cell development  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cell chemotaxis  (ISO)
cell maturation  (ISO)
cell migration  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to drug  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cellular stress response to acid chemical  (ISO)
commissural neuron axon guidance  (ISO)
coronary artery morphogenesis  (ISO)
coronary vein morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
endothelial cell chemotaxis  (ISO)
endothelial cell migration  (ISO)
epithelial cell differentiation  (ISO)
eye photoreceptor cell development  (ISO)
female pregnancy  (ISO)
heart morphogenesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
hyaluronan metabolic process  (ISO)
in utero embryonic development  (ISO)
induction of positive chemotaxis  (ISO)
kidney development  (ISO)
lactation  (ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung vasculature development  (ISO)
lymph vessel morphogenesis  (ISO)
lymphangiogenesis  (ISO)
macrophage differentiation  (ISO)
mammary gland alveolus development  (ISO)
mesoderm development  (ISO)
monocyte differentiation  (ISO)
motor neuron migration  (ISO)
mRNA stabilization  (ISO)
negative regulation of adherens junction organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood-brain barrier permeability  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of establishment of endothelial barrier  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of programmed cell death  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
nervous system development  (ISO)
neuron development  (ISO)
outflow tract morphogenesis  (ISO)
ovarian follicle development  (ISO)
positive chemotaxis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of axon extension involved in axon guidance  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell migration by vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (ISO)
positive regulation of cellular component movement  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of CREB transcription factor activity  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of histone deacetylase activity  (ISO)
positive regulation of lymphangiogenesis  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell chemotaxis  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein kinase C signaling  (ISO)
positive regulation of protein kinase D signaling  (ISO)
positive regulation of protein localization to early endosome  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of retinal ganglion cell axon guidance  (ISO)
positive regulation of signal transduction  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
positive regulation of trophoblast cell migration  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular permeability  (ISO)
post-embryonic camera-type eye development  (ISO)
primitive erythrocyte differentiation  (ISO)
regulation of cell shape  (ISO)
regulation of endothelial cell differentiation  (ISO)
regulation of growth  (ISO)
regulation of hematopoietic progenitor cell differentiation  (ISO)
regulation of nitric oxide mediated signal transduction  (ISO)
regulation of retinal ganglion cell axon guidance  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to cold  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to folic acid  (ISO)
response to hypoxia  (ISO)
response to oxygen levels  (ISO)
response to progesterone  (ISO)
response to vitamin A  (ISO)
sprouting angiogenesis  (ISO)
surfactant homeostasis  (ISO)
T-helper 1 type immune response  (ISO)
tube formation  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)
vascular endothelial growth factor receptor-2 signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
vascular wound healing  (ISO)
vasculature development  (ISO)
VEGF-activated neuropilin signaling pathway  (ISO)
wound healing  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Vegfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554379,527,445 - 9,541,908 (+)NCBIChiLan1.0ChiLan1.0
VEGFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl643,770,184 - 43,786,487 (+)EnsemblGRCh38hg38GRCh38
GRCh38643,770,209 - 43,786,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37643,737,946 - 43,754,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,845,931 - 43,862,202 (+)NCBINCBI36hg18NCBI36
Build 34643,845,923 - 43,860,314NCBI
Celera645,289,570 - 45,305,849 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef643,458,106 - 43,474,385 (+)NCBIHuRef
CHM1_1643,741,412 - 43,757,691 (+)NCBICHM1_1
Vegfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,327,919 - 46,343,303 (-)NCBIGRCm39mm39
GRCm39 Ensembl1746,327,919 - 46,343,295 (-)Ensembl
GRCm381746,016,993 - 46,032,377 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,016,993 - 46,032,369 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,153,942 - 46,169,326 (-)NCBIGRCm37mm9NCBIm37
MGSCv361745,480,574 - 45,495,331 (-)NCBImm8
Celera1749,448,065 - 49,463,499 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.79NCBI
Vegfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,955,300 - 14,970,641 (+)NCBI
Rnor_6.0 Ensembl917,340,341 - 17,355,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0917,340,341 - 17,355,681 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0916,232,415 - 16,247,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,520,730 - 10,536,071 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1910,519,065 - 10,531,506 (+)NCBI
Celera912,701,425 - 12,716,765 (+)NCBICelera
Cytogenetic Map9q12NCBI
VEGFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1644,651,855 - 44,666,353 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,650,365 - 44,666,353 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0643,361,053 - 43,377,366 (+)NCBIMhudiblu_PPA_v0panPan3
VEGFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,209,032 - 12,224,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,208,231 - 12,224,965 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,235,225 - 12,250,737 (+)NCBI
ROS_Cfam_1.01212,693,104 - 12,708,614 (+)NCBI
UMICH_Zoey_3.11212,217,730 - 12,233,243 (+)NCBI
UNSW_CanFamBas_1.01212,305,204 - 12,320,707 (+)NCBI
UU_Cfam_GSD_1.01212,398,451 - 12,413,981 (+)NCBI
Vegfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,698,881 - 47,715,068 (+)NCBI
SpeTri2.0NW_00493647616,245,134 - 16,261,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VEGFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,746,052 - 38,761,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,746,393 - 38,762,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2744,459,821 - 44,475,711 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VEGFA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,377,959 - 28,394,508 (-)NCBI
Vegfa
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475415,929,414 - 15,943,637 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013516949   ⟹   XP_013372403
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554379,527,445 - 9,541,908 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013372403 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013372403   ⟸   XM_013516949
- Sequence:


Additional Information

Database Acc Id Source(s)
NCBI Gene Vegfa ENTREZGENE