TIMP4 (TIMP metallopeptidase inhibitor 4) - Rat Genome Database

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Gene: TIMP4 (TIMP metallopeptidase inhibitor 4) Canis lupus familiaris
Analyze
Symbol: TIMP4
Name: TIMP metallopeptidase inhibitor 4
RGD ID: 12163814
Description: ENCODES a protein that exhibits enzyme inhibitor activity (inferred); metal ion binding (inferred); metalloendopeptidase inhibitor activity (inferred); INVOLVED IN Notch signaling pathway (ortholog); ovulation cycle (ortholog); response to cytokine (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Arteriovenous Fistula (ortholog); Breast Neoplasms (ortholog); FOUND IN extracellular space (ortholog); sarcomere (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: metalloproteinase inhibitor 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,399,522 - 6,405,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,399,522 - 6,405,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,435,643 - 6,441,210 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0206,428,241 - 6,462,722 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,428,701 - 6,439,507 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,146,856 - 6,152,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,497,799 - 6,503,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,473,392 - 6,478,960 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular matrix  (IBA,IEA)
extracellular space  (IBA,IEA,ISO)
sarcomere  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:26979595   PMID:30032202  


Genomics

Comparative Map Data
TIMP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,399,522 - 6,405,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,399,522 - 6,405,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,435,643 - 6,441,210 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0206,428,241 - 6,462,722 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,428,701 - 6,439,507 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,146,856 - 6,152,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,497,799 - 6,503,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,473,392 - 6,478,960 (+)NCBIUU_Cfam_GSD_1.0
TIMP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,153,068 - 12,158,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,153,068 - 12,158,912 (-)EnsemblGRCh38hg38GRCh38
GRCh37312,194,568 - 12,200,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,169,568 - 12,175,647 (-)NCBINCBI36Build 36hg18NCBI36
Build 34312,169,569 - 12,175,647NCBI
Celera312,132,043 - 12,138,067 (-)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,128,374 - 12,134,601 (-)NCBIHuRef
CHM1_1312,144,898 - 12,151,125 (-)NCBICHM1_1
T2T-CHM13v2.0312,151,357 - 12,157,146 (-)NCBIT2T-CHM13v2.0
Timp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,221,405 - 115,229,166 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,218,853 - 115,229,166 (-)EnsemblGRCm39 Ensembl
GRCm386115,244,444 - 115,252,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,241,892 - 115,252,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv376115,195,634 - 115,201,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,211,438 - 115,217,467 (-)NCBIMGSCv36mm8
Celera6117,084,697 - 117,090,930 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.29NCBI
Timp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,978,667 - 149,985,350 (-)NCBIGRCr8
mRatBN7.24148,306,021 - 148,312,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,304,490 - 148,312,558 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,531,322 - 154,537,832 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,314,411 - 150,320,921 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,938,223 - 148,944,733 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,156,948 - 147,163,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,156,948 - 147,163,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,445,694 - 210,452,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,375,072 - 151,381,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4137,199,851 - 137,206,370 (-)NCBICelera
Cytogenetic Map4q42NCBI
Timp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,685,031 - 14,693,211 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,689,016 - 14,693,211 (-)NCBIChiLan1.0ChiLan1.0
TIMP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,141,127 - 12,149,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,144,168 - 12,154,025 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0312,079,195 - 12,087,485 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,425,429 - 12,433,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,425,429 - 12,433,192 (-)Ensemblpanpan1.1panPan2
Timp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,413,957 - 17,420,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,489,545 - 1,495,478 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,488,993 - 1,496,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,179,806 - 68,190,942 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,179,803 - 68,191,199 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,371,793 - 75,377,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,134,133 - 48,140,870 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,134,637 - 48,140,600 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041118,360,254 - 118,370,994 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624956330,327 - 337,299 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624956331,275 - 341,561 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TIMP4
16 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 5 6
Low 5 5 16 6 3 6 12 4 5
Below cutoff 6 6 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008038   ⟹   ENSCAFP00000007442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl206,399,522 - 6,405,089 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051652   ⟹   ENSCAFP00845040526
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl206,428,701 - 6,439,507 (+)Ensembl
RefSeq Acc Id: NM_001314106   ⟹   NP_001301035
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1206,399,522 - 6,405,089 (+)NCBI
Dog10K_Boxer_Tasha206,435,643 - 6,441,210 (+)NCBI
ROS_Cfam_1.0206,428,679 - 6,434,247 (+)NCBI
UMICH_Zoey_3.1206,146,856 - 6,152,424 (+)NCBI
UNSW_CanFamBas_1.0206,497,799 - 6,503,367 (+)NCBI
UU_Cfam_GSD_1.0206,473,392 - 6,478,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038426344   ⟹   XP_038282272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0206,430,058 - 6,439,245 (+)NCBI
RefSeq Acc Id: XM_038426345   ⟹   XP_038282273
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0206,428,241 - 6,462,722 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001301035   ⟸   NM_001314106
- Peptide Label: precursor
- UniProtKB: E2RPY3 (UniProtKB/TrEMBL),   A0A8C0MFN7 (UniProtKB/TrEMBL),   A0A8C0QX53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000007442   ⟸   ENSCAFT00000008038
RefSeq Acc Id: XP_038282273   ⟸   XM_038426345
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038282272   ⟸   XM_038426344
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845040526   ⟸   ENSCAFT00845051652
Protein Domains
NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005002 Ensembl
  ENSCAFG00000054385 UniProtKB/TrEMBL
  ENSCAFG00030003959 UniProtKB/TrEMBL
  ENSCAFG00040022400 UniProtKB/TrEMBL
  ENSCAFG00845029189 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000102420.1 UniProtKB/TrEMBL
  ENSCAFT00030007326.1 UniProtKB/TrEMBL
  ENSCAFT00040041603.1 UniProtKB/TrEMBL
  ENSCAFT00845051652 ENTREZGENE
  ENSCAFT00845051652.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
  TIMP_C UniProtKB/TrEMBL
  TIMP_CS UniProtKB/TrEMBL
KEGG Report cfa:100688494 UniProtKB/TrEMBL
NCBI Gene TIMP4 ENTREZGENE
PANTHER PTHR11844 UniProtKB/TrEMBL
  PTHR11844:SF26 UniProtKB/TrEMBL
Pfam TIMP UniProtKB/TrEMBL
PROSITE NTR UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
SMART NTR UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/TrEMBL
UniProt A0A8C0MFN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QX53 ENTREZGENE
  E2RPY3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47378 ENTREZGENE