RHOA (ras homolog family member A) - Rat Genome Database

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Gene: RHOA (ras homolog family member A) Canis lupus familiaris
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Symbol: RHOA
Name: ras homolog family member A
RGD ID: 12222706
Description: ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin cytoskeleton reorganization (ortholog); androgen receptor signaling pathway (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Aicardi-Goutieres Syndrome 1 (ortholog); alopecia (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ras homolog gene family, member A; RHO1; rho1 GTP-binding protein; transforming protein RhoA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,743,026 - 39,805,566 (+)NCBI
ROS_Cfam_1.02040,180,779 - 40,244,414 (+)NCBI
UMICH_Zoey_3.12039,548,346 - 39,611,020 (+)NCBI
UNSW_CanFamBas_1.02039,951,968 - 40,014,480 (+)NCBI
UU_Cfam_GSD_1.02040,231,551 - 40,294,267 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
Aicardi-Goutieres Syndrome 1  (ISO)
alopecia  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Cocaine-Related Disorders  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous T cell lymphoma  (ISO)
ectodermal dysplasia  (ISO)
esophageal carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Facial Ectodermal Dysplasia  (ISO)
fetal alcohol syndrome  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypertension  (ISO)
Hypopigmentation  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
membranous glomerulonephritis  (ISO)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurocutaneous Syndromes  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
ovarian carcinoma  (ISO)
peripheral T-cell lymphoma  (ISO)
Pierson syndrome  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (ISO)
Stomach Neoplasms  (ISO)
T-Cell Lymphoma  (ISO)
tooth disease  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin cytoskeleton reorganization  (IEA,ISS)
actin filament organization  (IBA)
alpha-beta T cell lineage commitment  (IEA)
androgen receptor signaling pathway  (IEA,ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (IEA,ISO)
apical junction assembly  (IEA,ISS)
apolipoprotein A-I-mediated signaling pathway  (IEA)
beta selection  (IEA)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell junction assembly  (ISS)
cell migration  (IBA,ISS)
cell morphogenesis  (ISO)
cell-matrix adhesion  (IEA,ISO)
cellular response to chemokine  (IEA,ISS)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (IEA)
cerebral cortex cell migration  (IEA,ISO)
cleavage furrow formation  (ISS)
cortical cytoskeleton organization  (IBA)
cytoplasmic microtubule organization  (IEA,ISS)
cytoskeleton organization  (ISO)
embryonic cleavage  (ISO)
endothelial cell migration  (IEA,ISO)
endothelial tube lumen extension  (IEA,ISO)
establishment of epithelial cell apical/basal polarity  (IEA,ISS)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
establishment or maintenance of cell polarity  (IBA)
forebrain radial glial cell differentiation  (IEA,ISO)
GTP metabolic process  (ISO)
kidney development  (IEA,ISO)
meiotic spindle organization  (ISO)
mitotic cleavage furrow formation  (IEA,ISS)
mitotic spindle assembly  (IEA)
negative chemotaxis  (IEA)
negative regulation of cell death  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
negative regulation of cell size  (IEA)
negative regulation of cell-substrate adhesion  (IEA)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of oxidative phosphorylation  (IEA)
negative regulation of reactive oxygen species biosynthetic process  (IEA)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron projection morphogenesis  (ISO)
odontogenesis  (IEA,ISO)
ossification involved in bone maturation  (IEA)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of alpha-beta T cell differentiation  (IEA)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokinesis  (IEA,ISS)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISS)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA)
positive regulation of lipase activity  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of podosome assembly  (IEA,ISO)
positive regulation of protein serine/threonine kinase activity  (IEA,ISS)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of T cell migration  (IEA,ISS)
positive regulation of translation  (ISO)
positive regulation of vascular associated smooth muscle contraction  (IEA,ISO)
positive regulation of vasoconstriction  (ISO)
regulation of actin cytoskeleton organization  (IBA)
regulation of actin polymerization or depolymerization  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell migration  (ISS)
regulation of cell shape  (IBA)
regulation of dendrite development  (ISO)
regulation of microtubule cytoskeleton organization  (IEA)
regulation of modification of postsynaptic actin cytoskeleton  (IEA)
regulation of modification of synaptic structure  (ISO)
regulation of neural precursor cell proliferation  (IEA,ISO)
regulation of neuron projection development  (IEA,ISO)
regulation of osteoblast proliferation  (IEA)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to amino acid  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to xenobiotic stimulus  (ISO)
Rho protein signal transduction  (IEA,ISO,ISS)
Roundabout signaling pathway  (IEA,ISS)
skeletal muscle satellite cell migration  (ISS)
skeletal muscle tissue development  (IEA,ISO)
spindle localization  (ISO)
stress fiber assembly  (IBA,ISO,ISS)
stress-activated protein kinase signaling cascade  (ISO)
substantia nigra development  (ISO)
substrate adhesion-dependent cell spreading  (IEA,ISS)
trabecula morphogenesis  (IEA)
wound healing, spreading of cells  (ISS)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:2123294   PMID:16448388   PMID:16723500   PMID:16845171   PMID:17646397   PMID:18097951   PMID:20445174   PMID:21212278   PMID:22893699   PMID:24561621   PMID:28554775  


Genomics

Comparative Map Data
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,743,026 - 39,805,566 (+)NCBI
ROS_Cfam_1.02040,180,779 - 40,244,414 (+)NCBI
UMICH_Zoey_3.12039,548,346 - 39,611,020 (+)NCBI
UNSW_CanFamBas_1.02039,951,968 - 40,014,480 (+)NCBI
UU_Cfam_GSD_1.02040,231,551 - 40,294,267 (+)NCBI
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,388 - 49,402,293 (-)NCBICHM1_1
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBImm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,991,926 - 109,025,746 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0panPan3
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,239,560 - 64,285,154 (-)NCBI
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,836 - 32,003,722 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBI
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)Ensembl
Vero_WHO_p1.0NW_023666041156,205,022 - 156,258,776 (+)NCBI
Rhoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,316,122 - 3,361,820 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000035203   ⟹   ENSCAFP00000030438
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)Ensembl
RefSeq Acc Id: NM_001003273   ⟹   NP_001003273
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,824,575 - 39,887,215 (+)NCBI
Dog10K_Boxer_Tasha2039,743,026 - 39,805,566 (+)NCBI
ROS_Cfam_1.02040,180,802 - 40,243,541 (+)NCBI
UMICH_Zoey_3.12039,548,346 - 39,611,020 (+)NCBI
UNSW_CanFamBas_1.02039,951,968 - 40,014,480 (+)NCBI
UU_Cfam_GSD_1.02040,231,551 - 40,294,267 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038426374   ⟹   XP_038282302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02040,180,779 - 40,244,414 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001003273 (Get FASTA)   NCBI Sequence Viewer  
  XP_038282302 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA39802 (Get FASTA)   NCBI Sequence Viewer  
  CAI61735 (Get FASTA)   NCBI Sequence Viewer  
  P24406 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003273   ⟸   NM_001003273
- UniProtKB: F6XY66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000030438   ⟸   ENSCAFT00000035203
RefSeq Acc Id: XP_038282302   ⟸   XM_038426374
- Peptide Label: isoform X1

Promoters
RGD ID:13686875
Promoter ID:EPDNEW_C4944
Type:initiation region
Name:RHOA_1
Description:ras homolog family member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,824,640 - 39,824,700EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023066 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000030438 ENTREZGENE
Ensembl Transcript ENSCAFT00000035203 ENTREZGENE
NCBI Gene RHOA ENTREZGENE
UniProt F6XY66 ENTREZGENE
  P24406 ENTREZGENE
VGNC ID VGNC:81924 ENTREZGENE