CDKN1B (cyclin dependent kinase inhibitor 1B) - Rat Genome Database

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Gene: CDKN1B (cyclin dependent kinase inhibitor 1B) Canis lupus familiaris
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Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
RGD ID: 12203177
Description: ENCODES a protein that exhibits cyclin-dependent protein kinase activating kinase regulator activity (ortholog); cyclin-dependent protein serine/threonine kinase inhibitor activity (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to antibiotic (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN forkhead class A signaling pathway; G1/S transition pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); autosomal dominant intellectual developmental disorder 6 (ortholog); FOUND IN protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cyclin-dependent kinase inhibitor 1B; Kip1; p27; p27Kip1; putative cyclin-dependent kinase inhibitor p27
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12733,609,154 - 33,613,558 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2733,611,760 - 33,612,906 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2712,832,036 - 12,833,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02733,916,284 - 33,921,570 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2733,916,288 - 33,921,501 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12733,812,098 - 33,813,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02733,762,117 - 33,763,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02712,566,389 - 12,567,535 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
autosomal dominant intellectual developmental disorder 6  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cataract  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chloracne  (ISO)
chronic myeloid leukemia  (ISO)
Diabetic Nephropathies  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fallopian Tube Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
infertility  (ISO)
influenza  (ISO)
Intestinal Neoplasms  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
Leydig cell tumor  (ISO)
Liver Neoplasms  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Mesothelioma  (ISO)
multiple endocrine neoplasia  (ISO)
multiple endocrine neoplasia type 4  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
paraganglioma  (ISO)
pheochromocytoma  (ISO)
pituitary adenoma  (ISO)
Pituitary Neoplasms  (ISO)
primary hyperparathyroidism  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
senile cataract  (ISO)
Sezary's disease  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Testicular Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
autophagic cell death  (IEA)
cellular response to antibiotic  (IEA,ISO)
cellular response to hypoxia  (ISO)
cellular response to lithium ion  (IEA,ISO)
cellular response to organic cyclic compound  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IBA,IEA)
heart development  (IEA)
inner ear development  (IEA,ISO)
localization  (IEA)
negative regulation of cardiac muscle tissue regeneration  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IBA,IEA,ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
negative regulation of mitotic cell cycle  (IBA,IEA)
negative regulation of phosphorylation  (IEA)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
Notch signaling pathway  (IEA,ISO)
nuclear export  (IEA)
placenta development  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cellular process  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of microtubule polymerization  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
potassium ion transport  (IEA,ISO)
regulation of cell cycle  (IEA)
regulation of cell cycle G1/S phase transition  (IEA)
regulation of cell migration  (IEA,ISO)
regulation of exit from mitosis  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA)
regulation of lens fiber cell differentiation  (IEA,ISO)
regulation of mitotic cell cycle  (IEA,ISO)
response to amino acid  (ISO)
response to cadmium ion  (ISO)
response to estradiol  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16953075   PMID:19185891   PMID:20022446   PMID:22301074   PMID:22908227   PMID:23555276   PMID:27033900   PMID:30032202  


Genomics

Comparative Map Data
CDKN1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12733,609,154 - 33,613,558 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2733,611,760 - 33,612,906 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2712,832,036 - 12,833,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02733,916,284 - 33,921,570 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2733,916,288 - 33,921,501 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12733,812,098 - 33,813,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02733,762,117 - 33,763,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02712,566,389 - 12,567,535 (+)NCBIUU_Cfam_GSD_1.0
CDKN1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,717,368 - 12,722,369 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,685,498 - 12,722,369 (+)EnsemblGRCh38hg38GRCh38
GRCh371212,870,302 - 12,875,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,761,576 - 12,766,570 (+)NCBINCBI36Build 36hg18NCBI36
Build 341212,761,575 - 12,766,569NCBI
Celera1218,018,828 - 18,023,831 (+)NCBICelera
Cytogenetic Map12p13.1NCBI
HuRef1212,639,893 - 12,644,900 (+)NCBIHuRef
CHM1_11212,835,677 - 12,840,684 (+)NCBICHM1_1
T2T-CHM13v2.01212,590,905 - 12,595,906 (+)NCBIT2T-CHM13v2.0
Cdkn1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396134,897,364 - 134,902,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6134,897,364 - 134,902,476 (+)EnsemblGRCm39 Ensembl
GRCm386134,920,401 - 134,925,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,920,401 - 134,925,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv376134,870,419 - 134,875,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366134,886,110 - 134,889,751 (+)NCBIMGSCv36mm8
Celera6137,877,174 - 137,882,301 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.77NCBI
Cdkn1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84169,491,273 - 169,496,500 (+)NCBIGRCr8
mRatBN7.24167,760,067 - 167,765,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4167,760,181 - 167,764,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,053,581 - 174,058,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04169,836,661 - 169,841,462 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,460,545 - 168,465,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04168,689,043 - 168,694,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,689,163 - 168,693,964 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,962,218 - 232,967,323 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,841,705 - 171,846,506 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,086,631 - 172,091,508 (+)NCBI
Celera4156,357,827 - 156,362,628 (+)NCBICelera
Cytogenetic Map4q43NCBI
Cdkn1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554139,615,542 - 9,620,542 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,615,542 - 9,620,542 (+)NCBIChiLan1.0ChiLan1.0
CDKN1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21018,185,665 - 18,190,870 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11218,182,491 - 18,187,630 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,742,258 - 12,747,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,120,306 - 13,125,541 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,120,306 - 13,125,541 (+)Ensemblpanpan1.1panPan2
Cdkn1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494594,845,531 - 94,850,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365874,572,728 - 4,578,461 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365874,573,166 - 4,578,480 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl559,731,206 - 59,735,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1559,731,224 - 59,735,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDKN1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11112,612,064 - 12,617,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,612,079 - 12,617,531 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606922,701,998 - 22,707,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475225,203,474 - 25,207,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475225,202,474 - 25,207,107 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CDKN1B
44 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 1 10 6
Low 7
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000021002   ⟹   ENSCAFP00000019502
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2733,611,760 - 33,612,906 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041967   ⟹   ENSCAFP00845032915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2733,916,288 - 33,921,501 (-)Ensembl
RefSeq Acc Id: NM_001002957   ⟹   NP_001002957
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12733,611,760 - 33,612,906 (-)NCBI
Dog10K_Boxer_Tasha2712,832,036 - 12,833,182 (+)NCBI
ROS_Cfam_1.02733,919,799 - 33,920,945 (-)NCBI
UMICH_Zoey_3.12733,812,098 - 33,813,242 (-)NCBI
UNSW_CanFamBas_1.02733,762,117 - 33,763,263 (-)NCBI
UU_Cfam_GSD_1.02712,566,389 - 12,567,535 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038437725   ⟹   XP_038293653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02733,916,284 - 33,921,570 (-)NCBI
RefSeq Acc Id: NP_001002957   ⟸   NM_001002957
- UniProtKB: F1PGU6 (UniProtKB/TrEMBL),   A0A8C0NMF9 (UniProtKB/TrEMBL),   A0A8C0K074 (UniProtKB/TrEMBL),   Q68V02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000019502   ⟸   ENSCAFT00000021002
RefSeq Acc Id: XP_038293653   ⟸   XM_038437725
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NMF9 (UniProtKB/TrEMBL),   F1PGU6 (UniProtKB/TrEMBL),   A0A8C0K074 (UniProtKB/TrEMBL),   Q68V02 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032915   ⟸   ENSCAFT00845041967
Promoters
RGD ID:13688185
Promoter ID:EPDNEW_C6253
Type:initiation region
Name:CDKN1B_1
Description:cyclin dependent kinase inhibitor 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12733,612,972 - 33,613,032EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013244 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016933 UniProtKB/TrEMBL
  ENSCAFG00040023766 UniProtKB/TrEMBL
  ENSCAFG00845023770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021002.4 UniProtKB/TrEMBL
  ENSCAFT00030031250.1 UniProtKB/TrEMBL
  ENSCAFT00040044233.1 UniProtKB/TrEMBL
  ENSCAFT00845041967 ENTREZGENE
  ENSCAFT00845041967.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.365.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CDI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDI_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403429 UniProtKB/TrEMBL
NCBI Gene CDKN1B ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10265:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CDI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0K074 ENTREZGENE
  A0A8C0NMF9 ENTREZGENE, UniProtKB/TrEMBL
  CDN1B_CANLF UniProtKB/Swiss-Prot
  F1PGU6 ENTREZGENE, UniProtKB/TrEMBL
  Q68V02 ENTREZGENE, UniProtKB/TrEMBL
  Q6SLL5 ENTREZGENE
VGNC ID VGNC:39069 ENTREZGENE