BMP6 (bone morphogenetic protein 6) - Rat Genome Database

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Gene: BMP6 (bone morphogenetic protein 6) Canis lupus familiaris
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Symbol: BMP6
Name: bone morphogenetic protein 6
RGD ID: 12338962
Description: ENCODES a protein that exhibits BMP receptor binding (ortholog); growth factor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); cell differentiation (ortholog); cellular iron ion homeostasis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH Acute Otitis Media (ortholog); adult T-cell leukemia (ortholog); allergic contact dermatitis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: bone morphogenetic protein 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,780,763 - 7,833,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBI
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBI
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBI
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBI
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (ISO)
cell differentiation  (ISO)
cellular iron ion homeostasis  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to iron ion  (ISO)
cellular response to mechanical stimulus  (ISO)
endochondral ossification  (ISO)
eye development  (ISO)
immune response  (ISO)
inflammatory response  (ISO)
kidney development  (ISO)
male genitalia development  (ISO)
multicellular organismal iron ion homeostasis  (ISO)
negative regulation of adherens junction organization  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of aldosterone secretion  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular permeability  (ISO)
response to activity  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to magnesium ion  (ISO)
response to retinoic acid  (ISO)
SMAD protein signal transduction  (ISO)
type B pancreatic cell development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
BMP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,780,763 - 7,833,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBI
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBI
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBI
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBI
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBI
BMP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl67,726,099 - 7,881,728 (+)EnsemblGRCh38hg38GRCh38
GRCh3867,726,099 - 7,881,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3767,726,332 - 7,881,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,672,010 - 7,826,960 (+)NCBINCBI36hg18NCBI36
Build 3467,672,008 - 7,826,726NCBI
Celera68,956,438 - 9,111,399 (+)NCBI
Cytogenetic Map6p24.3NCBI
HuRef67,604,128 - 7,759,039 (+)NCBIHuRef
CHM1_167,728,829 - 7,884,079 (+)NCBICHM1_1
Bmp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391338,529,692 - 38,684,290 (+)NCBIGRCm39mm39
GRCm39 Ensembl1338,529,083 - 38,684,278 (+)Ensembl
GRCm381338,345,716 - 38,500,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,345,107 - 38,500,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371338,437,585 - 38,591,597 (+)NCBIGRCm37mm9NCBIm37
MGSCv361338,353,182 - 38,507,194 (+)NCBImm8
Celera1339,464,167 - 39,615,905 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.15NCBI
Bmp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21726,318,121 - 26,469,034 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1726,955,142 - 27,112,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01726,955,142 - 27,112,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01728,870,345 - 29,029,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,380,199 - 32,689,295 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11732,383,039 - 32,692,136 (-)NCBI
Celera1725,955,026 - 26,103,008 (-)NCBICelera
RH 3.4 Map17342.3RGD
Cytogenetic Map17p12NCBI
Bmp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,054,931 - 6,200,377 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,053,600 - 6,201,254 (-)NCBIChiLan1.0ChiLan1.0
BMP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.167,848,255 - 8,002,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,848,249 - 8,000,649 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v067,564,164 - 7,720,341 (+)NCBIMhudiblu_PPA_v0panPan3
Bmp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494616,438,976 - 16,602,907 (-)NCBI
SpeTri2.0NW_0049365344,707,658 - 4,871,865 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl75,058,817 - 5,211,316 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.175,058,817 - 5,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.275,163,209 - 5,313,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,279,243 - 64,436,356 (-)NCBI
ChlSab1.1 Ensembl1764,280,609 - 64,435,382 (-)Ensembl
Vero_WHO_p1.0NW_0236660447,712,261 - 7,873,910 (+)NCBI
Bmp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475617,742,822 - 17,894,931 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 6 6 3 2
Low 5 5 11 6 6 6 6 6 8 7 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000047626   ⟹   ENSCAFP00000038289
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)Ensembl
RefSeq Acc Id: XM_022414439   ⟹   XP_022270147
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1357,780,763 - 7,833,095 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038446326   ⟹   XP_038302254
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBI
RefSeq Acc Id: XM_038463028   ⟹   XP_038318956
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBI
RefSeq Acc Id: XM_038520493   ⟹   XP_038376421
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBI
RefSeq Acc Id: XM_038584127   ⟹   XP_038440055
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBI
RefSeq Acc Id: XM_038648534   ⟹   XP_038504462
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_022270147   ⟸   XM_022414439
- Sequence:
RefSeq Acc Id: ENSCAFP00000038289   ⟸   ENSCAFT00000047626
RefSeq Acc Id: XP_038376421   ⟸   XM_038520493
RefSeq Acc Id: XP_038504462   ⟸   XM_038648534
RefSeq Acc Id: XP_038302254   ⟸   XM_038446326
RefSeq Acc Id: XP_038318956   ⟸   XM_038463028
RefSeq Acc Id: XP_038440055   ⟸   XM_038584127
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032289 Ensembl
NCBI Gene BMP6 ENTREZGENE
VGNC ID VGNC:59134 ENTREZGENE