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Gene: E2F1 (E2F transcription factor 1) Canis lupus familiaris

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Symbol:

E2F1

Name:

E2F transcription factor 1

RGD ID:

12412586

Description:

ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein kinase binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to hypoxia (ortholog); cellular response to nerve growth factor stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN nuclear chromosome (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transcription factor E2F1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	22,895,149 - 22,904,689 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	22,878,402 - 22,904,656 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	22,540,395 - 22,549,906 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	23,581,877 - 23,591,392 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	23,581,862 - 23,616,878 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	22,874,367 - 22,883,878 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	22,967,923 - 22,977,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,399,012 - 23,408,523 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E2F1	Dog	Alzheimer's disease		ISO	RGD:730923	9068941	protein:increased expression:cerebral cortex,cytoplasm:	RGD	PMID:11939591\|REF_RGD_ID:10401093
E2F1	Dog	chronic myeloid leukemia		ISO	RGD:730923	9068941	mRNA:increased expression:blood	RGD	PMID:26460262\|REF_RGD_ID:13674165
E2F1	Dog	COVID-19		ISO	RGD:730923	9068941	mRNA:increased expression:peripheral blood mononuclear cell (human)	RGD	PMID:32228226\|REF_RGD_ID:28912744
E2F1	Dog	dementia		ISO	RGD:730923	9068941	associated with Down Syndrome;protein:increased expression:frontal cortex;	RGD	PMID:11423103\|REF_RGD_ID:10401091
E2F1	Dog	glioblastoma	disease_progression	ISO	RGD:730923	9068941		RGD	PMID:16264179\|REF_RGD_ID:13702471
E2F1	Dog	high grade glioma	severity	ISO	RGD:730923	9068941		RGD	PMID:28042322\|REF_RGD_ID:13702468
E2F1	Dog	Huntington's disease		ISO	RGD:728892	9068941	protein:increased expression:brain	RGD	PMID:18768156\|REF_RGD_ID:2316262
E2F1	Dog	Huntington's disease		ISO	RGD:730923	9068941	protein:increased expression:brain	RGD	PMID:18768156\|REF_RGD_ID:2316262
E2F1	Dog	lung adenocarcinoma		ISO	RGD:730923	9068941	mRNA:increased expression:lung	RGD	PMID:26695082\|REF_RGD_ID:13464334
E2F1	Dog	lung non-small cell carcinoma	treatment	ISO	RGD:730923	9068941		RGD	PMID:12358350\|PMID:28498400\|REF_RGD_ID:13464333\|REF_RGD_ID:13464343
E2F1	Dog	lung non-small cell carcinoma	severity	ISO	RGD:730923	9068941		RGD	PMID:23543735\|REF_RGD_ID:9590260
E2F1	Dog	lung non-small cell carcinoma	disease_progression	ISO	RGD:730923	9068941		RGD	PMID:12237873\|REF_RGD_ID:13464342
E2F1	Dog	lung small cell carcinoma		ISO	RGD:730923	9068941	mRNA, protein:increased expression:lung	RGD	PMID:11313916\|REF_RGD_ID:13464344
E2F1	Dog	lung small cell carcinoma	disease_progression	ISO	RGD:730923	9068941		RGD	PMID:24755270\|REF_RGD_ID:13464335
E2F1	Dog	lung small cell carcinoma	treatment	ISO	RGD:730923	9068941		RGD	PMID:23792570\|REF_RGD_ID:13464337
E2F1	Dog	lung squamous cell carcinoma	treatment	ISO	RGD:730923	9068941		RGD	PMID:28927142\|REF_RGD_ID:13464332
E2F1	Dog	Neoplasm Metastasis	severity	ISO	RGD:730923	9068941	protein:increased expression:bone (human)	RGD	PMID:29039472\|REF_RGD_ID:151347601
E2F1	Dog	osteosarcoma	severity	ISO	RGD:730923	9068941	protein:increased expression:bone (human)	RGD	PMID:29039472\|REF_RGD_ID:151347601
E2F1	Dog	osteosarcoma		ISO	RGD:730923	9068941	human cells in mouse model	RGD	PMID:29039472\|REF_RGD_ID:151347601
E2F1	Dog	pancreatic adenocarcinoma	treatment	ISO	RGD:730923	9068941	Human cells in a mouse model	RGD	PMID:28797284\|REF_RGD_ID:13838736
E2F1	Dog	pancreatic cancer	treatment	ISO	RGD:728892	9068941		RGD	PMID:28344092\|REF_RGD_ID:13838737
E2F1	Dog	pancreatic ductal adenocarcinoma		ISO	RGD:730923	9068941	protein:increased expression:pancreatic ductal cell, nucleus (human)	RGD	PMID:27573434\|REF_RGD_ID:13838738
E2F1	Dog	pancreatic ductal adenocarcinoma	severity	ISO	RGD:730923	9068941	protein:increased expression:pancreatic ductal cell, nucleus (human)	RGD	PMID:12650514\|REF_RGD_ID:13838735
E2F1	Dog	pancreatic ductal adenocarcinoma	severity	ISO	RGD:730923	9068941	DNA:amplification: : (human)	RGD	PMID:17233815\|REF_RGD_ID:13838739
E2F1	Dog	type 1 diabetes mellitus		ISO	RGD:730924	9068941	E2f1/E2f2 double knockout	RGD	PMID:15146237\|REF_RGD_ID:1300306
E2F1	Dog	urinary bladder cancer	disease_progression	ISO	RGD:730923	9068941	mRNA:increased expression:bladder	RGD	PMID:20421545\|REF_RGD_ID:13602004
E2F1	Dog	viral encephalitis		ISO	RGD:730923	9068941	associated with HIV Infections; protein:increased expression:brain, neuron, cytoplasm:	RGD	PMID:11896158\|REF_RGD_ID:10401094

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E2F1	Dog	genetic disease		ISO	RGD:730923	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar
E2F1	Dog	glutathione synthetase deficiency		ISO	RGD:730923	8554872	ClinVar Annotator: match by term: PYROGLUTAMIC ACIDURIA	ClinVar	PMID:12638941\|PMID:15717202\|PMID:28492532
E2F1	Dog	glutatione synthetase deficiency with 5-oxoprolinuria		ISO	RGD:730923	8554872	ClinVar Annotator: match by term: 5-OXOPROLINURIA DUE TO GLUTATHIONE SYNTHETASE DEFICIENCY	ClinVar	PMID:12638941\|PMID:15717202\|PMID:28492532
E2F1	Dog	hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase		ISO	RGD:730923	8554872	ClinVar Annotator: match by term: Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase	ClinVar	PMID:15024124\|PMID:20852937\|PMID:28492532
E2F1	Dog	long QT syndrome		ISO	RGD:730923	8554872	ClinVar Annotator: match by term: Long QT syndrome	ClinVar	PMID:28492532
E2F1	Dog	prostate cancer		ISO	RGD:730923	8554872	ClinVar Annotator: match by term: Malignant tumor of prostate	ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E2F1	Dog	Breast Neoplasms		ISO	RGD:730923	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:14672398
E2F1	Dog	Chemical and Drug Induced Liver Injury		ISO	RGD:730923	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:30515189
E2F1	Dog	disease of cellular proliferation		ISO	RGD:730923	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:29464002
E2F1	Dog	hepatocellular carcinoma		ISO	RGD:730923	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:12029619\|PMID:15565109\|PMID:28284560
E2F1	Dog	lung non-small cell carcinoma		ISO	RGD:730923	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:29754146
E2F1	Dog	melanoma		ISO	RGD:730923	9068941	CTD Direct Evidence: marker/mechanism\|therapeutic	CTD	PMID:15574415\|PMID:16827129

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E2F1	Dog	Sjogren's syndrome		ISO	RGD:730924	9068941	OMIM:270150	MouseDO
E2F1	Dog	type 1 diabetes mellitus		ISO	RGD:730924	9068941	OMIM:222100	MouseDO

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E2F1	Dog	anoikis	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	cellular response to fatty acid		ISO	RGD:728892	9068941		RGD	PMID:19180667\|REF_RGD_ID:2316259
E2F1	Dog	cellular response to hypoxia		ISO	RGD:728892	9068941		RGD	PMID:19088195\|REF_RGD_ID:2316261
E2F1	Dog	cellular response to nerve growth factor stimulus		ISO	RGD:728892	9068941		RGD	PMID:18367454\|REF_RGD_ID:8693614
E2F1	Dog	cellular response to xenobiotic stimulus	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	DNA damage checkpoint signaling	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	DNA-templated transcription	involved_in	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	forebrain development	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	intrinsic apoptotic signaling pathway by p53 class mediator	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	intrinsic apoptotic signaling pathway in response to DNA damage	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	lens fiber cell apoptotic process	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	mRNA stabilization	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	negative regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	negative regulation of fat cell differentiation	involved_in	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	negative regulation of fat cell proliferation	involved_in	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	negative regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	positive regulation of apoptotic process	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	positive regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	positive regulation of DNA-templated transcription	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	positive regulation of fibroblast proliferation	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	positive regulation of gene expression	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	positive regulation of glial cell proliferation		ISO	RGD:728892	9068941		RGD	PMID:21637599\|REF_RGD_ID:13702469
E2F1	Dog	positive regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	positive regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	quinolinate biosynthetic process	acts_upstream_of_or_within	ISO	RGD:730924	9068941	PMID:2419335	UniProt	PMID:2419335
E2F1	Dog	regulation of cell cycle	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR003316	150520179		InterPro	GO_REF:0000002
E2F1	Dog	regulation of DNA-templated transcription	acts_upstream_of_or_within	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	regulation of G1/S transition of mitotic cell cycle	acts_upstream_of	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	regulation of transcription by RNA polymerase II	involved_in	IEA	InterPro:IPR015633	150520179		InterPro	GO_REF:0000002
E2F1	Dog	regulation of transcription by RNA polymerase II	involved_in	IBA	FB:FBgn0011766\|FB:FBgn0024371\|MGI:101941\|MGI:103012\|MGI:1289147\|MGI:1354159\|MGI:1922038\|PANTHER:PTN000249624\|UniProtKB:A0AVK6\|UniProtKB:O00716\|UniProtKB:O75461\|UniProtKB:Q01094\|UniProtKB:Q14209\|UniProtKB:Q16254\|UniProtKB:Q96AV8\|ZFIN:ZDB-GENE-030131-3527\|ZFIN:ZDB-GENE-041111-260	150520179		GO_Central	GO_REF:0000033
E2F1	Dog	response to lipopolysaccharide	acts_upstream_of_or_within	ISO	RGD:730924	9068941	PMID:35263589	UniProt	PMID:35263589
E2F1	Dog	response to lipopolysaccharide	involved_in	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	spermatogenesis		ISO	RGD:728892	9068941		RGD	PMID:17147820\|REF_RGD_ID:2316265

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E2F1	Dog	centrosome	located_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	chromatin	located_in	IEA	UniProtKB:Q01094\|UniProtKB:Q61501\|ensembl:ENSMUSP00000099434\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	cytoplasm	located_in	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	nuclear chromosome	located_in	ISO	RGD:728892	9068941	PMID:24250814	UniProt	PMID:24250814\|REF_RGD_ID:151356618
E2F1	Dog	nucleoplasm	located_in	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
E2F1	Dog	nucleus	is_active_in	ISO	RGD:730924	9068941	PMID:10082561	UniProt	PMID:10082561
E2F1	Dog	nucleus	is_active_in	ISO	RGD:730923	9068941	PMID:28992046	UniProt	PMID:28992046
E2F1	Dog	nucleus	located_in	IEA	UniProtKB:Q01094\|UniProtKB:Q61501\|ensembl:ENSMUSP00000099434\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043
E2F1	Dog	protein-containing complex	part_of	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	Rb-E2F complex	part_of	IBA	PANTHER:PTN002636055\|UniProtKB:Q01094	150520179		GO_Central	GO_REF:0000033
E2F1	Dog	Rb-E2F complex	part_of	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	RNA polymerase II transcription regulator complex	part_of	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	transcription regulator complex	part_of	IEA	InterPro:IPR003316	150520179		InterPro	GO_REF:0000002
E2F1	Dog	transcription regulator complex	part_of	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
E2F1	Dog	calcium ion binding	enables	IEA	InterPro:IPR002048	150520179		InterPro	GO_REF:0000002
E2F1	Dog	cis-regulatory region sequence-specific DNA binding	enables	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	DNA binding	enables	IEA	UniProtKB-KW:KW-0238	150520179		UniProt	GO_REF:0000043
E2F1	Dog	DNA binding	enables	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	DNA-binding transcription activator activity	enables	IEA	UniProtKB:Q01094\|UniProtKB:Q61501\|ensembl:ENSMUSP00000099434\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	DNA-binding transcription factor activity	enables	IEA	UniProtKB:Q01094\|UniProtKB:Q61501\|ensembl:ENSMUSP00000099434\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	IBA	FB:FBgn0011766\|FB:FBgn0024371\|MGI:1289147\|MGI:1354159\|PANTHER:PTN000249624\|UniProtKB:A0AVK6\|UniProtKB:O00716\|UniProtKB:O75461\|UniProtKB:Q01094\|UniProtKB:Q14209\|UniProtKB:Q16254	150520179		GO_Central	GO_REF:0000033
E2F1	Dog	DNA-binding transcription factor binding	enables	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
E2F1	Dog	molecular adaptor activity	enables	ISO	RGD:730923	9068941	PMID:16360038	DisProt	PMID:16360038
E2F1	Dog	protein binding	enables	ISO	PR:Q08639	9068941	PMID:15448153	MGI	PMID:15448153
E2F1	Dog	protein binding	enables	ISO	PR:P25233	9068941	PMID:12198120	MGI	PMID:12198120
E2F1	Dog	protein binding	enables	ISO	PR:Q9CPR8\|PR:Q9QZ04	9068941	PMID:14593116	MGI	PMID:14593116
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P13405	9068941	PMID:36689330	UniProt	PMID:36689330
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P42669	9068941	PMID:10597240	UniProt	PMID:10597240
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P06400\|UniProtKB:Q14186	9068941	PMID:16360038, PMID:34591642	IntAct	PMID:16360038\|PMID:34591642
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q14186	9068941	PMID:20211142, PMID:24981860, PMID:27705803	IntAct	PMID:20211142\|PMID:24981860\|PMID:27705803
E2F1	Dog	protein binding	enables	ISO	UniProtKB:O14744\|UniProtKB:Q14186	9068941	PMID:22327218	IntAct	PMID:22327218
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P42224\|UniProtKB:Q9Y618	9068941	PMID:20195357	IntAct	PMID:20195357
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q923E4\|UniProtKB:Q96EB6	9068941	PMID:16892051	IntAct	PMID:16892051
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q13263\|UniProtKB:Q13547	9068941	PMID:17704056	UniProt	PMID:17704056
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q13547	9068941	PMID:9468139, PMID:9468140	IntAct	PMID:9468139\|PMID:9468140
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q96EB6	9068941	PMID:19188449	IntAct	PMID:19188449
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q96JM7	9068941	PMID:17517653, PMID:29691401	IntAct	PMID:17517653\|PMID:29691401
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P06400	9068941	PMID:12502741, PMID:16249186, PMID:16360038, PMID:16374512, PMID:17380128, PMID:19249677, PMID:20871633, PMID:23472054, PMID:29521627, PMID:34591612	IntAct	PMID:12502741\|PMID:16249186\|PMID:16360038\|PMID:16374512\|PMID:17380128\|PMID:19249677\|PMID:20871633\|PMID:23472054\|PMID:29521627\|PMID:34591612
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P06400\|UniProtKB:Q14186\|UniProtKB:Q92830	9068941	PMID:35140242	IntAct	PMID:35140242
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P25233	9068941	PMID:17108174	IntAct	PMID:17108174
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P25233\|UniProtKB:Q9CPR8	9068941	PMID:14593116	IntAct	PMID:14593116
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q92547	9068941	PMID:17006541	IntAct	PMID:17006541
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q92466	9068941	PMID:9418871	IntAct	PMID:9418871
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q92830	9068941	PMID:20972224, PMID:24502362	IntAct	PMID:20972224\|PMID:24502362
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q5H9I0	9068941	PMID:17062573	UniProt	PMID:17062573
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P05067	9068941	PMID:32814053	IntAct	PMID:32814053
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P49336	9068941	PMID:18794899	IntAct	PMID:18794899
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P09874	9068941	PMID:14627987, PMID:20133863	IntAct	PMID:14627987\|PMID:20133863
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q96IZ0	9068941	PMID:18660514	IntAct	PMID:18660514
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q9UPP1	9068941	PMID:20622854	UniProt	PMID:20622854
E2F1	Dog	protein binding	enables	ISO	UniProtKB:O60934	9068941	PMID:11486038	UniProt	PMID:11486038
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P08047	9068941	PMID:8657141	IntAct	PMID:8657141
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q8NEM0	9068941	PMID:18660752	IntAct	PMID:18660752
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P13405	9068941	PMID:20224733, PMID:8336704	BHF-UCL	PMID:20224733\|PMID:8336704
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q14188	9068941	PMID:7784053	GO_Central	PMID:7784053
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q14201	9068941	PMID:17690688	IntAct	PMID:17690688
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P51610	9068941	PMID:23629655	UniProt	PMID:23629655
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q13490	9068941	PMID:21653699	UniProt	PMID:21653699
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q14684	9068941	PMID:20040599	IntAct	PMID:20040599
E2F1	Dog	protein binding	enables	ISO	UniProtKB:O95361	9068941	PMID:20729920	IntAct	PMID:20729920
E2F1	Dog	protein binding		ISO	RGD:3540	9068941		RGD	PMID:9697699\|REF_RGD_ID:69955
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P03129	9068941	PMID:16061792, PMID:22810586	IntAct	PMID:16061792\|PMID:22810586
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P33568	9068941	PMID:9697699	IntAct	PMID:9697699\|REF_RGD_ID:69955
E2F1	Dog	protein binding	enables	ISO	UniProtKB:Q9Y4A5	9068941	PMID:11418595	UniProt	PMID:11418595
E2F1	Dog	protein binding	enables	ISO	UniProtKB:P23396	9068941	PMID:20605787	UniProt	PMID:20605787\|REF_RGD_ID:10402036
E2F1	Dog	protein dimerization activity	enables	IEA	InterPro:IPR032198	150520179		InterPro	GO_REF:0000002
E2F1	Dog	protein kinase binding		ISO	RGD:70982	9068941		RGD	PMID:18367454\|REF_RGD_ID:8693614
E2F1	Dog	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IEA	InterPro:IPR015633	150520179		InterPro	GO_REF:0000002
E2F1	Dog	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IBA	MGI:103012\|MGI:1289147\|PANTHER:PTN000249624\|UniProtKB:A0AVK6\|UniProtKB:Q16254	150520179		GO_Central	GO_REF:0000033
E2F1	Dog	sequence-specific DNA binding		ISO	RGD:728892	9068941		RGD	PMID:18096822\|REF_RGD_ID:2316264
E2F1	Dog	sequence-specific DNA binding	enables	IEA	UniProtKB:Q01094\|UniProtKB:Q61501\|ensembl:ENSMUSP00000099434\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	sequence-specific double-stranded DNA binding	enables	IEA	UniProtKB:Q01094\|ensembl:ENSP00000345571	150520179		Ensembl	GO_REF:0000107
E2F1	Dog	transcription cis-regulatory region binding	enables	IEA	UniProtKB:Q61501\|ensembl:ENSMUSP00000099434	150520179		Ensembl	GO_REF:0000107

PMID:22301074	PMID:30032202

E2F1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	22,895,149 - 22,904,689 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	22,878,402 - 22,904,656 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	22,540,395 - 22,549,906 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	23,581,877 - 23,591,392 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	23,581,862 - 23,616,878 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	22,874,367 - 22,883,878 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	22,967,923 - 22,977,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,399,012 - 23,408,523 (-)	NCBI		UU_Cfam_GSD_1.0

E2F1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	33,675,477 - 33,686,385 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	33,675,477 - 33,686,385 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	32,263,283 - 32,274,191 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	31,727,150 - 31,737,854 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	31,727,149 - 31,737,854	NCBI
Celera	20	29,016,324 - 29,027,242 (-)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	29,049,266 - 29,060,184 (-)	NCBI		HuRef
CHM1_1	20	32,164,384 - 32,175,302 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	35,402,008 - 35,412,916 (-)	NCBI		T2T-CHM13v2.0

E2f1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	154,401,320 - 154,411,812 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	154,401,327 - 154,411,812 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	154,559,400 - 154,569,892 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	154,559,407 - 154,569,892 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	154,385,375 - 154,395,588 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	154,251,080 - 154,261,293 (-)	NCBI		MGSCv36	mm8
Celera	2	160,474,227 - 160,486,251 (-)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	76.79	NCBI

E2f1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	163,524,739 - 163,535,563 (-)	NCBI		GRCr8
mRatBN7.2	3	143,064,535 - 143,075,362 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,049,478 - 143,075,361 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	146,931,136 - 146,941,990 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	155,549,300 - 155,560,154 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	153,288,668 - 153,299,512 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	150,062,895 - 150,073,721 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,047,826 - 150,073,721 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	156,435,530 - 156,446,390 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	145,032,489 - 145,043,729 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	144,943,133 - 144,943,246 (-)	NCBI
Celera	3	141,799,009 - 141,809,945 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

E2f1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	27,633,827 - 27,642,241 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	27,638,625 - 27,643,261 (+)	NCBI	ChiLan1.0	ChiLan1.0

E2F1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	39,366,654 - 39,382,253 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	39,359,755 - 39,370,541 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	29,963,083 - 29,973,860 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	31,103,764 - 31,115,211 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	31,103,764 - 31,110,604 (-)	Ensembl	panpan1.1		panPan2

E2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	171,848,495 - 171,859,005 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	6,896,063 - 6,900,026 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	6,894,827 - 6,901,058 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

E2F1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	37,178,599 - 37,189,883 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	37,178,587 - 37,190,118 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	42,116,195 - 42,125,518 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

E2F1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	37,968,541 - 37,980,461 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	37,968,556 - 37,980,326 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	88,901,404 - 88,913,369 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

E2f1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	5,602,432 - 5,612,951 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	5,602,432 - 5,612,951 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in E2F1
62 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005634944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005634945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038433535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038508717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038572031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038636281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000011898 ⟹ ENSCAFP00000011032

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000011921 ⟹ ENSCAFP00000011055

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,896,232 - 22,904,656 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000072769 ⟹ ENSCAFP00000064033

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000082615 ⟹ ENSCAFP00000063121

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,896,389 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000084659 ⟹ ENSCAFP00000048349

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,526 - 22,894,179 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000087491 ⟹ ENSCAFP00000059437

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000091089 ⟹ ENSCAFP00000066271

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

RefSeq Acc Id:

XM_005634945 ⟹ XP_005635002

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	24	22,895,149 - 22,904,689 (-)	NCBI
Dog10K_Boxer_Tasha	24	22,540,395 - 22,549,906 (-)	NCBI

Sequence:

show sequence

CCTGCCACCCGGGCCGCGCGGGCCGTGAGCGCCATGGCCGTGGCCGGGGCCCCCGCAGGCGGCCCATGCGCGCCGGCGCTGGAGGCCCTGCTCGGGGCCGGCGCGCTGCGGCTGCTCGACTCCTCGCA
GATCGTCATCATCTCCACGGCGCAGGACGCCAGCGCCCCGCCGGCCCCCGCCGGCCCGGCCGCGCCGGCCGCTGGCCCCCGCGACCCCGACCTGCTGCTCTTCGCCACGCCGCAGGCGCCCCGGCCCA
CACCCAGCGCGCCGCGCCCTGCGCTCGGCCGCCCGCCGGTAAAGCGGAGGTTGGACCTGGAAACTGACCATCAGTACCTGGCTGAGAGCAGTGGGCCAGCCCGGGGCAGAGGCCGCCACCCAGGAAAA
GGTGTGAAATCCCCAGGGGAGAAGTCACGCTATGAGACCTCACTGAATCTGACCACAAAACGCTTCCTGGAGCTGCTGAGCCGCTCGGCTGATGGCGTTGTTGATCTGAACTGGGCGGCTGAGGTGTT
GAAGGTGCAGAAACGGCGCATCTATGACATCACCAACGTCCTCGAGGGCATCCAGCTCATTGCCAAGAAGTCTAAGAACCACATCCAGTGGCTAGGCAGCCATGCAGCAGTGGGGATCAGTGGGCGGC
TTGAAGGACTGACTCAGGACCTCCGGCAGCTGCAGGAGAGTGAGCGGCAGCTGGACCACCTGATCCATATCTGCACCACACAACTGCGGCTGCTCGCTGAGGACTCCGACAGCCAGCGCCTGGCCTAC
GTGACCTGCCAGGACCTTCGTAGCATCGCAGACCCTGCAGAGCAGATGGTCATGGTGATCAAGGCCCCTCCTGAGACCCAGCTCCAAGCCATAGACTCCTCAGAGACCTTTCAGATCTCCCTTAAGAG
CAAACAAGGCCCCATTGACGTTTTCCTGTGCCCTGAGGAGAGTGCAGGCGGGATCAGCCCTGGGAAGACCCCATCCCAGGGGACAGCTTCTGGGGAGGAAGACAGGCCAGTTGACCCTGCCACCACAG
TGCCACCACCATCATCTCCCCCCTCATCCCCTGCTTCGGATCCCAGCCAGTCCCTGCTCAGCCTGGAGCAAGAACCTCTGCTTTCCCGGATGGGTGGCCTGCGGGCCCCCGTGGACGAGGACCGCCTG
TCCCCGCTGGTGGCGGCCGACTCGCTCCTGGAACATGCACGGGAGGATTTTTCCGGCCTCCTCCCTGAGGAGTTCATCAGCCTGTCCCCACCCCACGAGGCTCTCGACTACCACTTTGGCCTTGAGGA
GGGTGAGGGCATCAGAGACCTCTTCGACTGTGACTTTGGGGACCTTACCCCTCTGGATTTCTGATGGGGCTTAGGGGGACCAGGGCCTCCTGAGATGCCCACCCTGTCTCTGCAGCCCTGGAGCCCCC
TACCCCTGGCCGTCCTCCCAGCCCAATTGGAAACATTTAATTTATACCCCTCTCCCCTATCTCCAGAAGCTTTCTTGCTCTGGAGCCTGGCTACTGCCAGGAGGCTAAGCAAGCCAGGAAGGGAAGGA
TTCTGTTTGTGGTGTGTATGTGCATGCACCCAACACCCAACATGTGTGTTACACGGGGTGAATGGTGTGTGAGCATGTGTGTGTGCATGTACCGGGGAATGAAGGTGAACACATCTGTGCGTGCACTG
AAAACACGCCCCAGTGTGTCCACGTGTGTGTGCATGAGTCCATGTGTGCGCGTGGTGGGGGCTCTAACTGCACTTTTGGTCTCCTTGCTCCAGGGGCCCCACGAGGCCCAGGGTGGCCACCTGCCCCC
AGAATCCTGTGCGCTGACCAGGCCAGGTGGCGAGGCCTTGGCCTGCTTGTTTGCAGGACAGCGAGAGCACTTCTGTCGTCTTAAAGGTTTTTCTGATCGAAGCTTTAATGGAGCGTTATTTATTTATC
GAGGCCTCTTTGGCAAGCCTGGGGCACCAGCAAAGGGTAGGAGGGATGTGGGGCTGTTGCCCCAACTCCCTATAGCCCTGAGCAGGGCAGGGGTCCCTGAGCTATTCTTTGCCCTCCTCCGAAGGAGC
TGAGGCCTGAGCGGTTTATTTATTGGGAAAGTGAGGGAGGGAGCCAGACGGACGGACCGACTGACTAACAGCCATGGGTGGATCAAGGGGGTGGTCCCTCCCCTGGGGTCACTACAGGGCCCCAACTG
CCCCCCAGGATGGATGTGAGATGCGAGAGGTGAGTGGGGGACCTTCACTGACCGGGTGGGTAGGAGGGGTGGCTGAAGGGCTTCCCCTGGCCCAGACTGCGGGGAGGGGGGGCCCTCTGTCCCGCTCG
TTGCTCTGCCCCACTCGTTGCTCTGCCCCACCCTCCAATCTGCACTTTGATTTGCCTTCCTAACCGCTCTGTTCCCTCCTGCTTTGGTTTTAATAAATATTTTGATGGTGTTTGGGCTGGGTA

hide sequence

RefSeq Acc Id:

XM_038433535 ⟹ XP_038289463

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	24	23,581,877 - 23,591,392 (-)	NCBI

RefSeq Acc Id:

XM_038508717 ⟹ XP_038364645

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	24	22,874,367 - 22,883,878 (-)	NCBI

RefSeq Acc Id:

XM_038572031 ⟹ XP_038427959

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	24	23,399,012 - 23,408,523 (-)	NCBI

RefSeq Acc Id:

XM_038636281 ⟹ XP_038492209

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	24	22,967,923 - 22,977,434 (-)	NCBI


Protein RefSeqs	XP_005635002	(Get FASTA)	NCBI Sequence Viewer
	XP_038289463	(Get FASTA)	NCBI Sequence Viewer
	XP_038364645	(Get FASTA)	NCBI Sequence Viewer
	XP_038427959	(Get FASTA)	NCBI Sequence Viewer
	XP_038492209	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000011032.4
	ENSCAFP00000011055.5
	ENSCAFP00000048349.2
	ENSCAFP00000059437.2
	ENSCAFP00000066271.2
	ENSCAFP00000070321.1
	ENSCAFP00030030659.1
	ENSCAFP00030031196.1
	ENSCAFP00040010536.1
	ENSCAFP00845034835.1
	ENSCAFP00845034906
	ENSCAFP00845034906.1

RefSeq Acc Id:

XP_005635002 ⟸ XM_005634945

- UniProtKB:

A0A8C0Q8Y6 (UniProtKB/TrEMBL), A0A8I3PK29 (UniProtKB/TrEMBL), A0A8C0JV99 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISTAQDASAPPAPAGPAAPAAGPRDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRY
ETSLNLTTKRFLELLSRSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHAAVGISGRLEGLTQDLRQLQESERQLDHLIHICTTQLRLLAEDSDSQRLAYVTCQDLRSIAD
PAEQMVMVIKAPPETQLQAIDSSETFQISLKSKQGPIDVFLCPEESAGGISPGKTPSQGTASGEEDRPVDPATTVPPPSSPPSSPASDPSQSLLSLEQEPLLSRMGGLRAPVDEDRLSPLVAADSLLE
HAREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF

hide sequence

Ensembl Acc Id:

ENSCAFP00000011032 ⟸ ENSCAFT00000011898

Ensembl Acc Id:

ENSCAFP00000048349 ⟸ ENSCAFT00000084659

Ensembl Acc Id:

ENSCAFP00000011055 ⟸ ENSCAFT00000011921

Ensembl Acc Id:

ENSCAFP00000059437 ⟸ ENSCAFT00000087491

Protein Domains

ABM E2F/DP family winged-helix DNA-binding EF-hand

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000007429	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00000055011	UniProtKB/TrEMBL
	ENSCAFG00030019095	UniProtKB/TrEMBL
	ENSCAFG00030019453	UniProtKB/TrEMBL
	ENSCAFG00040006517	UniProtKB/TrEMBL
	ENSCAFG00845025182	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000011898.5	UniProtKB/TrEMBL
	ENSCAFT00000011921.6	UniProtKB/TrEMBL
	ENSCAFT00000084659.2	UniProtKB/TrEMBL
	ENSCAFT00000087491.2	UniProtKB/TrEMBL
	ENSCAFT00000091089.2	UniProtKB/TrEMBL
	ENSCAFT00000094699.1	UniProtKB/TrEMBL
	ENSCAFT00030035162.1	UniProtKB/TrEMBL
	ENSCAFT00030035765.1	UniProtKB/TrEMBL
	ENSCAFT00040012154.1	UniProtKB/TrEMBL
	ENSCAFT00845044456.1	UniProtKB/TrEMBL
	ENSCAFT00845044551	ENTREZGENE
	ENSCAFT00845044551.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	3.30.70.100	UniProtKB/TrEMBL
	6.10.250.540	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	ABM_dom	UniProtKB/TrEMBL
	Dimeric_a/b-barrel	UniProtKB/TrEMBL
	E2F	UniProtKB/TrEMBL
	E2F-DP_heterodim	UniProtKB/TrEMBL
	E2F_CC-MB	UniProtKB/TrEMBL
	E2F_WHTH_DNA-bd_dom	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	NECAB1/2/3	UniProtKB/TrEMBL
	Pmp4	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	cfa:485839	UniProtKB/TrEMBL
NCBI Gene	E2F1	ENTREZGENE
PANTHER	N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 3	UniProtKB/TrEMBL
	PEROXISOMAL MEMBRANE PROTEIN 4	UniProtKB/TrEMBL
	PEROXISOMAL MEMBRANE PROTEIN 4	UniProtKB/TrEMBL
	PTHR12081	UniProtKB/TrEMBL
	PTHR12178	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR E2F1	UniProtKB/TrEMBL
Pfam	ABM	UniProtKB/TrEMBL
	E2F_CC-MB	UniProtKB/TrEMBL
	E2F_TDP	UniProtKB/TrEMBL
	EF-hand_5	UniProtKB/TrEMBL
	Tim17	UniProtKB/TrEMBL
PROSITE	ABM	UniProtKB/TrEMBL
	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
SMART	E2F_TDP	UniProtKB/TrEMBL
	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF144074	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
	SSF54909	UniProtKB/TrEMBL
UniProt	A0A8C0JV99	ENTREZGENE
	A0A8C0NWJ1_CANLF	UniProtKB/TrEMBL
	A0A8C0Q8Y6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PK29	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3Q692_CANLF	UniProtKB/TrEMBL
	A0A8P0N9W4_CANLF	UniProtKB/TrEMBL
	A0A8P0NYD7_CANLF	UniProtKB/TrEMBL
	A0A8P0P8I8_CANLF	UniProtKB/TrEMBL
	A0A8P0PJZ3_CANLF	UniProtKB/TrEMBL
UniProt Secondary	A0A8P0THK6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-11-22	E2F1	E2F transcription factor 1	NECAB3	N-terminal EF-hand calcium binding protein 3	Name and Symbol changed	629549	APPROVED
2021-07-26	NECAB3	N-terminal EF-hand calcium binding protein 3	E2F1	E2F transcription factor 1	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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