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Gene: E2F1 (E2F transcription factor 1) Canis lupus familiaris

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Symbol:

E2F1

Name:

E2F transcription factor 1

RGD ID:

12412586

Description:

ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein kinase binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anoikis (ortholog); cellular response to fatty acid (ortholog); cellular response to hypoxia (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN nuclear chromosome (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transcription factor E2F1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	22,895,149 - 22,904,689 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	22,878,402 - 22,904,656 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	22,540,395 - 22,549,906 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	23,581,877 - 23,591,392 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	23,581,862 - 23,616,878 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	22,874,367 - 22,883,878 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	22,967,923 - 22,977,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,399,012 - 23,408,523 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chronic myeloid leukemia (ISO)

COVID-19 (ISO)

dementia (ISO)

disease of cellular proliferation (ISO)

genetic disease (ISO)

glioblastoma (ISO)

glutathione synthetase deficiency (ISO)

glutatione synthetase deficiency with 5-oxoprolinuria (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

Huntington's disease (ISO)

hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (ISO)

long QT syndrome (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

lung small cell carcinoma (ISO)

lung squamous cell carcinoma (ISO)

melanoma (ISO)

Neoplasm Metastasis (ISO)

osteosarcoma (ISO)

pancreatic adenocarcinoma (ISO)

pancreatic cancer (ISO)

pancreatic ductal adenocarcinoma (ISO)

prostate cancer (ISO)

Sjogren's syndrome (ISO)

type 1 diabetes mellitus (ISO)

urinary bladder cancer (ISO)

viral encephalitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anoikis (IEA,ISO)

cellular response to fatty acid (ISO)

cellular response to hypoxia (ISO)

cellular response to nerve growth factor stimulus (ISO)

cellular response to xenobiotic stimulus (IEA,ISO)

DNA damage checkpoint signaling (IEA)

DNA-templated transcription (IEA)

forebrain development (IEA,ISO)

intrinsic apoptotic signaling pathway by p53 class mediator (IEA,ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (IEA)

lens fiber cell apoptotic process (IEA,ISO)

mRNA stabilization (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of fat cell differentiation (IEA)

negative regulation of fat cell proliferation (IEA)

negative regulation of transcription by RNA polymerase II (IEA)

positive regulation of apoptotic process (IEA)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of fibroblast proliferation (IEA)

positive regulation of gene expression (IEA)

positive regulation of glial cell proliferation (ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of cell cycle (IEA,ISO)

regulation of DNA-templated transcription (IEA,ISO)

regulation of G1/S transition of mitotic cell cycle (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA,IEA)

response to lipopolysaccharide (IEA)

spermatogenesis (ISO)

Cellular Component

centrosome (IEA)

chromatin (IEA)

cytoplasm (IEA)

nuclear chromosome (ISO)

nucleoplasm (IEA)

nucleus (IEA,ISO)

protein-containing complex (IEA)

Rb-E2F complex (IBA,IEA)

RNA polymerase II transcription regulator complex (IEA)

transcription regulator complex (IEA)

Molecular Function

calcium ion binding (IEA)

cis-regulatory region sequence-specific DNA binding (IEA)

DNA binding (IEA)

DNA-binding transcription activator activity (IEA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

DNA-binding transcription factor binding (IEA)

metal ion binding (IEA)

molecular adaptor activity (ISO)

protein binding (ISO)

protein dimerization activity (IEA)

protein kinase binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA)

transcription cis-regulatory region binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

E2F1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	22,895,149 - 22,904,689 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	22,878,402 - 22,904,656 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	22,540,395 - 22,549,906 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	23,581,877 - 23,591,392 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	23,581,862 - 23,616,878 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	22,874,367 - 22,883,878 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	22,967,923 - 22,977,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,399,012 - 23,408,523 (-)	NCBI		UU_Cfam_GSD_1.0

E2F1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	33,675,477 - 33,686,385 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	33,675,477 - 33,686,385 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	32,263,283 - 32,274,191 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	31,727,150 - 31,737,854 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	31,727,149 - 31,737,854	NCBI
Celera	20	29,016,324 - 29,027,242 (-)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	29,049,266 - 29,060,184 (-)	NCBI		HuRef
CHM1_1	20	32,164,384 - 32,175,302 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	35,402,008 - 35,412,916 (-)	NCBI		T2T-CHM13v2.0

E2f1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	154,401,320 - 154,411,812 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	154,401,327 - 154,411,812 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	154,559,400 - 154,569,892 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	154,559,407 - 154,569,892 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	154,385,375 - 154,395,588 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	154,251,080 - 154,261,293 (-)	NCBI		MGSCv36	mm8
Celera	2	160,474,227 - 160,486,251 (-)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	76.79	NCBI

E2f1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	163,524,739 - 163,535,563 (-)	NCBI		GRCr8
mRatBN7.2	3	143,064,535 - 143,075,362 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,049,478 - 143,075,361 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	146,931,136 - 146,941,990 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	155,549,300 - 155,560,154 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	153,288,668 - 153,299,512 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	150,062,895 - 150,073,721 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,047,826 - 150,073,721 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	156,435,530 - 156,446,390 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	145,032,489 - 145,043,729 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	144,943,133 - 144,943,246 (-)	NCBI
Celera	3	141,799,009 - 141,809,945 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

E2f1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	27,633,827 - 27,642,241 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	27,638,625 - 27,643,261 (+)	NCBI	ChiLan1.0	ChiLan1.0

E2F1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	39,366,654 - 39,382,253 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	39,359,755 - 39,370,541 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	29,963,083 - 29,973,860 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	31,103,764 - 31,115,211 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	31,103,764 - 31,110,604 (-)	Ensembl	panpan1.1		panPan2

E2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	171,848,495 - 171,859,005 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	6,896,063 - 6,900,026 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	6,894,827 - 6,901,058 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

E2F1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	37,178,599 - 37,189,883 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	37,178,587 - 37,190,118 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	42,116,195 - 42,125,518 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

E2F1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	37,968,541 - 37,980,461 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	37,968,556 - 37,980,326 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	88,901,404 - 88,913,369 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

E2f1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	5,602,432 - 5,612,951 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	5,602,432 - 5,612,951 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in E2F1
62 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005634944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005634945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038433535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038508717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038572031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038636281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000011898 ⟹ ENSCAFP00000011032

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000011921 ⟹ ENSCAFP00000011055

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,896,232 - 22,904,656 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000072769 ⟹ ENSCAFP00000064033

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000082615 ⟹ ENSCAFP00000063121

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,896,389 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000084659 ⟹ ENSCAFP00000048349

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,526 - 22,894,179 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000087491 ⟹ ENSCAFP00000059437

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000091089 ⟹ ENSCAFP00000066271

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	24	22,878,402 - 22,894,213 (-)	Ensembl

RefSeq Acc Id:

XM_005634945 ⟹ XP_005635002

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	24	22,895,149 - 22,904,689 (-)	NCBI
Dog10K_Boxer_Tasha	24	22,540,395 - 22,549,906 (-)	NCBI

Sequence:

show sequence

CCTGCCACCCGGGCCGCGCGGGCCGTGAGCGCCATGGCCGTGGCCGGGGCCCCCGCAGGCGGCC
CATGCGCGCCGGCGCTGGAGGCCCTGCTCGGGGCCGGCGCGCTGCGGCTGCTCGACTCCTCGCA
GATCGTCATCATCTCCACGGCGCAGGACGCCAGCGCCCCGCCGGCCCCCGCCGGCCCGGCCGCG
CCGGCCGCTGGCCCCCGCGACCCCGACCTGCTGCTCTTCGCCACGCCGCAGGCGCCCCGGCCCA
CACCCAGCGCGCCGCGCCCTGCGCTCGGCCGCCCGCCGGTAAAGCGGAGGTTGGACCTGGAAAC
TGACCATCAGTACCTGGCTGAGAGCAGTGGGCCAGCCCGGGGCAGAGGCCGCCACCCAGGAAAA
GGTGTGAAATCCCCAGGGGAGAAGTCACGCTATGAGACCTCACTGAATCTGACCACAAAACGCT
TCCTGGAGCTGCTGAGCCGCTCGGCTGATGGCGTTGTTGATCTGAACTGGGCGGCTGAGGTGTT
GAAGGTGCAGAAACGGCGCATCTATGACATCACCAACGTCCTCGAGGGCATCCAGCTCATTGCC
AAGAAGTCTAAGAACCACATCCAGTGGCTAGGCAGCCATGCAGCAGTGGGGATCAGTGGGCGGC
TTGAAGGACTGACTCAGGACCTCCGGCAGCTGCAGGAGAGTGAGCGGCAGCTGGACCACCTGAT
CCATATCTGCACCACACAACTGCGGCTGCTCGCTGAGGACTCCGACAGCCAGCGCCTGGCCTAC
GTGACCTGCCAGGACCTTCGTAGCATCGCAGACCCTGCAGAGCAGATGGTCATGGTGATCAAGG
CCCCTCCTGAGACCCAGCTCCAAGCCATAGACTCCTCAGAGACCTTTCAGATCTCCCTTAAGAG
CAAACAAGGCCCCATTGACGTTTTCCTGTGCCCTGAGGAGAGTGCAGGCGGGATCAGCCCTGGG
AAGACCCCATCCCAGGGGACAGCTTCTGGGGAGGAAGACAGGCCAGTTGACCCTGCCACCACAG
TGCCACCACCATCATCTCCCCCCTCATCCCCTGCTTCGGATCCCAGCCAGTCCCTGCTCAGCCT
GGAGCAAGAACCTCTGCTTTCCCGGATGGGTGGCCTGCGGGCCCCCGTGGACGAGGACCGCCTG
TCCCCGCTGGTGGCGGCCGACTCGCTCCTGGAACATGCACGGGAGGATTTTTCCGGCCTCCTCC
CTGAGGAGTTCATCAGCCTGTCCCCACCCCACGAGGCTCTCGACTACCACTTTGGCCTTGAGGA
GGGTGAGGGCATCAGAGACCTCTTCGACTGTGACTTTGGGGACCTTACCCCTCTGGATTTCTGA
TGGGGCTTAGGGGGACCAGGGCCTCCTGAGATGCCCACCCTGTCTCTGCAGCCCTGGAGCCCCC
TACCCCTGGCCGTCCTCCCAGCCCAATTGGAAACATTTAATTTATACCCCTCTCCCCTATCTCC
AGAAGCTTTCTTGCTCTGGAGCCTGGCTACTGCCAGGAGGCTAAGCAAGCCAGGAAGGGAAGGA
TTCTGTTTGTGGTGTGTATGTGCATGCACCCAACACCCAACATGTGTGTTACACGGGGTGAATG
GTGTGTGAGCATGTGTGTGTGCATGTACCGGGGAATGAAGGTGAACACATCTGTGCGTGCACTG
AAAACACGCCCCAGTGTGTCCACGTGTGTGTGCATGAGTCCATGTGTGCGCGTGGTGGGGGCTC
TAACTGCACTTTTGGTCTCCTTGCTCCAGGGGCCCCACGAGGCCCAGGGTGGCCACCTGCCCCC
AGAATCCTGTGCGCTGACCAGGCCAGGTGGCGAGGCCTTGGCCTGCTTGTTTGCAGGACAGCGA
GAGCACTTCTGTCGTCTTAAAGGTTTTTCTGATCGAAGCTTTAATGGAGCGTTATTTATTTATC
GAGGCCTCTTTGGCAAGCCTGGGGCACCAGCAAAGGGTAGGAGGGATGTGGGGCTGTTGCCCCA
ACTCCCTATAGCCCTGAGCAGGGCAGGGGTCCCTGAGCTATTCTTTGCCCTCCTCCGAAGGAGC
TGAGGCCTGAGCGGTTTATTTATTGGGAAAGTGAGGGAGGGAGCCAGACGGACGGACCGACTGA
CTAACAGCCATGGGTGGATCAAGGGGGTGGTCCCTCCCCTGGGGTCACTACAGGGCCCCAACTG
CCCCCCAGGATGGATGTGAGATGCGAGAGGTGAGTGGGGGACCTTCACTGACCGGGTGGGTAGG
AGGGGTGGCTGAAGGGCTTCCCCTGGCCCAGACTGCGGGGAGGGGGGGCCCTCTGTCCCGCTCG
TTGCTCTGCCCCACTCGTTGCTCTGCCCCACCCTCCAATCTGCACTTTGATTTGCCTTCCTAAC
CGCTCTGTTCCCTCCTGCTTTGGTTTTAATAAATATTTTGATGGTGTTTGGGCTGGGTA

hide sequence

RefSeq Acc Id:

XM_038433535 ⟹ XP_038289463

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	24	23,581,877 - 23,591,392 (-)	NCBI

RefSeq Acc Id:

XM_038508717 ⟹ XP_038364645

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	24	22,874,367 - 22,883,878 (-)	NCBI

RefSeq Acc Id:

XM_038572031 ⟹ XP_038427959

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	24	23,399,012 - 23,408,523 (-)	NCBI

RefSeq Acc Id:

XM_038636281 ⟹ XP_038492209

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	24	22,967,923 - 22,977,434 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005635002	(Get FASTA)	NCBI Sequence Viewer
	XP_038289463	(Get FASTA)	NCBI Sequence Viewer
	XP_038364645	(Get FASTA)	NCBI Sequence Viewer
	XP_038427959	(Get FASTA)	NCBI Sequence Viewer
	XP_038492209	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000011032.4
	ENSCAFP00000011055.5
	ENSCAFP00000048349.2
	ENSCAFP00000059437.2
	ENSCAFP00000066271.2
	ENSCAFP00000070321.1
	ENSCAFP00030030659.1
	ENSCAFP00030031196.1
	ENSCAFP00040010536.1
	ENSCAFP00845034835.1
	ENSCAFP00845034906
	ENSCAFP00845034906.1

RefSeq Acc Id:

XP_005635002 ⟸ XM_005634945

- UniProtKB:

A0A8C0Q8Y6 (UniProtKB/TrEMBL), A0A8I3PK29 (UniProtKB/TrEMBL), A0A8C0JV99 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISTAQDASAPPAPAGPAAPAAGPRDPDLL
LFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRY
ETSLNLTTKRFLELLSRSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLG
SHAAVGISGRLEGLTQDLRQLQESERQLDHLIHICTTQLRLLAEDSDSQRLAYVTCQDLRSIAD
PAEQMVMVIKAPPETQLQAIDSSETFQISLKSKQGPIDVFLCPEESAGGISPGKTPSQGTASGE
EDRPVDPATTVPPPSSPPSSPASDPSQSLLSLEQEPLLSRMGGLRAPVDEDRLSPLVAADSLLE
HAREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF

hide sequence

Ensembl Acc Id:

ENSCAFP00000011032 ⟸ ENSCAFT00000011898

Ensembl Acc Id:

ENSCAFP00000048349 ⟸ ENSCAFT00000084659

Ensembl Acc Id:

ENSCAFP00000011055 ⟸ ENSCAFT00000011921

Ensembl Acc Id:

ENSCAFP00000059437 ⟸ ENSCAFT00000087491

Ensembl Acc Id:

ENSCAFP00000064033 ⟸ ENSCAFT00000072769

Ensembl Acc Id:

ENSCAFP00000063121 ⟸ ENSCAFT00000082615

Ensembl Acc Id:

ENSCAFP00000066271 ⟸ ENSCAFT00000091089

RefSeq Acc Id:

XP_038364645 ⟸ XM_038508717

RefSeq Acc Id:

XP_038492209 ⟸ XM_038636281

RefSeq Acc Id:	XP_038289463 ⟸ XM_038433535
- UniProtKB:	A0A8C0Q8Y6 (UniProtKB/TrEMBL), A0A8I3PK29 (UniProtKB/TrEMBL), A0A8C0JV99 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038427959 ⟸ XM_038572031
- UniProtKB:	A0A8C0JV99 (UniProtKB/TrEMBL), A0A8C0Q8Y6 (UniProtKB/TrEMBL), A0A8I3PK29 (UniProtKB/TrEMBL)

Protein Domains

ABM E2F/DP family winged-helix DNA-binding EF-hand

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000007429	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00000055011	UniProtKB/TrEMBL
	ENSCAFG00030019095	UniProtKB/TrEMBL
	ENSCAFG00030019453	UniProtKB/TrEMBL
	ENSCAFG00040006517	UniProtKB/TrEMBL
	ENSCAFG00845025182	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000011898.5	UniProtKB/TrEMBL
	ENSCAFT00000011921.6	UniProtKB/TrEMBL
	ENSCAFT00000084659.2	UniProtKB/TrEMBL
	ENSCAFT00000087491.2	UniProtKB/TrEMBL
	ENSCAFT00000091089.2	UniProtKB/TrEMBL
	ENSCAFT00000094699.1	UniProtKB/TrEMBL
	ENSCAFT00030035162.1	UniProtKB/TrEMBL
	ENSCAFT00030035765.1	UniProtKB/TrEMBL
	ENSCAFT00040012154.1	UniProtKB/TrEMBL
	ENSCAFT00845044456.1	UniProtKB/TrEMBL
	ENSCAFT00845044551	ENTREZGENE
	ENSCAFT00845044551.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	3.30.70.100	UniProtKB/TrEMBL
	6.10.250.540	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	ABM_dom	UniProtKB/TrEMBL
	Dimeric_a/b-barrel	UniProtKB/TrEMBL
	E2F	UniProtKB/TrEMBL
	E2F-DP_heterodim	UniProtKB/TrEMBL
	E2F_CC-MB	UniProtKB/TrEMBL
	E2F_WHTH_DNA-bd_dom	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	NECAB1/2/3	UniProtKB/TrEMBL
	Pmp4	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	cfa:485839	UniProtKB/TrEMBL
NCBI Gene	E2F1	ENTREZGENE
PANTHER	N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 3	UniProtKB/TrEMBL
	PEROXISOMAL MEMBRANE PROTEIN 4	UniProtKB/TrEMBL
	PEROXISOMAL MEMBRANE PROTEIN 4	UniProtKB/TrEMBL
	PTHR12081	UniProtKB/TrEMBL
	PTHR12178	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR E2F1	UniProtKB/TrEMBL
Pfam	ABM	UniProtKB/TrEMBL
	E2F_CC-MB	UniProtKB/TrEMBL
	E2F_TDP	UniProtKB/TrEMBL
	EF-hand_5	UniProtKB/TrEMBL
	Tim17	UniProtKB/TrEMBL
PROSITE	ABM	UniProtKB/TrEMBL
	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
SMART	E2F_TDP	UniProtKB/TrEMBL
	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF144074	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
	SSF54909	UniProtKB/TrEMBL
UniProt	A0A8C0JV99	ENTREZGENE
	A0A8C0NWJ1_CANLF	UniProtKB/TrEMBL
	A0A8C0Q8Y6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PK29	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3Q692_CANLF	UniProtKB/TrEMBL
	A0A8P0N9W4_CANLF	UniProtKB/TrEMBL
	A0A8P0NYD7_CANLF	UniProtKB/TrEMBL
	A0A8P0P8I8_CANLF	UniProtKB/TrEMBL
	A0A8P0PJZ3_CANLF	UniProtKB/TrEMBL
UniProt Secondary	A0A8P0THK6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-11-22	E2F1	E2F transcription factor 1	NECAB3	N-terminal EF-hand calcium binding protein 3	Name and Symbol changed	629549	APPROVED
2021-07-26	NECAB3	N-terminal EF-hand calcium binding protein 3	E2F1	E2F transcription factor 1	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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