TIMP2 (TIMP metallopeptidase inhibitor 2) - Rat Genome Database

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Gene: TIMP2 (TIMP metallopeptidase inhibitor 2) Canis lupus familiaris
Analyze
Symbol: TIMP2
Name: TIMP metallopeptidase inhibitor 2
RGD ID: 12436345
Description: ENCODES a protein that exhibits enzyme activator activity (ortholog); integrin binding (ortholog); metalloendopeptidase inhibitor activity (ortholog); INVOLVED IN aging (ortholog); cellular response to organic substance (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); Brain Injuries (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOW QUALITY PROTEIN: metalloproteinase inhibitor 2; metalloproteinase inhibitor 2; TIMP-2; tissue inhibitor of matrix metalloproteinase-2; tissue inhibitor of metalloproteinase-2; tissue inhibitor of metalloproteinases 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,521,882 - 2,533,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,521,882 - 2,533,989 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,159,531 - 3,168,419 (+)NCBI
Dog10K_Boxer_Tasha93,146,850 - 3,191,997 (+)NCBI
ROS_Cfam_1.093,140,666 - 3,188,540 (+)NCBI
UMICH_Zoey_3.193,175,669 - 3,184,556 (+)NCBI
UMICH_Zoey_3.193,162,992 - 3,208,134 (+)NCBI
UNSW_CanFamBas_1.093,288,768 - 3,333,886 (+)NCBI
UNSW_CanFamBas_1.093,301,440 - 3,310,326 (+)NCBI
UU_Cfam_GSD_1.093,369,678 - 3,414,817 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11182158   PMID:17604063   PMID:18717642   PMID:22520817   PMID:24639125   PMID:26335992  


Genomics

Comparative Map Data
TIMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,521,882 - 2,533,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,521,882 - 2,533,989 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,159,531 - 3,168,419 (+)NCBI
Dog10K_Boxer_Tasha93,146,850 - 3,191,997 (+)NCBI
ROS_Cfam_1.093,140,666 - 3,188,540 (+)NCBI
UMICH_Zoey_3.193,175,669 - 3,184,556 (+)NCBI
UMICH_Zoey_3.193,162,992 - 3,208,134 (+)NCBI
UNSW_CanFamBas_1.093,288,768 - 3,333,886 (+)NCBI
UNSW_CanFamBas_1.093,301,440 - 3,310,326 (+)NCBI
UU_Cfam_GSD_1.093,369,678 - 3,414,817 (+)NCBI
TIMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1778,852,977 - 78,925,387 (-)EnsemblGRCh38hg38GRCh38
GRCh381778,852,977 - 78,925,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,849,059 - 76,921,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361774,360,654 - 74,433,067 (-)NCBINCBI36hg18NCBI36
Build 341774,360,655 - 74,433,067NCBI
Celera1773,446,776 - 73,467,725 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1772,271,475 - 72,343,528 (-)NCBIHuRef
CHM1_11776,912,998 - 76,985,403 (-)NCBICHM1_1
Timp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,191,887 - 118,246,237 (-)NCBIGRCm39mm39
GRCm39 Ensembl11118,191,895 - 118,246,566 (-)Ensembl
GRCm3811118,301,061 - 118,355,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,301,069 - 118,355,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711118,162,375 - 118,216,725 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611118,117,151 - 118,171,501 (-)NCBImm8
Celera11130,046,014 - 130,100,382 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.09NCBI
Timp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210103,541,199 - 103,590,611 (-)NCBI
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Celera10102,103,187 - 102,150,797 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Timp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555063,768,646 - 3,813,820 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555063,769,113 - 3,812,896 (+)NCBIChiLan1.0ChiLan1.0
TIMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11778,476,807 - 78,495,885 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1778,476,807 - 78,495,649 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01772,928,692 - 73,001,892 (-)NCBIMhudiblu_PPA_v0panPan3
Timp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,160,813 - 3,179,526 (+)NCBI
SpeTri2.0NW_0049365943,232,433 - 3,244,241 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,254,493 - 3,300,835 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,254,794 - 3,300,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2123,294,254 - 3,340,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,819,591 - 70,850,471 (-)NCBI
ChlSab1.1 Ensembl1670,819,139 - 70,850,471 (-)Ensembl
Timp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248018,228,618 - 8,270,606 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 15 6 6 1 11 8 10 6
Low 7 6 6 5 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022422662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038610428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038624281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038624285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF095638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF188489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000039373   ⟹   ENSCAFP00000035219
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl92,521,882 - 2,533,989 (+)Ensembl
RefSeq Acc Id: NM_001003082   ⟹   NP_001003082
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.192,521,882 - 2,533,883 (+)NCBI
Dog10K_Boxer_Tasha93,146,850 - 3,191,997 (+)NCBI
ROS_Cfam_1.093,140,666 - 3,185,817 (+)NCBI
UMICH_Zoey_3.193,162,992 - 3,208,134 (+)NCBI
UNSW_CanFamBas_1.093,288,768 - 3,333,886 (+)NCBI
UU_Cfam_GSD_1.093,369,678 - 3,414,817 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022422662   ⟹   XP_022278370
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha93,159,532 - 3,168,419 (+)NCBI
RefSeq Acc Id: XM_038484763   ⟹   XP_038340691
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.193,175,669 - 3,184,556 (+)NCBI
RefSeq Acc Id: XM_038484764   ⟹   XP_038340692
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.193,175,669 - 3,184,556 (+)NCBI
RefSeq Acc Id: XM_038484765   ⟹   XP_038340693
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.193,175,670 - 3,184,556 (+)NCBI
RefSeq Acc Id: XM_038610428   ⟹   XP_038466356
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.093,301,440 - 3,310,326 (+)NCBI
RefSeq Acc Id: XM_038624281   ⟹   XP_038480209
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha93,159,531 - 3,168,419 (+)NCBI
RefSeq Acc Id: XM_038624285   ⟹   XP_038480213
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha93,159,531 - 3,168,419 (+)NCBI
RefSeq Acc Id: XM_038674944   ⟹   XP_038530872
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,153,349 - 3,162,236 (+)NCBI
RefSeq Acc Id: XM_038674945   ⟹   XP_038530873
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,153,349 - 3,162,236 (+)NCBI
RefSeq Acc Id: XM_038674946   ⟹   XP_038530874
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,153,350 - 3,162,236 (+)NCBI
RefSeq Acc Id: XM_038674947   ⟹   XP_038530875
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,152,768 - 3,188,540 (+)NCBI
RefSeq Acc Id: XM_038674948   ⟹   XP_038530876
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,147,421 - 3,188,540 (+)NCBI
RefSeq Acc Id: XM_038674949   ⟹   XP_038530877
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,152,833 - 3,188,540 (+)NCBI
RefSeq Acc Id: XM_038674950   ⟹   XP_038530878
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,159,656 - 3,188,540 (+)NCBI
RefSeq Acc Id: XM_038674951   ⟹   XP_038530879
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.093,162,906 - 3,188,540 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001003082   ⟸   NM_001003082
- Peptide Label: precursor
- UniProtKB: Q9TTY1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000035219   ⟸   ENSCAFT00000039373
RefSeq Acc Id: XP_038340692   ⟸   XM_038484764
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038340691   ⟸   XM_038484763
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038340693   ⟸   XM_038484765
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038466356   ⟸   XM_038610428
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038530876   ⟸   XM_038674948
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038530875   ⟸   XM_038674947
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038530877   ⟸   XM_038674949
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038530873   ⟸   XM_038674945
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530872   ⟸   XM_038674944
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530874   ⟸   XM_038674946
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530878   ⟸   XM_038674950
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038530879   ⟸   XM_038674951
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038480213   ⟸   XM_038624285
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038480209   ⟸   XM_038624281
- Peptide Label: isoform X1
RefSeq Acc Id: XP_022278370   ⟸   XM_022422662
- Peptide Label: isoform X1
Protein Domains
NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005528 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFG00040003116 UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000035219 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00040005109 UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000039373 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00040005922 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/Swiss-Prot
KEGG Report cfa:403633 UniProtKB/Swiss-Prot
NCBI Gene TIMP2 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11844:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1Q4F9_CANLF UniProtKB/TrEMBL
  Q9TTY1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O77804 UniProtKB/Swiss-Prot
  Q9TTE9 UniProtKB/Swiss-Prot