DPYD (dihydropyrimidine dehydrogenase) - Rat Genome Database
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Gene: DPYD (dihydropyrimidine dehydrogenase) Canis lupus familiaris
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Symbol: DPYD
Name: dihydropyrimidine dehydrogenase
RGD ID: 12386848
Description: ENCODES a protein that exhibits dihydropyrimidine dehydrogenase (NADP+) activity (ortholog); dihydrouracil dehydrogenase (NAD+) activity (ortholog); FAD binding (ortholog); INVOLVED IN aging (ortholog); circadian rhythm (ortholog); CMP catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dihydropyrimidine dehydrogenase [NADP(+)]
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl651,814,573 - 52,580,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1651,789,786 - 52,564,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Genomics

Comparative Map Data
DPYD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl651,814,573 - 52,580,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1651,789,786 - 52,564,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
DPYD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl197,077,743 - 97,995,000 (-)EnsemblGRCh38hg38GRCh38
GRCh38197,077,743 - 97,921,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,543,299 - 98,386,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,315,887 - 98,159,203 (-)NCBINCBI36hg18NCBI36
Build 34197,255,322 - 98,098,600NCBI
Celera195,797,301 - 96,640,303 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef195,664,181 - 96,508,076 (-)NCBIHuRef
CHM1_1197,659,318 - 98,502,216 (-)NCBICHM1_1
Dpyd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393118,355,758 - 119,226,573 (+)NCBIGRCm39mm39
GRCm383118,562,109 - 119,432,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv373118,265,096 - 119,135,836 (+)NCBIGRCm37mm9NCBIm37
MGSCv363118,554,182 - 119,424,922 (+)NCBImm8
Celera3124,970,410 - 125,843,833 (+)NCBICelera
Cytogenetic Map3G1NCBI
Dpyd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22206,609,043 - 207,474,982 (+)NCBI
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q41NCBI
Dpyd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554352,007,185 - 2,766,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554352,007,185 - 2,800,907 (-)NCBIChiLan1.0ChiLan1.0
DPYD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1198,457,934 - 99,300,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,736,145 - 100,576,663 (-)NCBIMhudiblu_PPA_v0panPan3
Dpyd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365371,660,461 - 2,439,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,458 - 120,712,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12035,376,738 - 36,215,388 (+)NCBI
ChlSab1.1 Ensembl2035,377,266 - 36,215,679 (+)Ensembl


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 21 6 5 6 6 6 10 6
Low 3 5 1 1 5 6 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022420437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022420438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038541239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038541240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038541241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038541242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038605389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038605390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038605391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038605392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038670024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038670025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038670026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038670027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000031930   ⟹   ENSCAFP00000029730
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl651,814,592 - 52,580,923 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063022   ⟹   ENSCAFP00000045114
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl651,814,573 - 52,563,522 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078643   ⟹   ENSCAFP00000057935
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl651,814,592 - 52,580,923 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000086283   ⟹   ENSCAFP00000048248
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl651,814,592 - 52,563,522 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000086874   ⟹   ENSCAFP00000047403
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl651,814,592 - 52,563,522 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090512   ⟹   ENSCAFP00000054999
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl651,814,592 - 52,563,522 (+)Ensembl
RefSeq Acc Id: XM_022420437   ⟹   XP_022276145
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1651,789,786 - 52,564,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022420438   ⟹   XP_022276146
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1651,881,388 - 52,564,802 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_022276145   ⟸   XM_022420437
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022276146   ⟸   XM_022420438
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000057935   ⟸   ENSCAFT00000078643
RefSeq Acc Id: ENSCAFP00000045114   ⟸   ENSCAFT00000063022
RefSeq Acc Id: ENSCAFP00000048248   ⟸   ENSCAFT00000086283
RefSeq Acc Id: ENSCAFP00000047403   ⟸   ENSCAFT00000086874
RefSeq Acc Id: ENSCAFP00000054999   ⟸   ENSCAFT00000090512
RefSeq Acc Id: ENSCAFP00000029730   ⟸   ENSCAFT00000031930
Protein Domains
4Fe-4S ferredoxin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020062 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000029730 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000045114 UniProtKB/TrEMBL
  ENSCAFP00000047403 UniProtKB/TrEMBL
  ENSCAFP00000048248 UniProtKB/TrEMBL
  ENSCAFP00000054999 UniProtKB/TrEMBL
  ENSCAFP00000057935 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031930 UniProtKB/TrEMBL
  ENSCAFT00000063022 UniProtKB/TrEMBL
  ENSCAFT00000078643 UniProtKB/TrEMBL
  ENSCAFT00000086283 UniProtKB/TrEMBL
  ENSCAFT00000086874 UniProtKB/TrEMBL
  ENSCAFT00000090512 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1060.10 UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
InterPro 4Fe4S_Fe-S-bd UniProtKB/TrEMBL
  4Fe4S_Fe_S_CS UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/TrEMBL
  DPD_II UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  Helical_ferredxn UniProtKB/TrEMBL
NCBI Gene DPYD ENTREZGENE
Pfam DHO_dh UniProtKB/TrEMBL
  Fer4_20 UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/TrEMBL
PROSITE 4FE4S_FER_1 UniProtKB/TrEMBL
  4FE4S_FER_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF46548 UniProtKB/TrEMBL
TIGRFAMs pyrD_sub1_fam UniProtKB/TrEMBL
UniProt A0A5F4BTD7_CANLF UniProtKB/TrEMBL
  A0A5F4BZQ5_CANLF UniProtKB/TrEMBL
  A0A5F4C3V1_CANLF UniProtKB/TrEMBL
  A0A5F4CL66_CANLF UniProtKB/TrEMBL
  A0A5F4CUE7_CANLF UniProtKB/TrEMBL
  E2RSQ9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40081 ENTREZGENE