ADGRB1 (adhesion G protein-coupled receptor B1) - Rat Genome Database

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Gene: ADGRB1 (adhesion G protein-coupled receptor B1) Canis lupus familiaris
Analyze
Symbol: ADGRB1
Name: adhesion G protein-coupled receptor B1
RGD ID: 12310955
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); lipopolysaccharide binding (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); postsynaptic actin cytoskeleton organization (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); genetic disease (ortholog); glioblastoma (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BAI1; brain-specific angiogenesis inhibitor 1; brain-specific angiogenesis inhibitor 1-like; classical arabinogalactan protein 5-like; LOC106559635; LOC106559636; splicing factor, proline- and glutamine-rich-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,627,791 - 36,649,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1336,614,498 - 36,690,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,495,752 - 36,557,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,023,275 - 37,084,917 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,023,070 - 37,084,917 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11336,742,111 - 36,803,620 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01336,831,945 - 36,893,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,253,730 - 37,315,304 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ADGRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,627,791 - 36,649,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1336,614,498 - 36,690,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,495,752 - 36,557,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,023,275 - 37,084,917 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,023,070 - 37,084,917 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11336,742,111 - 36,803,620 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01336,831,945 - 36,893,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,253,730 - 37,315,304 (+)NCBIUU_Cfam_GSD_1.0
ADGRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388142,449,649 - 142,545,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8142,449,430 - 142,545,009 (+)EnsemblGRCh38hg38GRCh38
GRCh378143,531,010 - 143,626,368 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,542,379 - 143,623,370 (+)NCBINCBI36Build 36hg18NCBI36
Build 348143,542,378 - 143,623,369NCBI
Celera8139,855,778 - 139,937,685 (+)NCBICelera
Cytogenetic Map8q24.3ENTREZGENE
HuRef8138,802,096 - 138,882,338 (+)NCBIHuRef
CHM1_18143,585,613 - 143,666,276 (+)NCBICHM1_1
T2T-CHM13v2.08143,591,907 - 143,688,308 (+)NCBIT2T-CHM13v2.0
Adgrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,388,045 - 74,461,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1574,388,044 - 74,461,314 (+)EnsemblGRCm39 Ensembl
GRCm381574,516,196 - 74,589,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,516,195 - 74,589,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371574,346,626 - 74,419,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361574,343,939 - 74,416,478 (+)NCBIMGSCv36mm8
Celera1576,016,847 - 76,094,001 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.22NCBI
Adgrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,293,681 - 108,365,892 (+)NCBIGRCr8
mRatBN7.27106,404,827 - 106,476,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,404,958 - 106,476,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,175,524 - 108,234,904 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,397,026 - 110,456,403 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,345,121 - 110,404,495 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07115,766,484 - 115,828,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07115,675,214 - 115,734,250 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,622,235 - 112,682,897 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17112,656,235 - 112,717,613 (+)NCBI
Celera7102,819,252 - 102,878,228 (+)NCBICelera
Cytogenetic Map7q34NCBI
Adgrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554541,237,363 - 1,314,127 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554541,250,261 - 1,313,547 (+)NCBIChiLan1.0ChiLan1.0
ADGRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27159,880,740 - 159,977,860 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18135,403,850 - 135,501,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08139,154,065 - 139,251,115 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18142,221,371 - 142,277,665 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,220,827 - 142,301,070 (+)Ensemblpanpan1.1panPan2
LOC101964702
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,864,971 - 1,887,131 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364709,248,319 - 9,313,230 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364709,247,749 - 9,313,230 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl41,582,330 - 1,647,573 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.141,582,321 - 1,658,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103237529
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18136,704,318 - 136,784,581 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8136,704,341 - 136,783,991 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660393,266,514 - 3,311,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473514,050,213 - 14,113,534 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473514,049,621 - 14,126,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADGRB1
280 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 20 6 5 6 6 12 10 6
Low 2 1 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022426506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038555664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000001959   ⟹   ENSCAFP00000001808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1336,614,498 - 36,690,936 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078502   ⟹   ENSCAFP00000045818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1336,614,498 - 36,682,645 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000083637   ⟹   ENSCAFP00000063611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1336,614,498 - 36,690,936 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092049   ⟹   ENSCAFP00000049983
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1336,614,498 - 36,639,789 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845025022   ⟹   ENSCAFP00845019683
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1337,023,070 - 37,084,917 (+)Ensembl
RefSeq Acc Id: XM_038428773   ⟹   XP_038284701
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,495,752 - 36,557,393 (+)NCBI
RefSeq Acc Id: XM_038428782   ⟹   XP_038284710
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,495,752 - 36,557,393 (+)NCBI
RefSeq Acc Id: XM_038428792   ⟹   XP_038284720
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,495,752 - 36,557,393 (+)NCBI
RefSeq Acc Id: XM_038428799   ⟹   XP_038284727
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,495,752 - 36,557,393 (+)NCBI
RefSeq Acc Id: XM_038428808   ⟹   XP_038284736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,495,752 - 36,557,393 (+)NCBI
RefSeq Acc Id: XM_038493436   ⟹   XP_038349364
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11336,742,111 - 36,803,620 (+)NCBI
RefSeq Acc Id: XM_038555664   ⟹   XP_038411592
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01337,253,730 - 37,315,304 (+)NCBI
RefSeq Acc Id: XM_038619562   ⟹   XP_038475490
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01336,831,945 - 36,893,408 (+)NCBI
RefSeq Acc Id: XM_038685159   ⟹   XP_038541087
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,023,275 - 37,084,917 (+)NCBI
RefSeq Acc Id: XM_038685160   ⟹   XP_038541088
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,023,275 - 37,084,917 (+)NCBI
RefSeq Acc Id: XM_038685161   ⟹   XP_038541089
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,023,275 - 37,084,917 (+)NCBI
RefSeq Acc Id: XM_038685162   ⟹   XP_038541090
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,023,275 - 37,084,917 (+)NCBI
RefSeq Acc Id: XM_038685163   ⟹   XP_038541091
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,023,275 - 37,084,917 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000045818   ⟸   ENSCAFT00000078502
RefSeq Acc Id: ENSCAFP00000001808   ⟸   ENSCAFT00000001959
RefSeq Acc Id: ENSCAFP00000063611   ⟸   ENSCAFT00000083637
RefSeq Acc Id: ENSCAFP00000049983   ⟸   ENSCAFT00000092049
RefSeq Acc Id: XP_038349364   ⟸   XM_038493436
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038475490   ⟸   XM_038619562
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038541087   ⟸   XM_038685159
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541088   ⟸   XM_038685160
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541089   ⟸   XM_038685161
- Peptide Label: isoform X3
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541090   ⟸   XM_038685162
- Peptide Label: isoform X4
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541091   ⟸   XM_038685163
- Peptide Label: isoform X5
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284701   ⟸   XM_038428773
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284710   ⟸   XM_038428782
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284720   ⟸   XM_038428792
- Peptide Label: isoform X3
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284727   ⟸   XM_038428799
- Peptide Label: isoform X4
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284736   ⟸   XM_038428808
- Peptide Label: isoform X5
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411592   ⟸   XM_038555664
- Peptide Label: isoform X8
- UniProtKB: A0A8I3NI13 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845019683   ⟸   ENSCAFT00845025022
Protein Domains
G-protein coupled receptors family 2 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001269 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845013988 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001959.6 UniProtKB/TrEMBL
  ENSCAFT00000083637.2 UniProtKB/TrEMBL
  ENSCAFT00845025022 ENTREZGENE
  ENSCAFT00845025022.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.610 UniProtKB/TrEMBL
  2.20.100.10 UniProtKB/TrEMBL
  2.60.220.50 UniProtKB/TrEMBL
  4.10.1240.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro AGRB_N UniProtKB/TrEMBL
  GAIN_dom_N UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_brain_angio_inhib UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene ADGRB1 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR B1 UniProtKB/TrEMBL
  ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  AGRB_N UniProtKB/TrEMBL
  GAIN UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  HRM UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS BAIPRECURSOR UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/TrEMBL
  TSP1REPEAT UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_3 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART GPS UniProtKB/TrEMBL
  HormR UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP SSF82895 UniProtKB/TrEMBL
UniProt A0A8I3NI13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S774_CANLF UniProtKB/TrEMBL
  A0A8P0TF38_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:58288 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 ADGRB1  adhesion G protein-coupled receptor B1  LOC106559635  splicing factor, proline- and glutamine-rich-like  Data merged from RGD:12356883 737654 PROVISIONAL
2021-01-14 ADGRB1  adhesion G protein-coupled receptor B1  LOC106559636  brain-specific angiogenesis inhibitor 1-like  Data merged from RGD:12277631 737654 PROVISIONAL
2017-09-12 LOC106559635  splicing factor, proline- and glutamine-rich-like    classical arabinogalactan protein 5-like  Symbol and/or name change 5135510 APPROVED