IL6 (interleukin 6) - Rat Genome Database

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Gene: IL6 (interleukin 6) Canis lupus familiaris
Analyze
Symbol: IL6
Name: interleukin 6
RGD ID: 12079702
Description: ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-6 receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN bone remodeling (ortholog); branching involved in salivary gland morphogenesis (ortholog); cell redox homeostasis (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH amphotericin B; arsenite(3-); lipopolysaccharide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-6; interleukin 6 (interferon, beta 2); interleukin-6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11436,474,268 - 36,478,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1436,015,351 - 36,019,602 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01436,398,579 - 36,402,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1436,397,705 - 36,402,833 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,519,712 - 36,523,966 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01436,216,365 - 36,220,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01436,553,276 - 36,557,530 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute-Phase Reaction  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
aortic valve disease 1  (ISO)
arteriovenous malformations of the brain  (ISO)
Ascorbic Acid Deficiency  (ISO)
aseptic meningitis  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
Bile Duct Neoplasms  (ISO)
biliary tract benign neoplasm  (ISO)
Brain Concussion  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Cadmium Poisoning  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Castleman disease  (ISO)
celiac disease  (ISO)
central nervous system disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemical Burns  (ISO)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
cochlear disease  (ISO)
colitis  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
conjunctival disease  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
disseminated intravascular coagulation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
eclampsia  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
epididymitis  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
familial mediterranean fever  (ISO)
Femoral Fractures  (ISO)
Fetal Inflammatory Response Syndrome  (ISO)
Fever  (ISO)
Foot Injuries  (ISO)
gastric adenocarcinoma  (ISO)
gastric dilatation  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
gingivitis  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Headache  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Heart Injuries  (ISO)
Heat Stress Disorders  (ISO)
Heat Stroke  (ISO)
Helicobacter Infections  (ISO)
hemarthrosis  (ISO)
Hemifacial Spasm  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
HIV Wasting Syndrome  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypercalcemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxaluria  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypoalbuminemia  (ISO)
hypogonadism  (ISO)
hypomyelinating leukodystrophy 5  (ISO)
Hypotension  (ISO)
idiopathic interstitial pneumonia  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
Intraventricular Hemorrhage  (ISO)
iron deficiency anemia  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kaposi's sarcoma  (ISO)
keratitis  (ISO)
keratoconjunctivitis sicca  (ISO)
Kidney Reperfusion Injury  (ISO)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (ISO)
learning disability  (ISO)
leishmaniasis  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
lymphoplasmacytic lymphoma  (ISO)
macular retinal edema  (ISO)
major depressive disorder  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
neurodegenerative disease  (ISO)
neuromyelitis optica  (ISO)
nodular goiter  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
osteoporosis  (ISO)
otitis media  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontal disease  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
peritonitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleural disease  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
polyneuropathy  (ISO)
Postmenopausal Osteoporosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
prediabetes syndrome  (ISO)
Premature Birth  (ISO)
Premature Obstetric Labor  (ISO)
primary ciliary dyskinesia  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
Pulmonary Contusion  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
quadriplegia  (ISO)
rectum cancer  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal vasculitis  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
secondary hyperparathyroidism  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
severe acute respiratory syndrome  (ISO)
Shwartzman phenomenon  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Compression  (ISO)
spinal cord disease  (ISO)
Spinal Cord Injuries  (ISO)
Spine Osteoarthritis  (ISO)
spondyloarthropathy  (ISO)
Spontaneous Abortions  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Subretinal Fibrosis  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
transverse myelitis  (ISO)
Tympanic Membrane Perforation  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
bone remodeling  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
cell differentiation  (IEA)
cell redox homeostasis  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-17  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to nutrient levels  (ISO)
cellular response to prolactin  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to virus  (ISO)
cytokine-mediated signaling pathway  (IEA)
defense response to protozoan  (ISO)
defense response to virus  (IEA)
endocrine pancreas development  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
gene expression  (ISO)
germinal center B cell differentiation  (ISO)
glucagon secretion  (ISO)
glucose homeostasis  (IEA,ISO,ISS)
hepatic immune response  (IEA)
hepatocyte proliferation  (ISS)
immune response  (IEA)
inflammatory response  (IEA)
inflammatory response to wounding  (IEA)
interleukin-6-mediated signaling pathway  (IEA,ISO,ISS)
liver regeneration  (ISS)
lymphocyte costimulation  (ISO)
muscle cell cellular homeostasis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of bone resorption  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of collagen biosynthetic process  (IEA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of interleukin-1-mediated signaling pathway  (ISO)
negative regulation of membrane potential  (ISO)
negative regulation of muscle organ development  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of primary miRNA processing  (IEA,ISO)
negative regulation of protein kinase activity  (ISO)
neuron projection development  (IEA)
neutrophil apoptotic process  (IEA,ISO)
positive regulation of acute inflammatory response  (IEA)
positive regulation of apoptotic DNA fragmentation  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of B cell activation  (IEA)
positive regulation of cell population proliferation  (IBA,IEA)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of estradiol secretion  (ISO)
positive regulation of extracellular matrix disassembly  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IEA)
positive regulation of gliogenesis  (ISO)
positive regulation of immunoglobulin production  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-21 production  (ISO)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of platelet aggregation  (IEA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO)
positive regulation of receptor signaling pathway via STAT  (IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of T cell proliferation  (IEA)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of translation  (IEA)
positive regulation of transmission of nerve impulse  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
positive regulation of vascular endothelial growth factor production  (IEA)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (ISO)
regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
regulation of glucagon secretion  (IEA,ISS)
regulation of insulin secretion  (IEA,ISS)
regulation of vascular endothelial growth factor production  (IEA)
response to activity  (ISS)
response to amino acid  (ISO)
response to auditory stimulus  (ISO)
response to bacterium  (ISO)
response to caffeine  (ISO)
response to calcium ion  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to glucocorticoid  (IEA)
response to Gram-positive bacterium  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
response to yeast  (ISO)
signal transduction  (IEA)
T cell activation  (ISO)
T follicular helper cell differentiation  (ISO)
T-helper 17 cell lineage commitment  (ISS)
T-helper 2 cell differentiation  (ISO)
vascular endothelial growth factor production  (IEA,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7671371   PMID:7913298   PMID:11730929   PMID:14734728   PMID:17806073   PMID:18717642   PMID:21115724   PMID:21708229   PMID:22301074   PMID:22381588   PMID:23659719   PMID:23978557  
PMID:25312048   PMID:25866911   PMID:27357498   PMID:30032202  


Genomics

Comparative Map Data
IL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11436,474,268 - 36,478,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1436,015,351 - 36,019,602 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01436,398,579 - 36,402,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1436,397,705 - 36,402,833 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,519,712 - 36,523,966 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01436,216,365 - 36,220,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01436,553,276 - 36,557,530 (+)NCBIUU_Cfam_GSD_1.0
IL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38722,727,200 - 22,731,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl722,725,884 - 22,732,002 (+)EnsemblGRCh38hg38GRCh38
GRCh37722,766,819 - 22,771,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,733,343 - 22,738,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 34722,540,059 - 22,544,856NCBI
Celera722,752,396 - 22,757,251 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef722,649,846 - 22,654,701 (+)NCBIHuRef
CHM1_1722,767,669 - 22,772,524 (+)NCBICHM1_1
T2T-CHM13v2.0722,861,319 - 22,867,916 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2722,817,875 - 22,822,730 (+)NCBI
Il6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,218,112 - 30,224,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,218,112 - 30,224,979 (+)EnsemblGRCm39 Ensembl
GRCm38530,013,114 - 30,019,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,013,114 - 30,019,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,339,701 - 30,346,508 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,343,948 - 30,350,755 (+)NCBIMGSCv36mm8
Celera527,530,266 - 27,537,070 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.7NCBI
Il6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr845,889,999 - 5,894,575 (-)NCBIGRCr8
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBICelera
Cytogenetic Map4q11NCBI
Il6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541025,079,835 - 25,084,390 (+)NCBIChiLan1.0ChiLan1.0
IL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2627,593,486 - 27,598,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,918,460 - 75,923,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0723,415,922 - 23,420,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1723,027,560 - 23,032,419 (+)NCBIpanpan1.1PanPan1.1panPan2
Il6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,842,756 - 183,843,378 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365497,015,595 - 7,016,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl991,506,421 - 91,511,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,081,042 - 101,085,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q14-q15NCBI
IL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12135,577,513 - 35,582,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,577,939 - 35,582,237 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604269,001,958 - 69,006,830 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247397,957,674 - 7,962,318 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247397,957,709 - 7,963,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL6
33 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5
Low 1 8 1 2 5 6 2
Below cutoff 4 4 10 2 2 4 1 2 8 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000004340   ⟹   ENSCAFP00000004016
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075666   ⟹   ENSCAFP00000053025
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015516   ⟹   ENSCAFP00845012051
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1436,397,705 - 36,402,833 (+)Ensembl
RefSeq Acc Id: NM_001003301   ⟹   NP_001003301
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11436,474,268 - 36,478,519 (+)NCBI
Dog10K_Boxer_Tasha1436,015,351 - 36,019,602 (+)NCBI
ROS_Cfam_1.01436,398,579 - 36,402,833 (+)NCBI
UMICH_Zoey_3.11436,519,712 - 36,523,966 (+)NCBI
UNSW_CanFamBas_1.01436,216,365 - 36,220,619 (+)NCBI
UU_Cfam_GSD_1.01436,553,276 - 36,557,530 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001003301   ⟸   NM_001003301
- Peptide Label: precursor
- UniProtKB: Q9MYZ7 (UniProtKB/Swiss-Prot),   P41323 (UniProtKB/Swiss-Prot),   A0A8C0QU81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000004016   ⟸   ENSCAFT00000004340
RefSeq Acc Id: ENSCAFP00000053025   ⟸   ENSCAFT00000075666
RefSeq Acc Id: ENSCAFP00845012051   ⟸   ENSCAFT00845015516


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002733 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030026220 UniProtKB/TrEMBL
  ENSCAFG00040006867 UniProtKB/TrEMBL
  ENSCAFG00845008825 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004340.5 UniProtKB/TrEMBL
  ENSCAFT00030048521.1 UniProtKB/TrEMBL
  ENSCAFT00040012785.1 UniProtKB/TrEMBL
  ENSCAFT00845015516 ENTREZGENE
  ENSCAFT00845015516.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403985 UniProtKB/Swiss-Prot
NCBI Gene IL6 ENTREZGENE
PANTHER INTERLEUKIN-6 UniProtKB/Swiss-Prot
  INTERLEUKIN-6 UniProtKB/Swiss-Prot
  INTERLEUKIN-6 UniProtKB/TrEMBL
  INTERLEUKIN-6 UniProtKB/TrEMBL
Pfam IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF IL6_MGF_GCSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS IL6GCSFMGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0Q9Q4_CANLF UniProtKB/TrEMBL
  A0A8C0QU81 ENTREZGENE
  A0A8I3N0D8_CANLF UniProtKB/TrEMBL
  A0A8P0S8T1_CANLF UniProtKB/TrEMBL
  G0ZJI8_CANLF UniProtKB/TrEMBL
  G0ZJI9_CANLF UniProtKB/TrEMBL
  IL6_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  Q9MYZ7 ENTREZGENE
UniProt Secondary Q9MYZ7 UniProtKB/Swiss-Prot
VGNC ID VGNC:41992 ENTREZGENE